Day: October 27, 2021

I found the field of Chemistry very interesting. Saw the article 4-Hydroxy-3-methyl-2(1H)-quinolone, originally discovered from a Brassicaceae plant, produced by a soil bacterium of the genus Burkholderia sp.: determination of a preferred tautomer and antioxidant activity published in 2020. Quality Control of 4-Hydroxyquinolin-2(1H)-one, Reprint Addresses Igarashi, Y (corresponding author), Toyama Prefectural Univ, Biotechnol Res Ctr, 5180 Kurokawa, Imizu, Toyama 9390398, Japan.; Igarashi, Y (corresponding author), Toyama Prefectural Univ, Dept Biotechnol, 5180 Kurokawa, Imizu, Toyama 9390398, Japan.. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one

4-Hydroxy-3-methyl-2(1H)-quinolone (1), a molecule known for a long time and recently discovered from a Brassicaceae plant Isatis tinctoria without providing sufficient evidence to support the structure, was isolated from a fermentation extract of Burkholderia sp. 3Y-MMP isolated from a soil by a Zn2+ enrichment culture. Detailed spectroscopic analyses by MS and NMR, combined with C-13 chemical shift comparison with literature values of the related compounds and a synthetic preparation of 1, allowed its first full NMR characterization and identification of 2-quinolone but not 2-quinolinol (2) as the preferred tautomer for this heterocyclic system. While the metal-chelating activity was negligible, compound 1 at 10 mu M, a concentration lower than that in liquid production cultures, quenched hydroxy radical-induced chemiluminescence emitted by luminol by 86%. Because some Burkholderia species are pathogenic to plants and animals, the above result suggests that 1 is a potential antioxidant to counteract reactive oxygen species-based immune response in the host organisms.

Quality Control of 4-Hydroxyquinolin-2(1H)-one. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Li, DD; Oku, N; Shinozaki, Y; Kurokawa, Y; Igarashi, Y or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C8H8O2. Recently I am researching about ALPHA-AMINO-ACIDS; ENANTIOSELECTIVE SYNTHESIS; DIASTEREODIVERGENT ACCESS; DUAL CATALYSIS; SPIROKETALS; CONSTRUCTION; GOLD, Saw an article supported by the National Key Research and Development Program of China [2017YFD0201404]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21873051]; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin). Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Wang, HK; Zeng, TL; Chang, WX; Liu, LY; Li, J. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

An efficient catalytic asymmetric cascade cycloaddition reaction of arylalkynols with dioxopyrrolidines was developed. This reaction was achieved using Au(I) and (R)-BINOL-Ti(IV) bimetallic catalysts and exclusively delivered a series of chiral oxo-bridged bicyclic benzooxacine compounds in up to 86% yield with 96% ee as well as >33:1 dr. Meanwhile, three new s bonds and three new stereogenic centers were formed in a one-pot process.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Wang, HK; Zeng, TL; Chang, WX; Liu, LY; Li, J or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4-Hydroxyquinolin-2(1H)-one. Recently I am researching about ACQUIRED-RESISTANCE; IN-VITRO; PROTEIN; DISCOVERY; DOCKING; PHOSPHORYLATION; ACTIVATION; PRODUCTS; QUINONES; BVD-523, Saw an article supported by the Cancer Prevention and Research Institute of Texas grant [RP160657]; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [R01 GM123252]; Welch FoundationThe Welch Foundation [F-1390]; Science and Technology Development Fund, STDF, EgyptScience and Technology Development Fund (STDF); NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [R01GM123252] Funding Source: NIH RePORTER. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Aly, AA; El-Sheref, EM; Bakheet, MEM; Mourad, MAE; Brase, S; Ibrahim, MAA; Nieger, M; Garvalov, BK; Dalby, KN; Kaoud, TS. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one

Approximately 60% of human cancers exhibit enhanced activity of ERK1 and ERK2, reflecting their multiple roles in tumor initiation and progression. Acquired drug resistance, especially mechanisms associated with the reactivation of the MAPK (RAF/MEK/ERK) pathway represent a major challenge to current treatments of melanoma and several other cancers. Recently, targeting ERK has evolved as a potentially attractive strategy to overcome this resistance. Herein, we report the design and synthesis of novel series of fused naphthofuro[3,2-c] quinoline-6,7,12-triones 3a-f and pyrano[3,2-c]quinoline-6,7,8,13-tetraones 5a,b and 6, as potential ERK inhibitors. New inhibitors were synthesized and identified by different spectroscopic techniques and X-ray crystallography. They were evaluated for their ability to inhibit ERK1/2 in an in vitro radioactive kinase assay. 3b and 6 inhibited ERK1 with IC50s of 0.5 and 0.19 mu M, and inhibited ERK2 with IC50s of 0.6 and 0.16 mu M respectively. Kinetic mechanism studies revealed that the inhibitors are ATP-competitive inhibitors where 6 inhibited ERK2 with a K-i of 0.09 mu M. Six of the new inhibitors were tested for their in vitro anticancer activity against the NCI-60 panel of tumor cell lines. Compound 3b and 6 were the most potent against most of the human tumor cell lines tested. Moreover, 3b and 6 inhibited the proliferation of the BRAF mutant A375 melanoma cells with IC50s of 3.7 and 0.13 mu M, respectively. In addition, they suppressed anchorage-dependent colony formation. Treatment of the A375 cell line with 3b and 6 inhibited the phosphorylation of ERK substrates p-90RSK and ELK-1 and induced apoptosis in a dose dependent manner. Finally, a molecular docking study showed the potential binding mode of 3b and 6 within the ATP catalytic binding site of ERK2.

Name: 4-Hydroxyquinolin-2(1H)-one. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; El-Sheref, EM; Bakheet, MEM; Mourad, MAE; Brase, S; Ibrahim, MAA; Nieger, M; Garvalov, BK; Dalby, KN; Kaoud, TS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 80-59-1. In 2019 INT J MOL SCI published article about SYRIAN CIVIL-WAR; IN-VITRO; CUTANEOUS LEISHMANIASIS; ANTILEISHMANIAL ACTIVITY; ANTIBACTERIAL ACTIVITY; MEDICINAL-PLANTS; NATURAL-PRODUCTS; CHENOPODIUM-AMBROSIOIDES; TRADITIONAL MEDICINE; MAIN COMPONENTS in [Delgado-Altamirano, Ronna] Univ Autonoma Queretaro, Fac Quim, Posgrad Ciencias Quim Biol, Cerro Campanas S-N, Queretaro 76010, Mexico; [Delgado-Altamirano, Ronna; Rojas-Molina, Alejandra] Univ Autonoma Queretaro, Fac Quim, Lab Invest Quim & Farmacol Prod Nat, Cerro Campanas S-N, Queretaro 76010, Mexico; [Isela Lopez-Palma, Rosa; Delgado-Dominguez, Jose; Becker, Ingeborg] Univ Nacl Autonoma Mexico, Hosp Gen Mexico Dr Eduardo Liceaga, Unidad Invest Med Expt, Lab Inmunoparasitol,Fac Med, Dr Balmis 148, Mexico City 06720, DF, Mexico; [Monzote, Lianet] Inst Med Trop Pedro Kouri, Dept Parasitol, Apdo Postal 601, Havana 10400, Cuba; [Fausto Rivero-Cruz, Jose] Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico; [Esturau-Escofet, Nuria] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico; [Vazquez-Landaverde, Pedro A.] Inst Politecn Nacl, Ctr Invest Ciencia Aplicada & Tecnol Avanzada, Unidad Queretaro, Cerro Blanco 141 Colonia Cimatario, Queretaro 76090, Mexico in 2019, Cited 79. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1.

Lantana camara (L.) is employed by several ethnical groups to treat numerous diseases. Although there are no ethnomedical reports on its use against leishmaniasis, organic extracts prepared from L. camara were shown to display leishmanicidal activity. In the present study, we carried out a bioassay-guided fractionation of the dichloromethane extract from Mexican L. camara in order to identify the compounds responsible for the leishmanicidal activity. Eighteen chromatographic fractions (FI-FXVIII) were evaluated in vitro against Leishmania mexicana and L. amazonensis. FII, FX, FXI, FXV, and FXVI showed significant activity against both Leishmania strains, the most potent of which was FXV. Eicosane (1), squalene (2), -ionone (3), caryophyllene oxide (4), -caryophyllene (5), hexanoic acid (6), tiglic acid (7), a mixture of lantanilic (8) and camaric (9) acids, and lantadene B (10) were identified and obtained from the active fractions and evaluated for their leishmanicidal activity. The mixture of lantanilic (8) and camaric (9) acids (79%/21%) was the most potent one (half maximal inhibitory concentration (IC50) = 12.02 +/- 0.36 M). This study indicates that this cultivar of L. camara has high potential for the development of phytomedicines or as a source of natural products, which might represent lead compounds for the design of new drugs against leishmaniasis.

SDS of cas: 80-59-1. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Delgado-Altamirano, R; Lopez-Palma, RI; Monzote, L; Delgado-Dominguez, J; Becker, I; Rivero-Cruz, JF; Esturau-Escofet, N; Vazquez-Landaverde, PA; Rojas-Molina, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Webb, EW; Park, JB; Cole, EL; Donnelly, DJ; Bonacorsi, SJ; Ewing, WR; Doyle, AG in AMER CHEMICAL SOC published article about ALIPHATIC CARBOXYLIC-ACIDS; DECARBOXYLATIVE FLUORINATION; SYNTHETIC METHODS; QUATERNARY CARBONS; FLUORIDE; ALKENES; DEOXYFLUORINATION; HYDROFLUORINATION; AMINOFLUORINATION; DIFLUORINATION in [Webb, Eric W.; Park, John B.; Doyle, Abigail G.] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA; [Cole, Erin L.; Donnelly, David J.; Bonacorsi, Samuel J.] Bristol Myers Squibb Res & Dev, PET Radiochem Synth, Discovery Chem Platforms, Princeton, NJ 08543 USA; [Ewing, William R.] Bristol Myers Squibb, Discovery Chem, Princeton, NJ 08543 USA in 2020.0, Cited 75.0. Application In Synthesis of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

We report a redox-neutral method for nucleophilic fluorination of N-hydroxyphthalimide esters using an Ir photocatalyst under visible light irradiation. The method provides access to a broad range of aliphatic fluorides, including primary, secondary, and tertiary benzylic fluorides as well as unactivated tertiary fluorides, that are typically inaccessible by nucleophilic fluorination due to competing elimination. In addition, we show that the decarboxylative fluorination conditions are readily adapted to radiofluorination with [F-18]KF. We propose that the reactions proceed by two electron transfers between the Ir catalyst and redox-active ester substrate to afford a carbocation intermediate that undergoes subsequent trapping by fluoride. Examples of trapping with O- and C-centered nucleophiles and deoxyfluorination via N-hydroxyphthalimidoyl oxalates are also presented, suggesting that this approach may offer a general blueprint for affecting redox-neutral S(N)1 substitutions under mild conditions.

Application In Synthesis of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Webb, EW; Park, JB; Cole, EL; Donnelly, DJ; Bonacorsi, SJ; Ewing, WR; Doyle, AG or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about EZH2 INHIBITOR 3-DEAZANEPLANOCIN; IN-VITRO EVALUATION; ANTIPROLIFERATIVE ACTIVITY; TUBULIN POLYMERIZATION; DERIVATIVES BEARING; CYTOTOXIC ACTIVITY; CANCER; CARDIOTOXICITY; ANTIOXIDANTS; THERAPY, Saw an article supported by the Hamdard National Foundation (HNF), New Delhi. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Iqbal, MA; Husain, A; Alam, O; Khan, SA; Ahmad, A; Haider, MR; Alam, MA. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Category: indole-building-block

In this study, two series of imidazopyridine-linked thiazolidinone rings (5a-hand6a-h) constituting 16 new compounds were synthesized and tested for their antiproliferative activity against a panel of three human cancer cell lines, that is, MCF-7 (human breast cancer), A549 (human lung cancer), and DU145 (human prostate cancer). Three compounds,5h,6f, and6h, exhibited remarkable results against all three cell lines, but compound6hwas found to be the most active one against the breast cancer cell line. Among all the synthesized compounds,6hdisplayed the highest antioxidant results. Furthermore, the potent compounds5h,6f, and6hshowed no signs of toxicity at doses ranging from 50 to 500 mg/kg of animal body weight. The biochemical parameters (SGOT and SGPT) of compound6hnearly matched the control in hepatotoxicity studies. The molecular docking and MM-GBSADG binding studies are in agreement with the in vitro anticancer and antioxidant activity results. The most promising compound6hwas found to have the highest docking score and binding energy, and its absorption, distribution, metabolism, and excretion (ADME) parameters are in the acceptable range. Thus, it can be concluded that6h, an imidazopyridine derivative endowed with a thiazolidinone ring system, has the potential to be developed as an anticancer agent.

Category: indole-building-block. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Iqbal, MA; Husain, A; Alam, O; Khan, SA; Ahmad, A; Haider, MR; Alam, MA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Afewerki, S; Palo-Nieto, C; Cordova, A in GEORG THIEME VERLAG KG published article about TRANSFER HYDROGENATION; MESOCELLULAR FOAM; SELECTIVE HYDROGENATION; NANOPARTICLES; SILICA; MILD; CARBOCYCLIZATION; DEOXYGENATION; ALDEHYDES; SECONDARY in [Afewerki, Samson; Palo-Nieto, Carlos; Cordova, Armando] Mid Sweden Univ, Dept Nat Sci, Holmgatan 10, S-85170 Sundsvall, Sweden in 2020.0, Cited 45.0. SDS of cas: 100-51-6. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

An efficient heterogeneous palladium-catalyzed transfer hydrogenolysis of primary, secondary, and tertiary benzylic alcohols using formic acid as hydrogen source has been developed. The resulting hydrocarbon products were obtained in excellent yields. Moreover, the system exhibits high chemoselectivity, reacting only with the hydroxy groups in the presence of other functional groups, and excellent recyclability.

About Benzyl Alcohol, If you have any questions, you can contact Afewerki, S; Palo-Nieto, C; Cordova, A or concate me.. SDS of cas: 100-51-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Song, WJ; Song, MX; Jiang, XM; Yi, XD; Lai, WK in SPRINGER published article about MODEL COMPOUNDS; HYDROGENOLYSIS; MECHANISM; DEPOLYMERIZATION; VALORIZATION; KINETICS; CHLORIDE; PHENOLS in [Song, Wenjing; Song, Mengxue; Jiang, Xingmao] Wuhan Inst Technol, Sch Chem Engn & Pharm, Hubei Key Lab Novel Chem Reactor & Green Chem Tec, Key Lab Green Chem Proc,Minist Educ, Wuhan 430073, Peoples R China; [Yi, Xiaodong; Lai, Weikun] Xiamen Univ, Coll Chem & Chem Engn, Natl Engn Lab Green Chem Prod Alcohols Ethers Est, Xiamen 361005, Peoples R China in 2021.0, Cited 32.0. HPLC of Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

Hydrolytic cleavage of C-O bond was systematically studied in acidic/alkaline aqueous solution. For phenethoxybenzene (PEB) hydrolysis, 2-phenylethanol and phenol were formed as main products in AlCl3 solutions, whereas styrene was preferred with Na2CO3. After a quantitative evaluation of the kinetics of elementary steps, it was concluded that both AlCl3 and Na2CO3 promoted protons assisted C-O bond scission in H2O, whereas alkaline enhanced the dehydration of produced 2-phenylethanol. Kinetic and isotope labeling experiments demonstrated that the hydrolytic rates of PEB were first order with respect to substrate concentrations, hydrolytic cleavage of C-O bond was rate-determining step. The study shed light on the promotional effects and hydrolytic mechanism over acid/base-catalyzed lignin depolymerization in water.

HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Song, WJ; Song, MX; Jiang, XM; Yi, XD; Lai, WK or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Palladium catalyzed carbonylations of alkenyl halides with formic acid to get corresponding alpha,beta-unsaturated carboxylic acids and esters WOS:000461410800017 published article about ACETIC-ANHYDRIDE; ORGANIC HALIDES; ARYL BROMIDES; OLEFINS; CO; HYDROCARBOXYLATION; HYDROXYCARBONYLATION; ALKYNES; HYDROESTERIFICATION in [Pongracz, Peter] Univ Pecs, Dept Inorgan Chem, H-7624 Pecs, Hungary; Janos Szentagothai Sci Ctr, MTA TKI Res Grp Select Chem Syntheses, H-7624 Pecs, Hungary in 2019, Cited 30. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1. Quality Control of (E)-2-Methylbut-2-enoic acid

Palladium-catalysed carbonylation reactions have been developed in the presence of formic acid as carbon monoxide source. alpha,beta-Unsaturated carboxylic acids and esters were synthesized by the transformation of alkenyl halides in moderate to good yields. The selection of the base proved to be crucial regarding the reaction outcome. A set of various substrates were proven under optimised reaction conditions. Compared to aliphatic alcohols, phenols showed excellent reactivity as O-nucleophiles.

Quality Control of (E)-2-Methylbut-2-enoic acid. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Bartal, B; Mikle, G; Kollar, L; Pongracz, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Palladium-catalyzed Tsuji-Trost-type reaction of benzofuran-2-ylmethyl acetates with nucleophiles published in 2021.0. Product Details of 150-76-5, Reprint Addresses Goggiamani, A; Iazzetti, A (corresponding author), Sapienza Univ Roma, Dipartimento Chim & Tecnol Farmaco, Ple A Moro 5, I-00185 Rome, Italy.. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol

The palladium-catalyzed benzylic-like nucleophilic substitution of benzofuran-2-ylmethyl acetate with N, S, O and C soft nucleophiles has been investigated. The success of the reaction is dramatically influenced by the choice of catalytic system: with nitrogen based nucleophiles the reaction works well with Pd-2(dba)(3)/dppf, while with sulfur, oxygen and carbo-nucleophiles [Pd(eta(3)-C3H5)Cl](2)/XPhos is more efficient. The regiochemical outcome shows that the nucleophilic substitution occurs only on the benzylic position of the eta(3)-(benzofuryl)methyl complex. The high to excellent yields and the simplicity of the experimental procedure make this protocol a versatile synthetic tool for the preparation of 2-substituted benzo[b]furans.

Product Details of 150-76-5. About Mequinol, If you have any questions, you can contact Arcadi, A; Fabrizi, G; Fochetti, A; Ghirga, F; Goggiamani, A; Iazzetti, A; Marrone, F; Mazzoccanti, G; Serraiocco, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles