Day: October 26, 2021

SDS of cas: 120-14-9. In 2021 RSC ADV published article about ONE-POT; MAGNETIC NANOPARTICLES; CLAISEN REARRANGEMENT; DERIVATIVES; EFFICIENT; GLYCALS; DRUGS; DECONTAMINATION; HETEROCYCLES; ANTICANCER in [Torabi, Morteza; Yarie, Meysam; Zolfigol, Mohammad Ali] Buali Sina Univ, Fac Chem, Dept Organ Chem, Hamadan 6517838683, Hamadan, Iran; [Rouhani, Shamila; Msagati, Titus A. M.] Univ South Africa, Coll Sci Engn & Technol, Inst Nanotechnol & Water Sustainabil iNanoWS, ZA-1709 Johannesburg, South Africa; [Azizi, Shohreh; Maaza, Malik] Univ South Africa, Coll Grad Studies, UNESCO UNISA Africa Chair Nanosci & Nanotech, POB 392, Pretoria, South Africa; [Azizi, Shohreh] iThemba LABS Natl Res Fdn, Nanosci African Network NANOAFNET, 1 Old Faure Rd,POB 722, ZA-7129 Western Cape, South Africa; [Olomola, Temitope O.] Obafemi Awolowo Univ, Dept Chem, Ife 220005, Nigeria; [Msagati, Titus A. M.] Nelson Mandela African Inst Sci & Technol, Sch Life Sci & Bioengn, POB 447, Arusha, Tanzania in 2021, Cited 96. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

In the present study, we reported the synthesis of a novel quinoline-based dendrimer-like ionic liquid. After characterization of the mentioned ionic liquid with suitable techniques such as Fourier transform infrared spectroscopy (FT-IR), energy dispersive X-ray spectroscopy (EDX), elemental mapping, thermogravimetric analysis (TGA) and derivative thermogravimetry (DTG), its catalytic performance was investigated in the synthesis of new pyridines with sulfonamide moiety via a cooperative vinylogous anomeric-based oxidation mechanism under mild reaction conditions. All target molecules were achieved in short reaction times and high yields.

SDS of cas: 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Torabi, M; Yarie, M; Zolfigol, MA; Rouhani, S; Azizi, S; Olomola, TO; Maaza, M; Msagati, TAM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S in SAGE PUBLICATIONS LTD published article about in [Aly, Ashraf A.; Hassan, Alaa A.; Mohamed, Nasr K.; Abd El-Haleem, Lamiaa E.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Brase, Stefan] Karlsruhe Inst Technol, Inst Biol & Chem Syst Funct Mol Syst IBCS FMS, Eggenstein Leopoldshafen, Germany in 2020, Cited 13. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

A novel series of 7,8-dichlorobenzofuro[3,2-c]quinoline-6,9,10(5H)-triones was obtained regioselectively in good yields. The products were formed by the reactions of the 4-hydroxy-2(1H)-quinolinones with 3,4,5,6-tetrachloro-1,2-benzoquinone in tetrahydrofuran as the solvent. Infrared, nuclear magnetic resonance (two-dimensional nuclear magnetic resonance), mass spectra and elemental analysis were used to elucidate the structures of new compounds.

Category: indole-building-block. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 150-19-6. In 2021.0 J ANAL APPL PYROL published article about THERMAL-DEGRADATION; THERMOCHEMICAL CONVERSION; CELLULOSE; LIGNIN; LEVOGLUCOSAN; HEMICELLULOSE; XYLAN; HYDROLYSIS; MECHANISMS; EXTRACTION in [Hubble, Andrew H.; Goldfarb, Jillian L.] Cornell Univ, Dept Biol & Environm Engn, Ithaca, NY 14853 USA in 2021.0, Cited 47.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

Before biobased fuels can replace fossil fuels, several key issues must be addressed. Bio-oils derived through pyrolysis of lignocellulosic material have high acidity and viscosity, and poor energy density and stability. To address these issues, this paper examines the individual and combined behavior of lignocellulosic feedstock components to shed light on the potential to generate preferential biofuel properties through biomass mixing. Dry lignocellulosic biomass is mostly composed of cell wall polysaccharides (cellulose, hemicellulose, lignin), which vary widely in type and concentration across biomasses. This heterogeneity leads to increased unpredictability in biobased fuel formation during pyrolysis. Using derivative thermogravimetric (DTG) analysis, gas chromatography-mass spectroscopy, and residual gas analysis, this work explores the synergistic interactions of lignocellulosic biomass components during pyrolysis to manipulate bio-oil and gas product composition based on desired compound classes. Cellulose, xylose, xylan, and lignin were blended at different ratios to determine the extent of synergistic effects during pyrolysis. For each mixture, an ‘expected’ outcome was developed by summing the individual behavior (e.g. mass loss rate, H-2 gas evolution, etc.) of the individual components based on mass fraction present. Mixtures containing lignin and/or xylan yield peak DTG mass loss rates at lower temperatures than predicted with corresponding reductions in biochar yield suggesting synergistic interactions that promote devolatilization. By itself, lignin produces large amounts of hydrogen gas, and when mixed with other biomasses promotes dehydrogenation. Lignin increases CO2 formation, resulting in lower oxygen concentrations in the bio-oil and biochar. While suppressing bio-oil generation, the presence of lignin – even at low concentrations – increases the number of phenol compounds produced, while decreasing the yield of furans. The synergistic interactions between different polysaccharides could be exploited depending on the desired biorefinery products – allowing for targeted selection of lignocellulosic biomass mixes to fine-tune resulting fuels.

Product Details of 150-19-6. About m-Methoxyphenol, If you have any questions, you can contact Hubble, AH; Goldfarb, JL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 120-14-9. Authors Kumari, M; Tahlan, S; Narasimhan, B; Ramasamy, K; Lim, SM; Shah, SAA; Mani, V; Kakkar, S in BMC published article about in [Kumari, Mukesh; Tahlan, Sumit; Narasimhan, Balasubramanian; Kakkar, Saloni] Maharshi Dayanand Univ, Fac Pharmaceut Sci, Rohtak 124001, Haryana, India; [Ramasamy, Kalavathy; Lim, Siong Meng; Shah, Syed Adnan Ali] Univ Teknol MARA UiTM, Fac Pharm, Bandar Puncak Alam 42300, Selangor Darul, Malaysia; [Ramasamy, Kalavathy; Lim, Siong Meng] Univ Teknol MARA UiTM, Collaborat Drug Discovery Res CDDR Grp, Pharmaceut Life Sci Community Res, Shah Alam 40450, Selangor Darul, Malaysia; [Shah, Syed Adnan Ali] Univ Teknol MARA UiTM, Atta Ur Rahman Inst Nat Prod Discovery AuRIns, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor Darul, Malaysia; [Mani, Vasudevan] Qassim Univ, Dept Pharmacol & Toxicol, Coll Pharm, Buraydah 51452, Saudi Arabia in 2021.0, Cited 27.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Background Triazole is an important heterocyclic moiety that occupies a unique position in heterocyclic chemistry, due to its large number of biological activities. It exists in two isomeric forms i.e. 1,2,4-triazole and 1,2,3-triazole and is used as core molecule for the design and synthesis of many medicinal compounds. 1,2,4-Triazole possess broad spectrum of therapeutically interesting drug candidates such as analgesic, antiseptic, antimicrobial, antioxidant, anti-urease, anti-inflammatory, diuretics, anticancer, anticonvulsant, antidiabetic and antimigraine agents. Methods The structures of all synthesized compounds were characterized by physicochemical properties and spectral means (IR and NMR). The synthesized compounds were evaluated for their in vitro antimicrobial activity against Gram-positive (B. subtilis), Gram-negative (P. aeruginosa and E. coli) bacterial and fungal (C. albicans and A. niger) strains by tube dilution method using ciprofloxacin, amoxicillin and fluconazole as standards. In-vitro antioxidant and anti-urease screening was done by DPPH assay and indophenol method, respectively. The in-vitro anticancer evaluation was carried out against MCF-7 and HCT116 cancer cell lines using 5-FU as standards. Results, discussion and conclusion The biological screening results reveal that the compounds T-5 (MICBS, EC = 24.7 mu M, MICPA, (CA) = 12.3 mu M) and T-17 (MICAN = 27.1 mu M) exhibited potent antimicrobial activity as comparable to standards ciprofloxacin, amoxicillin (MICCipro = 18.1 mu M, MICAmo = 17.1 mu M) and fluconazole (MICFlu = 20.4 mu M), respectively. The antioxidant evaluation showed that compounds T-2 (IC50 = 34.83 mu g/ml) and T-3 (IC50 = 34.38 mu g/ml) showed significant antioxidant activity and comparable to ascorbic acid (IC50 = 35.44 mu g/ml). Compounds T-3 (IC50 = 54.01 mu g/ml) was the most potent urease inhibitor amongst the synthesized compounds and compared to standard thiourea (IC50 = 54.25 mu g/ml). The most potent anticancer activity was shown by compounds T-2 (IC50 = 3.84 mu M) and T-7 (IC50 = 3.25 mu M) against HCT116 cell lines as compared to standard 5-FU (IC50 = 25.36 mu M).

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Kumari, M; Tahlan, S; Narasimhan, B; Ramasamy, K; Lim, SM; Shah, SAA; Mani, V; Kakkar, S or concate me.. Recommanded Product: 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H5F3O. Authors Mollasalehi, N; Francois-Moutal, L; Scott, DD; Tello, JA; Williams, H; Mahoney, B; Carlson, JM; Dong, Y; Li, XL; Miranda, VG; Gokhale, V; Wang, W; Barmada, SJ; Khanna, M in AMER CHEMICAL SOC published article about in [Mollasalehi, Niloufar; Francois-Moutal, Liberty; Scott, David D.; Tello, Judith A.; Williams, Haley; Carlson, Jacob M.; Miranda, Victor G.; Khanna, May] Univ Arizona, Coll Med, Dept Pharmacol, Tucson, AZ 85724 USA; [Mollasalehi, Niloufar; Francois-Moutal, Liberty; Scott, David D.; Tello, Judith A.; Williams, Haley; Carlson, Jacob M.; Miranda, Victor G.; Khanna, May] Ctr Innovat Brain Sci, Tucson, AZ 85721 USA; [Mollasalehi, Niloufar] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA; [Mahoney, Brendan] Univ Calif Los Angeles UCLA, Dept Chem & Biochem, Los Angeles, CA 90095 USA; [Dong, Yue; Wang, Wei] Univ Arizona, Coll Pharm, Arizona Ctr Drug Discovery, Tucson, AZ 85721 USA; [Dong, Yue; Wang, Wei] Univ Arizona, Coll Pharm, Pharmacol & Toxicol Dept, Tucson, AZ 85721 USA; [Li, Xingli; Barmada, Sami J.] Univ Michigan Hlth Syst, Dept Neurol, Ann Arbor, MI 48109 USA; [Gokhale, Vijay] Univ Arizona, Bio5 Inst, Tucson, AZ 85721 USA in 2020, Cited 23. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

In this study, we targeted the N-terminal domain (NTD) of transactive response (TAR) DNA binding protein (TDP-43), which is implicated in several neurodegenerative diseases. In silico docking of 50K compounds to the NTD domain of TDP-43 identified a small molecule (nTRD22) that is bound to the N-terminal domain. Interestingly, nTRD22 caused allosteric modulation of the RNA binding domain (RRM) of TDP-43, resulting in decreased binding to RNA in vitro. Moreover, incubation of primary motor neurons with nTRD22 induced a reduction of TDP-43 protein levels, similar to TDP-43 RNA binding-deficient mutants and supporting a disruption of TDP43 binding to RNA. Finally, nTRD22 mitigated motor impairment in a Drosophila model of amyotrophic lateral sclerosis. Our findings provide an exciting way of allosteric modulation of the RNA-binding region of TDP-43 through the N-terminal domain.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Mollasalehi, N; Francois-Moutal, L; Scott, DD; Tello, JA; Williams, H; Mahoney, B; Carlson, JM; Dong, Y; Li, XL; Miranda, VG; Gokhale, V; Wang, W; Barmada, SJ; Khanna, M or concate me.. Formula: C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019 SYNOPEN published article about DIRECT N-ALKYLATION; O-ALKYLATION; REDUCTIVE AMINATION; ARYL ETHERS; EFFICIENT SYNTHESIS; AROMATIC-AMINES; ALCOHOLS; PHENOLS; ANILINES; DERIVATIVES in [Jagtap, Sangeeta V.] Baburaoji Gholap Coll, Dept Chem, Pune 411027, Maharashtra, India; Savitribai Phule Pune Univ, Pune, Maharashtra, India in 2019, Cited 115. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Computed Properties of C7H5F3O

A simple and efficient protocol for base-mediated selective synthesis of 2-(arylamino)ethanols from primary aromatic amines and 2-aryloxyethanols from phenols, promoted by K (2) CO (3) has been achieved under mild conditions. Even in presence of excess alkyl halide, selective mono-N-alkylation has been achieved. Tolerance of a variety of functional groups is demonstrated by 15 examples of selective N-alkylation of aromatic amines and 19 examples of O-alkylation of phenols. The efficacy of the protocol is demonstrated by the formal synthesis of Ticlopidine (-(R)) , Vildagliptin (R) , Quetiapine (R) , and Gemfibrozil (R).

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Sonawane, RB; Sonawane, SR; Rasal, NK; Jagtap, SV or concate me.. Computed Properties of C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. In 2020 J IRAN CHEM SOC published article about BIOLOGICAL EVALUATION; SCHIFF-BASE; DNA-BINDING; METAL-COMPLEXES; ANTIBACTERIAL; AGENTS; IDENTIFICATION; NANOCOMPOSITE; PYRIMIDINES; ANALOGS in [Arshad, Mohammad] Shaqra Univ, Dept Basic Sci, Coll Med, Al Dawadmi, Saudi Arabia in 2020, Cited 67. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

An adequate enhancement in the development of resistance by microbial pathogens against the available chemotherapeutic agents prompted us to find out some new chemotherapeutic agents with significant therapeutic effect as antimicrobials. The present study reported the designing of 6-(1H-indol-3-yl)-4,5 ‘-bipyrimidine-2-amine (2) and its Schiff’s bases (3-12), and the computational studies were performed to assess properties (drug likeness and physicochemical). The computationally bioactive compounds (1-12) were then followed for synthesis, characterization, antimicrobial therapeutic effect and percent viability of cells. The antimicrobial therapeutic effect was obtained by disk diffusion method, in terms of zone of inhibition and minimum inhibitory concentration against the gram-positive and gram-negative bacteria [S. aureus (ATCC-25923), S. epidermidis (ATCC-29887)], [E. coli (ATCC-25922), P. mirabilis (ATCC-25933)]. The antimicrobial screening findings reveled that all the compounds (1-12) possessed very good activity and strongly recommended the computational results. The antibiotic ciprofloxacin and the solvent DMSO were used as positive and negative control in the study. The percent viability of the cells was observed using HepG2 cells by MTT assay and noticed that the percent viability of the cells was found in the range 93-97% at lowest concentration 3.125 mu M while 73-77% at the highest 100 mu M. All the compounds (1-12) and ciprofloxacin were then applied for molecular docking assessment to estimate the H-bonding with the residues of GlcN-6-P-synthase, and the findings revealed that significant H-bonding was observed with the binding affinity in the range of – 8.4 to 6.7 kcal/mol and – 7.6 to 6.0 kcal/mol, respectively. Graphic abstract

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Arshad, M or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Asparagine as a Green Organocatalyst for the Synthesis of 2-Aminothiazoles published in 2020.0. Computed Properties of C8H8O2, Reprint Addresses Safari, J (corresponding author), Univ Kashan, Coll Chem & Biochem, Dept Organ Chem, Lab Organ Compound Res, Kashan, IR, Iran.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

In this research, an efficient method for the one-pot synthesis of 2-aminothiazolesviathe reaction of thiourea with methylcarbonyls in the presence of iodine as an oxidant reagent has been developed using asparagine as a green organocatalyst at 80 degrees C in DMSO solvent. Advantages of this efficient method include greener and cleaner conditions, easy isolation of products, higher purity and excellent yield of products, and convenient manipulation.

Computed Properties of C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Safari, J; Shokrani, Z; Zarnegar, Z or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ASYMMETRIC HENRY REACTION; C-H AMINATION; STEREOCONTROLLED SYNTHESIS; INTERMOLECULAR REACTIONS; BOND FORMATION; ALCOHOLS; ETHERS; PSEUDOEPHEDRINE; CARBOCATIONS; 1,2-DIAMINES, Saw an article supported by the NSERCNatural Sciences and Engineering Research Council of Canada (NSERC); NSERC/Servier Senior Industrial Research Chair initiative. Recommanded Product: m-Methoxyphenol. Published in CANADIAN SCIENCE PUBLISHING in OTTAWA ,Authors: Hensienne, R; Cusson, JP; Chenard, E; Hanessian, S. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

A series of alkyl and alkenyl p-methoxy arenes containing alpha,beta-disubstituted diamino and amino alcohol groups were synthesized from beta-nitro and beta-azido benzylic alcohols in the presence of AuCl3 as catalyst. The formation of predominantly syn-disubstituted products were rationalized on the basis of mechanistic considerations and transition state models relying on A(1,3)-allylic strain. The products could have utility in the design of medicinally relevant compounds and as chiral ligands for asymmetric catalysis. A new synthesis of (+)-sertraline (Zoloft) was achieved.

Recommanded Product: m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Hensienne, R; Cusson, JP; Chenard, E; Hanessian, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Ren, SJ; Fu, JH; Cheng, DP; Li, XN; Xu, XL in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Ren, Shujian; Fu, Jiahui; Li, Xiaonian; Xu, Xiaoliang] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China; [Cheng, Dongping] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China in 2021.0, Cited 109.0. Recommanded Product: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Induced by visible light, a green approach for the highly substituted trifluoromethyl olefins has been developed by using alkyl boronic acid as a carbon radical precursor and the Boc-modified trifluoromethylated Baylis-Hillman adduct (BMTBHA) as an acceptor. This method starts from 1,1-disubstituted olefins without the external stoichiometric oxidant. (C) 2021 Elsevier Ltd. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Ren, SJ; Fu, JH; Cheng, DP; Li, XN; Xu, XL or concate me.. Recommanded Product: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles