Day: September 24, 2020

15861-24-2, Indole-5-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

15861-24-2, After introducing 5-cyanoindole, Boc2O, dichloromethane and DMAP into a 100 ml round-bottomed flask, the reaction medium is stirred at 0 C. under nitrogen for 2 hours. After disappearance of the starting cyanoindole, the reaction medium is poured into water and extracted with EtOAc. After drying and evaporating off the solvent, 1.7191 g of N-Boc-5-cyanoindole are obtained in the form of a yellowish powder. Rf (silica)=0.61; 7/3 cyclohexane/EtOAc. LC/MS m/z=242.

As the paragraph descriping shows that 15861-24-2 is playing an increasingly important role.

Reference£º
Patent; Aventis Pharma S.A.; US2004/242559; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17274-68-9,5-Bromo-3-(2-(pyrrolidin-1-yl)ethyl)-1H-indole,as a common compound, the synthetic route is as follows.

17274-68-9, (i) 5-(4-Hydroxythiapyran-4-yl)-3-(2-pyrrolidinylethyl)-1H-indole (56 %) from 5-bromo-3-(2-pyrrolidinylethyl)-1H-indole (Example 3b); mp 66 – 78 C; HRMS-FAB+ for C19H27N2OS: calculated MH+:331.18442; found MH+:331.18568.

The synthetic route of 17274-68-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NPS Allelix Corp.; EP944595; (2003); B1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

4769-96-4, 6-Nitro-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of compounds 1-4 (6.13 mmol) in ethanol (30 mL) was treated with 10% Pd/C (20 wt. %of 1-4) and subjected overnight to 50 psi H2 (g) in a Parr hydrogenation apparatus. The reaction mixture was filtered and concentrated in vacuo. Pure products 1M-4M were obtained via flash chromatography by eluting with a gradient of 30%-40% EtOAc/hexanes.

4769-96-4, As the paragraph descriping shows that 4769-96-4 is playing an increasingly important role.

Reference£º
Article; Zhang, Da-Jun; Sun, Wen-Fang; Zhong, Zhao-Jin; Gao, Rong-Mei; Yi, Hong; Li, Yu-Huan; Peng, Zong-Gen; Li, Zhuo-Rong; Molecules; vol. 19; 1; (2014); p. 925 – 939;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

90923-75-4, 1-Methyl-1H-indole-5-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,90923-75-4

Take (100mg, 0.535mmol)3-Bromo-1,2-phenylenediamine is dissolved in 5 mL of absolute ethanol,Add (102 mg, 0.641 mmol) 1-methylindole-5-aldehyde, (13.81 mg, 0.080 mmol) p-toluenesulfonic acid, and reflux for 24 h.The reaction was monitored by TLC. After the reaction was completed, the reaction solution was concentrated, and the concentrate was extracted with ethyl acetate-water.The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated.After column chromatography of petroleum ether-ethyl acetate 2: 1, 120 mg of solid was obtained with a yield of 68.8%.

90923-75-4 1-Methyl-1H-indole-5-carbaldehyde 7537534, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Southern Medical University; Chen Jianjun; Ren Yichang; Cheng Binbin; (19 pag.)CN110551104; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37865-86-4,6-Ethoxy-1H-indole,as a common compound, the synthetic route is as follows.

(b) Methyl 2-(6-Ethoxy-1H-indol -3-yl)oxoacetate A 2.0 M solution of oxalyl chloride in methylene chloride (6.65 mL, 13.3 mmol) was added to a solution of 6-ethoxyindole (2.0 g, 12.4 mmol) in ether (25 mL) dropwise over 10 min at 4 C. under N2. The resulting mixture was stirred for 1 h at 4 C. A 25% (w/w) sodium methoxide in methanol solution (6.2 mL, 28.5 mmol) was added at -78 C. The mixture was allowed to warm up to room temperature and stirred for 4 h. The reaction was quenched with water (50 mL) and extracted with methylene chloride. The organic solution was dried (MgSO4) and concentrated at reduced pressure. The residue was stirred in a solution of EtOAc (50 mL) and ether (50 mL) for 10 min. Solid was collected by filtration to give the title compound (2.2 g, 73%) after drying. 1H NR (CDCl3) delta 8.20 (s, 1H), 7.90 (d, J=9 Hz, 1H), 6.92 (s, 1H), 6.82 (d, J=9 Hz, 1H), 4.00 (q, J=6.5 Hz, 2H), 3.78 (s, 3H), 1.30 (t, J=6.5 Hz, 3H), 37865-86-4

As the paragraph descriping shows that 37865-86-4 is playing an increasingly important role.

Reference£º
Patent; Engler, Thomas Albert; Furness, Kelly Wayne; Malhotra, Sushant; Briggs, Stephen Lyle; Brooks, Harold Burns; Clawson, David Keyes; Sanchez-Martinez, Concepcion; Zhang, Faming; Zhu, Guoxin; US2004/48915; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1015460-59-9,7-Bromo-5H-pyrido[4,3-b]indole,as a common compound, the synthetic route is as follows.

Step 3: 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole A mixture of 7-bromo-5H-pyrido[4,3-b]indole (400 mg, 1.63 mmol), (6-fluoropyridin-3-yl)boronic acid (344 mg, 2.44 mmol), PdCl2(dppf) (120 mg, 0.163 mmol), tBu3PHBF4 (95 mg, 0.326 mmol) and Cs2CO3 (1.1 g, 3.26 mmol) in dioxane/water (20 mL, 20:1) was heated to 90 C. for 4 hours under N2. The solid was filtered and the filtrate was evaporated. The residue was purified by chromatography (silica gel, 200-300 mesh, CH2Cl2: MeOH=30:1) to afford 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole (250 mg, 59% yield).

1015460-59-9, 1015460-59-9 7-Bromo-5H-pyrido[4,3-b]indole 71079324, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Arvinas, Inc.; Crew, Andrew P.; Berlin, Michael; Flanagan, John J.; Dong, Hanqing; Ishchenko, Alexey; (559 pag.)US2018/125821; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74420-05-6,N-Methyl-4-chloro-7-azaindole,as a common compound, the synthetic route is as follows.,74420-05-6

To a 100 mL reaction vial was added 4-chloro-1-methyl-1H-pyrrole [2,3-b]pyridine (2.29 g, 10 mmol).Sodium sulfide (1.17 g, 15 mmol), N-methylpyrrolidone (30 mL), Heat to 80 C and stir the reaction for 3 hours. Then, cesium carbonate (6.52 g, 20 mmol) was added to the reaction flask. And 2-bromocyclobutylacetate (2.15 g, 11 mmol), Continue to react at 100 C for 2 hours, After completion of the reaction, water (150 mL) was added, and the mixture was extracted three times with ethyl acetate (3¡Á100 ml). The organic layers are combined and washed with saturated brine. Dry with sodium sulfate and filter. After rotary distillation, the intermediate was obtained as an intermediate 50.3 (2.11 g), yield 60%.

The synthetic route of 74420-05-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chengdu Haichuang Pharmaceutical Co., Ltd.; Fan Lei; Du Wu; Xu Kexin; Chen Ke; Wang Fei; Wu Xiaoquan; Luo Tongchuan; Zhang Shaohua; Li Xinghai; Chen Yuanwei; (67 pag.)CN108659000; (2018); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52488-36-5,4-Bromo-1H-indole,as a common compound, the synthetic route is as follows.,52488-36-5

[00653] To a solution of 4-bromo-1H-indole (2.0 g, 0.01 mol) in DMF (30 mL) was added NaH (0.6 g, 0.015 mol) at 0 C. The resultant solution was stirred at rt for 30 min, then Mel (1.42 g, 0.01 mol) was added and stirred at for 3 h. The reaction mixture was poured into ice-water and extracted with EtOAc, the organic phase was dried over Na2S04, filtered and concentrated, the crude was purified by SGC to obtain 4-bromo-1-methyl-1H-indole (1.05 g, 50%) as a yellow solid.

As the paragraph descriping shows that 52488-36-5 is playing an increasingly important role.

Reference£º
Patent; NAVITOR PHARMACEUTICALS, INC.; MAHONEY, Sarah; MOLZ, Lisa; NARAYAN, Sridhar; SAIAH, Eddine; (516 pag.)WO2018/191146; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.387-44-0,7-Fluoroindole,as a common compound, the synthetic route is as follows.

Synthesis of 3-(7-fluoro-1H-indol-3-yl)-indan-1-one (Method 1) Triethylamine (4.5 mL; 32 mmol; 1.2 equiv.) was added to 3-bromo-indan-1-one (5.6 g; 27 mmol) in 100 mL THF at 0 C. and stirred 1 h at r.t. The reaction mixture was filtered to remove triethylammonium bromide and concentrated in vacuo to give inden-1-one. 7-Fluoroindole (3.3 g, 22 mmol) and Sc(OTf)3 (550mg, 5 mol %) were added to inden-1-one in 100 mL CH2Cl2 at 0 C. The reaction mixture was allowed to warm to room temperature over night. 100 mL ethyl acetate was added and the mixture was filtered through a silica gel plug and concentrated in vacuo. After flash chromatography (heptane/ethyl acetate, silica gel) 5.9 g 3-(7-fluoro-1H-indol-3-yl)-indan-1-one (82%) was isolated.

387-44-0, As the paragraph descriping shows that 387-44-0 is playing an increasingly important role.

Reference£º
Patent; H. Lundbeck A/S; US2008/58329; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6960-42-5,7-Nitro-1H-indole,as a common compound, the synthetic route is as follows.

6960-42-5, To a solution of 7-nitro-indole (5.00 g, 30.84 mmol) in DMF (30 mL) was added bromine (1.6 mL, 33 mmol), and the mixture was stirred at rt for 8 h.Then the reaction mixture was quenched with a saturated aqueous sodium thiosulfate solution (100 mL), and the mixture was extracted with EtOAc (150 mL x 3). The combined organic layers were washed with saturated brine (100 mLx 3), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated in vacuo,and the residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 10/1) to give the title compound as yellow powder (7.21 g, 97%).MS (ESI, pos. ion) m/z: 242.95 [M+Hfb.

The synthetic route of 6960-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; REN, Qingyun; TANG, Changhua; YIN, Junjun; YI, Kai; ZHANG, Yingjun; (264 pag.)WO2018/33082; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles