Day: October 15, 2021

Application In Synthesis of (E)-2-Methylbut-2-enoic acid. In 2021 ORG LETT published article about DIRECT ORTHO ARYLATION; CARBOXYLIC-ACIDS; BENZOIC-ACIDS; BOND; PALLADIUM; HYDROARYLATION; OLEFINATION; ARYL; ALKYNES; ACTIVATION in [Hu, Zhiyong; Belitz, Florian; Zhang, Guodong; Papp, Florian; Goossen, Lukas J.] Ruhr Univ Bochum, Evonik Chair Organ Chem, D-44801 Bochum, Germany in 2021, Cited 68. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1.

In the presence of [p-cymene)RuCl2](2), (E)-configured alkenyl bromides couple with aromatic carboxylates to form orthovinylbenzoic acids. This C-H vinylation proceeds in high yields without any activating phosphine ligands and has an excellent functional group tolerance. Starting from commonly available (E/Z)-mixtures of alkenyl bromides, (E)-configured vinyl arenes or dienes are formed exclusively. Mechanistic studies show that this selectivity is achieved because the (E)configured alkenyl bromides undergo a smooth coupling, whereas the (Z)-isomers are rapidly eliminated with the formation of alkynes.

About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Hu, ZY; Belitz, F; Zhang, GD; Papp, F; Goossen, LJ or concate me.. Application In Synthesis of (E)-2-Methylbut-2-enoic acid

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 120-14-9. Authors Reihani, N; Kiyani, H in BENTHAM SCIENCE PUBL LTD published article about in [Reihani, Neda; Kiyani, Hamzeh] Damghan Univ, Sch Chem, POB 36716-41167, Damghan, Iran; [Kiyani, Hamzeh] Shahrekord Univ, Fac Sci, Dept Chem, Shahrekord, Iran in 2021.0, Cited 67.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

An efficient synthesis of 4-arylidene-3-alkylisoxazole-5(4H)-ones has been implemented via the three-component cyclocondensation of aryl(heteroaryl)aldehydes with hydroxylamine hydrochloride and beta-ketoesters. The potassium 2,5-dioxoimidazolidin-1-ide has been introduced as the new organocatalyst to facilitate this heterocyclization. In the current process, three starting materials, including substituted benzaldehydes/heterocyclic aromatic aldehydes, hydroxylamine hydrochloride, and ethyl acetoacetate/propyl acetoacetate/butyryl acetoacetate have been successfully used to synthesize the number of substituted isoxazole-5-(4H)-ones in good to high yields in ethylene glycol as a green reaction medium at 80 degrees C. The low catalyst loading is also a main advantage over some reported catalysts.

Product Details of 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Reihani, N; Kiyani, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Influence of vanillin acrylate and 4-acetylphenyl acrylate hydrophobic functional monomers on phase separation of N-isopropylacrylamide environmental terpolymer: fabrication and characterization WOS:000529690700006 published article about STIMULI-RESPONSIVE POLYMERS; THIN-FILMS; COPOLYMERS in [Abdelaty, Momen S. A.] Al Azhar Univ, Fac Sci Assiut, Chem Dept, Polymer Lap, Assiut 71524, Egypt in 2020.0, Cited 44.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Product Details of 99-93-4

In the present study, we synthesized new functional hydrophobic acrylate monomers. The first monomer was based on 4-acetylacetophenone, and the other one was based on vanillin as a renewable resource. The starting material was reacted with acryloyl chloride for the formation of 4-acetylphenyl acrylate (APA) and 4-formyl-2-methoxyphenylacrylate (vanillin acrylate) or (VA), respectively. The chemical structures were deduced by H-1 NMR, 13C NMR, and FTIR. The effect of these monomers on the transition temperature or lower critical solution temperature of thermo-responsive N-isopropylacrylamide was achieved by the free radical polymerization of three different molar concentrations of both APA and VA with NIPAAm in solution and using 2,2 ‘ azobis(isobutyronitrile) (AIBN) as an initiator. The terpolymers were chemically evaluated. They have been also investigated by gel permission chromatography (GPC) for molecular weight and molecular weight distribution; the glass temperatures were determined by differential scanning calorimetry DSC; X-ray diffraction (XRD) was used for the extent of crystallinity; scanning electron microscopy was used (SEM) for surface morphology. The phase separation and lower critical solution temperature T-c were measured using two methods: UV-Vis spectroscopy for turbidity measurements and micro-DSC of the polymer solution. In the future, we will use these polymers in the bio-separation process and the formation of a responsive hydrogel. [GRAPHICS] .

Product Details of 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Abdelaty, MSA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Krasowska, D; Iraci, N; Santi, C; Drabowicz, J; Cieslak, M; Kazmierczak-Baranska, J; Palomba, M; Krolewska-Golinska, K; Magiera, J; Sancineto, L in [Krasowska, Dorota; Drabowicz, Jozef; Sancineto, Luca] Polish Acad Sci, Ctr Mol & Macromol Studies, Div Organ Chem, Sienkiewicza 112, PL-90363 Lodz, Poland; [Iraci, Nunzio] Univ Salerno, Dept Pharm, Via G Paolo II 132, I-84084 Salerno, Italy; [Santi, Claudio; Palomba, Martina] Univ Perugia, Dept Pharmaceut Sci, Via Liceo 1, I-06123 Perugia, Italy; [Drabowicz, Jozef] Jan Dlugosz Univ Czestochowa, Inst Chem, Armii Krajowej 13-15, PL-42200 Czestochowa, Poland; [Cieslak, Marcin; Kazmierczak-Baranska, Julia; Krolewska-Golinska, Karolina; Magiera, Jakub] Polish Acad Sci, Ctr Mol & Macromol Studies, Div Bioorgan Chem, Sienkiewicza 112, PL-90363 Lodz, Poland published Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors in 2019.0, Cited 73.0. Recommanded Product: 100-51-6. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

A series of variously functionalized selenium-containing compounds were purposely synthesized and evaluated against a panel of cancer cell lines. Most of the compounds showed an interesting cytotoxicity profile with compound 5 showing a potent activity on MCF7 cells. The ethyl amino derivative 5 acts synergistically with cis-platin and inhibits the GST enzyme with a potency that well correlates with the cytotoxicity observed in MCF7 cells. A computational analysis suggests a possible binding mode on the GST enzyme. As the main outcome of the present study, the ethyl amino derivative 5 emerged as a valid lead compound for further, future developments.

Recommanded Product: 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Krasowska, D; Iraci, N; Santi, C; Drabowicz, J; Cieslak, M; Kazmierczak-Baranska, J; Palomba, M; Krolewska-Golinska, K; Magiera, J; Sancineto, L or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Pippione, AC; Sainas, S; Goyal, P; Fritzson, I; Cassiano, GC; Giraudo, A; Giorgis, M; Tavella, TA; Bagnati, R; Rolando, B; Caing-Carlsson, R; Costa, FTM; Andrade, CH; Al-Karadaghi, S; Boschi, D; Friemann, R; Lolli, ML in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about POTENT; DESIGN; TARGET; DSM265 in [Pippione, Agnese C.; Sainas, Stefano; Giraudo, Alessandro; Giorgis, Marta; Rolando, Barbara; Boschi, Donatella; Lolli, Marco L.] Univ Turin, Dept Sci & Drug Technol, Via Pietro Giuria 9, I-10125 Turin, Italy; [Goyal, Parveen; Caing-Carlsson, Rhawnie; Friemann, Rosmarie] Univ Gothenburg, Dept Chem & Mol Biol, Box 462, S-40530 Gothenburg, Sweden; [Goyal, Parveen] Inst Stem Cell Biol & Regenerat Med, Technol Adv Sci, Bengaluru 560065, India; [Fritzson, Ingela] Chemoswed, Celsiusgatan 35, S-21214 Malmo, Sweden; [Cassiano, Gustavo C.; Tavella, Tatyana A.; Costa, Fabio T. M.] Univ Estadual Campinas, Dept Genet Evolut & Bioagents, Lab Trop Dis Prof Luiz Jacintho da Silva, BR-13083864 Campinas, SP, Brazil; [Bagnati, Renzo] Ist Ric Farmacol Mario Negri IRCCS, Via La Masa 19, I-20156 Milan, Italy; [Andrade, Carolina Horta] Univ Fed Goias, LabMol, Fac Pharm, BR-74605170 Goiania, Go, Brazil; [Al-Karadaghi, Salam] Lund Univ, Dept Biochem & Struct Biol, Lund, Sweden; [Friemann, Rosmarie] Univ Gothenburg, Ctr Antibiot Resistance Res CARe, Box 440, S-40530 Gothenburg, Sweden in 2019, Cited 40. Application In Synthesis of 3-(Trifluoromethyl)phenol. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

Plasmodium falciparum dihydroorotate dehydrogenase (PJDHODH) has been clinically validated as a target for antimalarial drug discovery, as a triazolopyrimidine class inhibitor (DSM265) is currently undergoing clinical development. Here, we have identified new hydroxyazole scaffold-based PJDHODH inhibitors belonging to two different chemical series. The first series was designed by a scaffold hopping strategy that exploits the use of hydroxylated azoles. Within this series, the hydroxythiadiazole 3 was identified as the best selective PJDHODH inhibitor (IC50 12.0 mu M). The second series was designed by modulating four different positions of the hydroxypyrazole scaffold. In particular, hydroxypyrazoles 7e and 7f were shown to be active in the low mu M range (IC50 2.8 and 5.3 mu M, respectively). All three compounds, 3, 7e and 7f showed clear selectivity over human DHODH (IC50> 200 mu M), low cytotoxicity, and retained micromolar activity in P. falciparum-infected erythrocytes. The crystallographic structures of PJDHODH in complex with compounds 3 and 7e proved their binding mode, supplying essential data for future optimization of these scaffolds. (C) 2018 Elsevier Masson SAS. All rights reserved.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Pippione, AC; Sainas, S; Goyal, P; Fritzson, I; Cassiano, GC; Giraudo, A; Giorgis, M; Tavella, TA; Bagnati, R; Rolando, B; Caing-Carlsson, R; Costa, FTM; Andrade, CH; Al-Karadaghi, S; Boschi, D; Friemann, R; Lolli, ML or concate me.. Application In Synthesis of 3-(Trifluoromethyl)phenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Afzali, A; Abdollahi, MF; Zhang, BY; Zhao, YM in ROYAL SOC CHEMISTRY published article about CATION-RADICAL SALTS; PI-PI STACKING; ELECTRICAL-CONDUCTIVITY; MOLECULAR TWEEZERS; BUILDING-BLOCKS; DONOR in [Afzali, Azadeh; Abdollahi, Maryam F.; Zhao, Yuming] Mem Univ Newfoundland, Dept Chem, St John, NF A1B 3X7, Canada; [Zhang, Baiyu] Mem Univ Newfoundland, Fac Engn & Appl Sci, Northern Reg Persistent Organ Pollut Control NRPO, St John, NF A1B 3X5, Canada in 2021, Cited 64. Application In Synthesis of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Phenyl-dithiafulvene (Ph-DTF) and corresponding tetrathiafulvalene vinylogue (TTFV) systems functionalized with electron-donating methoxy and electron-withdrawing nitro groups, respectively, were synthesized and examined by UV-Vis absorption, cyclic voltammetric, and X-ray single-crystallographic analyses, in conjunction with density functional theory (DFT) calculations. Our studies unravel the donor/acceptor-substitution effects on the electronic absorption, electrochemical redox, and solid-state supramolecular self-assembling properties of these Ph-DTF and TTFV systems.

Application In Synthesis of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Afzali, A; Abdollahi, MF; Zhang, BY; Zhao, YM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors published in 2019. Formula: C9H7NO2, Reprint Addresses Aly, AA (corresponding author), Menia Univ, Fac Sci, Dept Chem, Al Minya 61519, Egypt.; Abuo-Rahma, GEDA (corresponding author), Menia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt.. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one

Two new series of diethyl 2-[2-(substituted-2-oxo-1,2-dihydroquinolin-4-yl)hydrazono]-succinates 6a-g and 1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been designed and synthesized. The structures of the synthesized compounds were proved by IR, mass, NMR (2D) spectra and elemental analyses. The target compounds were evaluated for their in vitro cytotoxic activity against 60 cancer cell lines according to NCI protocol. Consequently, seven compounds were further examined against the most sensitive cell lines, leukemia CCRFCEM, and MOLT-4. 5-Amino-1-(6-bromo-2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazole-3,4-dicarbonitrile (7f) was the most active product, with IC50= 1.35 uM and 2.42 uM against MOLT-4 and CCRF-CEM, respectively. Also, it showed a remarkable inhibitory activity compared to erlotinib on the EGFR TK with IC50 = 247.14 nM and 208.42 nM, respectively. Cell cycle analysis of MOLT-4 cells treated with 7f showed cell cycle arrest at G2/M phase (supported by Caspases, BAX and Bcl-2 studies) with a significant pro-apoptotic activity as indicated by annexin V-FITC staining. Moreover, the docking study indicated that both the pyrazole moiety and the quinolin-2-one ring showed good fitting into EGFR (PDB code: 1M17). In order to interpret SAR of the designed compounds, and provide a basis for further optimization, molecular docking of the synthesized compounds to known EGFR inhibitors was performed. The study illustrated the effect of several factors on the compounds’ activity.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Elbastawesy, MAI; Aly, AA; Ramadan, M; Elshaier, YAMM; Youssif, BGM; Brown, AB; Abuo-Rahma, GEDA or concate me.. Formula: C9H7NO2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Lv, HP; Laishram, RD; Chen, JC; Khan, R; Zhu, YB; Wu, SY; Zhang, JQ; Liu, XY; Fan, BM in ROYAL SOC CHEMISTRY published article about in [Lv, Haiping; Laishram, Ronibala Devi; Chen, Jingchao; Khan, Ruhima; Fan, Baomin] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, Yuehua St, Kunming 650500, Yunnan, Peoples R China; [Zhu, Yuanbin; Wu, Shiyuan] Yunnan Tiefeng High Tech Min Chem Co Ltd, Qingfeng Ind Pk, Lufeng 651200, Yunnan, Peoples R China; [Zhang, Jianqiang; Liu, Xingyuan] Puer Univ, Coll Biol & Chem, Puer 665000, Yunnan, Peoples R China in 2021, Cited 52. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

An efficient method for the dehydrogenative coupling of silanes with alcohols under photocatalysis was developed. The reaction proceeded in the presence of Ru(bpy)(3)Cl-2 (0.5 mol%) under visible light irradiation in acetonitrile at room temperature. The developed methodology was also applicable for the synthesis of silanols using water as a coupling partner.

Category: indole-building-block. About Mequinol, If you have any questions, you can contact Lv, HP; Laishram, RD; Chen, JC; Khan, R; Zhu, YB; Wu, SY; Zhang, JQ; Liu, XY; Fan, BM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes WOS:000537068500001 published article about CARBONYLATION REACTIONS; ENANTIOSELECTIVE SYNTHESIS; CYCLIZATION; ALKENES; ESTERS in [Yuan, Zhenbo; Zeng, Yuye; Feng, Ziwen; Guan, Zhe; Lin, Aijun; Yao, Hequan] China Pharmaceut Univ, State Key Lab Nat Med SKLNM, Sch Pharm, Nanjing 210009, Peoples R China; [Yuan, Zhenbo; Zeng, Yuye; Feng, Ziwen; Guan, Zhe; Lin, Aijun; Yao, Hequan] China Pharmaceut Univ, Dept Med Chem, Sch Pharm, Nanjing 210009, Peoples R China in 2020.0, Cited 52.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Recommanded Product: 4′-Hydroxyacetophenone

Transition-metal-catalyzed tandem Heck/carbonylation reaction has emerged as a powerful tool for the synthesis of structurally diverse carbonyl molecules, as well as natural products and pharmaceuticals. However, the asymmetric version was rarely reported, and remains a challenging topic. Herein, we describe a palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes. Alcohols, phenols and amines are employed as versatile coupling reagents for the construction of multifunctional chiral bicyclo[3.2.1]octanes with one all-carbon quaternary and two tertiary carbon stereogenic centers in high diastereo- and enantioselectivities. This study represents an important progress in both the asymmetric tandem Heck/carbonylation reactions and enantioselective difunctionalization of internal alkenes. Tandem Heck/carbonylation reaction gives access to ubiquitous carbonyl molecules, however the asymmetric version is rarely studied. Here, the authors synthesize chiral bicyclo[3.2.1]octanes with a palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes with alcohols, phenols and amines.

Recommanded Product: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Yuan, ZB; Zeng, YY; Feng, ZW; Guan, Z; Lin, AJ; Yao, HQ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Holota, S; Komykhov, S; Sysak, S; Gzella, A; Cherkas, A; Lesyk, R in MDPI published article about in [Holota, Serhii; Sysak, Stepan; Lesyk, Roman] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmaceut Organ & Bioorgan Chem, Pekarska 69, UA-79010 Lvov, Ukraine; [Holota, Serhii] Lesya Ukrainka Volyn Natl Univ, Dept Organ Chem & Pharm, Volya Ave 13, UA-43025 Lutsk, Ukraine; [Komykhov, Sergiy] Natl Acad Sci Ukraine, Inst Single Crystals, State Sci Inst, Nauky Ave 60, UA-61072 Kharkiv, Ukraine; [Komykhov, Sergiy] Kharkov Natl Univ, Appl Chem Dept, Svobody Sq 4, UA-61022 Kharkiv, Ukraine; [Gzella, Andrzej] Poznan Univ Med Sci, Dept Organ Chem, Grunwaldzka 6, PL-60780 Poznan, Poland; [Cherkas, Andriy] Danylo Halytsky Lviv Natl Med Univ, Dept Internal Med 1, Pekarska 69, UA-79010 Lvov, Ukraine; [Lesyk, Roman] Univ Informat Technol & Management Rzeszow, Fac Med, Dept Publ Hlth Dietet & Lifestyle Disorders, Sucharskiego 2, PL-35225 Rzeszow, Poland; [Cherkas, Andriy] Sanofi Aventis Deutschland GmbH, Team Early Projects Type Diabet 1, Therapeut Area Diabet & Cardiovasc Med, Res & Dev, Ind Pk Hochst H831, D-65926 Frankfurt, Germany in 2021.0, Cited 55.0. Recommanded Product: 120-14-9. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The present paper is devoted to the search for drug-like molecules with anticancer properties using the thiazolo[3,2-b][1,2,4]triazole-6-one scaffold. A series of 24 novel thiazolo-[3,2-b][1,2,4]triazole-6-ones with 5-aryl(heteryl)idene- and 5-aminomethylidene-moieties has been synthesized employing three-component and three-stage synthetic protocols. A mixture of Z/E-isomers was obtained in solution for the synthesized 5-aminomethylidene-thiazolo[3,2-b]-[1,2,4]triazole-6-ones. The compounds have been studied for their antitumor activity in the NCI 60 lines screen. Some compounds present excellent anticancer properties at 10 mu M. Derivatives 2h and 2i were the most active against cancer cell lines without causing toxicity to normal somatic (HEK293) cells. A preliminary SAR study had been performed for the synthesized compounds.

Recommanded Product: 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Holota, S; Komykhov, S; Sysak, S; Gzella, A; Cherkas, A; Lesyk, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles