Day: October 27, 2021

Authors Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S in SAGE PUBLICATIONS LTD published article about in [Aly, Ashraf A.; Hassan, Alaa A.; Mohamed, Nasr K.; Abd El-Haleem, Lamiaa E.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Brase, Stefan] Karlsruhe Inst Technol, Inst Biol & Chem Syst Funct Mol Syst IBCS FMS, Eggenstein Leopoldshafen, Germany in 2020, Cited 13. COA of Formula: C9H7NO2. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

A novel series of 7,8-dichlorobenzofuro[3,2-c]quinoline-6,9,10(5H)-triones was obtained regioselectively in good yields. The products were formed by the reactions of the 4-hydroxy-2(1H)-quinolinones with 3,4,5,6-tetrachloro-1,2-benzoquinone in tetrahydrofuran as the solvent. Infrared, nuclear magnetic resonance (two-dimensional nuclear magnetic resonance), mass spectra and elemental analysis were used to elucidate the structures of new compounds.

COA of Formula: C9H7NO2. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Terminaliamide, a new ceramide and other phytoconstituents from the roots of Terminalia mantaly H. Perrier and their biological activities WOS:000479988600001 published article about CEREBROSIDES; PLANTS in [Teinkela, Jean Emmanuel Mbosso] ULB, Fac Pharm, Unite Microbiol Chim Bioorgan & Macromol, Dept R3D, Brussels, Belgium; [Teinkela, Jean Emmanuel Mbosso; Fannang, Simone; Song, Achille Mbem] Univ Douala, Fac Med & Pharmaceut Sci, Dept Biol Sci, Douala, Cameroon; [Noundou, Xavier Siwe; Krause, Rui Werner Macedo] Rhodes Univ, Fac Sci, Dept Chem, Nanomat & Med Organ Chem Lab, Grahamstown, South Africa; [Noundou, Xavier Siwe; Hoppe, Heinrich C.] Rhodes Univ, Dept Biochem & Microbiol, Grahamstown, South Africa; [Nguedia, Jules Clement Assob] Univ Buea, Fac Hlth Sci, Programme Med, Buea, Cameroon in 2021.0, Cited 44.0. Computed Properties of C7H8O2. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

Terminaliamide (1), a new ceramide was isolated from the roots of Terminalia mantaly H. Perrier (Combretaceae) along with 4 known compounds (2-5). The structures of the compounds were elucidated using 1D and 2D NMR spectroscopy analysis and mass spectrometry. Compound 1 exhibited moderated antibacterial activity towards Staphylococcus aureus with MIC value of 62.5 mu g/mL. The crude MeOH extract (TMr) highly reduced Plasmodium falciparum growth with an IC50 value of 10.11 mu g/mL, while hexane fraction (F1) highly reduced Trypanosoma brucei brucei growth with an IC50 value of 5.60 mu g/mL. All tested samples presented little or no in vitro cytotoxicity on HeLa cell line. The present work confirms that T. mantaly is medicinally important and may be used effectively as an antimicrobial, an antiplasmodial and an antitrypanosomial with promising therapeutic index.

Computed Properties of C7H8O2. About Mequinol, If you have any questions, you can contact Teinkela, JEM; Noundou, XS; Fannang, S; Song, AM; Nguedia, JCA; Hoppe, HC; Krause, RWM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Rhodium(i)-catalyzed C6-selective C-H alkenylation and polyenylation of 2-pyridones with alkenyl and conjugated polyenyl carboxylic acids WOS:000496188700019 published article about DECARBOXYLATIVE COUPLING REACTIONS; DECARBONYLATIVE DIRECT OLEFINATION; C3-SELECTIVE DIRECT ALKYLATION; CINNAMIC-ACIDS; OXIDATIVE OLEFINATION; REGIOSELECTIVE SYNTHESIS; DIRECT ARYLATION; BOND ACTIVATION; DIRECTING GROUP; OXIME ESTERS in [Zhao, Haoqiang; Xu, Xin; Luo, Zhenli; Cao, Lei; Li, Bohan; Li, Huanrong; Xu, Lijin] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China; [Xu, Lijin; Fan, Qinghua] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China; [Xu, Lijin; Fan, Qinghua] Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China; [Zhao, Haoqiang; Walsh, Patrick J.] Univ Penn, Dept Chem, Penn Merck Lab High Throughput Expt, Ray & Diana Vagelos Labs, 231 South 34th St, Philadelphia, PA 19104 USA in 2019, Cited 156. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1. Product Details of 80-59-1

A versatile Rh(i)-catalyzed C6-selective decarbonylative C-H alkenylation of 2-pyridones with readily available, and inexpensive alkenyl carboxylic acids has been developed. This directed dehydrogenative cross-coupling reaction affords 6-alkenylated 2-pyridones that would otherwise be difficult to access using conventional C-H functionalization protocols. The reaction occurs with high efficiency and is tolerant of a broad range of functional groups. A wide scope of alkenyl carboxylic acids, including challenging conjugated polyene carboxylic acids, are amenable to this transformation and no addition of external oxidant is required. Mechanistic studies revealed that (1) Boc(2)O acts as the activator for the in situ transformation of the carboxylic acids into anhydrides before oxidative addition by the Rh catalyst, (2) a decarbonylation step is involved in the catalytic cycle, and (3) the C-H bond cleavage is likely the turnover-limiting step.

About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Zhao, HQ; Xu, X; Luo, ZL; Cao, L; Li, BH; Li, HR; Xu, LJ; Fan, QH; Walsh, PJ or concate me.. Product Details of 80-59-1

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: Benzyl Alcohol. In 2019.0 ACS SUSTAIN CHEM ENG published article about PONNDORF-VERLEY REDUCTION; SN-BETA ZEOLITES; GAMMA-VALEROLACTONE; LEVULINIC ACID; LIGNOCELLULOSIC BIOMASS; METHYL LEVULINATE; ETHYL LEVULINATE; USY ZEOLITE; DIELS-ALDER; CONVERSION in [Tang, Bo; Li, Shuang; Song, Wei-Chao; Yang, En-Cui; Zhao, Xiao-Jun] Tianjin Normal Univ, Tianjin Key Lab Struct & Performance Funct Mol, Key Lab Inorgan Organ Hybrid Funct Mat Chem, Minist Educ, 393 Binshui West Rd, Tianjin 300387, Peoples R China; [Guan, Naijia; Li, Landong] Nankai Univ, Sch Mat Sci & Engn, 38 Tongyan Rd, Tianjin 300350, Peoples R China; [Guan, Naijia; Li, Landong] Nankai Univ, Natl Inst Adv Mat, 38 Tongyan Rd, Tianjin 300350, Peoples R China in 2019.0, Cited 73.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

FAU-type hafnosilicate zeolite with a hierarchical structure (Hf-USY) was constructed through a post-synthesis strategy containing the controlled dealumination of the commercial H-USY zeolite and the subsequent dry impregnation of the Cp2HfCl2 precursor. The incorporation of Hf ions into the zeolite framework involved the interaction between the silanol groups from framework dealumination and Cp2HfCl2 molecules. Characterization results from UV-vis and X-ray photoelectron spectroscopy verified that the incorporated Hf ions mainly existed in the tetrahedrally coordinated form in the zeolite framework. The creation of Lewis acid sites associated with Hf incorporation was confirmed by Fourier transform infrared spectroscopy with pyridine and deuterated acetonitrile adsorption. The as-synthesized Hf-USY zeolite served as a highly efficient catalyst in the transfer hydrogenation of ethyl levulinate to gamma-valerolactone, outperforming the Sn- and Zr-silicate analogues. The Hf-USY catalyst also exhibited good performance in the transfer hydrogenation of more challenging substrates such as furanic, aromatic, as well as alkene-substituted carbonyl compounds into the corresponding alcohols. The influence of Lewis acid sites, preparation parameters, as well as the hydrogen donor on the catalytic activity of the Hf-USY zeolite was investigated in detail.

Name: Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Tang, B; Li, S; Song, WC; Yang, EC; Zhao, XJ; Guan, NJ; Li, LD or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Regio- and Stereoselective Synthesis of Enynyl-Aryl Ethers Enabled by Copper/Iodide Tandem Catalysis WOS:000481018100001 published article about C-H BOND; TERMINAL ALKYNES; COPPER; PALLADIUM; HALIDES; ALKENES; ESTERS; IODINATION; COMPLEXES; PHENOLS in [Wu, Yun-Bin; Xiao, Lin; Mao, Chun-Li; Zang, Zhong-Lin; Zhou, Cheng-He; Cai, Gui-Xin] Southwest Univ, Key Lab Luminescent & Real Time Analyt Chem, Minist Educ,Sch Chem & Chem Engn, Key Lab Appl Chem Chongqing Municipal,Inst Bioorg, Chongqing 400715, Peoples R China; [Cai, Gui-Xin] Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China in 2019, Cited 82. Category: indole-building-block. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

An approach to preparing enynyl-aryl ethers from phenols and phenylacetylenes is described. This method without extra ligands, overcoming the favored Glaser-Hay dimerization of alkyne, features a wide substrate scope (38 examples including endofolliculina and indole) and the merits of high atom and step economy, good regio- and stereoselectivity (Z-isomers major) in moderate to good isolated yields. Mechanistic studies show that the reaction is enabled by distinctive copper/iodide tandem catalysis.

Category: indole-building-block. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Wu, YB; Xiao, L; Mao, CL; Zang, ZL; Zhou, CH; Cai, GX or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bugaenko, DI; Yurovskaya, MA; Karchava, AV in [Bugaenko, Dmitry, I; Yurovskaya, Marina A.; Karchava, Alexander, V] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119992, Russia published Reaction of Pyridine-N-Oxides with Tertiary sp(2)-N-Nucleophiles: An Efficient Synthesis of Precursors for N-(Pyrid-2-yl)-Substituted N-Heterocyclic Carbenes in 2020, Cited 61. Category: indole-building-block. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

N-(Pyrid-2-yl)-substituted azolium and pyridinium salts, precursors for hybrid NHC-containing ligands, were obtained with excellent regioselectivity, employing a deoxygenative CH-functionalization of pyridine-N-oxides with substituted imidazoles, thiazoles, and pyridine. Unlike the traditional SNAr-based methods, this approach provides high yields for substrates bearing substituents of different electronic nature. The utility of azolium and pyridinium salts thus prepared was also highlighted by the synthesis of pyridyl-substituted imidazolyl-2-thione, benzodiazepine as well as 2-aminopyridines.

Category: indole-building-block. About m-Methoxyphenol, If you have any questions, you can contact Bugaenko, DI; Yurovskaya, MA; Karchava, AV or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 4-Methoxybenzaldehyde. Authors Yadav, MB; Lim, KT; Kim, JS; Jeong, YT in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Yadav, Maruti B.; Lim, Kwon Taek; Kim, Jong Su; Jeong, Yeon Tae] Pukyong Natl Univ, Dept Image Sci & Engn, Busan 608737, South Korea in 2021, Cited 46. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A simple and efficient synthetic protocol for the synthesis of methyl 4-(4-chlorophenyl)-5,7-dioxo-1-phenyl-1,4,5,6,7,8-hexahydropyrazolo [4′,3]:5,6] pyrano[2,3-d] pyrimidine-3-carboxylate derivatives via a one pot four-component reaction catalyzed by L-Proline has been successfully developed. This new protocol produces pyrano pyrimidine carboxylate derivatives in good to excellent yields, with operational simplicity. The remarkable features of this methodology are high yields, metal-free catalyst, easy work-up procedure, and a greener method that avoids toxic catalyst and hazardous solvents. (C) 2021 Elsevier Ltd. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Yadav, MB; Lim, KT; Kim, JS; Jeong, YT or concate me.. Recommanded Product: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about MULTIKINASE INHIBITOR; DISCOVERY; RESISTANCE; SORAFENIB; MUTATIONS; PATHWAY, Saw an article supported by the National Science FoundationNational Science Foundation (NSF) [CHE-1455306]; Canadian Cancer Society Research InstituteCanadian Cancer Society (CCS) [704116]; Canada Research Chair ProgramCanada Research Chairs; Canadian Institutes for Health ResearchCanadian Institutes of Health Research (CIHR) [FDN143277]; Stauffer Endowed Fellowship, USC Graduate School; USC Dornsife Chemical Biology Training Program; TD Bank postdoctoral fellowship; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [P30GM124165] Funding Source: NIH RePORTER. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Assadieskandar, A; Yu, CQ; Maisonneuve, P; Kunnov, I; Sicheri, F; Zhang, C. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol. Category: indole-building-block

One effective means to achieve inhibitor specificity for RAF kinases, an important family of cancer drug targets, has been to target the monomeric inactive state conformation of the kinase domain, which, unlike most other kinases, can accommodate sulfonamide-containing drugs such as vemurafenib and dabrafenib because of the presence of a unique pocket specific to inactive RAF kinases. We previously reported an alternate strategy whereby rigidification of a nonselective pyrazolo[3,4-d]pyrimidine-based inhibitor through ring closure afforded moderate but appreciable increases in selectivity for RAF kinases. Here, we show that a further application of the rigidification strategy to a different pyrazolopyrimidine-based scaffold dramatically improved selectivity for RAF kinases. Crystal structure analysis confirmed our inhibitor design hypothesis revealing that 21 engages an active-like state conformation of BRAF normally associated with poorly discriminating inhibitors. When screened against a panel of distinct cancer cell lines, the optimized inhibitor 21 primarily inhibited the proliferation of the expected BRAF(V600E)-harboring cell lines consistent with its kinome selectivity profile. These results suggest that rigidification could be a general and powerful strategy for enhancing inhibitor selectivity against protein kinases, which may open up therapeutic opportunities not afforded by other approaches.

Category: indole-building-block. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Assadieskandar, A; Yu, CQ; Maisonneuve, P; Kunnov, I; Sicheri, F; Zhang, C or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 4-Methoxybenzaldehyde. In 2021.0 RSC ADV published article about TOTAL ANTIOXIDANT CAPACITY; OXIDATIVE STRESS; PHENOLIC-COMPOUNDS; LEAVES; PROFILES; TYROSOL; TEMPERATURE; POLYPHENOLS; METABOLISM; BLACKBERRY in [El-Hawary, Seham S.] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo, Egypt; [Mohammed, Rabab; Hassan, Hossam M.] Beni Suef Univ, Fac Pharm, Dept Pharmacognosy, Bani Suwayf, Egypt; [El-Din, Marwa Emad; Hassan, Hossam M.] Nahda Univ, Fac Pharm, Dept Pharmacognosy, Bani Suwayf, Egypt; [Ali, Zeinab Y.] Egyptian Drug Author EDA, Dept Biochem, Giza 12553, Egypt; [Ali, Zeinab Y.] Natl Org Drug Control & Res NODCAR, Giza 12553, Egypt; [Rateb, Mostafa E.] Univ West Scotland, Sch Comp Engn & Phys Sci, Paisley PA1 2BE, Renfrew, Scotland; [El Naggar, El Moataz Bellah] Damanhur Univ, Fac Pharm, Dept Pharmacognosy, Elbehira 22511, Egypt; [Othman, Eman M.] Minia Univ, Fac Pharm, Dept Biochem, Al Minya 61519, Egypt; [Othman, Eman M.] Univ Wurzburg, Bioctr, Dept Bioinformat, Wurzburg, Germany; [Abdelmohsen, Usama Ramadan] Deraya Univ, Fac Pharm, Dept Pharmacognosy, New Minia 61111, Minia, Egypt; [Abdelmohsen, Usama Ramadan] Minia Univ, Fac Pharm, Dept Pharmacognosy, Al Minya 61519, Egypt in 2021.0, Cited 70.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

This work aims to explore the differences in phytochemical composition and biological properties of five strawberry hybrids (Fragaria x ananassa Duch.), and highlights the non-edible part (byproduct) as a source of self-remedy natural herb along with fruits. HPLC/DAD/HRESIMS technique was used in the dereplication of ten ethanolic extracts of five strawberry cultivars leaves and fruits (Festival, Red Merlin, Suzana, Tamar and Winter Dawn). Total phenolic and total flavonoid contents were established using Folin-Ciocalteu and aluminum chloride colorimetric assays, respectively. Ethanolic extracts of leaves and fruits from Festival and Red Merlin cultivars were selected to investigate their anti-hyperglycemic activity using streptozotocin-induced diabetic rats. Oxidative stress markers, lipid profile and kidney and liver function tests were assessed. The results revealed different chemical profiles of ten samples with the identification of 37 metabolites, represented mainly as flavonoids and phenolic acid derivatives. Phytochemical investigation resulted in the isolation of seven known phenolic compounds; quercetin, kaempferol, p-coumaric acid, p-tyrosol, methyl gallate, trans-tiliroside and eutigoside A. Suzana cultivar was the richest cultivar with flavonoids and total phenolics except for the total flavonoid content in leaves referred to Festival cultivar. Ethanolic extract of leaves, especially Festival cultivar was the most bioactive one. The results established the role of strawberry leaves along with fruits as an antioxidant and hypoglycemic natural remedy.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact El-Hawary, SS; Mohammed, R; El-Din, ME; Hassan, HM; Ali, ZY; Rateb, ME; El Naggar, EB; Othman, EM; Abdelmohsen, UR or concate me.. Recommanded Product: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Biosynthesized Selenium nanoparticles as a new catalyst in the synthesis of quinazoline derivatives in pentacyclic system with docking validation as (TRPV1) inhibitor WOS:000654634900006 published article about ATOMIC-ABSORPTION-SPECTROMETRY; TETRACHLOROSILANE; REAGENT in [Abdelghany, A. M.] Natl Res Ctr, Phys Div, Spect Dept, 33 El Behouth St, Cairo 12622, Egypt; [Soliman, Hanan A.] Natl Res Ctr, Photochem Dept, 33 El Behouth St, Cairo 12622, Egypt; [Khatab, Tamer K.] Natl Res Ctr, Organomet & Organometalloid Chem Dept, 33 El Behouth St, Cairo 12622, Egypt in 2021, Cited 34. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Computed Properties of C8H8O2

In recent years, a lot of benefits of Selenium have been discovered for humans, animals and chemical uses. Nano-Selenium was biosynthesized and characterized by using FTIR, UV/Vis., TEM/SAED, and mapping to ensure their crystallinity. The N-bridged imidazo-quinazoline derivatives were successfully synthesized in pentacyclic nonlinear ortho fused polynuclear by a one-pot reaction of aldehyde, beta-naphthol, and 2-aminobenzoimidazole in the presence of a catalytic amount of aqueous nano-Se as a highly efficient and facile catalyst at 70-80 degrees C. The molecular docking study as TRPV1 inhibitor compared with Rutaecarpine and Evodiamine as reference alkaloids ligands. (C) 2021 Elsevier B.V. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Abdelghany, AM; Soliman, HA; Khatab, TK or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles