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Peroxynitrite (ONOO?) is an important kind of reactive oxygen species (ROS), played an essential role in physiology and pathology. To date, various fluorescent probes for ONOO? have been constructed successfully, but these probes exhibit turn-on fluorescence signal in single channel. While, ratiometric fluorescent probes, especially those probes with large emission shift, are suitable for bioimage in two channels. Herein, a hemicyanine-based fluorescent probe named Cy-NH2 was designed and synthesized for ratiometric detection of ONOO?. The characteristics of Cy-NH2 are as follows: (1) The probe possesses a simple structure, which can be obtained by easy synthetic steps; (2) The ratiometric fluorescent probe owns large emission shift (248 nm) due to the disruption of pi-conjugation system caused by strong oxidizing ability of ONOO?; (3) The probe exhibits high sensitivity to ONOO? with 1728-fold enhancement of fluorescence intensity ratio and superior selectivity for ONOO? over various potentially interfering biological analytes; (4) The ratiometric fluorescent probe is applied for the image detection of exogenous and endogenous ONOO? in living cells successfully.
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Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles