Day: October 11, 2021

Recently I am researching about FERMENTATION CHARACTERISTICS; LACTOBACILLUS-BUCHNERI; FORAGE CROPS; FUNGAL COMMUNITIES; STABILITY; CORN; METAANALYSIS; INOCULATION; TEMPERATURE; MYCOTOXINS, Saw an article supported by the earmarked fund for Modern Agro-industry Technology Research System of China [CARS-34]; Education Ministry Chunhui projects [20191383]. Published in ELSEVIER in AMSTERDAM ,Authors: Guan, H; Shuai, Y; Ran, QF; Yan, YH; Wang, X; Li, DD; Cai, YM; Zhang, XQ. The CAS is 80-59-1. Through research, I have a further understanding and discovery of (E)-2-Methylbut-2-enoic acid. Product Details of 80-59-1

A full understanding of changes of the microbiome and metabolome during Napier grass silage in relation to aerobic exposure can improve the nutritional value and extend the aerobic stability of this important feed in tropical and subtropical regions. The round bale silage of Napier grass was prepared with deionized water (control) and screened strains Lactobacillus rhamnosus LR753 (LR753) and L. buchneri 40788 (LB). Silages were stored at ambient temperature (30-40 degrees C) for 60 days, followed by 2 and 4 days of aerobic exposure. Strains LB and LR753 significantly improved aerobic stability (>84 h vs. 18 h of control) of baled Napier grass silage by inhibiting the growth of Saccharomycetales as for the higher production of acetic acid (P < 0.05). Weissella and Issatchenkia spp. were the dominant bacteria and fungi in 60-day silage, respectively. LC-MS/MS detected a total of 426 metabolites throughout ensiling and aerobic exposure. With the decrease of Weissella spp. and the increase of Acetobacter spp., the metabolites associated with both were mainly odor-related (3-methylbutanoic acid, isoquinoline, and cuminaldehyde) and amines (tryptamine and tyramine) in control silage, while more antimicrobial activity metabolites were found in strains LB and LR753-treated silage (methylbutanoic acid, 1,2-propanediol, and tiglic acid). Screened local strain LR753 showed a promising potential for improving silage fermentation and aerobic stability of Napier grass. The present study indicates that adequately describing the microbiome and metabolome of silages during fermentation and aerobic exposure can improve ensiling practices and the screening of silage inoculants that act synergistically with the natural microbiome of the forage in hot and humid areas. Product Details of 80-59-1. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Guan, H; Shuai, Y; Ran, QF; Yan, YH; Wang, X; Li, DD; Cai, YM; Zhang, XQ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 99-93-4. In 2019 CHINESE J ORG CHEM published article about CARBONYL-COMPOUNDS; ASSISTED SYNTHESIS; ACID; OXIDATION; DERIVATIVES; OXIMATION; ISOXAZOLE; ALDEHYDES; CHLORIDE; ROUTE in [Liang, Ling; Mou, Jialing; Chen, Yue; Wang, Mengsha; Hong, Zhi] Taizhou Univ, Sch Pharmaceut & Mat Engn, Taizhou 318000, Peoples R China in 2019, Cited 67. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Oxime compounds were efficiently synthesized with aromatic or aliphatic ketones and hydroxylamine hydrochloride as raw materials in the PEG-400 solution, using cheap and readily available superfine kaolin as catalyst under microwave irradiation condition. The effects of the catalyst, the solvent type, reaction time, reaction temperature on the reaction were investigated. The structures of the products were detected by melting point, nuclear magnetic resonance, infrared spectroscopy and mass spectrometry data. This method has the advantages of short reaction times (5 similar to 15 min), good yields, and simple operation as well as environmental friendliness. In addition, the preliminary experiment shows that superfine kaolin could also catalyze transoximation reaction and preparation of oxime ether compounds under microwave irradiation with the yields of 42%similar to 67% and 59%similar to 72%.

SDS of cas: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Liang, L; Mou, JL; Chen, Y; Wang, MS; Hong, Z or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 ASIAN J ORG CHEM published article about CATALYZED SELECTIVE OXIDATION; AEROBIC OXIDATION; HYDROGEN-PEROXIDE; C-N; COPPER; METAL; ALDEHYDES; NANOPARTICLES; COMPLEXES; EFFICIENT in [Behera, Pradyota Kumar; Choudhury, Prabhupada; Sahu, Santosh Kumar; Sahu, Rashmi Ranjan; Rout, Laxmidhar] Berhampur Univ, Dept Chem, Berhampur 760007, Orissa, India; [Rout, Laxmidhar] IISER, Dept Chem, Berhampur 760010, Odisha, India; [Harvat, Alisha N.; McNulty, Caitlin; Stitgen, Abigail; Scanlon, Joseph] Ripon Coll, Ripon, WI 54971 USA; [Kar, Manoranjan] IIT Patna, Patna 801106, Bihar, India in 2021, Cited 113. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Product Details of 123-11-5

Though concept of oxygen bridged bimetallic catalyst for organic reaction is not well understood. Herein, we have tried to explain the concept by experimental as well as its support by full DFT study. We report here a competent protocol for dehydrogenative oxidation of benzylic alcohol using an oxygen bridged bimetallic CuMoO4 nano catalyst. Careful demonstration reveals that oxidation is not effective either with mono-metallic Cu (II) or Mo(VI); instead combination of both the metals through the oxygen bridge [Cu-O-Mo] unexpectedly and interestingly catalyzed the reaction efficiently. The new concept is strongly supported by computational DFT study. DFT study reveals dehydrogenative oxidation is preferred at copper centre over molybdenum and aromatic benzyl alcohols are greatly stabilised. Interaction barrier energy of monometallic CuO and MoO3 catalyst is much higher than bimetallic CuMoO4. Hydrogen transfer has larger barrier heights for CuO (31.5 kcal/mol) and MoO3 (40.3 kcal/mol) than bimetallic CuMoO4.

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Behera, PK; Choudhury, P; Sahu, SK; Sahu, RR; Harvat, AN; McNulty, C; Stitgen, A; Scanlon, J; Kar, M; Rout, L or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 3-Hydroxybenzaldehyde. I found the field of Chemistry very interesting. Saw the article Synthesis, antimicrobial, anticancer and QSAR studies of 1-[4-(substituted phenyl)-2-(substituted phenyl azomethyl)-benzo[b]-[1,4]diazepin-1-yl]-2-substituted phenylaminoethanones published in 2019.0, Reprint Addresses Narasimhan, B (corresponding author), Maharshi Dayanand Univ, Fac Pharmaceut Sci, Rohtak 124001, Haryana, India.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde.

A series of 1-[4-(substituted phenyl)-2-(substituted phenyl azomethyl)-benzo[b]-[1,4]diaze pin-1-yl]-2-substituted phenylaminoethanones (1-17) was synthesized and evaluated in vitro for its antimicrobial and anticancer activities. Results of antimicrobial screening indicated that 1-[4-[4-C hloro-phenyl)-2-[(3-nitro-phenylazo)-methyl]-benzo[b][1,4]diazepin-1-yl]-2-(2-methyl-5-nitro-phenyl amino)-ethanone (16) and 1-[4-(3,4-dimethoxy-phenyl)-2-[(4-nitro-phenylazo)-methyl]-benzo [b][1,4]diazepin-1-yl]-2-(3-nitrophenylamino)-ethanone (17) were found to be the most effective antimicrobial agents. The anticancer screening results indicated that 1-[4-(4-dimethylaminophenyl)-2-(p-tolylazo-methyl)-benzo[b][1,4]diazepin-1-yl]-2-phenyl aminoethanone (1, IC50 = 1.42 mu M/mL against HCT 116 cancer cell lines) was the most potent anticancer agent and was more potent than 5-FU. The results of QSAR studies demonstrated the importance of topological parameters, Kier’s alpha first order shape index (kappa alpha(1)) and valence zero order molecular connectivity index ((0)chi(v)) in describing antimicrobial activity, LUMO and kappa alpha(2) in describing anticancer activity of 1-[4-(substituted phenyl)-2-(substituted phenyl azomethyl)-benzo[b]-[1,4]diazepin-1-yl]-2-substitu ted phenylaminoethanones. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Quality Control of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Verma, D; Kumar, P; Narasimhan, B; Ramasamy, K; Mani, V; Mishra, RK; Majeed, AA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Wang, JS; Na, Y; Ying, J; Wu, XF in ROYAL SOC CHEMISTRY published article about in [Wang, Jian-Shu; Na, Yi; Ying, Jun] Zhejiang Sci Tech Univ, Key Lab Surface & Interface Sci Polymer Mat Zheji, Dept Chem, Hangzhou 310018, Peoples R China; [Wu, Xiao-Feng] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Liaoning, Peoples R China; [Wu, Xiao-Feng] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany in 2021.0, Cited 15.0. SDS of cas: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A palladium-catalyzed 1,2-amino carbonylation of 1,3-dienes with (N-SO2Py)-2-iodoanilines has been developed for the construction of 2,3-dihydroquinolin-4(1H)-one scaffolds. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source under the assistance of the N-SO2Py directing group, the reaction proceeded well to afford various 2,3-dihydroquinolin-4(1H)-ones in good yields (up to 88%). The effect of the directing groups was investigated and control experiments were performed to have a better understanding of the reaction pathway.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Wang, JS; Na, Y; Ying, J; Wu, XF or concate me.. SDS of cas: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH in SPRINGER WIEN published article about DERIVATIVES; INHIBITORS; FUROQUINOLINE; ALKALOIDS; MODEL in [Aly, Ashraf A.; Mohamed, Asmaa H.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Ishak, Esam] Al Azhar Univ, Fac Sci, Dept Chem, Assiut, Egypt; [Ishak, Esam] Jouf Univ, Coll Sci & Arts, Dept Chem, Alquurrayate, Saudi Arabia; [Shwaky, Ahmed M.] Umm Al Qura Univ, STU, Mecca, Saudi Arabia in 2020, Cited 31. Name: 4-Hydroxyquinolin-2(1H)-one. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

Quinoline-2,4-diones reacted with 2-[bis(methylthio)methylene]malononitrile in DMF/Et3N to produce 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carbonitriles and 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides in state of 2-imino-substituted 4-(methylthio)-5,6-dihydro-2H-pyrano[3,2-c]quinolone-3-carbonitriles. The structures of all new products were proved using NMR, IR, and mass spectral data. The possible mechanism for the reaction is also discussed. Graphic abstract

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH or concate me.. Name: 4-Hydroxyquinolin-2(1H)-one

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: Benzyl Alcohol. Gutierrez-Gamboa, G; Perez-Alvarez, EP; Rubio-Breton, P; Garde-Cerdan, T in [Gutierrez-Gamboa, G.; Perez-Alvarez, E. P.; Rubio-Breton, P.; Garde-Cerdan, T.] Univ La Rioja, Gobiemo La Rioja, Inst Ciencias Vid & Vino, Grp VIENAP,CSIC, Km 6,Carretera Burgos, Logrono 26007, Spain published Changes on grape volatile composition through elicitation with methyl jasmonate, chitosan, and a yeast extract in Tempranillo (Vitis vinifera L.) grapevines in 2019.0, Cited 43.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Elicitors play a key role against pathogen infestation, becoming as an alternative to chemical pesticides by the improving secondary metabolites synthesis. Their effect on grape volatile compounds has been little investigated. This field trial aimed to study the foliar application of methyl jasmonate (MeJ), chitosan (CHT), and a yeast extract (YE) on grape volatile compounds by HS-SPME-GC-MS. The results showed that, in general, foliar elicitor application decreased the synthesis of grape volatile compounds. Depending of the treatment, MeJ and CHT showed the lowest total amounts of terpenoids, C-13 norisoprenoids, benzenoids, and esters, together with the highest levels of C6 compounds. YE treatment applied to the grapevines barely affected the synthesis of volatile compounds in grapes. The importance of this work is to add information about the effects of elicitors on grape volatile composition in Tempranillo grapevines.

Name: Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Gutierrez-Gamboa, G; Perez-Alvarez, EP; Rubio-Breton, P; Garde-Cerdan, T or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 100-83-4. Recently I am researching about DRUG DISCOVERY; HEME-BINDING; DESIGN; MALARIA; ANTIBACTERIAL; ANALOGS; BEARING; 1,3,4-OXADIAZOLE; DOCKING; THIAZOLE, Saw an article supported by the Alexandria University-Research Enhancement Program (ALEXREP)Alexandria University [HLTH-13, BASIC-13]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Bekhit, AA; Saudi, MN; Hassan, AMM; Fahmy, SM; Ibrahim, TM; Ghareeb, D; El-Seidy, AM; Nasralla, SN; Bekhit, AEA. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

New 1,3,4-trisubstituted pyrazole derivatives were synthesized and evaluated for their antiplasmodial activity. Compounds 4b, 4c, 7a and 7d were the most potent antiplasmodial agents against P. berghei with percent of suppression ranging from 90 to 100%. They were also screened for their in vitro antimalarial activity against the chloroquine resistant strain P. faldparum, (RKL9). Compound 4c displayed the highest in vitro antimalarial activity; 13-fold higher than standard chloroquine phosphate. Molecular docking of the most active compounds against the wildtype and quadruple mutant pf DHFR-TS structures rationalized the in vitro antimalarial activity. Furthermore, these compounds exhibited reasonable in silico drug-likeness and pharmacokinetic properties. Toxicity studies of the most active compounds revealed that all tested compounds were non-toxic and well-tolerated up to 150 mg/kg via oral route and 75 mg/kg via parentral route. According to RBC hemolysis assay, it was found that compound 7a was the most potent anti-inflammatory and least toxic derivative with IC50 value 71-fold higher than IC50 value related to the antimalarial activity. Moreover, cytotoxicity assessment revealed that compound 4c was the least toxic derivative with IC50 value 70000-fold higher than IC50 value related to the antimalarial activity. (C) 2018 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Bekhit, AA; Saudi, MN; Hassan, AMM; Fahmy, SM; Ibrahim, TM; Ghareeb, D; El-Seidy, AM; Nasralla, SN; Bekhit, AEA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Dearomatization-Rearomatization Strategy for ortho-Selective Alkylation of Phenols with Primary Alcohols WOS:000602666800001 published article about ORTHO-ARYLATION; ARENES; ALKENYLATION; SUBSTITUTION; ANNULATION; CONVERSION; ETHERS in [Yu, Jianjin; Zeng, Huiying] Lanzhou Univ, State Key Lab Appl Organ Chem, 222 Tianshui Rd, Lanzhou 730000, Peoples R China; [Li, Chao-Jun] McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada; [Li, Chao-Jun] McGill Univ, FQRNT Ctr Green Chem & Catalysis, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada in 2021, Cited 63. Formula: C7H8O2. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

Phenols are common precursors and core structures of a variety of industrial chemicals ranging from pharmaceuticals to polymers. However, the synthesis of site-specifically substituted phenols is challenging, and thus the development of new methods for this purpose would be highly desirable. Reported here is a protocol for palladium-catalyzed ortho-selective alkylation reactions of phenols with primary alcohols by a dearomatization-rearomatization strategy, with water as the sole by-product. Various substituted phenols and primary alcohols were compatible with the standard reaction conditions. The detailed mechanism of this transformation was also investigated.

Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Yu, JJ; Li, CJ; Zeng, HY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 J FOOD SCI TECH MYS published article about THEOBROMA-CACAO L.; NUTRITIONAL COMPOSITION; SENSORY PROFILE; BEANS; AROMA; CULTIVARS; DATABASE; IMPACT; FOOD in [Bastos, Valdeci S.; Uekane, Thais M.; de Rezende, Claudia M.; Flosi Paschoalin, Vania M.; Del Aguila, Eduardo M.] Inst Quim, Ave Athos da Silveira Ramos,149,Cidade Univ, BR-21941909 Rio De Janeiro, RJ, Brazil; [Bastos, Valdeci S.] Inst Fed Educ Ciencia & Tecnol IFS, Parque Exposicoes Joao de Oliveira Dantas, BR-49680000 Nossa Senhora Da Gloria, SE, Brazil; [Bello, Neyde A.] CEPLAC, Km 22,Rodovia Ilheus Itabuna S-N, BR-45660000 Ilheus, BA, Brazil in 2019.0, Cited 35.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Quality Control of Benzyl Alcohol

The effects of indigenous fermentation on volatile compound profiles in a Theobroma cacao L, TSH565 clone, resistant to Moniliophtora perniciosa and Phytophthora spp. were evaluated in Southern Brazil. Sixty-three volatile flavor compounds in pulp and 36 in grains were identified by SPME-HS/GC-MS and classified as terpenes, alcohols, esters, ketones and aldehydes, among others. The relative amount of these compounds and their evolution until the end of the fermentation process were assessed in both fresh and fermented grains/pulp masses. -myrcene and -cis-ocimene, among terpenes, were detected in high amounts and are associated to a fine chocolate aroma. The sensory evaluation of chocolates manufactured from the fermented cocoa was performed by trained panelists, which defined 15 sensory descriptors. Chocolates from the TSH565 cultivar were characterized by a rich, fruity, intense cocoa flavor and bitterness, which are valuable sensorial and commercial attributes.

Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Bastos, VS; Uekane, TM; Bello, NA; de Rezende, CM; Paschoalin, VMF; Del Aguila, EM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles