Day: October 20, 2021

Recently I am researching about FACTOR RECEPTOR KINASE; SUBSTITUTED QUINOLINONES; PYRAZOLE DERIVATIVES; POTENTIAL ANTICANCER; ERLOTINIB; CANCER; CRIZOTINIB; CHEMISTRY; ASSAY, Saw an article supported by the . Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Elbastawesy, MAI; Aly, AA; Ramadan, M; Elshaier, YAMM; Youssif, BGM; Brown, AB; Abuo-Rahma, GEDA. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one. Safety of 4-Hydroxyquinolin-2(1H)-one

Two new series of diethyl 2-[2-(substituted-2-oxo-1,2-dihydroquinolin-4-yl)hydrazono]-succinates 6a-g and 1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been designed and synthesized. The structures of the synthesized compounds were proved by IR, mass, NMR (2D) spectra and elemental analyses. The target compounds were evaluated for their in vitro cytotoxic activity against 60 cancer cell lines according to NCI protocol. Consequently, seven compounds were further examined against the most sensitive cell lines, leukemia CCRFCEM, and MOLT-4. 5-Amino-1-(6-bromo-2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazole-3,4-dicarbonitrile (7f) was the most active product, with IC50= 1.35 uM and 2.42 uM against MOLT-4 and CCRF-CEM, respectively. Also, it showed a remarkable inhibitory activity compared to erlotinib on the EGFR TK with IC50 = 247.14 nM and 208.42 nM, respectively. Cell cycle analysis of MOLT-4 cells treated with 7f showed cell cycle arrest at G2/M phase (supported by Caspases, BAX and Bcl-2 studies) with a significant pro-apoptotic activity as indicated by annexin V-FITC staining. Moreover, the docking study indicated that both the pyrazole moiety and the quinolin-2-one ring showed good fitting into EGFR (PDB code: 1M17). In order to interpret SAR of the designed compounds, and provide a basis for further optimization, molecular docking of the synthesized compounds to known EGFR inhibitors was performed. The study illustrated the effect of several factors on the compounds’ activity.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Elbastawesy, MAI; Aly, AA; Ramadan, M; Elshaier, YAMM; Youssif, BGM; Brown, AB; Abuo-Rahma, GEDA or concate me.. Safety of 4-Hydroxyquinolin-2(1H)-one

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Wu, Z; Jiang, H; Zhang, YH in ROYAL SOC CHEMISTRY published article about ARYL BROMIDES; BETA-LACTAMS; HALIDES; BONDS; BENZYLATION; COMBINATION; DERIVATIVES; DESIGN; PHENOL in [Wu, Zhuo; Jiang, Hang; Zhang, Yanghui] Tongji Univ, Shanghai Key Lab Chem Assessment & Sustainabil, Sch Chem Sci & Engn, 1239 Siping Rd, Shanghai 200092, Peoples R China in 2021.0, Cited 77.0. Quality Control of m-Methoxyphenol. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

Transition-metal-catalyzed cross-electrophile C(sp(2))-(sp(3)) coupling and C-H alkylation reactions represent two efficient methods for the incorporation of an alkyl group into aromatic rings. Herein, we report a Pd-catalyzed cascade cross-electrophile coupling and C-H alkylation reaction of 2-iodo-alkoxylarenes with alkyl chlorides. Methoxy and benzyloxy groups, which are ubiquitous functional groups and common protecting groups, were utilized as crucial mediators via primary or secondary C(sp(3))-H activation. The reaction provides an innovative and convenient access for the synthesis of alkylated phenol derivatives, which are widely found in bioactive compounds and organic functional materials.

Quality Control of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Wu, Z; Jiang, H; Zhang, YH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry; Physics very interesting. Saw the article Aqueous extract of Shikakai; a green solvent for deoximation reaction: Mechanistic approach from experimental to theoretical published in 2020.0. Formula: C7H6O2, Reprint Addresses Das, D (corresponding author), Sukanti Degree Coll, Dept Chem, Subarnapur, Odisha, India.; Mohapatra, RK (corresponding author), Govt Coll Engn, Dept Chem, Keonjhar, Odisha, India.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

This article describes a green method for regeneration of carbonyl compounds from various types of oxime compounds under microwave radiation using I-2 and aqueous saponin solution isolated from Shikakai. Effect of saponin concentration on yield percentage of regenerated different types of carbonyl compounds has been discussed. A correlation has been established between saponin concentration and yield percentage of carbonyl compounds. Mechanism of interaction between oxime and saponin is established on the basis of density functional theory. In addition, the quantum chemical parameters for saponin have been determined. Furthermore, electrostatic surface analysis of the saponin is carried out to confirm the mechanism of interaction between saponin and oximes. (C) 2020 Elsevier B.V. All rights reserved.

Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Das, D; Sarangi, AK; Mohapatra, RK; Parhi, PK; Mahal, A; Sahu, R; Kudrat-E-Zahan, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Al Mahmud, H; Seo, H; Kim, S; Islam, MI; Sultana, OF; Nam, KW; Lee, BE; Sadu, VS; Lee, KI; Song, HY in [Al Mahmud, Hafij; Seo, Hoonhee; Kim, Sukyung; Islam, Md Imtiazul; Sultana, Omme Fatema; Song, Ho-Yeon] Soonchunhyang Univ, Sch Med, Dept Microbiol & Immunol, Cheonan 31151, Chungnam, South Korea; [Nam, Kung-Woo] Soonchunhyang Univ, Dept Life Sci & Biotechnol, Asan 31538, Chungnam, South Korea; [Lee, Byung-Eui] Soonchunhyang Univ, Sch Life Sci, Dept Chem, Asan 31538, Chungnam, South Korea; [Sadu, Venkata S.; Lee, Kee-In] Univ Sci & Technol, Major Green Chem & Environm Biotechnol, Daejeon 34113, South Korea; [Lee, Kee-In] Korea Res Inst Chem Technol, Green Chem Div, Daejeon 34114, South Korea published Synthesis and activity of BNF15 against drug-resistant Mycobacterium tuberculosis in 2021.0, Cited 41.0. Recommanded Product: 150-19-6. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

Aim: Tuberculosis is the leading cause of mortality among infectious diseases worldwide. Finding a new competent anti tubercular therapy is essential. Materials & methods: We screened thousands of compounds and evaluated their efficacy against Mycobacterium tuberculosis. Results: Initially, 2-nitronaphtho[2,3-b]benzofuran-6,11-dione was active against M. tuberculosis. Next, among x15 newly synthesized derivatives, BNF15 showed promising effect against all drug-sensitive and drug-resistant M. tuberculosis (MIC: 0.02-0.78 mu g/ml). BNF15 effectively killed intracellular M. tuberculosis and nontuberculous mycobacteria. BNF15 exhibited a prolonged post antibiotic effect superior to isoniazid, streptomycin, and ethambutol and synergistic interaction with rifampicin. In acute oral toxicity test, BNF15 did not show toxic effect at a concentration up to 2000 mg/kg. Conclusion: These results highlight the perspective of BNF15 to treat drug-resistant M. tuberculosis.

Recommanded Product: 150-19-6. About m-Methoxyphenol, If you have any questions, you can contact Al Mahmud, H; Seo, H; Kim, S; Islam, MI; Sultana, OF; Nam, KW; Lee, BE; Sadu, VS; Lee, KI; Song, HY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about AGENTS, Saw an article supported by the Organic Chemistry Department of Chemistry and Chemical Engineering Research Center of Iran, Tehran, Iran. Published in ELSEVIER in AMSTERDAM ,Authors: Mohammadi, AA; Taheri, S; Ghaderi, P; Ahdenov, R; Azizian, H; Mohammadi-Khanaposhtani, M; Faramarzi, MA; Larijani, B; Mahdavi, M. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde. Computed Properties of C8H8O2

In this study, new tri-amides 5a-1 have been synthesized via a one-pot four-component Ugi reaction between repaglinide, aniline derivatives, aldehyde derivatives, and cyclohexyl isocyanide in good yields. These compounds were evaluated against yeast alpha-glucosidase. Obtained in vitro alpha-glucosidase results demonstrated that all the synthesized compounds 5a-1 were more potent than standard inhibitor acarbose. Among them, the most potent compounds were compounds 5j, 5k, and 5h. The kinetic analysis of the most potent compound 5j revealed that this compound is a competitive inhibitor for alpha-glucosidase (K-i = 24 mu M). Furthermore, docking study of the most potent compounds was also performed in the alpha-glucosidase active site to find interaction modes and binding energies of these compounds. (C) 2020 Elsevier B.V. All rights reserved.

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Mohammadi, AA; Taheri, S; Ghaderi, P; Ahdenov, R; Azizian, H; Mohammadi-Khanaposhtani, M; Faramarzi, MA; Larijani, B; Mahdavi, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 80-59-1. Recently I am researching about NOVO ASYMMETRIC-SYNTHESIS; SMALL-MOLECULE SIGNALS; CAENORHABDITIS-ELEGANS; METABOLOMICS REVEALS; BUILDING-BLOCKS; BIOSYNTHESIS; METABOLISM; PERCEPTION; RESISTANCE; PATTERNS, Saw an article supported by the Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81573314]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ3707]; Changsha Science and Technology Projects [kq1701088, kq2001032]; National Key Research and Development Program of China [2016YFD0100602]; Huazhong Agricultural University Scientific & Technological SelfInnovation Foundation [2662017PY009]; Central South University. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Ning, S; Zhang, L; Ma, JJ; Chen, L; Zeng, GY; Yang, C; Zhou, YJ; Guo, XL; Deng, X. The CAS is 80-59-1. Through research, I have a further understanding and discovery of (E)-2-Methylbut-2-enoic acid

A highly efficient and modular synthesis of nematode pheromone ascarosides was developed, which highlights a 4-step scalable synthesis of the common intermediate 10 in 23% yield from commercially available l-rhamnose by using orthoesterification/benzylation/orthoester rearrangement as the key step. Six diverse ascarosides were synthesized accordingly. Notably, biological investigations revealed that ascr#1 and ascr#18 treatment resulted in enhanced callose accumulation in Arabidopsis leaves. And ascr#18 also increased the expression of defense-related genes such as PR1, PDF1.2, LOX2 and AOS, which might contribute to the enhanced plant defense responses. This study not only allows a facile access to 1-O, 2-O, and 4-O substituted ascarosides, but also provides valuable insights into their biological activities in inducing plant defense response, as well as their mode of action.

SDS of cas: 80-59-1. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Ning, S; Zhang, L; Ma, JJ; Chen, L; Zeng, GY; Yang, C; Zhou, YJ; Guo, XL; Deng, X or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Visible-light assisted of nano Ni/g-C3N4 with efficient photocatalytic activity and stability for selective aerobic C-H activation and epoxidation published in 2020.0. Formula: C8H8O2, Reprint Addresses Hosseini-Sarvari, M (corresponding author), Shiraz Univ, Fac Sci, Dept Chem, Shiraz 7194684795, Iran.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

A selective, economical, and ecological protocol has been described for the oxidation of methyl arenes and their analogs to the corresponding carbonyl compounds and epoxidation reactions of alkenes with molecular oxygen (O-2) or air as a green oxygen source, under mild reaction conditions. The nano Ni/g-C3N4 exhibited high photocatalytic activity, stability, and selectivity in the C-H activation of methyl arenes, methylene arenes, and epoxidation of various alkenes under visible- light irradiation without the use of an oxidizing agent and under base free conditions. (C) 2020 Elsevier B.V. All rights reserved.

Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Hosseini-Sarvari, M; Akrami, Z or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Triethylammonium Hydrogen Sulfate [Et3NH][HSO4]-Catalyzed Rapid and Efficient Multicomponent Synthesis of Pyrido[2,3-d]pyrimidine and Pyrazolo[3,4-b]pyridine Hybrids WOS:000677481800042 published article about ONE-POT SYNTHESIS; IONIC LIQUIDS; PYRAZOLE DERIVATIVES; TEMPERATURE; SOLVENTS; DESIGN; AGENTS; ACID in [Jadhav, Chetan; Nipate, Amol; Chate, Asha; Gill, Charansingh] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, Maharashtra, India in 2021.0, Cited 55.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Quality Control of 3,4-Dimethoxybenzaldehyde

An operationally simple, one-pot multicomponent reaction has been developed for the assembly of pyrido[2,3-d]pyrimidine and pyrazolo[3,4-b]pyridine derivatives (4a-4am) in excellent yields (92-94%) with high purity. The reactions were easy to perform simply by mixing of electron-rich amino heterocycles (including aminouracils and aminopyrazoles), aldehyde, and acyl acetonitrile in the presence of [Et3NH][HSO4] under solvent-free conditions. The remarkable feature of the present approach is that the ionic liquid possesses dual solvent-catalytic engineering capability. Results of this study revealed that 1 mmol of the ionic liquid catalyst under solvent-free conditions at 60 degrees C is the best reaction parameter for the construction of fused pyridine and pyrimidine derivatives in excellent yields. The present methodology showed good results under gram-scale conditions, thereby indicating its applicability in industrial as well as academic settings in the near future.

Quality Control of 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Jadhav, C; Nipate, A; Chate, A; Gill, C or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Formation of furo[3,2-c]quinolone-2-carbonitriles and 4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides from reaction of quinoline-2,4-diones with 2-[bis(methylthio)methylene]malononitrile WOS:000513256900009 published article about DERIVATIVES; INHIBITORS; FUROQUINOLINE; ALKALOIDS; MODEL in [Aly, Ashraf A.; Mohamed, Asmaa H.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Ishak, Esam] Al Azhar Univ, Fac Sci, Dept Chem, Assiut, Egypt; [Ishak, Esam] Jouf Univ, Coll Sci & Arts, Dept Chem, Alquurrayate, Saudi Arabia; [Shwaky, Ahmed M.] Umm Al Qura Univ, STU, Mecca, Saudi Arabia in 2020, Cited 31. HPLC of Formula: C9H7NO2. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

Quinoline-2,4-diones reacted with 2-[bis(methylthio)methylene]malononitrile in DMF/Et3N to produce 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carbonitriles and 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides in state of 2-imino-substituted 4-(methylthio)-5,6-dihydro-2H-pyrano[3,2-c]quinolone-3-carbonitriles. The structures of all new products were proved using NMR, IR, and mass spectral data. The possible mechanism for the reaction is also discussed. Graphic abstract

HPLC of Formula: C9H7NO2. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Nakayama, Y; Maser, MR; Okita, T; Dubrovskiy, AV; Campbell, TL; Reisman, SE in AMER CHEMICAL SOC published article about in [Nakayama, Yasuaki; Maser, Michael R.; Okita, Tatsuya; Dubrovskiy, Anton, V; Campbell, Taryn L.; Reisman, Sarah E.] CALTECH, Warren & Katharine Schlinger Lab Chem & Chem Engn, Div Chem & Chem Engn, Pasadena, CA 91125 USA in 2021.0, Cited 38.0. Formula: C7H8O2. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

The first total synthesis of the cytotoxic alkaloid ritterazine B is reported. The synthesis features a unified approach to both steroid subunits, employing a titanium-mediated propargylation reaction to achieve divergence from a common precursor. Other key steps include gold-catalyzed cycloisomerizations that install both spiroketals and late stage C-H oxidation to incorporate the C7′ alcohol.

Formula: C7H8O2. About Mequinol, If you have any questions, you can contact Nakayama, Y; Maser, MR; Okita, T; Dubrovskiy, AV; Campbell, TL; Reisman, SE or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles