Day: October 12, 2021

An article Fabrication of mesoporous SiO2/Au/Co3O4 hollow spheres catalysts with core-shell structure for liquid phase oxidation of benzyl alcohol to benzaldehyde WOS:000486134100014 published article about HIGHLY SELECTIVE OXIDATION; SOLVENT-FREE OXIDATION; FREE AEROBIC OXIDATION; SUPPORTED NANO-GOLD; MOLECULAR-OXYGEN; HYDROGEN-PEROXIDE; AU NANOPARTICLES; CARBON NITRIDE; PALLADIUM; METAL in [Yuan, Shenhao; Lv, Xushuai; Zhang, Yiwei; Wu, Yangjin; Mao, Chunfeng; Zhou, Yuming; Chen, Wenxia; Wang, Yanyun] Southeast Univ, Sch Chem & Chem Engn, Jiangsu Optoelect Funct Mat & Engn Lab, Nanjing 211189, Jiangsu, Peoples R China in 2019.0, Cited 58.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Quality Control of Benzyl Alcohol

A core-shell structure Au-based catalysts mSiO(2)/Au/Co3O4-HS were successfully derived from in-situ growth ZIF-67 hollow spheres, which were synthesized by a one-step soft template method. The samples were characterized by SEM, TEM, EDX, XPS, XRD and BET to confirm its successful preparation and structural features. The catalytic performance of the catalysts were evaluated by liquid phase oxidation of benzyl alcohol to benzaldehyde with O-2 as the oxidant under alkaline conditions. The experimental results illustrated that reaction conditions, including effect of catalyst amount, oxygen flow rate, reaction temperature and reaction time, were optimized to be 40 mg, 50 ml/min, 140 degrees C and 5 h, respectively. Meanwhile, 55% conversion of benzyl alcohol and 84% selectivitiy to benzaldehyde together with the excellent reusability and stability were achieved under optimal reaction conditions, which was attributed to the core-shell structure leading to the encapsulation of Au NPs and provision of multiple active reaction interface. Based on the intermediates formed from the de-protonation of substrate, a plausible oxidation reaction mechanism with mSiO(2)/Au/Co3O4 -HS catalysts was tentatively proposed to study the relationship between structure and catalytic performance. (C) 2019 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Yuan, SH; Lv, XS; Zhang, YW; Wu, YJ; Mao, CF; Zhou, YM; Chen, WX; Wang, YY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Chloro and bromo-pyrazole curcumin Knoevenagel condensates augmented anticancer activity against human cervical cancer cells: design, synthesis, in silico docking and in vitro cytotoxicity analysis WOS:000505521900015 published article about NF-KAPPA-B; DRUG-DELIVERY; CHITOSAN MICROSPHERES; ANALOGS; INHIBITION; ACTIVATION; APOPTOSIS; MELANOMA; BETA; IKK in [Chaudhary, Monika] IK Gujral Punjab Tech Univ, Jalandhar, Punjab, India; [Chaudhary, Monika] Hindu Coll Pharm, Dept Med Chem, Sonepat, India; [Kumar, Neeraj; Chandra, Ramesh] Univ Delhi, Dept Chem, Delhi, India; [Baldi, Ashish] Maharaja Ranjit Singh Punjab Tech Univ, Dept Pharmaceut Sci & Technol, Bathinda, India; [Chandra, Ramesh] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, Delhi, India; [Babu, M. Arockia; Madan, Jitender] Chandigarh Coll Pharm, Dept Pharmaceut, Mohali 140307, Punjab, India in 2020.0, Cited 41.0. HPLC of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

With an endeavor to develop novel curcumin analogs as potential anti-cancer agents, we designed and synthesized a series of Knoevenagel condensates by clubbing pyrazole carbaldehydes at the active methylene carbon atom of the curcumin backbone. Molecular docking studies were carried out to target the proposed derivatives on human kinase beta (IKK beta), a potential anti-cancer target. The chloro derivative displayed five hydrogen bond interactions with a docking score of -11.874 kcal/mol higher than curcumin (docking score = -7.434 kcal/mol). This was supported by the fact that the propellant shaped derivatives fitted aptly into the binding pocket. Molecular simulations studies were also conducted on the lead molecule and the results figured out that the stable complexes were developed as the minimal deviations per residue of protein within the range of 0.11-0.92 angstrom. The screened compounds were synthesized, characterized and evaluated in vitro for cytotoxicity against cervical cancer cell line, HeLa using standard cell proliferation assay. Chloro derivative and bromo analog demonstrated IC50 (half maximal inhibitory concentration) value of 14.2 and 18.6 mu g/ml, respectively, significantly lower than 42.4 mu g/ml of curcumin and higher than 0.008 mu g/ml of paclitaxel. Induction of apoptosis was evaluated in the terms of cleavage of caspase-3 enzyme and they also exhibited 69.6 and 65.4% of apoptosis significantly higher than 19.9% induced by curcumin. In conclusion, chloro and bromo derivatives must be evaluated under a set of stringent in vitro and in vivo parameters for translating in to a clinically viable product. Communicated by Ramaswamy H. Sarma

HPLC of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Chaudhary, M; Kumar, N; Baldi, A; Chandra, R; Babu, MA; Madan, J or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 100-83-4. You, SY; Zhang, RL; Cai, MZ in [You, Shengyong; Zhang, Rongli; Cai, Mingzhong] Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China; [You, Shengyong; Zhang, Rongli; Cai, Mingzhong] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China; [You, Shengyong] Jiangxi Acad Sci, Inst Appl Chem, Nanchang 330029, Jiangxi, Peoples R China published A Magnetically Recyclable Palladium-Catalyzed Formylation of Aryl Iodides with Formic Acid as CO Source: A Practical Access to Aromatic Aldehydes in 2021, Cited 68. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

A magnetically recyclable palladium-catalyzed formylation of aryl iodides under CO gas-free conditions has been developed by using a bidentate phosphine ligand-modified magnetic nanoparticles-anchored- palladium(II) complex [2P-Fe3O4@SiO2-Pd(OAc)(2)] as catalyst, yielding a wide variety of aromatic aldehydes in moderate to excellent yields. Here, formic acid was employed as both the CO source and the hydrogen donor with iodine and PPh3 as the activators. This immobilized palladium catalyst can be obtained via a simple preparative procedure and can be facilely recovered simply by using an external magnetic field, and reused at least 9 times without any apparent loss of catalytic activity.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact You, SY; Zhang, RL; Cai, MZ or concate me.. SDS of cas: 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Synthesis of Spiro-dihydrofuran in the Presence of a Novel and Reusable Nanocatalyst Cu (II)-Glycerol/MCM-41 published in 2019.0. Safety of 3-Hydroxybenzaldehyde, Reprint Addresses Pesyan, NN (corresponding author), Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh 57159, Iran.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

The use of supported Cu complex on mesoporous as a novel, efficient, heterogeneous, reusable and green catalyst for the synthesis of spiro-dihydrofuran derivatives is reported. This methodology is effective for the reaction of dimedone with a wide range of aldehyde in the presence of BrCN and triethylamine. The structure of catalyst was characterized by different techniques such as EDX, SEM, TGA, ICP-OES, XRD, TEM, FT-IR, and BET. The recycled nanocatalyst was used at least five times with no significant loss of its activity.

Safety of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Batmani, H; Pesyan, NN; Havasi, F; Aalinejad, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ENANTIOSELECTIVE SYNTHESIS; BOND ACTIVATION; ARYL ETHERS; ALKYLATION; CYCLOADDITION; FLAVONOIDS; ALKYNES; ALKENYLATION; CYCLIZATION; ALCOHOLS, Saw an article supported by the National Science FoundationNational Science Foundation (NSF) [CHE-1664652]; National Institute of Health General Medical Science [R15 GM109273]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Mokar, BD; Yi, CS. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol. Quality Control of m-Methoxyphenol

Chromene and benzoxacyclic derivatives were efficiently synthesized from the ruthenium-catalyzed dehydrative C-H coupling reaction of phenols with alpha,beta-unsaturated carbonyl compounds. The cationic ruthenium-hydride complex was found to be an effective catalyst for the coupling and annulation of phenols with enals to form chromene products. The coupling of phenols with linear enones afforded 2,4-disubstituted chromene derivatives, whereas the analogous coupling with cyclic enones yielded 9-hydroxybenzoxazole products. The reaction of 3,5-dimethoxyphenol with PhCH=CHCDO resulted in the chromene product with a significant H/D exchange to both benzylic and vinyl positions. The most significant carbon isotope effect from the coupling of 3,5-dimethoxyphenol with 4-methoxycinnamaldehyde was observed on the a-olefinic carbon of the chromene product (C(2) = 1.067). A Hammett plot from the coupling of 3,5-dimethoxyphenol with para-substituted p-X-C6H4CH=CHCHO displayed a linear correlation, with a strong promotional effect by an electron -withdrawing group (rho = +1.5; X = OCH3, CH3, H, F, Cl). Several biologically active chromenone derivatives were synthesized by using the catalytic coupling method. The catalytic method provides an expedient synthetic protocol for the coupling of phenols with alpha,beta-unsaturated carbonyl compounds without employing reactive reagents or forming any wasteful byproducts.

Quality Control of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Mokar, BD; Yi, CS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of (E)-2-Methylbut-2-enoic acid. Authors Shimshoni, JA; Barel, S; Mulder, PPJ in MDPI published article about in [Shimshoni, Jakob A.] Agr Res Org, Dept Food Qual & Safety, Volcani Ctr, Inst Postharvest & Food Sci, IL-753593 Rishon Letsyion, Israel; [Barel, Shimon] Kimron Vet Inst, Dept Toxicol, IL-50250 Bet Dagan, Israel; [Mulder, Patrick P. J.] Wageningen Univ & Res, Wageningen Food Safety Res, POB 230, NL-6700 AE Wageningen, Netherlands in 2021, Cited 32. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1

Pyrrolizidine alkaloids (PAs) are genotoxic carcinogenic phytotoxins mostly prevalent in the Boraginaceae, Asteraceae and Fabaceae families. Heliotropium species (Boraginaceae) are PA-producing weeds, widely distributed in the Mediterranean region, that have been implicated with lethal intoxications in livestock and humans. In Israel, H. europaeum, H. rotundifolium and H. suaveolens are the most prevalent species. The toxicity of PA-producing plants depends on the PA concentration and composition. PAs occur in plants as mixtures of dozens of various PA congeners. Hence, the risk arising from simultaneous exposure to different congeners has to be evaluated. The comparative risk evaluation of the three Heliotropium species was based on recently proposed interim relative potency (iREP) factors, which take into account certain structural features as well as in vitro and in vivo toxicity data obtained for several PAs of different classes. The aim of the present study was to determine the PA profile of the major organ parts of H. europaeum, H. rotundifolium and H. suaveolens in order to assess the plants’ relative toxic potential by utilizing the iREP concept. In total, 31 different PAs were found, among which 20 PAs were described for the first time for H. rotundifolium and H. suaveolens. The most prominent PAs were heliotrine-N-oxide, europine-N-oxide and lasiocarpine-N-oxide. Europine-N-oxide displayed significant differences among the three species. The PA levels ranged between 0.5 and 5% of the dry weight. The flowers of the three species were rich in PAs, while the PA content in the root and flowers of H. europaeum was higher than that of the other species. H. europaeum was found to pose a higher risk to mammals than H. rotundifolium, whereas no differences were found between H. europaeum and H. suaveolens as well as H. suaveolens and H. rotundifolium.

About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Shimshoni, JA; Barel, S; Mulder, PPJ or concate me.. Safety of (E)-2-Methylbut-2-enoic acid

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Recently I am researching about ORGANIC FLUOROPHORES; DYE; OSTEOSARCOMA; FLUORESCENCE; MECHANISMS; RELEASE; DESIGN; BRIGHT; PROBES, Saw an article supported by the National Key R&D Program of China [2020YFA0908800]; NSFCNational Natural Science Foundation of China (NSFC) [81773674, 81573383]; Shenzhen Science and Technology Research Grant [JCYJ20190808152019182]; National Natural Science Foundation of Hubei Province [2017CFA024, 2017CFB711]; Applied Basic Research Program of Wuhan Municipal Bureau of Science and Technology [2019020701011429]; Tibet Autonomous Region Science and Technology Plan Project Key Project [XZ201901-GB-11]; Local Development Funds of Science and Technology Department of Tibet [XZ202001YD0028C]; Chengdu University of Traditional Chinese Medicine [CZYJC1903]; Health Commission of Hubei Province Scientific Research Project [WJ2019M177, WJ2019M178]; China Scholarship CouncilChina Scholarship Council; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; Hubei Province Scientific and Technical Innovation Key Project. Published in NATURE RESEARCH in BERLIN ,Authors: Zhou, H; Zeng, XD; Li, AG; Zhou, WY; Tang, L; Hu, WB; Fan, QL; Meng, XL; Deng, H; Duan, L; Li, YQ; Deng, ZX; Hong, XC; Xiao, YL. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

NIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule NIR-II fluorophores have been discovered with donor-acceptor-donor (D-A-D) or symmetrical structures, and upconversion-mitochondria-targeted NIR-II dyes have not been reported. Herein, we report development of D-A type thiopyrylium-based NIR-II fluorophores with frequency upconversion luminescence (FUCL) at similar to 580nm upon excitation at similar to 850nm. H4-PEG-PT can not only quickly and effectively image mitochondria in live or fixed osteosarcoma cells with subcellular resolution at 1nM, but also efficiently convert optical energy into heat, achieving mitochondria-targeted photothermal cancer therapy without ROS effects. H4-PEG-PT has been further evaluated in vivo and exhibited strong tumor uptake, specific NIR-II signals with high spatial and temporal resolution, and remarkable NIR-II image-guided photothermal therapy. This report presents the first D-A type thiopyrylium NIR-II theranostics for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and excellent photothermal efficiency. Currently available mitochondria-targeted fluorescent dyes emit only one color in the visible or NIR-I and their applications are limited. Here, the authors develop upconversion mitochondria-targeted NIR-II fluorophores for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and photothermal efficiency

Category: indole-building-block. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zhou, H; Zeng, XD; Li, AG; Zhou, WY; Tang, L; Hu, WB; Fan, QL; Meng, XL; Deng, H; Duan, L; Li, YQ; Deng, ZX; Hong, XC; Xiao, YL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about AEROBIC OXIDATION; CATALYTIC-ACTIVITY; PD NANOPARTICLES; CARBON NANOTUBE; GOLD CLUSTERS; SIZE; SUPPORT; PHASE; CO, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51601032, 51601119]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [N170204015]; Provincial science and technology project/doctor start fund [20170520385]; Kay Lab for ATM of Northeastern University. Published in IOP PUBLISHING LTD in BRISTOL ,Authors: Zhou, J; Cao, XQ; Zhang, Y; Chen, J; Li, S. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol. Name: Benzyl Alcohol

In this work, a low temperature plasma reduction technology is developed for the preparation of AuPd alloy nanocatalyst. The HAuCl4 and PdCl2 mixture as catalyst precursor was directly decomposed on MgO support by plasma to form AuPd nanoalloy. Results demonstrated that the final particles states of nanoalloys prepared by this technique including size, morphology, and chemical valence are highly dependent on temperature of plasma treatment. The catalytic performance of AuPd/MgO in the selective oxidation of benzyl alcohols can be tailored by optimizing the synthesis parameter. A relative low temperature in plasma process prevents particles migration and helps to maintain the small size that favors high activity. The AuPd nanoparticles with diameter about 3.5 nm by optimizing the plasma treatment condition exhibit superior conversion and TOF compared to catalyst prepared by the traditional high temperature H2 reduction method. It is believed that the low temperature plasma technology has a unique advantage for the preparation of high-quality alloy nanocatalyst and could be extended for fabricating the other alloy nanocatalysts.

Name: Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Zhou, J; Cao, XQ; Zhang, Y; Chen, J; Li, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis of Co-MOF/COF nanocomposite: application as a powerful and recoverable catalyst in the Knoevenagel reaction WOS:000558615800001 published article about COVALENT ORGANIC FRAMEWORKS; MIXED MATRIX MEMBRANES; CRYSTALLINE; ENERGY; FABRICATION; ADSORPTION; SEPARATION; POLYIMIDE; DESIGN in [Rahmati, Ensiyeh; Rafiee, Zahra] Univ Yasuj, Dept Chem, Yasuj 7591874831, Iran in 2021, Cited 52. SDS of cas: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A novel mesoporous composite was prepared through the hybridization of cobalt-based metal-organic framework (Co-MOF) and covalent organic framework (COF) based on melamine and terephthaldehyde (Co-MOF/COF) and characterized by FT-IR, SEM, XRD, EDS, BET, and STA analyses. The resultant composite was utilized as a robust recoverable catalyst in the condensation of several aldehydes with malononitrile to produce benzylidenemalononitrile derivatives in 62-94% yields under solvent-free conditions at room temperature using 15 mg of the catalyst and 5-60 min of reaction. The examination of catalytic performance of designated Co-MOF/COF exhibited an outstanding activity for the Knoevenagel condensation in a very short time. The recoverability, reusability and durability of Co-MOF/COF have also been investigated under applied conditions.

SDS of cas: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Rahmati, E; Rafiee, Z or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 80-59-1. Recently I am researching about ACETIC-ANHYDRIDE; ORGANIC HALIDES; ARYL BROMIDES; OLEFINS; CO; HYDROCARBOXYLATION; HYDROXYCARBONYLATION; ALKYNES; HYDROESTERIFICATION, Saw an article supported by the European UnionEuropean Commission; European Social FundEuropean Social Fund (ESF) [EFOP-3.6.1.-16-2016- 00004]; Ministry of Human Capacities [ONKP-17-4-II]; [GINOP-2.3.2-15-2016-00049]; [OTKAK113177]. Published in ELSEVIER SCIENCE BV in AMSTERDAM ,Authors: Bartal, B; Mikle, G; Kollar, L; Pongracz, P. The CAS is 80-59-1. Through research, I have a further understanding and discovery of (E)-2-Methylbut-2-enoic acid

Palladium-catalysed carbonylation reactions have been developed in the presence of formic acid as carbon monoxide source. alpha,beta-Unsaturated carboxylic acids and esters were synthesized by the transformation of alkenyl halides in moderate to good yields. The selection of the base proved to be crucial regarding the reaction outcome. A set of various substrates were proven under optimised reaction conditions. Compared to aliphatic alcohols, phenols showed excellent reactivity as O-nucleophiles.

SDS of cas: 80-59-1. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Bartal, B; Mikle, G; Kollar, L; Pongracz, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles