Day: September 30, 2021

Huynh, TKC; Nguyen, THA; Nguyen, TCT; Hoang, TKD in [Thi-Kim-Chi Huynh; Thi-Hong-An Nguyen; Thi-Cam-Thu Nguyen; Thi-Kim-Dung Hoang] Inst Chem Technol VAST, 01 Mac Dinh Chi Str,Dist 1, Ho Chi Minh City, Vietnam; [Thi-Kim-Chi Huynh; Thi-Kim-Dung Hoang] Grad Univ Sci & Technol VAST, 18 Hoang Quoc Viet Str, Hanoi, Vietnam; [Thi-Cam-Thu Nguyen] Ton Duc Thang Univ, 19 Nguyen Huu Tho Str,Dist 7, Ho Chi Minh City, Vietnam published Synthesis and insight into the structure-activity relationships of 2-phenylbenzimidazoles as prospective anticancer agents in 2020.0, Cited 36.0. Product Details of 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

In order to explore and develop new anticancer agents, three series of 2-phenylbenzimidazoles, 15-46, were condensed under simple and mild conditions using sodium metabisulfite as an oxidation agent and another series, 47-55, were obtained via a reduction reaction using sodium borohydride. All the compounds synthesized were evaluated for their in vitro anticancer activities against three human cancer cell lines. The novel compound 38 was found to be the most potent multi cancer inhibitor against A549, MDA-MB-231, and PC3 cell lines (IC50 values 4.47, 4.68 and 5.50 mu g mL(-1), respectively). In addition, compound 40 exhibited the best IC50 value of 3.55 mu g mL(-1) against the MDA-MB-231 cell line. The results demonstrated that introducing a new substituent to compounds 37-55 could improve their antiproliferative activities.

Product Details of 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Huynh, TKC; Nguyen, THA; Nguyen, TCT; Hoang, TKD or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 SYNLETT published article about PALLADIUM-CATALYZED ARYLATION; ARYL BENZYL SULFOXIDES; PROTON-PUMP INHIBITOR; SULFENATE ANIONS; ASYMMETRIC-SYNTHESIS; CHIRAL SULFOXIDES; ENANTIOSELECTIVE ARYLATION; ENANTIOPURE SULFOXIDES; SELECTIVE OXIDATION; DIARYL SULFOXIDES in [Ji, Yuan-Zhao; Li, Hui-Jing; Yang, Hao-Ran; Zhang, Zheng-Yan; Xie, Li-Jun; Wu, Yan-Chao] Harbin Inst Technol, Sch Marine Sci & Technol, 2 Wenhuaxi Rd, Weihai 264209, Peoples R China; [Li, Hui-Jing; Wu, Yan-Chao] Weihai Inst Marine Biomed Ind Technol, Wendeng Dist 264400, Weihai, Peoples R China in 2020.0, Cited 91.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. COA of Formula: C7H8O2

A new transition-metal-free route for the direct sulfinylation of electron-rich aromatics with sodium arylsulfinates in the presence of TMSOTf is reported. Various electron-rich aromatics, including pyrroles, thiophenes, indoles, and electron-rich arenes, with sodium arylsulfinates are converted into the corresponding sulfoxides in moderate to excellent yields. This protocol possesses many advantages such as readily available and stable starting materials, broad substrate scopes, and transition-metal-free reaction conditions.

About m-Methoxyphenol, If you have any questions, you can contact Ji, YZ; Li, HJ; Yang, HR; Zhang, ZY; Xie, LJ; Wu, YC or concate me.. COA of Formula: C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H8O. In 2019.0 INT J POLYM SCI published article about FABRICATION; CAPSULES; COATINGS in [Yan, Xiaoxing] Nanjing Forestry Univ, Coinnovat Ctr Efficient Proc & Utilizat Forest Re, Nanjing 210037, Jiangsu, Peoples R China; [Yan, Xiaoxing; Chang, Yijuan; Qian, Xingyu] Nanjing Forestry Univ, Coll Furnishings & Ind Design, Nanjing 210037, Jiangsu, Peoples R China in 2019.0, Cited 23.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Urea formaldehyde resin-coated epoxy resin microcapsules were prepared by two-step in situ polymerization. The effects of five factors on the yield, coverage rate, repair rate, and morphology of the microcapsules were investigated by five factors and four levels of orthogonal test. These five factors were the mass ratio of the core to the wall material (Wcore:Wwall), the mass ratio of the emulsifier to the core material (Wemulsifier:Wcore), stirring rate, deposition time, and mass ratio of the emulsifier solution to the core material (Wemulsifier solution:Wcore). The ideal technological level of microcapsule synthesis was determined. According to the results of the range and variance of yield, coverage rate, and repair rate, the comprehensive properties of microcapsules became ideal. At this time, the Wcore:Wwall was 0.8 : 1, Wemulsifier:Wcore was 1 : 100, stirring rate was 600 r/min, deposition time was 32 h, and Wemulsifier solution:Wcore was 8 : 1. When the concentration of microcapsules in the epoxy resin was 10.0%, the self-repair rate was the best and the repair rate was 114.77%. This study is expected to provide a reference value for the preparation of a microcapsule self-healing technology and lay a foundation for the subsequent development of self-healing materials.

About Benzyl Alcohol, If you have any questions, you can contact Yan, XX; Chang, YJ; Qian, XY or concate me.. COA of Formula: C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 3-(Trifluoromethyl)phenol. I found the field of Chemistry very interesting. Saw the article Ambident Reactivity of Phenolate Anions Revisited: A Quantitative Approach to Phenolate Reactivities published in 2019, Reprint Addresses Ofial, AR; Mayr, H (corresponding author), Ludwig Maximilians Univ Munchen, Dept Chem, Butenandtstr 5-13, D-81377 Munich, Germany.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol.

Prompted by the observation that the regioselectivities of phenolate reactions (C versus O attack) are opposite to the predictions by the principle of hard and soft acids and bases, we performed a comprehensive experimental and computational investigation of phenolate reactivities. Rate and equilibrium constants for the reactions of various phenolate ions with benzhydrylium ions (Aryl(2)CH(+)) and structurally related quinone methides have been determined photometrically in polar aprotic solvents. Quantum chemical calculations at the SMD(MeCN)/M06-2X/6-31+G(d,p) level confirmed that O attack is generally favored under kinetically controlled conditions, whereas C attack is favored under thermodynamically controlled conditions. Exceptions are diffusion limited reactions with strong electrophiles, which give mixtures of products arising from O and C attack, as well as reactions with metal alkoxides in nonpolar solvents, where oxygen attack is blocked by strong ion pairing. The Lewis basicity (LB) and nucleophilicity (N, s(N)) parameters of phenolates determined in this work can be used to predict whether their reactions with electrophiles are kinetically or thermodynamically controlled and whether the rates are activation-or diffusion-limited. Comparison of the measured rate constants for the reactions of phenolates with carbocations with the Gibbs energies for single electron transfer manifests that these reactions proceed via polar mechanisms.

Application In Synthesis of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Mayer, RJ; Breugst, M; Hampel, N; Ofial, AR; Mayr, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article ZnO nanostructures: a heterogeneous catalyst for the synthesis of benzoxanthene and pyranopyrazole scaffolds via a multi-component reaction strategy WOS:000613923500015 published article about ONE-POT SYNTHESIS; COMPONENT REACTIONS; DERIVATIVES; XANTHENE; ACID; NANOCRYSTALLINE; PHOTOCATALYST; ULTRAVIOLET; TRIFLATE; FILMS in [Chhattise, Prakash; Chabukswar, Vasant] SavitribaiPhule Pune Univ, NowrosjeeWadia Coll, Ness Wadia Nanomat Res Ctr, Dept Chem, Pune, Maharashtra, India; [Chhattise, Prakash; Pandit, Vikram] SavitribaiPhule Pune Univ, Haribhai V Desai Collge, Dept Chem, Pune 411002, Maharashtra, India; [Saleh, Suheb] Minist Educ, Outstanding Secondary Sch, Anbar, Iraq; [Arbuj, Sudhir] Ctr Mat Elect Technol, Mat Renewable Energy Div, Pashan Rd, Pune 411008, Maharashtra, India in 2020.0, Cited 40.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. COA of Formula: C7H6O2

A hydrothermal technique is employed for the preparation of nanostructured ZnO. The reaction was carried out at 180 degrees C for 2 h in the presence of ethylenediamine (EDA) as a capping agent and was characterized by X-ray diffraction (XRD), scanning electron microscopy (FESEM), and transmission electron microscopy (TEM). XRD indicates the formation of highly crystalline ZnO having a wurtzite structure. FESEM analysis validates the formation of a submicron size spherical shaped marigold flower like morphology. The nanostructured ZnO was screened for its catalytic activity as a heterogeneous catalyst for the multicomponent synthesis of benzoxanthenes and pyranopyrazole derivatives in good to excellent yield. The major advantages associated with this methodology include ease of separation and reusability of the catalyst, easy work-up and short reaction time.

COA of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Chhattise, P; Saleh, S; Pandit, V; Arbuj, S; Chabukswar, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Munoz, A; Leo, P; Orcajo, G; Martinez, F; Calleja, G in [Munoz, Antonio; Orcajo, Gisela; Calleja, Guillermo] Rey Juan Carlos Univ, Dept Chem Energy & Mech Technol, C Tulipan S-N, Mostoles 28933, Spain; [Leo, Pedro; Martinez, Fernando] Rey Juan Carlos Univ, Dept Chem & Environm Technol, C Tulipan S-N, Mostoles 28933, Spain published URJC-1-MOF as New Heterogeneous Recyclable Catalyst for C-Heteroatom Coupling Reactions in 2019, Cited 41. Recommanded Product: 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Guillermo Calleja and co-workers from @urjc describe URJC-1-MOF as a new heterogeneous recyclable catalyst for c-heteroatom coupling reactions The capacity of copper-based URJC-1-MOF as a MOF catalyst in cross-coupling reactions has been evaluated, focusing on the Chan-Lam-Evans arylation-type reactions on amines and alcohols without extra additives or ligands. The extraordinary chemical and structural stability of URJC-1-MOF and its good specific surface, make this material a promising alternative to homogeneous Cu (II) catalysts for cross-coupling reactions. URJC-1-MOF showed a remarkable catalytic activity for cross-coupling C-N and C-O reactions, higher than other heterogeneous and homogeneous copper-based catalyst, such as CuO, HKUST-1, Cu-MOF-74, Cu(OAc)(2) and CuSO4.5H(2)O. Moreover, its easy recovery by simple filtration and reusability in successive runs without any loss of activity and stability, demonstrates the potential of URJC-1-MOF as an alternative catalyst for this kind of reactions in different chemical media of industrial interest.

Recommanded Product: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Munoz, A; Leo, P; Orcajo, G; Martinez, F; Calleja, G or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Zhao, ZH; He, YH; Li, M; Xu, JZ; Li, XG; Zhang, LZ; Gu, LJ in PERGAMON-ELSEVIER SCIENCE LTD published article about AMINES; ACIDS in [Zhao, Zhiheng; He, Yonghui; Li, Ming; Xu, Jiazhe; Zhang, Lizhu; Gu, Lijun] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650500, Yunnan, Peoples R China; [Zhao, Zhiheng; He, Yonghui; Li, Ming; Xu, Jiazhe; Zhang, Lizhu; Gu, Lijun] Yunnan Minzu Univ, Minist Educ, Kunming 650500, Yunnan, Peoples R China; [Gu, Lijun] Guizhou Univ, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China; [Li, Xiangguang] Kunming Univ, Sch Chem & Chem Engn, Kunming 650214, Yunnan, Peoples R China in 2021.0, Cited 40.0. HPLC of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

An electrochemical multicomponent [3 + 1 + 1] annulation used for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed under transition-metal-, acid-, base- and external-oxidant-free conditions. In an undivided cell, a variety of hydrazones and aldehydes smoothly participate in this transformation to furnish a range of substituted 1,2,4-triazoles. The reaction constitutes a new transformation from hydrazones, aldehydes and NH4OAc into 1,2,4-triazoles, providing a unifying, simple and environmentally friendly approach to the currently available methods. (C) 2021 Elsevier Ltd. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zhao, ZH; He, YH; Li, M; Xu, JZ; Li, XG; Zhang, LZ; Gu, LJ or concate me.. HPLC of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article gamma-C (sp(3))-H bond functionalisation of alpha,beta-unsaturated amides through an umpolung strategy WOS:000519705100004 published article about MUKAIYAMA ALDOL REACTIONS; LEWIS-BASE ACTIVATION; CARBOXYLIC-ACIDS; ALPHA,BETA-DEHYDROGENATION; CONDENSATION; AMIDATION; EFFICIENT; ARYLATION; PEPTIDES; ACETALS in [Futaki, Erika; Takeda, Norihiko; Yasui, Motohiro; Miyata, Okiko; Ueda, Masafumi] Kobe Pharmaceut Univ, Higashinada Ku, Kobe, Hyogo 6588558, Japan; [Shinada, Tetsuro; Miyata, Okiko] Osaka City Univ, Grad Sch Sci, Sumiyoshi Ku, Osaka 5588585, Japan in 2020, Cited 52. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1. Safety of (E)-2-Methylbut-2-enoic acid

The nucleophilic gamma-phenylation and gamma-alkylation of alpha,beta-unsaturated amides have been developed. This umpolung reaction allows the regioselective introduction of phenyl and alkyl groups to a vinylketene N,O-acetal, which is generated in situ from an alpha,beta-unsaturated N-alkoxyamide, followed by N-O bond cleavage in a two-step, one-pot process.

About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Futaki, E; Takeda, N; Yasui, M; Shinada, T; Miyata, O; Ueda, M or concate me.. Safety of (E)-2-Methylbut-2-enoic acid

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Combined high degree of carboxylation and electronic conduction in graphene acid sets new limits for metal free catalysis in alcohol oxidation WOS:000492396300024 published article about OXIDE; REDUCTION in [Blanco, Matias; Mosconi, Dario; Agnoli, Stefano; Granozzi, Gaetano] Univ Padua, INSTM Unit, Dept Chem Sci, Via F Marzolo 1, I-35131 Padua, Italy; [Otyepka, Michal; Medved, Miroslav; Bakandritsos, Aristides] Palacky Univ Olomouc, Fac Sci, Reg Ctr Adv Technol & Mat, Slechtitelu 27, Olomouc 77146, Czech Republic; [Otyepka, Michal] Palacky Univ Olomouc, Fac Sci, Dept Phys Chem, 17 Listopadu 1192-12, Olomouc 77146, Czech Republic in 2019.0, Cited 38.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Formula: C7H8O

Graphene oxide, the most prominent carbocatalyst for several oxidation reactions, has severe limitations due to the overstoichiometric amounts required to achieve practical conversions. Graphene acid, a well-defined graphene derivative selectively and homogeneously covered by carboxylic groups but maintaining the high electronic conductivity of pristine graphene, sets new activity limits in the selective and general oxidation of a large gamut of alcohols, even working at 5 wt% loading for at least 10 reaction cycles without any influence from metal impurities. According to experimental data and first principles calculations, the selective and dense functionalization with carboxyl groups, combined with excellent electron transfer properties, accounts for the unprecedented catalytic activity of this graphene derivative. Moreover, the controlled structure of graphene acid allows shedding light upon the critical steps of the reaction and regulating precisely its selectivity toward different oxidation products.

About Benzyl Alcohol, If you have any questions, you can contact Blanco, M; Mosconi, D; Otyepka, M; Medved, M; Bakandritsos, A; Agnoli, S; Granozzi, G or concate me.. Formula: C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors WOS:000479184600037 published article about FACTOR RECEPTOR KINASE; SUBSTITUTED QUINOLINONES; PYRAZOLE DERIVATIVES; POTENTIAL ANTICANCER; ERLOTINIB; CANCER; CRIZOTINIB; CHEMISTRY; ASSAY in [Elbastawesy, Mohammed A., I; Ramadan, Mohamed] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut 71524, Egypt; [Aly, Ashraf A.] Menia Univ, Fac Sci, Dept Chem, Al Minya 61519, Egypt; [Elshaier, Yaseen A. M. M.] Univ Sadat City, Fac Pharm, Dept Organ & Med Chem, Menoufia 32958, Egypt; [Youssif, Bahaa G. M.] Assiut Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut 71526, Egypt; [Brown, Alan B.] Florida Inst Technol, Program Chem, Melbourne, FL 32901 USA; [Abuo-Rahma, Gamal El-Din A.] Menia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt in 2019, Cited 50. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3. Formula: C9H7NO2

Two new series of diethyl 2-[2-(substituted-2-oxo-1,2-dihydroquinolin-4-yl)hydrazono]-succinates 6a-g and 1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been designed and synthesized. The structures of the synthesized compounds were proved by IR, mass, NMR (2D) spectra and elemental analyses. The target compounds were evaluated for their in vitro cytotoxic activity against 60 cancer cell lines according to NCI protocol. Consequently, seven compounds were further examined against the most sensitive cell lines, leukemia CCRFCEM, and MOLT-4. 5-Amino-1-(6-bromo-2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazole-3,4-dicarbonitrile (7f) was the most active product, with IC50= 1.35 uM and 2.42 uM against MOLT-4 and CCRF-CEM, respectively. Also, it showed a remarkable inhibitory activity compared to erlotinib on the EGFR TK with IC50 = 247.14 nM and 208.42 nM, respectively. Cell cycle analysis of MOLT-4 cells treated with 7f showed cell cycle arrest at G2/M phase (supported by Caspases, BAX and Bcl-2 studies) with a significant pro-apoptotic activity as indicated by annexin V-FITC staining. Moreover, the docking study indicated that both the pyrazole moiety and the quinolin-2-one ring showed good fitting into EGFR (PDB code: 1M17). In order to interpret SAR of the designed compounds, and provide a basis for further optimization, molecular docking of the synthesized compounds to known EGFR inhibitors was performed. The study illustrated the effect of several factors on the compounds’ activity.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Elbastawesy, MAI; Aly, AA; Ramadan, M; Elshaier, YAMM; Youssif, BGM; Brown, AB; Abuo-Rahma, GEDA or concate me.. Formula: C9H7NO2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles