Day: October 22, 2021

I found the field of Chemistry very interesting. Saw the article Synthesis and Characterization of Pine-cone Derived Carbon-based Solid Acid: a Green and Recoverable Catalyst for the Synthesis of Pyrano_pyrazole, Amino-benzochromene, Amidoalkyl Naphthol and Thiazolidinedione Derivatives published in 2021. Category: indole-building-block, Reprint Addresses Pourmousavi, SA (corresponding author), Damghan Univ, Sch Chem, Damghan 36715364, Iran.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

In this report, SO3H-functionalized Carbon nanoparticles (Pine-SO3H) with high acid density have been synthesized by the thermal treatment of sulfuric acid with Pine-Cone as carbon-based at 180 degrees C in a sealed autoclave in a one-step procedure. The resulted Nanocatalyst was characterized by FT-IR, TGA, XRD, FE-SEM and elemental analysis (EA). The result of characterization was shown that the carbon-based acid is amorphous with polycyclic aromatic carbon sheets attached plentiful -OH, -COOH, and -SO3H groups. The catalytic activities of Pine-SO3H was investigated in the highly efficient synthesis of pyrano[2,3-c] pyrazole, amino-benzochromenes, amidoalkyl naphthol and 5-arylidene-2,4-thiazolidinedione derivatives. The application of Pine-SO3H in the synthesis offers several advantages such as simple procedure with an easy work-up, recoverable catalyst, mild condition, eco-friendliness, excellent yields, short reaction times and use of an inexpensive catalyst.

Category: indole-building-block. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Ghorbani, F; Pourmousavi, SA; Kiyani, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ALZHEIMERS-DISEASE; A-BETA; CHEMICAL-SYNTHESIS; DESIGN; ABAD/17-BETA-HSD10; IDENTIFICATION; OPTIMIZATION; DERIVATIVES; CHEMISTRY; PEPTIDE, Saw an article supported by the Merck Sharpe & Dome e Faculte de medecine (Universite Laval); Mitacs Inc (Montreal, QC, Canada); foundation of CHU de Quebec (Endocrinology and Nephrology Unit); Faculty of Medicine of Universite Laval. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Boutin, S; Maltais, R; Roy, J; Poirier, D. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Formula: C7H6O2

17beta-Hydroxysteroid dehydrogenase type 10 (17 beta-HSD10) is the only mitochondrial member of 17 beta-HSD family. This enzyme can oxidize estradiol (E2) into estrone (E1), thus reducing concentration of this neuroprotective steroid. Since 17 beta-HSD10 possesses properties that suggest a possible role in Alzheimer’s disease, its inhibition appears to be a therapeutic strategy. After we identified the androsterone (ADT) derivative 1 as a first steroidal inhibitor of 17 beta-HSD10, new analogs were synthesized to increase the metabolic stability, to improve the selectivity of inhibition over 17 beta-HSD3 and to optimize the inhibitory potency. From six D-ring derivatives of 1 (17-C = O), two compounds (17 beta-H/17 alpha-OH and 17 beta-OH/17aC CH) were more metabolically stable and did not inhibit the 17 beta-HSD3. Moreover, solid phase synthesis was used to extend the molecular diversity on the 3b-piperazinylmethyl group of the steroid base core. Eight over 120 new derivatives were more potent inhibitors than 1 for the transformation of E2 to E1, with the 4-(4-trifluoromethyl-3-methoxybenzyl)piperazin-1-ylmethyl-ADT (D-3,7) being 16 times more potent (IC50 = 0.14 mM). Finally, D-ring modification of D-3,7 provided 17 beta-OH/17 alpha-C CH derivative 25 and 17 beta-H/17 alpha-OH derivative 26, which were more potent inhibitor than 1 (1.8 and 2.4 times, respectively). (C) 2020 Elsevier Masson SAS. All rights reserved.

Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Boutin, S; Maltais, R; Roy, J; Poirier, D or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zhang, W; Yang, W; Zhao, WX in [Zhang, Wu; Yang, Wen; Zhao, Wanxiang] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometries, Changsha 410082, Hunan, Peoples R China published Lewis acid-promoted site-selective cyanation of phenols in 2020.0, Cited 66.0. COA of Formula: C7H8O2. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

An efficient Lewis acid-promoted site-selective electrophilic cyanation of 3-substituted and 3,4-disubstituted phenols has been developed. The cyanation reactions using MeSCN as the cyanating reagent proceeded efficiently to afford a wide range of 2-hydroxybenzonitriles with high efficiency and excellent regioselectivity. This protocol could provide a practical method for the synthesis and modification of biologically active molecules.

COA of Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Zhang, W; Yang, W; Zhao, WX or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: m-Methoxyphenol. I found the field of Chemistry very interesting. Saw the article A total synthesis of (+)-brazilin published in 2020.0, Reprint Addresses Yang, XH (corresponding author), Shanxi Canc Inst, Lab Anim Ctr, Taiyuan 030013, Peoples R China.; Wang, XJ; Wang, LP (corresponding author), Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China.. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol.

Described herein is a concise total synthesis of (+)-brazilin from readily available 4-bromo-1,2dimethoxybenzene. In this synthetic route, a Sharpless asymmetric dihydroxylation was employed to introduce the chiral hydroxyl group, and trifluoroacetic acid (TFA) catalyzed one-pot intramolecular tandem Prins/Friedel-Crafts reaction was also involved as the key transformation in the construction of the hybrid chromane and indane framework. (C) 2020 Elsevier Ltd. All rights reserved.

Name: m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Huang, SP; Ou, WT; Li, W; Xiao, HS; Pang, YY; Zhou, Y; Wang, XJ; Yang, XH; Wang, LP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Growth Kinetics, Metabolites Production and Expression Profiling of Picrosides Biosynthetic Pathway Genes in Friable Callus Culture ofPicrorhiza kurroaRoyle ex Benth WOS:000553276000002 published article about PLANT-PICRORHIZA-KURROA; ANTIOXIDANT ACTIVITY; MEDICINAL HERB; SECONDARY METABOLITES; CONSERVATION; REGENERATION; ENHANCEMENT in [Partap, Mahinder; Kumar, Pankaj; Ashrita; Warghat, Ashish R.] CSIR, Biotechnol Div, Cell & Tissue Engn Lab, Inst Himalayan Bioresource Technol, Palampur 176061, Himachal Prades, India; [Partap, Mahinder; Ashrita; Kumar, Dinesh; Warghat, Ashish R.] Acad Sci & Innovat Res, New Delhi, India; [Kumar, Pawan; Kumar, Dinesh] CSIR, Nat Prod Chem & Proc Dev Div, Inst Himalayan Bioresource Technol, Palampur 176061, Himachal Prades, India in 2020.0, Cited 41.0. Product Details of 99-93-4. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

The rising demand for picrosides commercially and over-exploitation ofPicrorhiza kurroafrom natural habitat has to initiate alternative strategies for sustainable production of metabolites. In the present research, wild leaf explant ofP. kurroawas used to produce friable callus under different culture condition, i.e., dark and light with two temperature variants (15 degrees C and 25 degrees C). Afterward, callus cell lines were screened based on growth biomass and metabolites content accumulation. The results revealed, maximum callus growth index along with antioxidant potential (IC50-40.88 mu g/mL) and total phenol content (41.35 mu g/mg) were observed under dark 25 degrees C. However, under light 15 degrees C, highest accumulation of picroside II (0.58 mu g/mg), cinnamic acid (0.15 mu g/mg),p-hydroxy acetophenone (0.30 mu g/mg), total flavonoids (77.30 mu g/mg), nitrogen (7.06%), carbohydrates (18.03%), and protein (44.12%) were detected. Major reported metabolite in callus was picroside I (1.63 mu g/mg) under dark 15 degrees C. For the first time, picroside III content (range 0.15-0.56 mu g/mg) was also detected and quantified in leaf-derived calli. Expression profiling of picroside biosynthetic pathway genes showed a positive correlation with the observed metabolites. Furthermore, an optimized protocol of metabolites enriched callus biomass could be used as potential strategy for sustainable production of picrosides at commercial scale.

Product Details of 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Partap, M; Kumar, P; Ashrita; Kumar, P; Kumar, D; Warghat, AR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Host RNA quality control as a hepatitis B antiviral target WOS:000657774400001 published article about NONCANONICAL POLY(A) POLYMERASE; POLYADENYLATION SIGNAL; MOLECULAR-BIOLOGY; STEM-LOOP; VIRUS; DEGRADATION; EXOSOME; TRAMP; DECAY; TRANSCRIPTS in [Block, Timothy M.; Zhou, Tianlun] Baruch S Blumberg Inst, Doylestown, PA 18902 USA; [Young, John A. T.] F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Roche Pharma Res & Early Dev, Basel, Switzerland; [Javanbakht, Hassan] SQZ Biotechnol, 200 Arsenal Yards Blvd,Suite 210, Watertown, MA 02472 USA; [Sofia, Michael J.] Arbutus Biopharma Inc, 701 Vet Circle, Warminster, PA 18974 USA in 2021, Cited 69. Computed Properties of C9H7NO2. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

Inhibition of the host RNA polyadenylating polymerases, PAPD5 and PAPD7 (PAPD5/7), with dihydroquinolizinone, a small orally available, molecule, results in a rapid and selective degradation of hepatitis B virus (HBV) RNA, and hence reduction in the amounts of viral gene products. DHQ, is a first in class investigational agent and could represent an entirely new category of HBV antivirals. PAPD5 and PAPD7 are noncanonical, cell specified, polyadenylating polymerases, also called terminal nucleotidyl transferases 4B and 4A (TENT4B/A), respectively. They are involved in the degradation of poor-quality cell transcripts, mostly noncoding RNAs and in the maturation of a sub-set of transcripts. They also appear to play a role in shielding some mRNA from degradation. The results of studies with DHQ, along with other recent findings, provide evidence that repression of the PAPD5/7 arm of the cell RNA quality control pathway, causes a profound (multifold) reduction rather than increase, in the amount of HBV pre-genomic, pre-core and HBsAg mRNA levels in tissue culture and animal models, as well. In this review we will briefly discuss the need for new HBV therapeutics and provide background about HBV transcription. We also discuss cellular degradation of host transcripts, as it relates to a new family of anti-HBV drugs that interfere with these processes. Finally, since HBV mRNA maturation appears to be selectively sensitive to PAPD5/7 inhibition in hepatocytes, we discuss the possibility of targeting host RNA quality control as an antiviral strategy.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Block, TM; Young, JAT; Javanbakht, H; Sofia, MJ; Zhou, TL or concate me.. Computed Properties of C9H7NO2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C7H5F3O. Recently I am researching about BOND FORMATION; ALKYL-HALIDES; PHOTOREDOX; BORYLATION; COBALT; SIZE; DIBORYLMETHANE; NANOPARTICLES; CONSTRUCTION; CARBANIONS, Saw an article supported by the China Scholarship Council (CSC)China Scholarship Council. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhang, LM; Si, XJ; Rominger, F; Hashmi, ASK. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Geminal diboronates have attracted significant attention because of their unique structures and reactivity. However, benzofuran-, indole-, and benzothiophene-based benzylic gem-diboronates, building blocks for biologically relevant compounds, are unknown. A promising protocol using visible light and aryl iodides for constructing valuable building blocks, including benzofuran-, indole-, and benzothiophene-based benzylic gem-diboronates, via radical carbo-cyclization/gem-diborylation of alkynes with a high functional group tolerance is presented. The utility of these gem-diboronates has been demonstrated by a 10 g scale conversion, by versatile transformations, by including the synthesis of approved drug scaffolds and two approved drugs, and even by polymer synthesis. The mechanistic investigation indicates that the merging of the dinuclear gold catalyst (photoexcitation by 315-400 nm UVA light) with Na2CO3 is directly responsible for photosensitization of aryl iodides (photoexcitation by 254 nm UV light) with blue LED light (410-490 nm, lambda(max) = 465 nm) through an energy transfer (EnT) process, followed by homolytic cleavage of the C-I bond in the aryl iodide substrates.

HPLC of Formula: C7H5F3O. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Zhang, LM; Si, XJ; Rominger, F; Hashmi, ASK or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design, synthesis and evaluation of dihydropyranoindole derivatives as potential cholinesterase inhibitors against Alzheimer’s disease WOS:000647575300007 published article about INDOLE-DERIVATIVES; BIOLOGICAL EVALUATION; ACETYLCHOLINESTERASE; AGENTS; ANTIOXIDANT; RAT in [Shaikh, Sarfaraz; Pavale, Ganesh; Uparkar, Jasmin; Ramana, M. M., V] Univ Mumbai, Dept Chem, Santacruz E, Mumbai 400098, Maharashtra, India; [Dhavan, Pratik; Jadhav, B. L.] Univ Mumbai, Dept Life Sci, Santacruz E, Mumbai 400098, Maharashtra, India; [Singh, Pinky; Vaidya, S. P.] Haffkine Inst, Dept Microbiol, Mumbai 400012, Maharashtra, India in 2021, Cited 41. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. HPLC of Formula: C8H8O2

A series of novel dihydropyranoindole derivatives containing sulphonamide group were designed, synthesized and evaluated for in-vitro anti-cholinesterase activity. The result showed that all the compounds exhibited potent acetylcholinesterase (AChE) activity (IC50 = 0.41-8.79 mu M) while demonstrated moderate to good activity for butyrylcholinesterase (BuChE) (IC50 = 1.17-30.17 mu M). The tested compounds exhibited selectivity towards AChE over BuChE. Compound 5o was most potent towards both AChE (IC50 = 0.41 mu M) and BuChE (IC50 = 1.17 mu M) when compared to standard galantamine and rivastigmine. Enzyme kinetics and molecular docking studies revealed that compound 5o shows mixed type inhibition and binds to peripheral anionic site (PAS) and the catalytic sites (CAS) of both the enzymes. Furthermore, cell viability studies were also performed against N2a cells along with neuroprotection studies against H2O2 in the same cell line. Antioxidant studies using DPPH radical and H2O2 were also performed which revealed that all compounds possessed some antioxidant activity. Also, DNA damage protection assay for compound 5o was performed implying that compound 5o was protective in nature. ADME studies were also performed which demonstrated good pharmacokinetics. These findings indicated that dihydropyranoindole derivatives could be possible drug lead in the search for new multifunctional AD drugs.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Shaikh, S; Pavale, G; Dhavan, P; Singh, P; Uparkar, J; Vaidya, SP; Jadhav, BL; Ramana, MMV or concate me.. Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ghorbani, F; Pourmousavi, SA; Kiyani, H in [Ghorbani, Fatemeh; Pourmousavi, Seied Ali; Kiyani, Hamzeh] Damghan Univ, Sch Chem, Damghan 36715364, Iran; [Pourmousavi, Seied Ali] Damghan Univ, Inst Biol Sci, Damghan 3671641167, Iran published Synthesis and Characterization of Pine-cone Derived Carbon-based Solid Acid: a Green and Recoverable Catalyst for the Synthesis of Pyrano_pyrazole, Amino-benzochromene, Amidoalkyl Naphthol and Thiazolidinedione Derivatives in 2021, Cited 66. Name: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

In this report, SO3H-functionalized Carbon nanoparticles (Pine-SO3H) with high acid density have been synthesized by the thermal treatment of sulfuric acid with Pine-Cone as carbon-based at 180 degrees C in a sealed autoclave in a one-step procedure. The resulted Nanocatalyst was characterized by FT-IR, TGA, XRD, FE-SEM and elemental analysis (EA). The result of characterization was shown that the carbon-based acid is amorphous with polycyclic aromatic carbon sheets attached plentiful -OH, -COOH, and -SO3H groups. The catalytic activities of Pine-SO3H was investigated in the highly efficient synthesis of pyrano[2,3-c] pyrazole, amino-benzochromenes, amidoalkyl naphthol and 5-arylidene-2,4-thiazolidinedione derivatives. The application of Pine-SO3H in the synthesis offers several advantages such as simple procedure with an easy work-up, recoverable catalyst, mild condition, eco-friendliness, excellent yields, short reaction times and use of an inexpensive catalyst.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Ghorbani, F; Pourmousavi, SA; Kiyani, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 4-Methoxybenzaldehyde. Recently I am researching about PHOTOCATALYTIC ACTIVITY; AEROBIC OXIDATION; TITANIUM-DIOXIDE; FACILE SYNTHESIS; ANATASE TIO2; BENZALDEHYDE; ENHANCEMENT; HETEROSTRUCTURE; NANOCOMPOSITES; NANOPARTICLES, Saw an article supported by the Science Achievement Scholarship of Thailand; Chiang Mai University; Global Partnership Research Fund through Center of Excellence in Materials Science and Technology and Office of National Higher Education Science Research and Innovation Policy Council (NXPO); TRF Distinguished Research Professor Award [DPG6080002]; ARCAustralian Research Council [DE160100504, CE140100012]; Graduate School. Published in ELSEVIER in AMSTERDAM ,Authors: Japa, M; Tantraviwat, D; Phasayavan, W; Nattestad, A; Chen, J; Inceesungvorn, B. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

N-doped TiO2, denoted as T_400, was prepared simply by the facile thermal hydrolysis of TiOSO4 using NH4OH as both a precipitating agent and a nitrogen source. Compared to TiO2 without nitrogen doping, T_400 provides superior photocatalytic activity toward the selective oxidation of benzyl alcohol and benzylamine under visible light irradiation, with > 85 % conversion and > 95 % selectivity to benzaldehyde and N-benzylidenebenzylamine products, respectively. The increased photoactivity of T_400 is ascribed to enhanced visible-light absorption and efficient photogenerated charge transfer and separation as supported by UV-vis DRS, photoelectrochemical and VB-XPS results. The catalyst can tolerate the presence of substituent groups in benzyl alcohol and benzelamine molecules as > 80 % conversion and > 95 % selectivity are still achieved, which expands the scope of substrates and catalyst utilization. Band energy level of N-doped TiO2 compared to that of undoped TiO2 is determined using Mott-Schottky and UV-vis DRS measurements. Possible mechanisms for the formation of benzaldehyde and N-benzylidenebenzylamine over N-doped TiO2 are proposed. This work presents a simple synthesis of N-doped TiO2, using a low-cost and easily handled inorganic titanium salt instead of air/moisture-sensitive alkoxide precursors and reveals its potential application toward photocatalytic synthesis of organic fine chemicals under visible light.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Japa, M; Tantraviwat, D; Phasayavan, W; Nattestad, A; Chen, J; Inceesungvorn, B or concate me.. Safety of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles