Day: October 28, 2021

Recommanded Product: 4-Methoxybenzaldehyde. Authors Mansour, SY; Sayed, GH; Marzouk, MI; Shaban, SS in TAYLOR & FRANCIS INC published article about in [Mansour, S. Y.; Sayed, G. H.; Marzouk, M. I.; Shaban, S. S.] Ain Shams Univ, Fac Sci, Chem Dept, Heterocycl Synthet Lab, Cairo, Egypt in 2021.0, Cited 22.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The 2-Aminonicotinonitrile derivative was reacted with different bi-functional reagents such as formamide, thiourea, acetic anhydride, and phthalic anhydride under optimized conditions to give pyrimidine, thiourea, acetamide, and isoindoline derivatives, respectively, When it was treated with active methylene reagents as malononitrile, phenacyl bromide, and ethyl bromoacetate under varied experimental modulation, it afforded 1, 8-naphthyridine, ethyl, and methylamino nicotinonitrile derivatives, respectively. Also, it was reacted with p-toluene sulfonyl chloride, chloroacetyl chloride, and benzoyl chloride to give sulfonamide, 2-chloro-N-acetamide, and benzamide derivatives, respectively. Likewise, it was reacted with diethyl malonate, ethyl cyanoacetate, and cyano acetic acid to give ethylpropanoate, naphthyridine, and cyano acetamide derivatives, respectively. However, treatment of ethylpropanoate and cyano acetamide derivatives with hydrazine hydrate gave pyrazole and 5-amino-pyrazole nicotinonitrile derivatives, respectively. In addition, it was reacted with p-anisaldehyde, phenyl isocyanate, and triethyl orthoformate to give benzylamino nicotinonitrile, phenyl urea, and N-formamide derivatives, respectively. Furthermore, it was reacted with nitrous acid then coupled with aniline; it was also reacted with isatine and 1,3- dibromo propane to give oxoindoline derivative, and the dimer. Elemental analyses, together with spectroscopic data including IR, H-1-NMR in addition to C-13-NMR and mass spectra submit proofs for the chemical structures for all compounds. [GRAPHICS]

Recommanded Product: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Mansour, SY; Sayed, GH; Marzouk, MI; Shaban, SS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis, anti-oomycete activity, and SAR studies of paeonol derivatives WOS:000512395000001 published article about PHYTOPHTHORA-CAPSICI; BOTRYTIS-CINEREA; TREE PEONY; ANALOGS; RESISTANCE; SEED in [Tian, Yue-E; Sun, Di; Han, Xiao-Xiao; Yang, Jin-Ming; Zhang, Song; Feng, Nan-Nan; Zhu, Li-Na; Xu, Zhong-Yuan; Che, Zhi-Ping; Liu, Sheng-Ming; Lin, Xiao-Min; Jiang, Jia; Chen, Gen-Qiang] Henan Univ Sci & Technol, Coll Forestry, Dept Plant Protect, Lab Pharmaceut Design & Synth, Luoyang 471023, Peoples R China in 2021.0, Cited 25.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Safety of m-Methoxyphenol

Three series of sulfonate derivatives of paeonol were synthesized and screened in vitro for their anti-oomycete activity against P. capsici, respectively. Among all the compounds, 4m displayed the best promising and pronounced anti-oomycete activity against P. capsici than zoxamide, with the EC50 values of 24.51 and 26.87 mg/L, respectively. The results show that acetyl and 4-OCH3 are two necessary groups. The existence of these two sites is closely related to the anti-oomycete activity. Relatively speaking, hydroxyl group is well tolerated, and the results showed that after modification of hydroxyl group with sulfonyl, the anti-oomycete activity was significantly increased. [GRAPHICS] .

Safety of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Tian, YE; Sun, D; Han, XX; Yang, JM; Zhang, S; Feng, NN; Zhu, LN; Xu, ZY; Che, ZP; Liu, SM; Lin, XM; Jiang, J; Chen, GQ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis of Co-MOF/COF nanocomposite: application as a powerful and recoverable catalyst in the Knoevenagel reaction WOS:000558615800001 published article about COVALENT ORGANIC FRAMEWORKS; MIXED MATRIX MEMBRANES; CRYSTALLINE; ENERGY; FABRICATION; ADSORPTION; SEPARATION; POLYIMIDE; DESIGN in [Rahmati, Ensiyeh; Rafiee, Zahra] Univ Yasuj, Dept Chem, Yasuj 7591874831, Iran in 2021, Cited 52. COA of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A novel mesoporous composite was prepared through the hybridization of cobalt-based metal-organic framework (Co-MOF) and covalent organic framework (COF) based on melamine and terephthaldehyde (Co-MOF/COF) and characterized by FT-IR, SEM, XRD, EDS, BET, and STA analyses. The resultant composite was utilized as a robust recoverable catalyst in the condensation of several aldehydes with malononitrile to produce benzylidenemalononitrile derivatives in 62-94% yields under solvent-free conditions at room temperature using 15 mg of the catalyst and 5-60 min of reaction. The examination of catalytic performance of designated Co-MOF/COF exhibited an outstanding activity for the Knoevenagel condensation in a very short time. The recoverability, reusability and durability of Co-MOF/COF have also been investigated under applied conditions.

COA of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Rahmati, E; Rafiee, Z or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about PHOTOINDUCED ELECTRON-TRANSFER; AGGREGATION-INDUCED EMISSION; BENZYL ALCOHOL; CATALYTIC-ACTIVITY; AROMATIC ALCOHOLS; TITANIUM-DIOXIDE; MOLECULAR-OXYGEN; CHARGE-TRANSFER; NANOCOMPOSITE; ALDEHYDES, Saw an article supported by the Asahi Glass Foundation; 100th Anniversary Chulalongkorn University Fund for Doctoral Scholarship; 90th Anniversary Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund); Sci-Super IV Fund from the Faculty of Science, Chulalongkorn University; ESF Nachwuchsforschergruppe E-PISA [100310500]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Phuangburee, T; Solonenko, D; Plainpan, N; Thamyongkit, P; Zahn, DRT; Unarunotai, S; Tuntulani, T; Leeladee, P. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol. Application In Synthesis of Benzyl Alcohol

Modification of graphene oxide (GO) with porphyrins, TPP and ZnTPP (TPP = 5,10,15,20-tetraphenyl-21H,23H-porphine), was achieved by facile synthesis through a self-assembly process. GO-porphyrins composites were characterized by scanning electron microscopy, and UV-visible, fluorescence, photoluminescence and Raman spectroscopy, which confirmed the successful attachment of TPP and ZnTPP onto the GO surface via pi-pi stacking. The coordination of oxygen functional groups on GO to the Zn center of ZnTPP was also observed. The latter interaction was proposed to account for the lower catalytic activity of the GO-ZnTPP composite compared to that of the GO-TPP one because it hindered the accessible active sites on the GO surface, i.e. epoxy groups. Compared to unmodified GO and pristine porphyrins, the GO-porphyrin composites exhibited remarkable photocatalytic enhancement under irradiation using a light emitting diode. Moreover, the GO-TPP composite was shown to be a competent and reusable photocatalyst for selective alcohol oxidation under mild conditions, affording desired products in moderate to excellent yields.

Application In Synthesis of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Phuangburee, T; Solonenko, D; Plainpan, N; Thamyongkit, P; Zahn, DRT; Unarunotai, S; Tuntulani, T; Leeladee, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3,4-Dimethoxybenzaldehyde. Milovic, E; Jankovic, N; Vranes, M; Stefanovic, S; Petronijevic, J; Joksimovic, N; Muskinja, J; Ratkovic, Z in [Milovic, Emilija; Petronijevic, Jelena; Joksimovic, Nenad; Ratkovic, Zoran] Univ Kragujevac, Fac Sci, Dept Chem, Radoja Domanovica 12, Kragujevac 34000, Serbia; [Jankovic, Nenad; Muskinja, Jovana] Univ Kragujevac, Inst Informat Technol Kragujevac, Dept Sci, Kragujevac 34000, Serbia; [Vranes, Milan] Univ Novi Sad, Fac Sci, Dept Chem Biochem & Environm Protect, Trg Dositeja Obradovica 3, Novi Sad 21000, Serbia; [Stefanovic, Srdan] Inst Meat Hyg & Technol, Kacanskog 13, Belgrade 11000, Serbia published Green one-pot synthesis of pyrido-dipyrimidine DNA-base hybrids in water in 2021.0, Cited 67.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

Reactions in water as a safe and cheap solvent is a major goal of green chemistry. Actual synthesis of pyrido-dipyrimidine scaffold, named DNA-base hybrids, involves catalysis in hazardous solvents. Here we synthesised pyrido-dipyrimidines by one-pot heterocyclization of thiobarbituric acid, vanillic aldehydes and amines in water. Enamine and vanillidene are key intermediates of the Biginelli-like reaction mechanism. Our synthetic method displays several benefits such as the use of a green medium and various substrates, and yields up to 99%.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Milovic, E; Jankovic, N; Vranes, M; Stefanovic, S; Petronijevic, J; Joksimovic, N; Muskinja, J; Ratkovic, Z or concate me.. Recommanded Product: 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Oladipo, SD; Yusuf, TL; Zamisa, SJ; Shapi, M; Ajayi, TJ in [Oladipo, Segun D.; Yusuf, Tunde L.; Zamisa, Sizwe J.] Univ KwaZulu Natal, Sch Chem & Phys, Private Bag X54001, ZA-4000 Durban, South Africa; [Oladipo, Segun D.] Olabisi Onabanjo Univ, Dept Chem Sci, PMB 2002, Ago Iwoye, Nigeria; [Yusuf, Tunde L.] Univ Johannesburg, Dept Chem Sci, POB 17011, ZA-2028 Johannesburg, South Africa; [Shapi, Micheal; Ajayi, Tomilola J.] Mangosuthu Univ Technol, Dept Chem, ZA-4000 Durban, South Africa published Synthesis, crystal structure, Hirshfeld surface analysis and DFT studies of N-(2,6-diisopropylphenyl)-1-(4-methoxyphenyl) methanimine in 2021, Cited 83. Safety of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

We report the synthesis of a new Schiffbase(N-(2,6-diisopropylphenyl)-1-(4-methoxyphenyl) methanimine) 1; derived from the condensation of 4-methoxybenzaldehyde and 2,6-diisopropylaniline in 1:1 mole ratio. The compound was elucidated by single-crystal X-ray diffraction, C-13, and H-1, NMR, FTIR, UV-vis spectroscopies. The molecular geometries of the new Schiffbase were investigated using the DFT/B3LYP method using 6-311++G (2d,2p) basis set. The optimized structure of the studied compound is consistent with the finding of the X-ray analysis. In addition, Time-dependent density functional theory (TD-DFT) analysis was applied to shed more light on the manner of the electronic transitions determined in the UV-Vis spectra. Hirshfeld surface analyses for the compound were presented and discussed. The Experimental and theoretical result for geometric and spectroscopic parameters were in good agreement. (C) 2021 Elsevier B.V. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Oladipo, SD; Yusuf, TL; Zamisa, SJ; Shapi, M; Ajayi, TJ or concate me.. Safety of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer cell lines WOS:000651228800015 published article about GROWTH-FACTOR RECEPTOR; BIOLOGICAL EVALUATION in [Aziz, Marian W.; Elgendy, Adel A.] Misr Int Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt; [Kamal, Aliaa M.; Mohamed, Khaled O.] Cairo Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Cairo, Egypt; [Kamal, Aliaa M.] October Univ Modern Sci & Arts MSA, Fac Pharm, Dept Pharmaceut Chem, Giza, Egypt in 2021.0, Cited 43.0. Safety of 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

New acetamide (IV a-e) and 1,3-thiazolidinone derivatives (VII a-e) were designed, synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines along with their lead compounds (erlotinib and gefitinib). The newly designed compounds were prepared according to the adopted procedures in schemes 1 and 2 from their quinazolinone parents. 3D QSAR pharmacophore and docking molecular modeling protocols were conducted using Discovery Studio program, beside a full biological assay for these compounds. The cytotoxicity evaluation demonstrated that compounds IVb, IVc, VIIa, VIIb, VIId exhibited potent cytotoxic activities against both MCF-7 and A549 cell lines. Moreover, the molecular modeling studies corroborated to the affinity of the compounds towards EGFR. Consequently, these five compounds were then screened for their EGFR inhibition and evaluated as well for their toxicity to normal cells, which revealed that the acetamide derivative IVc and the thiazolidinone derivative VIIa were the most potent and least toxic. DNA flow cytometry analysis was conducted for compounds IVc and VIIa, which indicated that they both induced arrest at G2/M phase of the cell cycle.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Aziz, MW; Kamal, AM; Mohamed, KO; Elgendy, AA or concate me.. Safety of 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 150-19-6. Yang, J; Zhen, L; Jiang, LQ in [Yang, Jun; Zhen, Long; Jiang, Liqin] East China Normal Univ China, Sch Chem & Mol Engn, 500 Dongchuan Rd, Shanghai 200241, Peoples R China published Synthesis of N,N-Disubstituted Thiocarbamates from Thiocarbamoyl Fluorides with Alcohols/Phenols/Thiophenols/Thioalcohols Through Copper Catalysis in 2019.0, Cited 31.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

Traditional methods for preparing N,N-disubstituted thiocarbamates require highly toxic, flammable and volatile reagents, or their derivatives. Recently, we developed a general method for thiocarbamoyl fluorides from safe, cheap, and easily available starting materials. Reported reactions involving thioyl fluoride with nucleophiles are very scarce. In this report, copper catalyzed reaction of thiocarbamoyl fluorides with phenols/thiophenols/alcohols/thioalcohols under Na2CO3 at 50 degrees C or at 80 degrees C in CH3CN were first developed, affording the corresponding N,N-disubstituted thiocarbamates in moderate to excellent yields. When alcohols are cheap and their boiling points are less than 120 degrees C or they are water-soluble, CuCl catalyzed reaction of thiocarbamoyl fluorides with alcohols at 50 degrees C was also developed. The reaction has good functional group tolerance. Methoxy, methyl, chloro, bromo, nitro, even ester functional groups were all tolerated. Control reactions demonstrated that copper catalyst played the key role on the success of these novel reactions.

About m-Methoxyphenol, If you have any questions, you can contact Yang, J; Zhen, L; Jiang, LQ or concate me.. Product Details of 150-19-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Speri, E; Kim, C; De Benedetti, S; Qian, YY; Lastochkin, E; Fishovitz, J; Fisher, JF; Mobashery, S in [Speri, Enrico; Kim, Choon; De Benedetti, Stefania; Qian, Yuanyuan; Lastochkin, Elena; Fishovitz, Jennifer; Fisher, Jed F.; Mobashery, Shahriar] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA published Cinnamonitrile Adjuvants Restore Susceptibility to beta-Lactams against Methicillin-Resistant Staphylococcus aureus in 2019, Cited 49. Application In Synthesis of 3-(Trifluoromethyl)phenol. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

beta-Lactams are used routinely to treat Staphylococcus aureus infections. However, the emergence of methicillin-resistant S. aureus (MRSA) renders them clinically precarious. We describe a class of cinnamonitrile adjuvants that restore the activity of oxacillin (a penicillin member of the beta-lactams) against MRSA. The lead adjuvants were tested against six important strains of MRSA, one vancomycin-intermediate S. aureus (VISA) strain, and one linezolid-resistant S. aureus strain. Five compounds out of 84 total compounds showed broad potentiation. At 8 mu M (E)-3-(5-(3,4-dichlorobenzy1)-2-(trifluoromethoxy)phenyl)-2-(methylsulfonyl)acrylonitrile (26) potentiated oxacillin with a >4000-fold reduction of its MIC (from 256 to 0.06 mg.L-1). This class of adjuvants holds promise for reversal of the resistance phenotype of MRSA.

Application In Synthesis of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Speri, E; Kim, C; De Benedetti, S; Qian, YY; Lastochkin, E; Fishovitz, J; Fisher, JF; Mobashery, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C9H10O3. Authors Yadav, U; Vanjari, Y; Laxmikeshav, K; Tokala, R; Niggula, PK; Kumar, M; Talla, V; Kamal, A; Shankaraiah, N in BENTHAM SCIENCE PUBL LTD published article about in [Yadav, Upasana; Vanjari, Yogesh; Laxmikeshav, Kritika; Tokala, Ramya; Niggula, Praveen K.; Shankaraiah, Nagula] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Hyderabad 500037, India; [Kumar, Manoj; Talla, Venu] Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmacol & Toxicol, Hyderabad 500037, India; [Kamal, Ahmed] Jamia Hamdard, Sch Pharmaceut Educ & Res SPER, New Delhi 110062, India in 2021, Cited 66. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Objective: To synthesize a series of phenanthrene-thiazolidinedione hybrids and explore their cytotoxic potential against human cancer cell lines of A-549 (lung cancer), HCT-116 and HT-29 (colon cancer), MDA MB-231 (triple-negative breast cancer), BT-474 (breast cancer) and (mouse melanoma) B16F10 cells. Methods: A new series of phenanthrene-thiazolidinedione hybrids was synthesized via Knoevenagel condensation of phenanthrene-9-carbaldehyde and N-alkylated thiazolidinediones. The cytotoxicity (IC50) of the synthesized compounds was determined by MTT assay. Apoptotic assays like (AO/EB) and DAPI staining, cell cycle analysis, JC-1 staining and Annexin V binding assay studies were performed for the most active compound (Z)- 3-(4-bromobenzyl)-5-((2,3,6,7-tetramethoxyphenanthren-9-yl)methylene)thiazolidine-2,4-dione (17b). Molecular docking, dynamics and evaluation of pharmacokinetic (ADME/T) properties were also carried out by using Schrodinger. Results and Discussion: From the series of tested compounds, 17b unveiled promising cytotoxic action with an IC50 value of 0.985 +/- 0.02 mu M on HCT-116 human colon cancer cells. The treatment of HCT-116 cells with 17b demonstrated distinctive apoptotic morphology like shrinkage of cells, horseshoe-shaped nuclei formation and chromatin condensation. The flow-cytometry analysis revealed the G(0)/G(1) phase cell cycle arrest in a dosedependent fashion. The AO/EB, DAPI, DCFDA, Annexin-V and JC-1 staining studies were performed in order to determine the effect of the compound on cell viability. Computational studies were performed by using Schrodinger to determine the stability of the ligand with the DNA. Conclusion: The current study provides an insight into developing a series of phenanthrene thiazolidinedione derivatives as potential DNA interactive agents which might aid in colon cancer therapy.

HPLC of Formula: C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Yadav, U; Vanjari, Y; Laxmikeshav, K; Tokala, R; Niggula, PK; Kumar, M; Talla, V; Kamal, A; Shankaraiah, N or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles