Day: October 26, 2021

I found the field of Chemistry very interesting. Saw the article KSCN and K2CO3 mediated one-pot synthesis of cyclopropanyl coumarin derivatives published in 2021.0. Formula: C8H8O2, Reprint Addresses Shivashankar, K (corresponding author), Bangalore Univ, Dept Chem, Cent Coll Campus, Bangalore, Karnataka, India.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

A novel and efficient one-pot method has been developed for the synthesis of cyclopropanes by the cyclization of 4-bromomethylcoumrains, benzaldehydes and active methylene groups in 1:1 acetonitrile and water solvent in the presence of KSCN and K2CO3 as a catalyst at room temperature for 2-5 h. The significant attraction of this procedure is environmentally benign, simple procedure, the ready accessibility of the catalyst, excellent yield and mild reaction conditions. The structure of the target molecule (4b) was confirmed by X-ray diffraction. [GRAPHICS] .

Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Imrankhan, M; Shivashankar, K or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020 MOLECULES published article about STEP ECONOMY PASE; ONE-POT; CORROSION-INHIBITORS; MULTICOMPONENT REACTIONS; ORGANIC-SYNTHESIS; MILD-STEEL; PARTITION-COEFFICIENTS; ATOM ECONOMY; EFFICIENT; DERIVATIVES in [Ryzhkov, Fedor, V; Ryzhkova, Yuliya E.; Elinson, Michail N.; Fakhrutdinov, Artem N.; Vereshchagin, Anatoly N.; Egorov, Mikhail P.] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Leninsky Pr 47, Moscow 119991, Russia; [Vorobyev, Stepan V.] Gubkin Russian State Univ Oil & Gas, Dept Organ Chem & Petr Chem, 65 Leninsky Prospect, Moscow 119991, Russia in 2020, Cited 63. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3. Category: indole-building-block

The Pot, Atom, and Step Economy (PASE) approach is based on the Pot economy principle and unites it with the Atom and Step Economy strategies; it ensures high efficiency, simplicity and low waste formation. The PASE approach is widely used in multicomponent chemistry. This approach was adopted for the synthesis of previously unknown hydroxyquinolinone substituted chromeno[2,3-b]pyridines via reaction of salicylaldehydes, malononitrile dimer and hydroxyquinolinone. It was shown that an ethanol-pyridine combination is more beneficial than other inorganic or organic catalysts. Quantum chemical studies showed that chromeno[2,3-b]pyridines has potential for corrosion inhibition. Real time H-1 NMR monitoring was used for the investigation of reaction mechanism and 2-((2H-chromen-3-yl)methylene)malononitrile was defined as a key intermediate in the reaction.

Category: indole-building-block. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Ryzhkov, FV; Ryzhkova, YE; Elinson, MN; Vorobyev, SV; Fakhrutdinov, AN; Vereshchagin, AN; Egorov, MP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Delgado-Altamirano, R; Lopez-Palma, RI; Monzote, L; Delgado-Dominguez, J; Becker, I; Rivero-Cruz, JF; Esturau-Escofet, N; Vazquez-Landaverde, PA; Rojas-Molina, A in [Delgado-Altamirano, Ronna] Univ Autonoma Queretaro, Fac Quim, Posgrad Ciencias Quim Biol, Cerro Campanas S-N, Queretaro 76010, Mexico; [Delgado-Altamirano, Ronna; Rojas-Molina, Alejandra] Univ Autonoma Queretaro, Fac Quim, Lab Invest Quim & Farmacol Prod Nat, Cerro Campanas S-N, Queretaro 76010, Mexico; [Isela Lopez-Palma, Rosa; Delgado-Dominguez, Jose; Becker, Ingeborg] Univ Nacl Autonoma Mexico, Hosp Gen Mexico Dr Eduardo Liceaga, Unidad Invest Med Expt, Lab Inmunoparasitol,Fac Med, Dr Balmis 148, Mexico City 06720, DF, Mexico; [Monzote, Lianet] Inst Med Trop Pedro Kouri, Dept Parasitol, Apdo Postal 601, Havana 10400, Cuba; [Fausto Rivero-Cruz, Jose] Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico; [Esturau-Escofet, Nuria] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico; [Vazquez-Landaverde, Pedro A.] Inst Politecn Nacl, Ctr Invest Ciencia Aplicada & Tecnol Avanzada, Unidad Queretaro, Cerro Blanco 141 Colonia Cimatario, Queretaro 76090, Mexico published Chemical Constituents with Leishmanicidal Activity from a Pink-Yellow Cultivar of Lantana camara var. aculeata (L.) Collected in Central Mexico in 2019, Cited 79. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1.

Lantana camara (L.) is employed by several ethnical groups to treat numerous diseases. Although there are no ethnomedical reports on its use against leishmaniasis, organic extracts prepared from L. camara were shown to display leishmanicidal activity. In the present study, we carried out a bioassay-guided fractionation of the dichloromethane extract from Mexican L. camara in order to identify the compounds responsible for the leishmanicidal activity. Eighteen chromatographic fractions (FI-FXVIII) were evaluated in vitro against Leishmania mexicana and L. amazonensis. FII, FX, FXI, FXV, and FXVI showed significant activity against both Leishmania strains, the most potent of which was FXV. Eicosane (1), squalene (2), -ionone (3), caryophyllene oxide (4), -caryophyllene (5), hexanoic acid (6), tiglic acid (7), a mixture of lantanilic (8) and camaric (9) acids, and lantadene B (10) were identified and obtained from the active fractions and evaluated for their leishmanicidal activity. The mixture of lantanilic (8) and camaric (9) acids (79%/21%) was the most potent one (half maximal inhibitory concentration (IC50) = 12.02 +/- 0.36 M). This study indicates that this cultivar of L. camara has high potential for the development of phytomedicines or as a source of natural products, which might represent lead compounds for the design of new drugs against leishmaniasis.

Category: indole-building-block. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Delgado-Altamirano, R; Lopez-Palma, RI; Monzote, L; Delgado-Dominguez, J; Becker, I; Rivero-Cruz, JF; Esturau-Escofet, N; Vazquez-Landaverde, PA; Rojas-Molina, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Sustainable Synthetic Approaches for 3-Aminoimidazo-fused Heterocycles via Groebke-Blackburn-Bienayme Process published in 2020.0. Safety of 3-Hydroxybenzaldehyde, Reprint Addresses Yamajala, RBRD (corresponding author), SASTRA, Dept Chem, Sch Chem & Biotechnol, Thanjavur 613401, India.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

Two different sustainable and efficient synthetic methods have been developed for the synthesis of a variety of 3-aminoimidazo fused heterocycles by one-pot three component reaction of 2-aminoazines, aldehydes and isocyanides. The methods adopted were (a) aqueous micellar mediated condition (method A) (b) VB(1)catalyzed reaction under solvent-free condition (method B). Excellent yields were obtained for a broad range of biologically significant imidazopyridine core molecules under green conditions at room temperature. Synthesis in aqueous micellar medium, mild reaction conditions, organocatalyst, easy work-up and isolation, and gram scale synthesis, are some of the advantages of these protocols.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Mathavan, S; Yamajala, RBRD or concate me.. Safety of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 86-95-3. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Design, synthesis and biological evaluation of fused naphthofuro[3,2-c]quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma published in 2019, Reprint Addresses Aly, AA (corresponding author), Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt.; Kaoud, TS (corresponding author), Univ Texas Austin, Div Chem Biol & Med Chem, Austin, TX 78712 USA.. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one.

Approximately 60% of human cancers exhibit enhanced activity of ERK1 and ERK2, reflecting their multiple roles in tumor initiation and progression. Acquired drug resistance, especially mechanisms associated with the reactivation of the MAPK (RAF/MEK/ERK) pathway represent a major challenge to current treatments of melanoma and several other cancers. Recently, targeting ERK has evolved as a potentially attractive strategy to overcome this resistance. Herein, we report the design and synthesis of novel series of fused naphthofuro[3,2-c] quinoline-6,7,12-triones 3a-f and pyrano[3,2-c]quinoline-6,7,8,13-tetraones 5a,b and 6, as potential ERK inhibitors. New inhibitors were synthesized and identified by different spectroscopic techniques and X-ray crystallography. They were evaluated for their ability to inhibit ERK1/2 in an in vitro radioactive kinase assay. 3b and 6 inhibited ERK1 with IC50s of 0.5 and 0.19 mu M, and inhibited ERK2 with IC50s of 0.6 and 0.16 mu M respectively. Kinetic mechanism studies revealed that the inhibitors are ATP-competitive inhibitors where 6 inhibited ERK2 with a K-i of 0.09 mu M. Six of the new inhibitors were tested for their in vitro anticancer activity against the NCI-60 panel of tumor cell lines. Compound 3b and 6 were the most potent against most of the human tumor cell lines tested. Moreover, 3b and 6 inhibited the proliferation of the BRAF mutant A375 melanoma cells with IC50s of 3.7 and 0.13 mu M, respectively. In addition, they suppressed anchorage-dependent colony formation. Treatment of the A375 cell line with 3b and 6 inhibited the phosphorylation of ERK substrates p-90RSK and ELK-1 and induced apoptosis in a dose dependent manner. Finally, a molecular docking study showed the potential binding mode of 3b and 6 within the ATP catalytic binding site of ERK2.

Recommanded Product: 86-95-3. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; El-Sheref, EM; Bakheet, MEM; Mourad, MAE; Brase, S; Ibrahim, MAA; Nieger, M; Garvalov, BK; Dalby, KN; Kaoud, TS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about SEQUENTIAL THERMAL DISSOLUTION; CATALYZED OXIDATION; MILD DEGRADATION; BITUMINOUS COAL; EXTRACTION; IDENTIFICATION; ALKYLBENZENES; FEATURES; ORIGIN; BONDS, Saw an article supported by the Fundamental Research Funds for the Central Universities of ChinaFundamental Research Funds for the Central Universities [2018QNA15]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M630630]. Category: indole-building-block. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Liu, FJ; Zong, ZM; Li, WT; Zhu, XN; Wei, XY; Tang, MC; Huang, ZX. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

Converting lignite into soluble organic compounds (SOCs) under mild conditions is significant for both evaluating molecular structure and producing clean fuels/chemicals. A three-step dissociation, i.e., sequential extraction, sequential thermal dissolution (TD), and ruthenium-ion-catalyzed oxidation (RICO), was adopted to convert the organic matter (OM) in Xiaolongtan lignite (XL) into SOCs. The perspectives on chemicals, geo-chemical information, and structural characteristics of XL were evaluated based on the molecular compositions of SOCs. Much higher yields of SOCs were obtained from TD than from extraction, which could be attributed to the thermal dissociation of non-covalent interactions in XL. Normal alkanes, alkyl-substituted benzenes, alkyl substituted phenols, ketones, and aliphatic esters are the main group components released from TD. A series of important biomarkers were released and their distributions and evolution pathways during XL-forming process imply that higher terrestrial plants could be the main input of the OM in XL. Benzenecarboxylic acids were produced from TD residue in high selectivity via the RICO. According to the results from the RICO, the insoluble macromolecular structures in XL are rich in peri-condensed aromatics along with some cata-condensed aromatics and polyaryls, and -CH3 is the major alkyl side chain on the aromatic rings. Adjacent aromatic moieties are mainly connected each other directly by C-ar-C-ar bridged bonds.

Category: indole-building-block. About Benzyl Alcohol, If you have any questions, you can contact Liu, FJ; Zong, ZM; Li, WT; Zhu, XN; Wei, XY; Tang, MC; Huang, ZX or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Salimi, M; Esmaeli-nasrabadi, F; Sandaroos, R in [Salimi, Mehri; Esmaeli-nasrabadi, Farzaneh; Sandaroos, Reza] Univ Birjand, Fac Sci, Dept Chem, POB 97175-615, Birjand, Iran published Effective and selective aerobic oxidation of primary and secondary alcohols using CoFe2O4@HT@Imine-Cu(II)and TEMPO in the air atmosphere in 2021, Cited 54. Computed Properties of C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

In this study, we present a versatile and easy procedure for modifying a cobalt ferrite nanoparticle step by step. A new nanocatalyst was prepared via Cu(II)immobilized onto CoFe2O4@HT@Imine. The catalyst was fully characterized by Fourier-transform infrared (FT-IR), energy-dispersive X-ray spectroscopy (EDX), field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), and vibrating sample magnetometer (VSM) analyses. The current procedure as a green protocol offers benefits including a simple operational method, an excellent yield of products, mild reaction conditions, minimum chemical wastes, and short reaction times. Without any significant reduction in the catalytic performance, up to five recyclability cycles of the catalyst were obtained. The optimization results suggest that the best condition in the oxidation of benzyl alcohol derivatives is 0.003 g of the CoFe2O4@HT@Imine-Cu(II)catalyst, TEMPO, at 70 degrees C under solvent-free condition and air.

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Salimi, M; Esmaeli-nasrabadi, F; Sandaroos, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Catalytic Photoredox Allylation of Aldehydes Promoted by a Cobalt Complex WOS:000603454300001 published article about CARBONYL-COMPOUNDS; ASYMMETRIC ALLYLATION; ALLYLIC ACETATES; METAL-COMPLEXES; EFFICIENT; HALIDES; FUNCTIONALIZATION; TRANSFORMATIONS; IMINES in [Gualandi, Andrea; Rodeghiero, Giacomo; Moreno-Cabrerizo, Cristina; Foucher, Charles; Marchini, Marianna; Ceroni, Paola; Giorgio Cozzi, Pier] Alma Mater Studiorum Univ Bologna, Dipartimento Chim G Ciamician, Via Selmi 2, I-40126 Bologna, Italy; [Rodeghiero, Giacomo; Perciaccante, Rossana; Jansen, Thomas Paul] Cyanagen Srl, Via Stradelli Guelfi 40-C, I-40138 Bologna, Italy; [Moreno-Cabrerizo, Cristina] Univ Alicante, Fac Ciencias, Dept Quim Organ, E-03080 Alicante, Spain; [Moreno-Cabrerizo, Cristina] Univ Alicante, Fac Ciencias, Ctr Innovac Quim Avanzada ORFEO CINQA, E-03080 Alicante, Spain; [Foucher, Charles] Ecole Natl Super Chim Paris, 11 Rue Pierre & Marie Curie, F-75231 Paris 05, France in 2021, Cited 70. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Recommanded Product: 123-11-5

The preparation of homoallylic alcohols by addition of organometallic allyl compounds to carbonyls is an important strategy in organic chemistry. Allylating organometallic cobalt species can be generated employing stoichiometric quantities of Zn acting as reductant. To avoid the employment of stoichiometric amount of Zn, we have developed an allylation reaction of aromatic and aliphatic aldehydes promoted by photoredox catalysis in the presence of a cobalt complex, and we present herein a full account of our research. In the presence of the abundant CoBr2 (10 mol %), 4,4 ‘-di-tert-butyl-2,2 ‘-dipyridyl (dtbbpy, 10 mol %), allyl acetate (3 equiv.), [Ir(dtbbpy)(ppy)(2)]PF6 (ppy=2-phenylpyridine, 2 mol %), and N,N-diisopropylethylamine (4 equiv.), an allylation of aldehydes is taking place, in moderate to good yields. Substrates scope, limitations, and photophysical investigations of this new process are reported.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Gualandi, A; Rodeghiero, G; Perciaccante, R; Jansen, TP; Moreno-Cabrerizo, C; Foucher, C; Marchini, M; Ceroni, P; Cozzi, PG or concate me.. Recommanded Product: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of (E)-2-Methylbut-2-enoic acid. Authors Ouyang, J; Kennemur, JL; Kanta, D; Fares, C; List, B in AMER CHEMICAL SOC published article about in [Ouyang, Jie; Kennemur, Jennifer L.; Kanta, De Chandra; Fares, Christophe; List, Benjamin] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany in 2019, Cited 43. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1

We report a catalytic asymmetric Nazarov cyclization of simple, acylic, alkyl-substituted divinyl ketones using our recently disclosed strong and confined imidodiphosphorimidate Bronsted acids. The corresponding monocyclic cyclopentenones are formed in good yields and excellent regio-, diastereo-, and enantioselectivities. Further, the chemical utility of the obtained enantiopure cyclopentenones is demonstrated.

Application In Synthesis of (E)-2-Methylbut-2-enoic acid. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Ouyang, J; Kennemur, JL; Kanta, D; Fares, C; List, B or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Solid-liquid extraction of iodide and bromide from aqueous media by a new water-insoluble phenoxycalix[4]pyrrole-epichlorohydrin polymer WOS:000479062100009 published article about ANION-BINDING; RECOGNITION; RECEPTORS; CAVITY in [AlHaddad, Nancy; Cazier-Dennin, Francine; Danjou, Pierre-Edouard] Univ Littoral Cote dOpale, Unite Chim Environm & Interact Vivant, EA 4492, 145 Ave Maurice Schumann,MREI 1, Dunkerque, France; [AlHaddad, Nancy; Rifai, Ahmad] Lebanese Natl Council Sci Res, Lebanese Atom Energy Commiss, BP 11-8281, Beirut 11072260, Lebanon; [Kasprowiak, Amaury] Univ Littoral Cote dOpale, Dept Chim, 220 Ave Univ, Dunkerque, France in 2019.0, Cited 29.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. SDS of cas: 99-93-4

The present study describes the synthesis of the first phenoxycalix[4]pyrrole-epichlorohydrin based polymer. The advantage of the latter resides in its fast-single step synthesis protocol, low cost, water insolubility and its unexpected anion extraction capacity. The study of this polymer by various solid/liquid extractions with halides in aqueous solutions and quantitative ion chromatography analysis showed that unlike other calix[4]pyrrole-based entities, this polymer extracts iodide rather than bromide and fluoride owing to the presence of large extraction pockets. Evidence of an anion exchange process involving preferably chloride and bromide was also highlighted.

SDS of cas: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact AlHaddad, N; Rifai, A; Kasprowiak, A; Cazier-Dennin, F; Danjou, PE or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles