Day: October 9, 2021

Category: indole-building-block. In 2020 ORG CHEM FRONT published article about SUZUKI-MIYAURA; ALKYL-HALIDES; ASYMMETRIC 1,4-ADDITION; ADDRESSING CHALLENGES; OXIDATIVE ADDITION; GRIGNARD-REAGENTS; CHLORIDES; TOSYLATES; BROMIDES; SECONDARY in [Lee, Hang Wai; So, Chau Ming; Yuen, On Ying; Wong, Wing Tak; Kwong, Fuk Yee] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China; [Lee, Hang Wai; So, Chau Ming; Wong, Wing Tak] Hong Kong Polytech Univ, Shenzhen Res Inst SZRI, Shenzhen, Peoples R China; [Yuen, On Ying; Kwong, Fuk Yee] Chinese Univ Hong Kong, Dept Chem, Shatin, Peoples R China in 2020, Cited 72. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

The first palladium-catalyzed cross-coupling reaction of aryl/heteroaryl and alkenyl mesylates and tosylates with aryl titanium as the multi-functional reagent is reported. Using the catalyst system of Pd(OAc)(2) associated with the new NMe2-CM-Phos (L14), a broad range of electron-rich, electron-neutral, electron-deficient, and sterically hindered aryl/heteroaryl and alkenyl mesylates and tosylates are well coupled with aryl titanium reagents to give the corresponding products in good to excellent yields. The catalyst loading down to 0.2 mol% Pd and the reaction time shortening to 10 min can be achieved. The reaction can be easily scaled up to the gram scale without diminishing the product yield.

About m-Methoxyphenol, If you have any questions, you can contact Lee, HW; So, CM; Yuen, OY; Wong, WT; Kwong, FY or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C9H10O3. In 2021.0 ENVIRON SCI TECHNOL published article about PHASE REACTIONS; IONIC-STRENGTH; RATE CONSTANTS; PHOTOCHEMICAL DEGRADATION; MOLECULAR COMPOSITION; HYDROXYL RADICALS; LIGHT-ABSORPTION; EMISSION FACTORS; BROWN CARBON; OXIDATION in [Ma, Lan; Guzman, Chrystal; Tran, Theodore; Anastasio, Cort] Univ Calif Davis, Dept Land Air & Water Resources, Davis, CA 95616 USA; [Niedek, Christopher; Zhang, Qi] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA in 2021.0, Cited 80.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

Biomass burning emits large amounts of phenols, which can partition into cloud/fog drops and aerosol liquid water (ALW) and react to form aqueous secondary organic aerosol (aqSOA). Triplet excited states of organic compounds (C-3*) are likely oxidants, but there are no rate constants with highly substituted phenols that have high Henry’s law constants (K-H) and are likely important in ALW. To address this gap, we investigated the kinetics of six highly substituted phenols with the triplet excited state of 3,4-dimethoxybenzaldehyde. Second-order rate constants at pH 2 are all fast, (2.6-4.6) x 10(9) M-1 s(-1), while values at pH 5 are 2-5 times smaller. Rate constants are reasonably described by a quantitative structure-activity relationship with phenol oxidation potentials, allowing rate constants of other phenols to be predicted. Triplet-phenol kinetics are unaffected by ammonium sulfate, sodium chloride, galactose (a biomass-burning sugar), or Fe(III). In contrast, ammonium nitrate increases the rate of phenol loss by making hydroxyl radicals, while Cu(II) inhibits phenol decay. Mass yields of aqueous SOA from triplet reactions are large and range from 59 to 99%. Calculations using our data along with previous oxidant measurements indicate that phenols with high KH can be an important source of aqSOA in ALW, with 3C* typically the dominant oxidant.

Computed Properties of C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Ma, L; Guzman, C; Niedek, C; Tran, T; Zhang, Q; Anastasio, C or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Gold-Catalyzed Hydrophenoxylation of Propargylic Alcohols and Amines: Synthesis of Phenyl Enol Ethers WOS:000473116000011 published article about C-C; INTRAMOLECULAR HYDROALKOXYLATION; INTERMOLECULAR HYDROALKOXYLATION; HIGHLY EFFICIENT; ALKYNES; HYDROAMINATION; COMPLEXES; TRANSFORMATION; CYCLOISOMERIZATION; ACETALS in [Laserna, Victor; Rojas, Catherine Jeapes; Sheppard, Tom D.] UCL, Dept Chem, 20 Gordon St, London WC1H 0AJ, England in 2019, Cited 43. HPLC of Formula: C7H5F3O. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

A practical method for the synthesis of phenyl enol ethers is reported. The combination of a gold(I) catalyst and potassium carbonate selectively mediates the addition of phenols to propargylic alcohols/amines in a chemo-, regio-, and stereoselective fashion in high yield. The resulting enol ethers are formed exclusively with a Z-configuration and can be obtained from a wide array of phenols and propargylic alcohols or amines with the reaction showing excellent functional group tolerance.

HPLC of Formula: C7H5F3O. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Laserna, V; Rojas, CJ; Sheppard, TD or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article The preparation and photocatalytic activity of Ag-Pd/g-C3N4 for the coupling reaction between benzyl alcohol and aniline WOS:000488661800014 published article about G-C3N4; NANOPARTICLES; COMPOSITES; EVOLUTION; DRIVEN; CARBON; TIO2 in [Ma, Jingjing; Yu, Xiujuan; Liu, Xiaoling; Li, Haiying; Hao, Xueli; Li, Jingyi] Inner Mongolia Univ, Coll Chem & Chem Engn, Hohhot 010021, Inner Mongolia, Peoples R China; [Yu, Xiujuan] Hebei North Univ, Hebei Key Lab Neuropharmacol, Zhangiakou 075000, Hebei, Peoples R China in 2019.0, Cited 25.0. Quality Control of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

In this study, the carrier g-C3N4 was prepared by melamine, and the Ag-Pd/g-C3N4 catalyst was synthesized by the NaBH4 reduction method. Different characterization techniques, including SEM, TEM, XRD, UV-vis DRS, XPS, photoluminescence spectra (PL) and BET, were employed to investigate the morphology and optical properties of the as-prepared samples. The Ag-Pd/g-C3N4 catalyst was used for the synthesis of imine from a benzyl alcohol and aniline. The results show that when the total loading of Ag and Pd is 2 wt%, and the mass ratio of Ag and Pd is 1:1, the activity of the catalyst is the highest (The highest conversion of aniline is 86.7% and the product selectivity is > 99%.). The reaction is optimized by changing the type of solvent, the type and amount of base, the type of catalyst, and the amount of reactants. The optimal reaction conditions are 6 ml of n-hexane, 1.4 mmol of Cs2CO3, 50 mg of the Ag-Pd/g-C3N4 (2 wt%, 1:1), and 2:1 mol ratio of benzyl alcohol and aniline. Under optimal reaction conditions, alcohol derivatives and amine derivatives were investigated to determine the suitable range of the catalyst for alcohols and amines. Then, the effects of different light intensities and wavelengths on the reaction were explored. Additionally, the catalyst’s recycling ability was tested, and it was found to be relatively stable. The effect of reactive groups on the mechanism shows that the reaction is mainly achieved by the synergy between h(+), e(-) and center dot O-2(-).

Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Ma, JJ; Yu, XJ; Liu, XL; Li, HY; Hao, XL; Li, JY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Biomimetic synthesis and anti-inflammatory evaluation of violacin A analogues WOS:000656969600006 published article about III POLYKETIDE SYNTHASE; NF-KAPPA-B; METABOLITES; MECHANISM; OXIDASE in [Wu, Wenxi; Mu, Yu; Liu, Bo; Wang, Zixuan; Guan, Peipei; Han, Li; Huang, Xueshi] Northeastern Univ, Coll Life & Hlth Sci, Inst Microbial Pharmaceut, Shenyang 110819, Peoples R China; [Jiang, Mingguo] Guangxi Univ Nationalities, Sch Marine Sci & Biotechnol, Guangxi Key Lab Polysaccharide Mat & Modificat, Nanning 530008, Peoples R China in 2021, Cited 25. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Category: indole-building-block

Violacin A, a chromanone derivative, isolated from a fermentation broth of Streptomyces violaceoruber, has excellent anti-inflammatory potential. Herein, a biogenetically modeled approach to synthesize violacin A and twenty-five analogues was described, which involved the preparation of aromatic polyketide precursor through Claisen condensation and its spontaneous cyclization. The inhibitory effect on nitric oxide (NO) production of all synthetic molecules was evaluated by lipopolysaccharide (LPS)-induced Raw264.7 cells. The results revealed that introduction of aliphatic amine moieties on C-7 obviously improved the anti-inflammation effect of violacin A, and also the aromatic ether instead of ketone group at side chain was favorable to increase the activity. Among them, analogue 7a and 16d were screened as the most effective anti-inflammatory candidates. Molecular mechanism research revealed that 7a and 16d acquired anti-inflammatory ability due to the inhibition of NF-KB signaling pathway.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Wu, WX; Mu, Y; Liu, B; Wang, ZX; Guan, PP; Han, L; Jiang, MG; Huang, XS or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors published in 2019.0. COA of Formula: C7H8O, Reprint Addresses Tawfik, HO (corresponding author), Tanta Univ, Fac Pharm, Dept Pharmaceut Chem, El Giesh St, Tanta 31527, Egypt.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

A series of twenty-one 3,4-dihydropyrimidine derivatives bearing the heterocyclic 1,3-benzodioxole at position 4 in addition to different substituents at positions 2, 3 and 5 were designed and synthesized as monastrol analogs. The novel synthesized compounds were screened for their cytotoxic activity towards 60 cancer cell lines according to NCI (USA) protocol. Compounds 10b and 15 showed the best antitumor activity against most cell lines. Compound 15 was subsequently tested in 5-doses mode and displayed high selectivity towards CNS, prostate and leukemia subpanel with selectivity ratios of 22.30, 15.38 and 12.56, respectively at GI(50) level. The IC50 of compounds 9d, 10b, 12, 15 and 16 against kinesin enzyme were 3.86 +/- 0.12, 10.70 +/- 0.35, 3.95 +/- 0.12, 4.36 +/- 0.14, and 14.07 +/- 0.45 mu M respectively, while the prototype compound, monastrol, reported IC50 value of 20 +/- 0.42 mu M. The safest compound among test compounds against normal cell line (HEK 293) is 10b with IC50 value of 62.02 +/- 2.42 mu M/ml in comparison to doxorubicin (IC50 = 11.34 +/- 0.44 mu M/ml). Cell cycle analysis of SNB-75 cells treated with compound 15 showed cell cycle arrest at G2/M phase. Further, the assay of levels of active caspase-3 and caspase-9 was investigated. Moreover, Molecular docking of compounds, 9d, 10b, 12, 15, 16, monastrol and mon-97 was performed to study the interaction between inhibitors and the kinesin spindle protein allosteric binding site.

COA of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Tawfik, HO; El-Hamamsy, MH; Sharafeldin, NA; El-Moselhy, TF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ACTIVATED RECEPTORS ALPHA; FREE FATTY-ACIDS; BIOLOGICAL EVALUATION; ANTIDIABETIC ACTIVITY; GENE-EXPRESSION; MANNICH BASES; PPAR; THIAZOLIDINEDIONE; DESIGN; SILICO, Saw an article supported by the Department of Science and technology, New Delhi, India (DST), India [DST/Inspire Fellow/2014/266, DST/Inspire Fellow/2014/258]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Kapoor, G; Pathak, DP; Bhutani, R; Husain, A; Jain, S; Iqbal, MA. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. HPLC of Formula: C7H6O2

A new series of octadec-9-enoic acid schiff base entities (S1-S30) were designed and synthesized targeting peroxisome proliferator activated receptor-gamma for agonist action. Molinspiration software (online) was used to estimate drug like molecular properties of the metabolites. Docking disquisition on co-crystallized protein of PPAR-gamma (PDB ID 1FM9) was carried out which showed S21, S10 and S7 as best situated in the vital sites of receptor having docking scores – 9.19, – 8.68 and – 8.64 respectively. Free binding energy measured using model of Maestro 9.0 and was in range of from – 40.01 and – 80.54 kcal/mol, significant when compared with pioglitazone (- 51.58 Kcal/mol). Seven best docked derivatives were assessed for in-vivo oral glucose tolerance on normal rats and anti-hyperglycaemic activity by streptozotocin induced diabetes model. S21 unveiled to be the best measured analogue among all the synthesized entities. Encouraging outcomes motivates fatty acids for further development of more effective and safer compounds.

HPLC of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Kapoor, G; Pathak, DP; Bhutani, R; Husain, A; Jain, S; Iqbal, MA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Zinc(II)-Catalyzed Synthesis of Secondary Amides from Ketones via Beckmann Rearrangement Using Hydroxylamine-O-sulfonic Acid in Aqueous Media WOS:000579422600014 published article about KETOXIMES; LACTAMS; REAGENT; OXIME; MILD in [Verma, Saumya; Kumar, Puneet; Chandra, Dinesh; Yadav, Ajay K.; Jat, Jawahar L.] Babasaheb Bhimrao Ambedkar Univ Cent Univ, Dept Chem, Lucknow, Uttar Pradesh, India; [Khatana, Anil K.; Tiwari, Bhoopendra] Ctr Biomed Res, Div Mol Synth & Drug Discovery, SGPGIMS Campus,Raebareli Rd, Lucknow, Uttar Pradesh, India in 2020.0, Cited 56.0. Category: indole-building-block. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A zinc(II)-catalyzed single-step protocol for the Beckmann rearrangement using hydroxylamine-O-sulfonic acid (HOSA) as the nitrogen source in water was developed. This direct method efficiently produces secondary amides under open atmosphere in a pure form after basic aqueous workup. It is environmentally benign and operationally simple.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Verma, S; Kumar, P; Khatana, AK; Chandra, D; Yadav, AK; Tiwari, B; Jat, JL or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about CHAGAS-DISEASE; BENZNIDAZOLE; POSACONAZOLE; CHALLENGES; COMPLEXES; DESIGN, Saw an article supported by the . Published in ELSEVIER in AMSTERDAM ,Authors: da Silva, AA; Maia, PID; Lopes, CD; de Albuquerque, S; Valle, MS. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde. SDS of cas: 120-14-9

Chagas disease is a neglected disease, being one of the leading causes of death from infectious diseases. In view of the severity of this pathology, this work describes the synthesis of new thiosemicarbazones derived from chalcones and dibenzalacetones as potential drugs for the treatment of this disease. The structures of all compounds were elucidated by infrared (IR) and nuclear magnetic resonance (H-1 and C-13 NMR) spectroscopies. The chalcone derived thiosemicarbazones 10-14 were tested against the intracellular amastigote form of the protozoan Trypanosoma cruzi and had their cytotoxicity assessed using LLC-MK2 cells. The compound 10 (IC50 = 12.25 mu M) presented the best activity when compared with the standard drug benznidazole (IC50 = 5.64 mu M). (C) 2021 Elsevier B.V. All rights reserved.

SDS of cas: 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact da Silva, AA; Maia, PID; Lopes, CD; de Albuquerque, S; Valle, MS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021.0 APPL CLAY SCI published article about KNOEVENAGEL CONDENSATION; PALLADIUM-CATALYSTS; GOLD NANOPARTICLES; EFFICIENT; REDUCTION; LDH; FABRICATION; GRAPHENE; NANOCOMPOSITES; COMPOSITES in [Yang, Yu] Hebei Normal Univ, Element Educ Dept, Shijiazhuang 050024, Hebei, Peoples R China; [Yang, Yu; Zhu, Wenjing; Cui, Donghui; Lu, Changli] Northeast Normal Univ, Coll Chem, Changchun 130024, Peoples R China in 2021.0, Cited 52.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Quality Control of 4-Methoxybenzaldehyde

A novel type of multicomponent nanocomposite of LDH@PDA@PNIPAM@Pd/carbon dots (CDs) was successfully constructed for highly efficient heterogeneous catalytic reduction from two-dimensional layer double hydroxide (LDH) nanosheet functionalized with thermo-responsive PNIPAM polymer brushes based on the mussel-inspired chemistry. CDs were used as a reductant and stabilizer by in situ loading metal Pd onto LDH@PDA@PNIPAM. Compared with LDH@PDA@PNIPAM@Pd catalyst without CDs modification, the designed LDH@PDA@PNIPAM@Pd/CDs nanohybrid catalyst had better catalytic reduction ability for various dyes and nitrophenol thanks to the synergistic catalytic effect between metal active center and CDs, LDH and their high dispersion stability. Especially, a good catalytic reduction activity was demonstrated for methylene blue (MB) with a high TOF (545.2 min(-1)). Furthermore, the nanohybrid presented interesting thermo-responsive catalytic property due to the existence of PNIPAM polymer chains. In addition, the prepared catalyst also exhibited outstanding catalytic property for the Knoevenagel condensation reaction. Our study provides a new way for the composite preparation of organic-inorganic hybrid materials by polymer and inorganic materials, and shows great potential in the field of catalytic applications.

Quality Control of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Yang, Y; Zhu, WJ; Cui, DH; Lu, CL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles