Day: October 20, 2021

HPLC of Formula: C7H8O. In 2019.0 MOLECULES published article about CARCINOMA-CELLS; ACID; EXPRESSION; PROTEINS; GROWTH; DEATH; LUNG; VIVO; METASTASIS; INHIBITOR in [Mahajna, Shahinaz; Kadan, Sleman; Saad, Bashar; Zaid, Hilal] Al Qasemi Acad Coll, Qasemi Res Ctr, POB 124, IL-30100 Baqa El Gharbia, Israel; [Mahajna, Shahinaz; Ginsberg, Doron] Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-5299 Ramat Gan, Israel; [Kadan, Sleman] Hebrew Univ Jerusalem, Inst Chem, Casali Ctr Appl Chem, IL-91904 Jerusalem, Israel; [Tietel, Zipora] Volcani Ctr, ARO, Dept Postharvest Sci Fresh Produce, IL-7505101 Bet Dagan, Israel; [Saad, Bashar; Khasib, Said; Tumeh, Aziz; Zaid, Hilal] Arab Amer Univ, Fac Sci, POB 240, Jenin 009704, Palestine in 2019.0, Cited 79.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Naturally derived drugs and plant-based products are attractive commodities that are being explored for cancer treatment. This in vitro study aimed to investigate the role of Hypericum triquetrifolium (50% ethanol: 50% water) extract (HTE) treatment on apoptosis, cell cycle modulation, and cell cycle arrest in human colon cancer cell line (HCT-116). HTE induced cell death via an apoptotic process, as assayed by an Annexin V-Cy3 assay. Exposing HCT-116 cells to 0.064, 0.125, 0.25, and 0.5 mg/mL of HTE for 24 h led to 50 +/- 9%, 71.6 +/- 8%, 85 +/- 5%, and 96 +/- 1.5% apoptotic cells, respectively. HCT-116 cells treated with 0.25 and 0.5 mg/mL HTE for 3 h resulted in 38.9 +/- 1.5% and 57.2 +/- 3% cleavage of caspase-3-specific substrate, respectively. RT-PCR analysis revealed that the HTE extract had no effect on mRNA levels of Apaf-1 and NOXA. Moreover, the addition of 0.125 mg/mL and 0.25 mg/mL HTE for 24 h was clearly shown to attenuate the cell cycle progression machinery in HCT-116 cells. GC/MS analysis of the extract identified 21 phytochemicals that are known as apoptosis inducers and cell cycle arrest agents. All the compounds detected are novel in H. triquetrifolium. These results suggest that HTE-induced apoptosis of human colon cells is mediated primarily through the caspase-dependent pathway. Thus, HTE appears to be a potent therapeutic agent for colon cancer treatment.

HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Mahajna, S; Kadan, S; Tietel, Z; Saad, B; Khasib, S; Tumeh, A; Ginsberg, D; Zaid, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about IN-VITRO; DRUG-DELIVERY; BRASILIENSIS; GEL; FORMULATION; EPIDEMIOLOGY; SCHENCKII; HYDROGEL; RELEASE; UPDATE, Saw an article supported by the CAPESCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES); CNPqConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [305915/2017-7, 303713/2014-3]; FAPERJFundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ) [E-26/2002.800/2017, E-26/2003.085/2016, E-26/200.930/2017]. Application In Synthesis of Benzyl Alcohol. Published in ELSEVIER SCIENCE INC in NEW YORK ,Authors: Ferreira, PG; Noronha, L; Teixeira, R; Vieira, I; Borba-Santos, LP; Vicosa, A; de Moraes, M; Calil-Elias, S; de Freitas, Z; da Silva, FC; Rozental, S; Futuro, DO; Ferreira, VF. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

The aim of this study was to develop a microemulsion (ME) formulation containing an association of itraconazole (ITC) and clotrimazole (CLT) as a transdermal delivery system for the treatment of sporotrichosis. Pseudoternary phase diagrams were constructed to optimize the ME formulation. The ME formulation selected contained 1% (w/w) ITC and 1% (w/w) CLT and was composed of 23.07% Tween (R) 60 (surfactant), 23.07% propylene glycol (cosurfactant/cosolvent), 30.77% benzyl alcohol (oil), and 21.09% water. The ITC/CLT-loaded ME (ITC/ CLT-ME) had a droplet size value of 217 +/- 0.9 nm, with a poly-dispersity index of 0.5 +/- 0.1. Permeation experiments on pig ear skin were conducted for ITC/CLT-ME, and the results indicated that the drug permeation performance was influenced by CLT, indicating that CLT acts as a promoter enhancer. In the in vitro antifungal activity assay using Sporothrix brasiliensis yeast, the inhibition halo produced by ITC/CLT-ME exhibited a mean diameter of 43.67 +/- 2.31 mm. The ITC/CLT-ME formulation did not cause skin irritation in mice. The results suggest that ITC/CLT-ME is a promising tool for the transdermal treatment of sporotrichosis. (c) 2020 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.

Application In Synthesis of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Ferreira, PG; Noronha, L; Teixeira, R; Vieira, I; Borba-Santos, LP; Vicosa, A; de Moraes, M; Calil-Elias, S; de Freitas, Z; da Silva, FC; Rozental, S; Futuro, DO; Ferreira, VF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Jia, RF; Zhang, J; Bertagnin, C; Cherukupalli, S; Ai, W; Ding, X; Li, Z; Zhang, JW; Ju, H; Ma, XL; Loregian, A; Huang, B; Zhan, P; Liu, XY in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Jia, Ruifang; Cherukupalli, Srinivasulu; Ai, Wei; Ding, Xiao; Li, Zhuo; Zhang, Jiwei; Ju, Han; Zhan, Peng; Liu, Xinyong] Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Dept Med Chem,Key Lab Chem Biol,Minist Educ, 44 West Culture Rd, Jinan 250012, Shandong, Peoples R China; [Zhang, Jian] Shandong Univ, Hosp 2, Cheeloo Coll Med, Inst Med Sci, Jinan 250033, Shandong, Peoples R China; [Bertagnin, Chiara; Loregian, Arianna] Univ Padua, Dept Mol Med, Via Gabelli 63, I-35121 Padua, Italy; [Ma, Xiuli; Huang, Bing] Shandong Acad Agr Sci, Inst Poultry Sci, 1 Jiaoxiao Rd, Jinan 250023, Shandong, Peoples R China; [Zhan, Peng; Liu, Xinyong] China Belgium Collaborat Res Ctr Innovat Antivira, 44 West Culture Rd, Jinan 250012, Shandong, Peoples R China in 2021, Cited 41. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

Encouraged by our earlier discovery of N1-selective inhibitors, the 150-cavity of influenza virus neuraminidases (NAs) could be further exploited to yield more potent oseltamivir derivatives. Herein, we report the design, synthesis and biological evaluation of a series of novel oseltamivir derivatives via the structural modifications at C-5-NH2 of oseltamivir targeting 150-cavity. Among them, compound 5c bearing 4-(3-methoxybenzyloxy)benzyl group exhibited the most potent activity, which was lower or modestly improved activities than oseltamivir carboxylate (OSC) against N1 (H1N1), N1 (H5N1) and N1 (H5N1-H274Y). Specifically, there was 30-fold loss of activity against the wild-type strain H1N1. However, 5c displayed 4.85-fold more potent activity than OSC against H5N1-H274Y NA. Also, 5c demonstrated low cytotoxicity in vitro and no acute toxicity in mice. Molecular docking studies provided insights into the high potency of 5c against N1 and N1-H274Y mutant NAs. Besides, the in silico prediction of physicochemical properties and CYP enzymatic inhibitory ability of representative compounds were conducted to evaluate their drug-like properties. (C) 2020 Elsevier Masson SAS. All rights reserved.

Category: indole-building-block. About m-Methoxyphenol, If you have any questions, you can contact Jia, RF; Zhang, J; Bertagnin, C; Cherukupalli, S; Ai, W; Ding, X; Li, Z; Zhang, JW; Ju, H; Ma, XL; Loregian, A; Huang, B; Zhan, P; Liu, XY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 123-11-5. Authors Nagy, MI; Darwish, KM; Kishk, SM; Tantawy, MA; Nasr, AM; Qushawy, M; Swidan, SA; Mostafa, SM; Salama, I in MDPI published article about in [Nagy, Manar, I; Darwish, Khaled M.; Kishk, Safaa M.; Mostafa, Samia M.; Salama, Ismail] Suez Canal Univ, Fac Pharm, Dept Med Chem, Ismailia 41522, Egypt; [Tantawy, Mohamed A.] Natl Res Ctr, Hormones Dept, Med Res Div, Giza 12622, Egypt; [Nasr, Ali M.] Port Said Univ, Fac Pharm, Dept Pharmaceut, Port Said 42526, Egypt; [Nasr, Ali M.; Qushawy, Mona] Sinai Univ, Fac Pharm, Dept Pharmaceut, Alarish 45511, North Sinai, Egypt; [Qushawy, Mona] Univ Tabuk, Fac Pharm, Dept Pharmaceut, Tabuk 71491, Saudi Arabia; [Swidan, Shady A.] British Univ Egypt, Fac Pharm, Dept Pharmaceut, Cairo 11837, Egypt; [Swidan, Shady A.] British Univ Egypt, Fac Pharm, Ctr Drug Res & Dev CDRD, Cairo 11837, Egypt in 2021.0, Cited 90.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Cancer is a multifactorial disease necessitating identification of novel targets for its treatment. Inhibition of Bcl-2 for triggered pro-apoptotic signaling is considered a promising strategy for cancer treatment. Within the current work, we aimed to design and synthesize a new series of benzimidazole- and indole-based derivatives as inhibitors of Bcl-2 protein. The market pan-Bcl-2 inhibitor, obatoclax, was the lead framework compound for adopted structural modifications. The obatoclax’s pyrrolylmethine linker was replaced with straight alkylamine or carboxyhydrazine methylene linkers providing the new compounds. This strategy permitted improved structural flexibility of synthesized compounds adopting favored maneuvers for better fitting at the Bcl-2 major hydrophobic pocket. Anti-cancer activity of the synthesized compounds was further investigated through MTT-cytotoxic assay, cell cycle analysis, RT-PCR, ELISA and DNA fragmentation. Cytotoxic results showed compounds 8a, 8b and 8c with promising cytotoxicity against MDA-MB-231/breast cancer cells (IC50 = 12.69 +/- 0.84 to 12.83 +/- 3.50 mu M), while 8a and 8c depicted noticeable activities against A549/lung adenocarcinoma cells (IC50 = 23.05 +/- 1.45 and 11.63 +/- 2.57 mu M, respectively). The signaling Bcl-2 inhibition pathway was confirmed by molecular docking where significant docking energies and interactions with key Bcl-2 pocket residues were depicted. Moreover, the top active compound, 8b, showed significant upregulated expression levels of pro-apoptotic/anti-apoptotic of genes; Bax, Bcl-2, caspase-3, -8, and -9 through RT-PCR assay. Improving the compound’s pharmaceutical profile was undertaken by introducing 8b within drug-solid/lipid nanoparticle formulation prepared by hot melting homogenization technique and evaluated for encapsulation efficiency, particle size, and zeta potential. Significant improvement was seen at the compound’s cytotoxic activity. In conclusion, 8b is introduced as a promising anti-cancer lead candidate that worth future fine-tuned lead optimization and development studies while exploring its potentiality through in-vivo preclinical investigation.

Recommanded Product: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Nagy, MI; Darwish, KM; Kishk, SM; Tantawy, MA; Nasr, AM; Qushawy, M; Swidan, SA; Mostafa, SM; Salama, I or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Luo, NH; Liao, JH; Ouyang, L; Wen, HL; Zhong, YH; Liu, JT; Tang, WP; Luo, RS in [Luo, Nianhua; Liao, Jianhua; Ouyang, Lu; Wen, Huiling; Zhong, Yuhong; Luo, Renshi] Gannan Med Univ, Sch Pharmaceut Sci, Ganzhou 341000, Jiangxi, Peoples R China; [Liao, Jianhua; Liu, Jitian; Tang, Weiping] Univ Wisconsin, Sch Pharm, Madison, WI 53705 USA published Highly Selective Hydroxylation and Alkoxylation of Silanes: One-Pot Silane Oxidation and Reduction of Aldehydes/Ketones in 2020.0, Cited 48.0. Name: Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

An efficient chemoselective iridium-catalyzed method for the hydroxylation and alkoxylation of organosilanes to generate hydrogen gas and silanols or silyl ethers was developed. A variety of sterically hindered silanes with alkyl, aryl, and ether groups were tolerated. Furthermore, this atom-economical catalytic protocol can be used for the synthesis of silanediols and silanetriols. A one-pot silane oxidation and chemoselective reduction of aldehydes/ketones was also realized.

About Benzyl Alcohol, If you have any questions, you can contact Luo, NH; Liao, JH; Ouyang, L; Wen, HL; Zhong, YH; Liu, JT; Tang, WP; Luo, RS or concate me.. Name: Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Hydrotalcites as catalyst in suitable multicomponent synthesis of uracil derivatives WOS:000662269700006 published article about ONE-POT SYNTHESIS; BIGINELLI-TYPE REACTION; MG-AL HYDROTALCITES; SOLVENT-FREE; HETEROGENEOUS CATALYSTS; EFFICIENT SYNTHESIS; IONIC LIQUID; SOLID BASE; MECHANISM; CONDENSATION in [Nope, Eliana; Sathicq, Angel G.; Romanelli, Gustavo] Univ Nacl La Plata, Ctr Invest & Desarrollo Ciencias Aplicadas Dr Jor, CONICET, CINDECA,CCT La Plata,CIC,PBA, Calle 47 257,B1900AJK, La Plata, Argentina; [Martinez, Jose J.; Rojas, Hugo] Univ Pedag & Tecnol Colombia UPTC, Fac Ciencias, Escuela Ciencias Quim, Ave Cent Norte, Tunja, Boyaca, Colombia; [Romanelli, Gustavo] Univ Nacl La Plata, Fac Ciencias Agr & Forestales, Catedra Quim Organ, Ctr Invest Sanidad Vegetal CISaV, Calles 60 & 119 S-N,B1904AAN, La Plata, Argentina in 2021.0, Cited 61.0. HPLC of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Uracil compounds participate in a wide range of biological activities; however, reports on their synthesis using heterogeneous catalysts are scarce. In this work, the multicomponent synthesis of uracil derivatives assisted by layered double hydroxides (LDH) was studied under green chemistry conditions. The incorporation of Ni2+ or Co2+ was successfully performed by co-precipitation method. The yields to uracil derivatives are associated with the presence of weak basic sites and a better interaction of the reagents when the reaction is carried out in solvent-free conditions. The reaction pathway involves the formation of an enone between benzaldehyde and ethyl cyanoacetate, and subsequent reaction with urea, which is assisted by the presence of a basic catalyst. The scope of this synthesis is illustrated with nine examples.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Nope, E; Sathicq, AG; Martinez, JJ; Rojas, H; Romanelli, G or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 100-51-6. Authors Shang, XJ; Zhang, C; Zhao, J; Shao, P; Lu, HJ; Yan, FL in WILEY-V C H VERLAG GMBH published article about in [Shang, Xiao-Jun; Zhang, Chong; Zhao, Jie; Lu, Hui-Juan; Yan, Fu-Lin] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China; [Shang, Xiao-Jun] Xinxiang Med Univ, Affiliated Hosp 1, Weihui 453100, Henan, Peoples R China; [Shao, Peng] Zhengzhou Univ, Zhengzhou Cent Hosp, Zhengzhou 450007, Henan, Peoples R China in 2019.0, Cited 13.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

The aim of this study was to determine the antitumor activity of diterpenoid compounds. A series of modified diterpenoid derivatives (3-26) were obtained from the natural products enmein (1) and nodosin (2), using simple synthetic methods. The structures of the synthesized compounds were established through H-1 NMR, C-13 NMR and HRMS. The compounds were screened using a CCK8 assay for their antiproliferative activities against K562 and HepG2 human cancer cells. Most of the target compounds showed improved antiproliferative activity against K562 and HepG2 human cancer cells compared with natural enmein (1) and nodosin (2). 6-Propynyloxy-enmein (13), 6- propynyloxy-nodosin (25) and 6-cyclopropylmethoxy-nodosin (26) exhibited strong inhibitory activity against K562 cells with IC50 values of 3.58 +/- 0.16, 1.89 +/- 0.18, and 4.86 +/- 0.30 mu g/mL, respectively.

SDS of cas: 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Shang, XJ; Zhang, C; Zhao, J; Shao, P; Lu, HJ; Yan, FL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H8O. In 2019.0 CHEM SCI published article about D TRIMETHYL ETHER; TOPOISOMERASE-I; ARYLATION; PYRROLES; CONSTRUCTION; DERIVATIVES in [Shirley, Harry J.; Koyioni, Maria; Muncan, Filip; Donohoe, Timothy J.] Univ Oxford, Dept Chem, Chem Res Lab, Mansfield Rd, Oxford OX1 3TA, England in 2019.0, Cited 42.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Pyruvic acid and other -keto acids are frequently encountered as intermediates in metabolic pathways, yet their application in total synthesis has met with limited success. In this work, we present a bioinspired strategy that utilizes highly functionalized OBO (oxabicyclo[2.2.2]octyl) orthoester masked -ketoacids as key intermediates for the construction of both type I and II lamellarin alkaloids. Lamellarin D was synthesized, via a key 1,4-dicarbonyl, in 7 steps and 22% yield from pyruvic acid. Key steps in the synthesis involve one-pot double enolate functionalisation of 1 followed by double annulation to form the target pyrrole/N-vinyl pyrrole core and late-stage direct C-H arylation. Lastly, a novel OBO-masked -cyano ketone, synthesized from 1, proved to be a valuable intermediate for construction of the type II lamellarin core via HBr-mediated cyclisation. In this way, lamellarin Q was synthesized in 7 steps and 20% yield from pyruvic acid.

Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Shirley, HJ; Koyioni, M; Muncan, F; Donohoe, TJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Singh, A; Cullen, JK; Bruce, ZC; Reddell, P; Munch, G; Raju, R in PERGAMON-ELSEVIER SCIENCE LTD published article about OLEANANE-TYPE; FLOWER BUDS; SAPONINS; FRUITS in [Singh, Ahilya; Munch, Gerald; Raju, Ritesh] Western Sydney Univ, Dept Pharmacol, Campbelltown Campus, Sydney, NSW, Australia; [Reddell, Paul] QBiot Ltd, POB 1, Yungaburra, Qld, Australia; [Cullen, Jason K.; Bruce, Zara C.] QIMR Berghofer Med Res Inst, Herston, Qld, Australia in 2020, Cited 13. Name: (E)-2-Methylbut-2-enoic acid. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1

Chromatographic separation of the extracts of the Australian rainforest plant Ternstroemia cherryi led to the isolation of five undescribed barrigenol-like triterpenoids, ternstroenols A – E, from the fruits and three known ones from the leaves. Ternstroenols A – E represent a new form of structural diversity, being the first in its kind to incorporate a trans- 2, 4, 6- decatrienoyl moiety at C-22. The structures of the ternstroenols were assigned by detailed spectroscopic analysis, degradation and chemical derivatization. All compounds exhibited potent antiinflammatory activity in LPS and IFN-gamma activated RAW 264.7 macrophages, with IC50, values as low as 0.7 mu M. Despite the remarkable potency, high levels of unwanted cell growth inhibition was also observed, which prompted their cytotoxic evaluation in U87/U251 human glioblastoma cell lines.

Name: (E)-2-Methylbut-2-enoic acid. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Singh, A; Cullen, JK; Bruce, ZC; Reddell, P; Munch, G; Raju, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 80-59-1. Authors Boyko, YD; Huck, CJ; Ning, S; Shved, AS; Yang, C; Chu, T; Tonogai, EJ; Hergenrother, PJ; Sarlah, D in AMER CHEMICAL SOC published article about in [Boyko, Yaroslav D.; Huck, Christopher J.; Ning, Shang; Shved, Alexander S.; Yang, Cheng; Chu, Tiffany; Tonogai, Emily J.; Hergenrother, Paul J.; Sarlah, David] Univ Illinois, Dept Chem, Roger Adams Lab, Urbana, IL 61801 USA; [Boyko, Yaroslav D.; Huck, Christopher J.; Shved, Alexander S.; Tonogai, Emily J.; Hergenrother, Paul J.; Sarlah, David] Univ Illinois, Canc Ctr Illinois, Urbana, IL 61801 USA; [Tonogai, Emily J.; Hergenrother, Paul J.] Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USA in 2021, Cited 108. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1

The isomalabaricanes comprise a large family of marine triterpenoids with fascinating structures that have been shown to be selective and potent apoptosis inducers in certain cancer cell lines. In this article, we describe the successful total syntheses of the isomalabaricanes stelletin A, stelletin E, and rhabdastrellic acid A, as well as the development of a general strategy to access other natural products within this unique family. High-throughput experimentation and computational chemistry methods were used in this endeavor. A preliminary structure-activity relationship study of stelletin A revealed the trans-syn-trans core motif of the isomalabaricanes to be critical for their cytotoxic activity.

Product Details of 80-59-1. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Boyko, YD; Huck, CJ; Ning, S; Shved, AS; Yang, C; Chu, T; Tonogai, EJ; Hergenrother, PJ; Sarlah, D or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles