Day: October 27, 2021

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. In 2021.0 MOL DIVERS published article about DERIVATIVES; FLAVONES; TUBULIN; DESIGN; ARREST in [Thorat, Nitin M.; Thopate, Shankar R.] Ahmednagar Coll, Prof John Barnabas Post Grad Sch Biol Studies, Dept Chem, Stn Rd, Ahmednagar 414001, Maharashtra, India; [Thorat, Nitin M.] Maharaja Jivajirao Shinde Arts Sci Commerce Coll, Dept Chem, Shrigonda 413701, Maharashtra, India; [Sarkate, Aniket P.] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem Technol, Aurangabad 431004, Maharashtra, India; [Lokwani, Deepak K.] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Shirpur 425405, Maharashtra, India; [Tiwari, Shailee V.] Durgamata Inst Pharm, Dept Pharmaceut Chem, Parbhani 431401, Maharashtra, India; [Azad, Rajaram] Univ Hyderabad, Dept Anim Biol, Hyderabad 500046, India; [Thopate, Shankar R.] Shri Sadguru Gangageer Maharaj Sci Gautam Arts &, Dept Chem, Ahmednagar 423601, Maharashtra, India in 2021.0, Cited 31.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

Series of novel N-benzyl derivatives of 6-aminoflavone (9a-n) were synthesized and evaluated for anticancer and topoisomerase II enzyme inhibition activity. All the synthesized compounds were screened for in vitro anticancer activity against human breast cancer cell line (MCF-7) and human lung cancer cell line (A-549). Among the synthesized compounds, 9f and 9g were found to be the most potent anticancer agents against human breast cancer cell line (MCF-7) with IC50 values of 9.35 mu M and 9.58 mu M, respectively. Compounds 9b, 9c and 9n exhibited promising anticancer activity against human lung cancer cell line (A-549) with 43.71%, 46.48% and 44.26% inhibition at the highest concentration of 10 mu M, respectively. Compounds 9c, 9f and 9g have ability to inhibit the topoisomerase II enzyme. Compound 9f showed most potent topoisomerase II enzyme inhibition activity with IC50 value of 12.11 mu M. Further, these compounds have a high potential to be developed as a promising topoisomerase II inhibitors.

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Thorat, NM; Sarkate, AP; Lokwani, DK; Tiwari, SV; Azad, R; Thopate, SR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Physiology; Respiratory System very interesting. Saw the article E-cigarettes and health risks: more to the flavor than just the name published in 2021.0. Name: 3,4-Dimethoxybenzaldehyde, Reprint Addresses Ween, MP (corresponding author), Royal Adelaide Hosp, Dept Thorac Med, Adelaide, SA, Australia.; Ween, MP (corresponding author), Univ Adelaide, Sch Med, Adelaide, SA, Australia.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

The growing interest in regulating flavored E-liquids must incorporate understanding of the flavoring profile of each E-liquid-which flavorings (flavoring chemicals) are present and at what concentrations not just focusing on the flavor on the label. We investigated the flavoring profile of 10 different flavored E-liquids. We assessed bronchial epithelial cell viability and apoptosis, phagocytosis of bacteria and apoptotic cells by macrophages after exposure to E-cigarette vapor extract (EVE). We validated our data in normal human bronchial epithelial cells (NHBE) and alveolar macrophages (AM) from healthy donors. We also assessed cytokine release and validated in the saliva from E-cigarette users. Increased necrosis/apoptosis (16.1-64.5% apoptosis) in 16HBE cells was flavor dependent, and NHBEs showed an increased susceptibility to flavors. In THP-1 differentiated macrophages phagocytosis was also flavor dependent, with AM also showing increased susceptibility to flavors. Further, Banana and Chocolate were shown to reduce surface expression of phagocytic target recognition receptors on alveolar macrophages. Banana and Chocolate increased IL-8 secretion by NHBE, whereas all 4 flavors reduced AM IL-1 beta secretion, which was also reduced in the saliva of E-cigarette users compared with healthy controls. Flavorant profiles of E-liquids varied from simple 2 compound mixtures to complex mixtures containing over a dozen flavorants. E-liquids with high benzene content, complex flavoring profiles, high chemical concentration had the greatest impacts. The Flavorant profile of E-liquids is key to disruption of the airway status quo by increasing bronchial epithelial cell apoptosis, causing alveolar macrophage phagocytic dysfunction, and altering airway cytokines.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Ween, MP; Moshensky, A; Thredgold, L; Bastian, NA; Hamon, R; Badiei, A; Nguyen, PT; Herewane, K; Jersmann, H; Bojanowski, CM; Shin, J; Reynolds, PN; Alexander, LEC; Hodge, SJ or concate me.. Name: 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors WOS:000479184600037 published article about FACTOR RECEPTOR KINASE; SUBSTITUTED QUINOLINONES; PYRAZOLE DERIVATIVES; POTENTIAL ANTICANCER; ERLOTINIB; CANCER; CRIZOTINIB; CHEMISTRY; ASSAY in [Elbastawesy, Mohammed A., I; Ramadan, Mohamed] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut 71524, Egypt; [Aly, Ashraf A.] Menia Univ, Fac Sci, Dept Chem, Al Minya 61519, Egypt; [Elshaier, Yaseen A. M. M.] Univ Sadat City, Fac Pharm, Dept Organ & Med Chem, Menoufia 32958, Egypt; [Youssif, Bahaa G. M.] Assiut Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut 71526, Egypt; [Brown, Alan B.] Florida Inst Technol, Program Chem, Melbourne, FL 32901 USA; [Abuo-Rahma, Gamal El-Din A.] Menia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt in 2019, Cited 50. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3. Recommanded Product: 86-95-3

Two new series of diethyl 2-[2-(substituted-2-oxo-1,2-dihydroquinolin-4-yl)hydrazono]-succinates 6a-g and 1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been designed and synthesized. The structures of the synthesized compounds were proved by IR, mass, NMR (2D) spectra and elemental analyses. The target compounds were evaluated for their in vitro cytotoxic activity against 60 cancer cell lines according to NCI protocol. Consequently, seven compounds were further examined against the most sensitive cell lines, leukemia CCRFCEM, and MOLT-4. 5-Amino-1-(6-bromo-2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazole-3,4-dicarbonitrile (7f) was the most active product, with IC50= 1.35 uM and 2.42 uM against MOLT-4 and CCRF-CEM, respectively. Also, it showed a remarkable inhibitory activity compared to erlotinib on the EGFR TK with IC50 = 247.14 nM and 208.42 nM, respectively. Cell cycle analysis of MOLT-4 cells treated with 7f showed cell cycle arrest at G2/M phase (supported by Caspases, BAX and Bcl-2 studies) with a significant pro-apoptotic activity as indicated by annexin V-FITC staining. Moreover, the docking study indicated that both the pyrazole moiety and the quinolin-2-one ring showed good fitting into EGFR (PDB code: 1M17). In order to interpret SAR of the designed compounds, and provide a basis for further optimization, molecular docking of the synthesized compounds to known EGFR inhibitors was performed. The study illustrated the effect of several factors on the compounds’ activity.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Elbastawesy, MAI; Aly, AA; Ramadan, M; Elshaier, YAMM; Youssif, BGM; Brown, AB; Abuo-Rahma, GEDA or concate me.. Recommanded Product: 86-95-3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 98-17-9. Ye, LB; Han, C; Shi, PQ; Gao, W; Mei, WJ in [Ye, Lianbao; Han, Chao; Shi, Peiqi; Gao, Wei] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China; [Mei, Wenjie] Guangdong Pharmaceut Univ, Guangdong Prov Engn Technol Ctr Mol Probes & Biom, Guangzhou 510006, Guangdong, Peoples R China published Copper-catalyzed synthesis of phenol and diaryl ether derivatives via hydroxylation of diaryliodoniums in 2019, Cited 53. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

A copper-catalysed hydroxylation of diaryliodoniums to generate phenols and diaryl ethers is reported. This method allows the synthesis of diversely functionalized phenols under mild reaction conditions without the need for a strong inorganic base or an expensive noble-metal catalyst. Significantly, convenient application of diaryliodoniums is demonstrated in the preparation of diaryl ethers in a one-pot operation.

Product Details of 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Ye, LB; Han, C; Shi, PQ; Gao, W; Mei, WJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Zhang, LY; Ye, M; Shi, YH; Zhu, HP; Chi, LJ; Pan, CX; Xu, YN; Zheng, X; Xiang, HP; Li, CL in ELSEVIER published article about IN-VITRO; MYRISTICA-FRAGRANS; ANGELICA-DAHURICA; PATCHOULI ALCOHOL; INFLAMMATION; INHIBITION in [Zhang, Lanyue; Ye, Mao; Shi, Yaohui; Zhu, Haiping; Chi, Lejing; Pan, Chunxing; Xu, Yani; Li, Chunlian] Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China; [Xiang, Hongping] Guangdong Univ Technol, Sch Mat & Energy, Guangzhou 510006, Peoples R China; [Zheng, Xi] Rutgers State Univ, Susan Lehman Cullman Lab Canc Res, Ernest Mario Sch Pharm, Dept Chem Biol, 164 Frelinghuysen Rd, Piscataway, NJ 08854 USA in 2021, Cited 42. Computed Properties of C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Essential oils extracted from herbs have been utilized in food and medicine on the account of their increasing physicochemical characteristics. This present study aimed to investigate the phytochemical components, antiinflammatory, cytotoxic, anti-microbial and anti-oxidant activities of essential oils from Pogostemon cablin (P. cablin), Angelica dahurica (A. dahurica) and Myristica fragrans (M. fragrans), all belong to medicine food homology herbs. Approximately 107 components were identified by gas chromatography mass spectrometry (GC-MS) from these essential oils. The main compounds of P. cablin essential oils (PCEOs) were patchouli alcohol (27.72%), alpha-buaiacene (17.94%) and alpha-guaiene (14.15%); in A. dahurica essential oils (ADEOs) were anethole (24.91%) and cinnamaldehyde (18.35%); and in M. fragrans essential oils (MFEOs) were (1S)-(-)-alpha-pinene (23.39%), alpha-terpineol (18.60%) and caryophyllene (10.34%). These essential oils were found to have strong antiinflammatory activities through decreasing the production of cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), nuclear factor-kappa B p65 (P65) and tumor necrosis factor-alpha (TNF-alpha). These essential oils also had significant anti-bacterial activities against both Gram-negative and Gram-positive strains and anti-fungal activities. Moreover, effective anti-oxidant properties of three essential oils were estimated (0.001962%-0.19%). The study also explored the effect of these essential oils on the survival of Brain microglia (BV2) microglial cells (IC50 = 145.50-281.52 mu g/mL). Based on these bioactivities, these essential oils could be used as food additives, fragrances, cosmetics and health products.

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zhang, LY; Ye, M; Shi, YH; Zhu, HP; Chi, LJ; Pan, CX; Xu, YN; Zheng, X; Xiang, HP; Li, CL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Catalytic application of sulfamic acid-functionalized magnetic Fe3O4 nanoparticles (SA-MNPs) for protection of aromatic carbonyl compounds and alcohols: experimental and theoretical studies WOS:000601124900038 published article about EFFICIENT CATALYST; SULFONIC-ACID; GAMMA-FE2O3 NANOPARTICLES; SULFURIC-ACID; ACETALIZATION; ACETALS; METHOXYMETHYLATION; ALDEHYDES; DITHIOACETALIZATION; HYDROLYSIS in [Khaef, Sepideh; Zolfigol, Mohammad Ali; Yarie, Meysam] Bu Ali Sina Univ, Dept Organ Chem, Fac Chem, Hamadan, Hamadan, Iran; [Khaef, Sepideh; Taherpour, Avat Arman] Razi Univ, Dept Organ Chem, Fac Chem, Kermanshah, Iran in 2020.0, Cited 92.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Name: Benzyl Alcohol

Protection techniques of functional groups within the structure of organic compounds are important synthetic methods against unwanted attacks from various reagents during synthetic sequences. Acetal and thioacetal groups are well known as protective functional groups in organic reactions. In this study, acetalization of carbonyl compounds with diols and dithiols and methoxymethylation of alcohols with formaldehyde dimethyl acetal (FDMA) have been carried out using sulfamic acid-functionalized magnetic Fe3O4 nanoparticles (SA-MNPs) as a heterogeneous solid acid catalyst. Products were characterized by FT-IR and NMR spectroscopies. The structural and electronic properties of some products were computed by quantum mechanical (QM) methods. Depending on the stereochemistry and electronic properties that were obtained by computational results, we have suggested that hyperconjugation plays a key role in the structural properties of 2-phenyl-1,3-dioxolane derivatives, and also the electron transfer between pi-electrons of the aromatic ring with the 3d orbital of S-atoms influences the 2-phenyl-1,3-dithiane derivatives’ structure.

Name: Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Khaef, S; Zolfigol, MA; Taherpour, AA; Yarie, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Efficient solvent- and temperature-tuned access to aldoxime ethers and phenolic functions by Pd-catalyzed C-O cross-coupling of aldoximes with aryl bromides and bromo-chalcones WOS:000509895700019 published article about ARYLOXIME ETHERS; OXIME ETHERS; PHENYLBORONIC ACIDS; REARRANGEMENT; BENZOFURANS; CYCLIZATION; ARYLATION; DERIVATIVES; COMPLEX in [Reeta; Kaushik, Kumar; Singh, Raj Pal] DRDO, Ctr Fire Explos & Environm Safety, Delhi, India; [Reeta] Univ Delhi, Dept Chem, Delhi, India; [Rangarajan, T. M.; Singh, Rishi Pal] Univ Delhi, Sri Venkateswara Coll, Dept Chem, New Delhi, India; [Singh, Manjula] Univ Delhi, Shivaji Coll, Dept Chem, New Delhi, India in 2020.0, Cited 69.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

A single method with a functionality switching option was developed for the first time for the Pd-catalyzed C-O cross-coupling of aryl bromides and bromo-chalcones with aldoximes. The ligand tBuXPhos (L2) was found to be an effective supporting ligand for the Pd-catalyzed coupling of aldoximes with bromo coupling partners. The functionality switching from oxime ethers to a phenolic or hydroxy group was driven by solvent or temperature. This method offers the products in good to excellent yields in short reaction times.

Safety of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Reeta; Rangarajan, TM; Kaushik, K; Singh, RP; Singh, M; Singh, RP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C7H8O. Recently I am researching about TORULASPORA-DELBRUECKII; SHERRY WINES; RED WINES; AROMA; SACCHAROMYCES; COMPONENTS; IMPACT, Saw an article supported by the Universita degli Studi di Milano [Piano di Sostegno alla Ricerca 2015/2017-Linea 2] Funding Source: Medline. Published in MDPI in BASEL ,Authors: Fracassetti, D; Bottelli, P; Corona, O; Foschino, R; Vigentini, I. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

In this study, Cabernet Sauvignon and Chardonnay musts, and fruit juices from cherry, kiwi, peach, and strawberry were co-fermented with Saccharomyces cerevisiae EC1118 and Torulaspora delbrueckii UMY196 at two different proportions (80:20 (v/v) and 60:40 (v/v)). The most pleasant fruit-based drink was obtained with Cabernet Sauvignon must and kiwi juice in a proportion of 60:40 and fermented with T. delbrueckii. This beverage was produced in higher volume to simulate a scale-up, and the aromatic profile, sensory description, and consumer acceptability were determined. The most powerful odorants of the kiwi-based drink were ethyl octanoate, phenylethanal, ethyl hexanoate, vinyl-guaiacol, benzaldehyde, and nonanal, for which the odor activity values were 21.1, 3.3, 2.6, 2.2, 1.9, and 1.6, respectively. These findings were in accordance with the sensory analysis, since the emerged descriptors were fruity (ethyl octanoate), honey and floral (phenylethanal), apple and peach (ethyl hexanoate), and citrus (nonanal). The consumers judged the kiwi-based drink acceptable (67%) and 39% of them would buy it. The reliable fermentation of a grape must/fruit juice was demonstrated. The kiwi-based drink represents an innovative and pleasant beverage with a positive impact on sustainability as its production can limit the loss of fresh fruits, as well as contribute to the enological field.

About Benzyl Alcohol, If you have any questions, you can contact Fracassetti, D; Bottelli, P; Corona, O; Foschino, R; Vigentini, I or concate me.. Computed Properties of C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H8O. I found the field of Chemistry very interesting. Saw the article Adsorption Energies of Oxygenated Aromatics and Organics on Rhodium and Platinum in Aqueous Phase published in 2020.0, Reprint Addresses Goldsmith, BR; Singh, N (corresponding author), Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA.; Goldsmith, BR; Singh, N (corresponding author), Univ Michigan, Catalysis Sci & Technol Inst, Ann Arbor, MI 48109 USA.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol.

Accurately predicting adsorption energies of oxygenated aromatic and organic molecules on metal catalysts in the aqueous phase is challenging despite its relevance to many catalytic reactions such as biomass hydrogenation and hydrodeoxygenation. Here, we report the aqueous-phase adsorption enthalpies and free energies of phenol, benzaldehyde, furfural, benzyl alcohol, and cyclohexanol on polycrystalline Pt and Rh determined via experimental isotherms and density functional theory modeling. The experimental aqueous heats of adsorption for all organics are similar to 50 to 250 kJ mol(-1) lower than calculated gas-phase heats of adsorption, with a larger decrease for Rh compared with that for Pt. Unlike in gas phase, phenol and other aromatic organics adsorb with similar strength on Pt and Rh in aqueous phase. The similar aqueous adsorption strength of phenol and benzaldehyde on Pt and Rh explains their comparable aqueous-phase hydrogenation activities, which are rate-limited by a Langmuir-Hinshelwood surface reaction. A widely used implicit solvation model largely overpredicts the heats of adsorption for all organics compared with experimental measurements. However, accounting for the enthalpic penalty of displacing multiple water molecules upon organic adsorption using a bond-additivity model gives a much closer agreement between experimental measurements and predicted heats of adsorption. This bond-additivity model explains that the similar adsorption strength of organics on Pt and Rh in aqueous phase is due to the stronger adhesion of water to Rh than that on Pt, which offsets the stronger gas-phase organic adsorption energy on Rh. The data reported herein also provides a valuable resource for benchmarking methods for predicting aqueous-phase adsorption energies of CS/C6 organics on metal surfaces.

Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Akinola, J; Barth, I; Goldsmith, BR; Singh, N or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Ben Hsouna, A; Dhibi, S; Dhifi, W; Ben Saad, R; Brini, F; Hfaidh, N; Mnif, W in ROYAL SOC CHEMISTRY published article about ACTIVATED PROTEIN-KINASES; HEPATOPROTECTIVE ACTIVITY; ANTIOXIDANT ACTIVITIES; CARBON-TETRACHLORIDE; CYTOKINE PRODUCTION; PLANT; INTERLEUKIN-10; TOXICITY; EXTRACTS; SYSTEM in [Ben Hsouna, Anis] Fac Sci Gafsa, Dept Life Sci, Zarroug 2112, Gafsa, Tunisia; [Ben Hsouna, Anis; Ben Saad, Rania] Ctr Biotechnol Sfax, Lab Biotechnol & Plant Improvement, Sfax, Tunisia; [Dhibi, Sabah; Brini, Faical; Hfaidh, Najla] Fac Sci Gafsa, Unit Macromol Biochem & Genet, Sidi Ahmed Zarrouk 2112, Gafsa, Tunisia; [Dhifi, Wissal] Biotechpole Sidi Thabet, Higher Inst Biotechnol Sidi Thabet, LR17 ES03 Physiopathol Food & Biomolecules, Ariana 2020, Tunisia; [Mnif, Wissem] Univ Bisha, Fac Sci & Arts Balgarn, Dept Chem, POB 199, Bisha 61922, Saudi Arabia; [Mnif, Wissem] Univ Manouba, ISBST, BVBGR, LR11ES31,Biotechpole Sidi Thabet, Ariana 2020, Tunisia in 2019.0, Cited 56.0. Quality Control of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

The present study evaluates the chemical profiling of the essential oil of a halophyte, L. maritima (LmEO), and its protective potential against CCl4-induced oxidative stress in rats. Forty compounds have been identified in LmEO. The major components are alpha-pinene (3.51%), benzyl alcohol (8.65%), linalool (22.43%), pulegone (3.33%), 1-phenyl butanone (7.33%), globulol (4.32%), gamma-terpinene (6.15%), terpinen-4-ol (4.31%), alpha-terpineol (3.9%), ledol (3.59%), epi-alpha-cadinol (3.05%) and alpha-cadinol (4.91%). In comparison with the CCl4-intoxicated group, LmEO treatment resulted in decreased liver serum marker enzymes, decreased lipid peroxidation and increased antioxidant enzyme levels, with overall further amelioration of oxidative stress. The administration of LmEO to CCl4-treated rats at a dose of 250 mg kg(-1) body weight significantly reduced the toxic effects and the oxidative stress on the liver, thus validating the traditional medicinal claim of this plant. Moreover, the anti-inflammatory activity of LmEO was evaluated in lipopolysaccharide-stimulated murine RAW 264.7 cells. Our oil could modulate the inflammatory mode of the macrophages by causing reduction in iNOS and COX2 enzymes as well as in IL-1 beta, IL-6, and TNF-alpha cytokine levels. These findings suggest that LmEO exerts anti-inflammatory effects by regulating the expression of inflammatory cytokines.

Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Ben Hsouna, A; Dhibi, S; Dhifi, W; Ben Saad, R; Brini, F; Hfaidh, N; Mnif, W or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles