Day: October 12, 2021

Authors Milovic, E; Jankovic, N; Bogdanovic, GA; Petronijevic, J; Joksimovic, N in PERGAMON-ELSEVIER SCIENCE LTD published article about BIGINELLI REACTION; DERIVATIVES; TRICKS in [Milovic, Emilija; Petronijevic, Jelena; Joksimovic, Nenad] Univ Kragujevac, Fac Sci, Dept Chem, Radoja Domanovica 12, Kragujevac 34000, Serbia; [Jankovic, Nenad] Univ Kragujevac, Inst Informat Technol Kragujevac, Dept Sci, Kragujevac 34000, Serbia; [Bogdanovic, Goran A.] Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, POB 522, Belgrade 11001, Serbia in 2021, Cited 30. Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A simple on water approach for the synthesis of novel tetrahydropyrimidine (THPM) derivatives has been developed under a green and sustainable fashion. For the first time, a deuterated Biginelli’s hybrid was synthesized. Novel THPMs are suitable for further derivatization and could be an excellent toolkit for lead-oriented synthesis and/or cross-coupling reactions. (C) 2020 Elsevier Ltd. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Milovic, E; Jankovic, N; Bogdanovic, GA; Petronijevic, J; Joksimovic, N or concate me.. Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article 4-Hydroxy-3-methyl-2(1H)-quinolone, originally discovered from a Brassicaceae plant, produced by a soil bacterium of the genus Burkholderia sp.: determination of a preferred tautomer and antioxidant activity WOS:000548343000001 published article about 2,4-DIHYDROXYQUINOLINE; DERIVATIVES; QUINOLINE; ANALOGS in [Li, Dandan; Oku, Naoya; Igarashi, Yasuhiro] Toyama Prefectural Univ, Biotechnol Res Ctr, 5180 Kurokawa, Imizu, Toyama 9390398, Japan; [Li, Dandan; Oku, Naoya; Igarashi, Yasuhiro] Toyama Prefectural Univ, Dept Biotechnol, 5180 Kurokawa, Imizu, Toyama 9390398, Japan; [Shinozaki, Yukiko] Toyama Coll, Natl Inst Technol, 13 Hongo Machi, Toyama, Toyama 9398630, Japan; [Kurokawa, Yoichi] Fukui Prefectural Univ, Dept Biosci & Biotechnol, Eiheiji Cho, Fukui, Japan in 2020, Cited 45. Computed Properties of C9H7NO2. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

4-Hydroxy-3-methyl-2(1H)-quinolone (1), a molecule known for a long time and recently discovered from a Brassicaceae plant Isatis tinctoria without providing sufficient evidence to support the structure, was isolated from a fermentation extract of Burkholderia sp. 3Y-MMP isolated from a soil by a Zn2+ enrichment culture. Detailed spectroscopic analyses by MS and NMR, combined with C-13 chemical shift comparison with literature values of the related compounds and a synthetic preparation of 1, allowed its first full NMR characterization and identification of 2-quinolone but not 2-quinolinol (2) as the preferred tautomer for this heterocyclic system. While the metal-chelating activity was negligible, compound 1 at 10 mu M, a concentration lower than that in liquid production cultures, quenched hydroxy radical-induced chemiluminescence emitted by luminol by 86%. Because some Burkholderia species are pathogenic to plants and animals, the above result suggests that 1 is a potential antioxidant to counteract reactive oxygen species-based immune response in the host organisms.

Computed Properties of C9H7NO2. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Li, DD; Oku, N; Shinozaki, Y; Kurokawa, Y; Igarashi, Y or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Malasala, S; Ahmad, MN; Akunuri, R; Shukla, M; Kaul, G; Dasgupta, A; Madhavi, YV; Chopra, S; Nanduri, S in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Malasala, Satyaveni; Akunuri, Ravikumar; Madhavi, Y., V; Nanduri, Srinivas] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Hyderabad 500037, Telangana, India; [Ahmad, Md Naiyaz; Shukla, Manjulika; Kaul, Grace; Dasgupta, Arunava; Chopra, Sidharth] CSIR Cent Drug Res Inst, Div Microbiol, Sitapur Rd,Sect 10, Lucknow 226031, Uttar Pradesh, India; [Ahmad, Md Naiyaz; Kaul, Grace; Dasgupta, Arunava; Chopra, Sidharth] AcSIR, Sect 19, Ghaziabad 201002, Uttar Pradesh, India in 2021.0, Cited 58.0. Computed Properties of C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Owing to the rapid rise in antibiotic resistance, infectious diseases have become serious threat to public health. There is an urgent need to develop new antimicrobial agents with diverse chemical structures and novel mechanisms of action to overcome the resistance. In recent years, Quinazoline-benzimidazole hybrids have emerged as a new class of antimicrobial agents active against S. aureus and M. tuberculosis. In the current study, we designed and synthesized fifteen new Quinazoline-benzimidazole hybrids and evaluated them for their antimicrobial activity against S. aureus ATCC 29213 and M. tuberculosis H37Rv. These studies led to the identification of nine potent antibacterial agents 8a, 8b, 8c, 8d, 8f, 8g, 8h, 8i and 10c with MICs in the range of 4-64 mu g/mL. Further, these selected compounds were found to possess potent antibacterial potential against a panel of drug-resistant clinical isolates which include methicillin and vancomycin-resistant S. aureus. The selected compounds were found to be less toxic to Vero cells (CC50 = 40->= 200 mu g/mL) and demonstrated a favourable selectivity index. Based on the encouraging results obtained these new benzimidazol-2-yl quinazoline derivatives have emerged as promising antimicrobial agents for the treatment of MDR-S. aureus and Mycobacterial infections. (C) 2020 Elsevier Masson SAS. All rights reserved.

Computed Properties of C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Malasala, S; Ahmad, MN; Akunuri, R; Shukla, M; Kaul, G; Dasgupta, A; Madhavi, YV; Chopra, S; Nanduri, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 RSC ADV published article about TOPOISOMERASE-I INHIBITION; ANTIPROLIFERATIVE ACTIVITY; ANTITUMOR-ACTIVITY; BENZIMIDAZOLES; CYTOTOXICITY; DOCKING in [Thi-Kim-Chi Huynh; Thi-Hong-An Nguyen; Thi-Cam-Thu Nguyen; Thi-Kim-Dung Hoang] Inst Chem Technol VAST, 01 Mac Dinh Chi Str,Dist 1, Ho Chi Minh City, Vietnam; [Thi-Kim-Chi Huynh; Thi-Kim-Dung Hoang] Grad Univ Sci & Technol VAST, 18 Hoang Quoc Viet Str, Hanoi, Vietnam; [Thi-Cam-Thu Nguyen] Ton Duc Thang Univ, 19 Nguyen Huu Tho Str,Dist 7, Ho Chi Minh City, Vietnam in 2020.0, Cited 36.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 100-83-4

In order to explore and develop new anticancer agents, three series of 2-phenylbenzimidazoles, 15-46, were condensed under simple and mild conditions using sodium metabisulfite as an oxidation agent and another series, 47-55, were obtained via a reduction reaction using sodium borohydride. All the compounds synthesized were evaluated for their in vitro anticancer activities against three human cancer cell lines. The novel compound 38 was found to be the most potent multi cancer inhibitor against A549, MDA-MB-231, and PC3 cell lines (IC50 values 4.47, 4.68 and 5.50 mu g mL(-1), respectively). In addition, compound 40 exhibited the best IC50 value of 3.55 mu g mL(-1) against the MDA-MB-231 cell line. The results demonstrated that introducing a new substituent to compounds 37-55 could improve their antiproliferative activities.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Huynh, TKC; Nguyen, THA; Nguyen, TCT; Hoang, TKD or concate me.. Recommanded Product: 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Py-GC/MS analysis on product distribution of two-staged biomass pyrolysis WOS:000457854800007 published article about BIO-OIL; TG-FTIR; CELLULOSE; LIGNIN; TEMPERATURE; MECHANISM; TORREFACTION; SEPARATION; QUALITY in [Cai, Wenwen; Liu, Qian; Shen, Dekui; Wang, Jingzhen] Southeast Univ, Key Lab Energy Thermal Convers & Control, Sch Energy & Environm, Minist Educ, Nanjing 210096, Jiangsu, Peoples R China in 2019.0, Cited 31.0. Product Details of 150-19-6. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

Two-staged pyrolysis of biomass was proposed as a promising method by which liquid products would be less diverse and more concentrated, and beneficial to further upgrading or extracting chemicals. Rice straw, cedar wood, and dalbergia wood were selected as representative biomass materials. Thermogravimetric Fourier-transform infrared spectroscopy (TG-FTIR) was initially used to analyze biomass and the three main components. According to the pyrolysis characteristics and the volatile release processes, 270-360 degrees C was selected as the optional temperature range for the low-temperature stage of the two-staged pyrolysis. Then, Pyrolysis Gas Chromatography Mass Spectrometry (Py-GC/MS) was used in two stages to analyze three types of biomass, with the first stage at 270 degrees C, 320 degrees C, or 360 degrees C and then the second stage at 550 degrees C. The two-staged pyrolysis could efficiently separate biomass pyrolysis products, especially the enrichment of organic acids, alcohols, and aldehydes in the first stage, and the enrichment of phenolic substances in the second stage. The optimum temperature of the first stage was 320 degrees C, which was suitable for three different kinds of biomass.

Product Details of 150-19-6. About m-Methoxyphenol, If you have any questions, you can contact Cai, WW; Liu, Q; Shen, DK; Wang, JZ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Selective functionalisation of aromatic alcohols with supramolecularly regulated gold(i) catalysts published in 2020.0. Formula: C7H8O2, Reprint Addresses Vidal-Ferran, A (corresponding author), Inst Chem Res Catalonia ICIQ, Av Paisos Catalans 16, Tarragona 43007, Spain.; Vidal-Ferran, A (corresponding author), Univ Barcelona, Dept Inorgan & Organ Chem, Sect Inorgan Chem, Carrer Marti i Franques 1-11, Barcelona 08028, Spain.; Vidal-Ferran, A (corresponding author), ICREA, Pg Lluis Co 23, Barcelona 08010, Spain.. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

Phosphite-based Au(i) catalytic systems containing an array of structurally diverse polyether-based regulation sites were designed and synthesised. These catalysts have been successfully tested in the Au(i)-catalysed C-H functionalisation of phenols and related derivatives with gold-carbenes derived from diazo compounds. Regulation of the steric congestion around the catalytic Au(i) centreviaion-dipole interactions with an external regulation agent led to an enhancement of both the activity and selectivity of the reaction. This new approach in supramolecular gold(i) catalysis has been applied to the derivatisation of an array of substituted phenols and related substrates and to the preparation of an advanced synthetic intermediate of the anticancer agent tamoxifen. The effects of the regulation agent on the selectivity and yield of the reaction have been studied and rationalised using DFT-D calculations.

Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Carreras, L; Franconetti, A; Grabulosa, A; Frontera, A; Vidal-Ferran, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H6O2. In 2019.0 CATAL LETT published article about MULTICOMPONENT REACTION; PALLADIUM; NANOPARTICLES; 3-COMPONENT; GENERATION; PD in [Taherinia, Zahra; Ghorbani-Choghamarani, Arash; Hajjami, Maryam] Ilam Univ, Dept Chem, Fac Sci, POB 69315516, Ilam, Iran in 2019.0, Cited 39.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

In the present study, peptide nanofiber was used to immobilize zinc oxide. This nanoparticle was prepared through self-assembly in an aqueous solution. The structural properties of the prepared catalyst were examined by a series of techniques, such as FT-IR, EDS, SEM, TEM, XRD, ICP-OES (inductively coupled plasma optical emission spectrometry), and ultraviolet-visible (UV-Vis) spectroscopy. TEM images showed the necklace model for peptide nanofiber decorated with zinc oxide. The versatility of the method was investigated by N-arylation using reaction of amines with hydroxybenzotriazole as a novel phenylating reagent, one-pot synthesis of imidazoheterocycles by a three-component reaction of 2-aminopyridine, aldehyde, terminal alkyne and preparation of tetracyclic quinazolinone ring by one-pot reaction of isatoic anhydride, amine, and ninhydrin. High yields, low cost of catalyst, environmental friendliness, efficient recovery and recyclability of catalyst are the most important features of this catalytic system. [GRAPHICS] .

Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Taherinia, Z; Ghorbani-Choghamarani, A; Hajjami, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019 J ORG CHEM published article about SIDEROPHORE BIOSYNTHESIS; NUCLEOSIDE ANTIBIOTICS; ARYL FLUOROSULFONATES; MECHANISM; FLUORIDE; ACYLTRANSFERASE; TUBERCULOSIS; ASCAMYCIN; PHENOLS; TARGET in [Gilles, Philippe; Veryser, Cedrick; Vangrunderbeeck, Sarah; Ceusters, Sam; De Borggraeve, Wim M.] Katholieke Univ Leuven, Dept Chem, Mol Design & Synth, Celestijnenlaan 200F,Box 2404, B-3001 Leuven, Belgium; [Van Meervelt, Luc] Katholieke Univ Leuven, Dept Chem, Biochem Mol & Struct Biol, Celestijnenlaan 200F,Box 2404, B-3001 Leuven, Belgium in 2019, Cited 34. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Recommanded Product: 98-17-9

A novel synthetic strategy toward N-acyl sulfamates was developed. Interestingly, fluorosulfates, a new emerging class of electrophiles, were used to construct the sulfamate core. This precludes handling of chlorosulfonyl isocyanate and sulfamoyl chloride. In combination with amides, a wide and diverse set of N-acyl sulfamates was synthesized, including functionalized bioactive compounds. Furthermore, initial results showed that this method is also amenable to access N-thioacyl sulfamates.

Recommanded Product: 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Gilles, P; Veryser, C; Vangrunderbeeck, S; Ceusters, S; Van Meervelt, L; De Borggraeve, WM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 J MOL STRUCT published article about CHAGAS-DISEASE; BENZNIDAZOLE; POSACONAZOLE; CHALLENGES; COMPLEXES; DESIGN in [da Silva, Aline Alves; Valle, Marcelo Siqueira] Univ Fed Sao Joao Del Rei, Dept Ciencias Nat, BR-36301160 Sao Joao Del Rei, MG, Brazil; [Maia, Pedro Ivo da Silva] Univ Fed Triangulo Mineiro, Dept Quim, BR-38025440 Uberaba, MG, Brazil; [Lopes, Carla Duque; de Albuquerque, Sergio] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ave Cafes S-N, BR-14040903 Ribeirao Preto, SP, Brazil; [Lopes, Carla Duque; de Albuquerque, Sergio] Univ Sao Paulo, USP, FCFRP, Ave Cafes S-N, BR-14040903 Ribeirao Preto, SP, Brazil; [Lopes, Carla Duque] Ctr Univ Estacio Ribeirao Preto, Abraao Issa Halach St 980, BR-14096160 Ribeirao Preto, SP, Brazil in 2021, Cited 28. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Product Details of 120-14-9

Chagas disease is a neglected disease, being one of the leading causes of death from infectious diseases. In view of the severity of this pathology, this work describes the synthesis of new thiosemicarbazones derived from chalcones and dibenzalacetones as potential drugs for the treatment of this disease. The structures of all compounds were elucidated by infrared (IR) and nuclear magnetic resonance (H-1 and C-13 NMR) spectroscopies. The chalcone derived thiosemicarbazones 10-14 were tested against the intracellular amastigote form of the protozoan Trypanosoma cruzi and had their cytotoxicity assessed using LLC-MK2 cells. The compound 10 (IC50 = 12.25 mu M) presented the best activity when compared with the standard drug benznidazole (IC50 = 5.64 mu M). (C) 2021 Elsevier B.V. All rights reserved.

Product Details of 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact da Silva, AA; Maia, PID; Lopes, CD; de Albuquerque, S; Valle, MS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article Photoinduced hydroxylation of arylboronic acids with molecular oxygen under photocatalyst-free conditions published in 2019. SDS of cas: 98-17-9, Reprint Addresses Zhou, YB; Liu, MC (corresponding author), Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Photoinduced hydroxylation of boronic acids with molecular oxygen under photocatalyst-free conditions is reported, providing a green entry to a variety of phenols and aliphatic alcohols in a highly concise fashion. This new protocol features photocatalyst-free conditions, wide substrate scope and excellent functional group compatibility.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Xu, YT; Li, CY; Huang, XB; Gao, WX; Zhou, YB; Liu, MC; Wu, HY or concate me.. SDS of cas: 98-17-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles