Day: October 22, 2021

An article Efficient methylation of anilines with methanol catalysed by cyclometalated ruthenium complexes WOS:000639998200015 published article about HYDROGEN-TRANSFER REDUCTION; MONO-N-METHYLATION; BORROWING HYDROGEN; PINCER RUTHENIUM; OS COMPLEXES; AMINES; KETONES; LIGANDS; RU; HETEROCYCLES in [Piehl, Patrick; Amuso, Roberta; Spannenberg, Anke; Neumann, Helfried; Beller, Matthias] Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany; [Amuso, Roberta; Gabriele, Bartolo] Univ Calabria, Dept Chem & Chem Technol, Lab Ind & Synthet Organ Chem LISOC, Via Pietro Bucci 12-C, I-87036 Arcavacata Di Rende, CS, Italy in 2021.0, Cited 63.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Formula: C7H8O

Cyclometalated ruthenium complexes 4-10 allow the effective methylation of anilines with methanol to selectively give N-methylanilines. This hydrogen autotransfer procedure proceeds under mild conditions (60 degrees C) in a practical manner (NaOH as base). Mechanistic investigations suggest an active homogenous ruthenium complex and beta-hydride elimination of methanol as the rate determining step.

About Benzyl Alcohol, If you have any questions, you can contact Piehl, P; Amuso, R; Spannenberg, A; Gabriele, B; Neumann, H; Beller, M or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 123-11-5. Authors Paul, A; Shipman, MA; Onabule, DY; Sproules, S; Symes, MD in ROYAL SOC CHEMISTRY published article about in [Paul, Avishek; Shipman, Michael A.; Onabule, Dolapo Y.; Sproules, Stephen; Symes, Mark D.] Univ Glasgow, Sch Chem, WestCHEM, Univ Ave, Glasgow G12 8QQ, Lanark, Scotland in 2021, Cited 30. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The enhancement of reactivity inside supramolecular coordination cages has many analogies to the mode of action of enzymes, and continues to inspire the design of new catalysts for a range of reactions. However, despite being a near-ubiquitous class of reactions in organic chemistry, enhancement of the reduction of carbonyls to their corresponding alcohols remains very much underexplored in supramolecular coordination cages. Herein, we show that encapsulation of small aromatic aldehydes inside a supramolecular coordination cage allows the reduction of these aldehydes with the mild reducing agent sodium cyanoborohydride to proceed with high selectivity (ketones and esters are not reduced) and in good yields. In the absence of the cage, low pH conditions are essential for any appreciable conversion of the aldehydes to the alcohols. In contrast, the specific microenvironment inside the cage allows this reaction to proceed in bulk solution that is pH-neutral, or even basic. We propose that the cage acts to stabilise the protonated oxocarbenium ion reaction intermediates (enhancing aldehyde reactivity) whilst simultaneously favouring the encapsulation and reduction of smaller aldehydes (which fit more easily inside the cage). Such dual action (enhancement of reactivity and size-selectivity) is reminiscent of the mode of operation of natural enzymes and highlights the tremendous promise of cage architectures as selective catalysts.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Paul, A; Shipman, MA; Onabule, DY; Sproules, S; Symes, MD or concate me.. SDS of cas: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C7H8O2. In 2021.0 ORG BIOMOL CHEM published article about H BOND FUNCTIONALIZATION; FRIEDEL-CRAFTS REACTION; C-H; SYNTHETIC APPLICATIONS; ARYL; ALKYLATION; NAPHTHOLS; ACCESS; CHLORINATION; METHYLATION in [Tang, Zhiqiong; Li, Dongdong; Yue, Yidi; Peng, Dan; Liu, Lu] East China Normal Univ, Sch Chem & Mol Engn, 500 Dongchuan Rd, Shanghai 200241, Peoples R China; [Liu, Lu] East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai 200062, Peoples R China in 2021.0, Cited 69.0. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5.

We have developed a Bronsted acid catalysed highly ortho-selective functionalization of free phenols with readily available N,O-acetals under mild conditions, furnishing various corresponding aminomethylated phenol products in moderate to excellent yields. The salient features of this transformation include mild conditions, good substrate scope, excellent ortho-selectivity, high efficiency, and ease of further transformation.

HPLC of Formula: C7H8O2. About Mequinol, If you have any questions, you can contact Tang, ZQ; Li, DD; Yue, YD; Peng, D; Liu, L or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zhou, MX; He, ED; Zhang, L; Chen, JZ; Zhang, ZF; Liu, YG; Zhang, WB in [Zhou, Muxing; He, Ende; Zhang, Lu; Zhang, Zhenfeng; Liu, Yangang; Zhang, Wanbin] Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China; [Chen, Jianzhong; Zhang, Wanbin] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China published Development of a new bicyclic imidazole nucleophilic organocatalyst for direct enantioselective C-acylation in 2019, Cited 62. Quality Control of m-Methoxyphenol. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

A novel chiral nucleophilic organocatalyst easily synthesized from simple starting materials bearing a 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine skeleton has been developed and successfully applied in the direct enantioselective C-acylation of 3-substituted benzofuranones. Its catalytic efficiency was shown to be comparable to that of the previously reported chiral 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole catalyst. A wide range of 3,3-disubstituted benzofuranones, possessing a quaternary stereocenter, were synthesized with high yields and enantioselectivities.

About m-Methoxyphenol, If you have any questions, you can contact Zhou, MX; He, ED; Zhang, L; Chen, JZ; Zhang, ZF; Liu, YG; Zhang, WB or concate me.. Safety of m-Methoxyphenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C9H7NO2. Authors Chheda, PR; Kummer, DA; Nishimura, RT; McClure, KJ; Venkatesan, H in AMER CHEMICAL SOC published article about in [Kummer, David A.] Lundbeck La Jolla Res Ctr Inc, San Diego, CA 92121 USA; [Chheda, Pratik R.; Nishimura, Rachel T.; McClure, Kelly J.; Venkatesan, Hariharan] Janssen Res & Dev, Discovery Chem, San Diego, CA 92121 USA in 2021, Cited 63. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

A one-pot, Hantzsch ester-mediated Knoevenagel condensation-reduction reaction has been developed for alkylation of a wide range of substituted 2,4-quinoline diols and 2,4-pyridine diols with aldehydes. The process is operationally simple to perform, scalable, and provides highly useful C-3 alkylated quinoline and pyridine diols in yields of 58-92%. The alkylation products can be converted to 2,4-dihaloquinoline and pyridine substrates for further functionalization.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Chheda, PR; Kummer, DA; Nishimura, RT; McClure, KJ; Venkatesan, H or concate me.. Recommanded Product: 4-Hydroxyquinolin-2(1H)-one

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Ru-Catalyzed (E)-Specific ortho-C-H Alkenylation of Arenecarboxylic Acids by Coupling with Alkenyl Bromides WOS:000649477300059 published article about DIRECT ORTHO ARYLATION; CARBOXYLIC-ACIDS; BENZOIC-ACIDS; BOND; PALLADIUM; HYDROARYLATION; OLEFINATION; ARYL; ALKYNES; ACTIVATION in [Hu, Zhiyong; Belitz, Florian; Zhang, Guodong; Papp, Florian; Goossen, Lukas J.] Ruhr Univ Bochum, Evonik Chair Organ Chem, D-44801 Bochum, Germany in 2021, Cited 68. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1. Safety of (E)-2-Methylbut-2-enoic acid

In the presence of [p-cymene)RuCl2](2), (E)-configured alkenyl bromides couple with aromatic carboxylates to form orthovinylbenzoic acids. This C-H vinylation proceeds in high yields without any activating phosphine ligands and has an excellent functional group tolerance. Starting from commonly available (E/Z)-mixtures of alkenyl bromides, (E)-configured vinyl arenes or dienes are formed exclusively. Mechanistic studies show that this selectivity is achieved because the (E)configured alkenyl bromides undergo a smooth coupling, whereas the (Z)-isomers are rapidly eliminated with the formation of alkynes.

Safety of (E)-2-Methylbut-2-enoic acid. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Hu, ZY; Belitz, F; Zhang, GD; Papp, F; Goossen, LJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthetic Entry to Polyfunctionalized Molecules through the [3+2]-Cycloaddition of Thiocarbonyl Ylides WOS:000484082700015 published article about CARBON QUATERNARY STEREOCENTERS; 6+3 CYCLOADDITION; MESO COMPOUNDS; GENERATION; CONSTRUCTION; PRESSURE; SULFUR; DENDRALENES; THIOPHENES; SULFONIUM in [Haut, Franz-Lucas; Habiger, Christoph; Muller, Thomas; Magauer, Thomas] Leopold Franzens Univ Innsbruck, Inst Organ Chem, Innrain 80-82, A-6020 Innsbruck, Austria; [Haut, Franz-Lucas; Habiger, Christoph; Muller, Thomas; Magauer, Thomas] Leopold Franzens Univ Innsbruck, Ctr Mol Biosci, Innrain 80-82, A-6020 Innsbruck, Austria; [Speck, Klaus; Mayer, Peter; Korber, Johannes Nepomuk] Ludwig Maximilians Univ Munchen, Dept Chem & Pharm, Butenandtstr 5-13, D-81377 Munich, Germany; [Wurst, Klaus] Leopold Franzens Univ Innsbruck, Inst Gen Inorgan & Theoret Chem, Innrain 80-82, A-6020 Innsbruck, Austria in 2019.0, Cited 63.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Computed Properties of C7H8O

Here we present a comprehensive study on the [3+2]-cycloaddition of thiocarbonyl ylides with a wide variety of alkenes and alkynes. The obtained dihydro- and tetrahydrothiophene products serve as exceptionally versatile intermediates providing access to thiophenes, dienes, dendralenes, and vic-quarternary carbon centers. The use of high-pressure conditions enables thermally unstable, sterically encumbered or moderately reactive substrates to undergo the cycloaddition under mild conditions, thereby increasing the yield by up to 58%. In addition, we showcase its utility by the formal syntheses of the pharmaceuticals NGB 4420 and tenilapine.

About Benzyl Alcohol, If you have any questions, you can contact Haut, FL; Habiger, C; Speck, K; Wurst, K; Mayer, P; Korber, JN; Muller, T; Magauer, T or concate me.. Name: Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Catalytic Asymmetric Intermolecular Radical Aminotrifluoromethylation of Alkenes with Hydrazines by Cu(I)/CPA Cooperative Catalysis WOS:000573846600001 published article about UNACTIVATED ALKENES; INTRAMOLECULAR AMINOTRIFLUOROMETHYLATION; TRIFLUOROMETHYLATION; OLEFINS; AMINOPERFLUOROALKYLATION; AMINODIFLUOROMETHYLATION; DIFUNCTIONALIZATION; FUNCTIONALIZATION; FLUORINATION in [Wang, Zhe; Shi, Zhichao; Zhan, Feng; Lin, Jin-Shun] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; [Wang, Zhe; Shi, Zhichao; Zhan, Feng; Lin, Jin-Shun; Jiang, Yuyang] Tsinghua Shenzhen Int Grad Sch, State Key Lab Chem Oncogen, Key Lab Chem Biol, Shenzhen 518055, Peoples R China; [Cheng, Jiang-Tao; Wang, Na; Jiang, Sheng-Peng; Liu, Xin-Yuan] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China; [Cheng, Jiang-Tao; Wang, Na; Jiang, Sheng-Peng; Liu, Xin-Yuan] Southern Univ Sci & Technol, Dept Chem, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China; [Jiang, Yuyang] Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China in 2021.0, Cited 77.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Name: 4′-Hydroxyacetophenone

A first catalytic enantioselective intermolecular radical aminotrifluoromethylation of alkene with hydrazine and Togni’s reagent by Cu(I)/CPA cooperative catalysis has been reported, accessing diversely substituted CF3-containing enantioenriched diarylmethylamines bearing an alpha-tertiary stereocenter with high enantioselectivity and excellent chemoselectivity. The highly asymmetric induction of C-N bond formation between hydrazine and the carbocation intermediate was achieved by using a CPA catalystviahydrogen-bonding and ion pair interaction.

Name: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Wang, Z; Cheng, JT; Shi, ZC; Wang, N; Zhan, F; Jiang, SP; Lin, JS; Jiang, YY; Liu, XY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H6O2. Verma, PR; Payra, S; Khan, F; Penta, S; Banerjee, S in [Verma, Padma Rani; Khan, Fahmida; Penta, Santosh] Natl Inst Technol Raipur, Dept Chem, GE Rd, Raipur 492010, CG, India; [Payra, Soumen; Banerjee, Subhash] Guru Ghasidas Vishwavidyalaya, Dept Chem, Bilaspur 495009, CG, India published CuBr2@g-C3N4-Catalyzed Highly Selective Aerobic Oxidation of Alcohol and Toluene Derivatives in 2020.0, Cited 73.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Polymeric graphitic carbon nitride (g-C3N4) supported CuBr2 hybrid material (CuBr2@g-C3N4) was developed by impregnation of CuBr2 on g-C3N4 sheets. The morphology and physiochemical properties were analyzed by powder XRD, SEM, and HRTEM studies. The hybrid CuBr2@g-C3N4 material showed excellent selectivity in the aerobic oxidation of primary/secondary alcohols and benzoins to the corresponding carbonyl compounds in absence of any oxidizing agents. Further, CuBr2@g-C3N4 demonstrated direct oxidation of toluene derivatives to corresponding aldehydes in excellent yields. The g-C3N4 support provides excellent stability and heterogeneity to CuBr2 and was recovered simply by filtration and reused for ten times without appreciable loss in catalytic activity.

Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Verma, PR; Payra, S; Khan, F; Penta, S; Banerjee, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Direct use of the solid waste from oxytetracycline fermentation broth to construct Hf-containing catalysts for Meerwein-Ponndorf-Verley reactions published in 2021.0. Safety of 3,4-Dimethoxybenzaldehyde, Reprint Addresses Zhou, HC; He, RX (corresponding author), Inner Mongolia Univ Technol, Inner Mongolia Key Lab High Value Funct Utilizat, Coll Chem Engn, Hohhot 010051, Inner Mongolia, Peoples R China.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

The oxytetracycline fermentation broth residue (OFR) is an abundant solid waste in the fermentation industry, which is hazardous but tricky to treat. The resource utilization of the waste OFR is still challenging. In this study, a novel route of using OFR was proposed that OFR was used as the organic ligands to construct a new hafnium based catalyst (Hf-OFR) for Meerwein-Ponndorf-Verley (MPV) reactions of biomass-derived platforms. The acidic groups in OFR were used to coordinate with Hf4+, and the carbon skeleton structures in OFR were used to form the spatial network structures of the Hf-OFR catalyst. The results showed that the synthesized Hf-OFR catalyst could catalyze the MPV reduction of various carbonyl compounds under relatively mild reaction conditions, with high conversions and yields. Besides, the Hf-OFR catalyst could be recycled at least 5 times with excellent stability in activity and structures. The prepared Hf-OFR catalyst possesses the advantages of high efficiency, a simple preparation process, and low cost in ligands. The proposed strategy of constructing catalysts using OFR may provide new routes for both valuable utilization of the OFR solid waste in the fermentation industry and the construction of efficient catalysts for biomass conversion.

Safety of 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Chen, YX; Yao, XF; Wang, XL; Zhang, XF; Zhou, HC; He, RX; Liu, QS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles