Month: October 2021

Recently I am researching about C-H FUNCTIONALIZATION; PHOTOREDOX CATALYSIS; CARBONYL-COMPOUNDS; COUPLING REACTIONS; NICKEL CATALYSIS; GRIGNARD; HYDROGEN; HALIDES; IMINES; REAGENTS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21702113, 22071102, 91956110]; Thousand Talents Plan of Central Plains; Key Scientific Research Projects of Higher Education Institutions in Henan Province [20A150029]; National Science FoundationNational Science Foundation (NSF) [CHE-1554906]; Robert A. Welch FoundationThe Welch Foundation [D-1361]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Zhang, S; Li, LJ; Li, JJ; Shi, JX; Xu, K; Gao, WC; Zong, LY; Li, GG; Findlater, M. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde. Category: indole-building-block

Arylation of carbonyls, one of the most common approaches toward alcohols, has received tremendous attention, as alcohols are important feedstocks and building blocks in organic synthesis. Despite great progress, there is still a great gap to develop an ideal arylation method featuring mild conditions, good functional group tolerance, and readily available starting materials. We now show that electrochemical arylation can fill the gap. By taking advantage of synthetic electrochemistry, commercially available aldehydes (ketones) and benzylic alcohols can be readily arylated to provide a general and scalable access to structurally diverse alcohols (97 examples, >10 gram-scale). More importantly, convergent paired electrolysis, the ideal but challenging electrochemical technology, was employed to transform low-value alcohols into more useful alcohols. Detailed mechanism study suggests that two plausible pathways are involved in the redox neutral alpha-arylation of benzylic alcohols.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Zhang, S; Li, LJ; Li, JJ; Shi, JX; Xu, K; Gao, WC; Zong, LY; Li, GG; Findlater, M or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3-Hydroxybenzaldehyde. Recently I am researching about POLO-LIKE KINASE; CANCER, Saw an article supported by the China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019TQ0215]; Program of Liaoning Revitalization Talents Program [XLYC1808037]; Doctoral Scientific Research Foundation of Liaoning Province [2020-BS-130]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Li, ZW; Xu, L; Zhu, LY; Zhao, YF; Hu, T; Yin, BX; Liu, YJ; Hou, YL. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

A series of novel pteridinone derivatives possessing a hydrazone moiety were designed, synthesized and evaluated for their biological activity. Most of the synthesized compounds demonstrated moderate to excellent activity against A549, HCT116 and PC-3 cancer cell lines. In particular, compound L-19 exhibited the most potent antiproliferative effects on three cell lines with IC50 values of 3.23 mu M, 4.36 mu M and 8.20 mu M, respectively. In kinase assays, the compound L-19 also showed potent inhibition activity toward PLK1 with % inhibition values of 75.1. Further mechanism studies revealed that compound L-19 significantly inhibited proliferation of HCT-116 cell lines, induced a great decrease in mitochondrial membrane potential resulting in apoptosis of cancer cells, inhibited the migration of tumor cells, and arrested G1 phase of HCT116 cells.

Recommanded Product: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Li, ZW; Xu, L; Zhu, LY; Zhao, YF; Hu, T; Yin, BX; Liu, YJ; Hou, YL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S; Polamo, M; Nieger, M; Brown, AB in [Aly, Ashraf A.; Hassan, Alaa A.; Mohamed, Nasr K.; Abd El-Haleem, Lamiaa E.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Braese, Stefan] Karlsruhe Inst Technol, Inst Organ Chem, D-76131 Karlsruhe, Germany; [Braese, Stefan] Karlsruhe Inst Technol, Inst Toxicol & Genet, D-76344 Eggenstein Leopoldshafen, Germany; [Polamo, Mika; Nieger, Martin] Univ Helsinki, Dept Chem, POB 55,AI Virtasen Aukio 1, Helsinki 00014, Finland; [Brown, Alan B.] Florida Inst Technol, Chem Program, Melbourne, FL 32901 USA published Synthesis of New Fused Heterocyclic 2-Quinolones and 3-Alkanonyl-4-Hydroxy-2-Quinolones in 2019, Cited 31. Computed Properties of C9H7NO2. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-c:5,6-c ‘]difuro[2,3-c:4,5-c ‘]-diquinoline-6,14(5H,12H)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl- butane-1,4-diones and 4-(benzo-[d]oxazol-2-yl)-3-hydroxy-1H-[4,5]oxazolo[3,2-a]pyridine-1-one. The new candidates were synthesized and identified by different spectroscopic techniques, and X-ray crystallography.

Computed Properties of C9H7NO2. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S; Polamo, M; Nieger, M; Brown, AB or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Paul, A; Shipman, MA; Onabule, DY; Sproules, S; Symes, MD in ROYAL SOC CHEMISTRY published article about in [Paul, Avishek; Shipman, Michael A.; Onabule, Dolapo Y.; Sproules, Stephen; Symes, Mark D.] Univ Glasgow, Sch Chem, WestCHEM, Univ Ave, Glasgow G12 8QQ, Lanark, Scotland in 2021, Cited 30. Application In Synthesis of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The enhancement of reactivity inside supramolecular coordination cages has many analogies to the mode of action of enzymes, and continues to inspire the design of new catalysts for a range of reactions. However, despite being a near-ubiquitous class of reactions in organic chemistry, enhancement of the reduction of carbonyls to their corresponding alcohols remains very much underexplored in supramolecular coordination cages. Herein, we show that encapsulation of small aromatic aldehydes inside a supramolecular coordination cage allows the reduction of these aldehydes with the mild reducing agent sodium cyanoborohydride to proceed with high selectivity (ketones and esters are not reduced) and in good yields. In the absence of the cage, low pH conditions are essential for any appreciable conversion of the aldehydes to the alcohols. In contrast, the specific microenvironment inside the cage allows this reaction to proceed in bulk solution that is pH-neutral, or even basic. We propose that the cage acts to stabilise the protonated oxocarbenium ion reaction intermediates (enhancing aldehyde reactivity) whilst simultaneously favouring the encapsulation and reduction of smaller aldehydes (which fit more easily inside the cage). Such dual action (enhancement of reactivity and size-selectivity) is reminiscent of the mode of operation of natural enzymes and highlights the tremendous promise of cage architectures as selective catalysts.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Paul, A; Shipman, MA; Onabule, DY; Sproules, S; Symes, MD or concate me.. Application In Synthesis of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Chemoselective Thioacetalisation and Transthioacetalisation of Aldehydes Catalyzed by PVP-I WOS:000488160100028 published article about ACIDIC IONIC LIQUID; CARBONYL-COMPOUNDS; EFFICIENT CATALYST; REUSABLE CATALYST; HIGHLY EFFICIENT; CONVENIENT CATALYST; THIOACETALIZATION; DITHIOACETALIZATION; SOLVENT; MILD in [Hu, Peng-Fei; Dong, Bin; Zhou, Zhi-Peng; Zeng, Bu-Bing] East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China; [Chen, Wei-Dong] East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China in 2019.0, Cited 70.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 100-83-4

Thioacetals of various aldehydes were obtained directly from aldehydes or by a transthioacetalisation process from O,O-acetals catalyzed by Povidone-iodine (PVP-I) with good to excellent yields. Attractive features of this method include mild reaction conditions, low catalyst loading, recyclability of catalyst, facile purification of products, and high synthetic efficiency.

Recommanded Product: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Hu, PF; Dong, B; Zhou, ZP; Chen, WD; Zeng, BB or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 4-Hydroxyquinolin-2(1H)-one. In 2019 J HETEROCYCLIC CHEM published article about TETRAPROPYLAMMONIUM BROMIDE; BIOLOGICAL EVALUATION; DERIVATIVES; CATALYST; WATER in [Marjani, Ahmad Poursattar; Khalafy, Jabbar; Farajollahi, Ayda] Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh, Iran in 2019, Cited 41. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

Quality Control of 4-Hydroxyquinolin-2(1H)-one. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about DERIVATIVES; INHIBITORS; FUROQUINOLINE; ALKALOIDS; MODEL, Saw an article supported by the . Computed Properties of C9H7NO2. Published in SPRINGER WIEN in WIEN ,Authors: Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one

Quinoline-2,4-diones reacted with 2-[bis(methylthio)methylene]malononitrile in DMF/Et3N to produce 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carbonitriles and 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides in state of 2-imino-substituted 4-(methylthio)-5,6-dihydro-2H-pyrano[3,2-c]quinolone-3-carbonitriles. The structures of all new products were proved using NMR, IR, and mass spectral data. The possible mechanism for the reaction is also discussed. Graphic abstract

Computed Properties of C9H7NO2. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 4-Methoxybenzaldehyde. Authors Elfinger, M; Schonauer, T; Thoma, SLJ; Staglich, R; Drechsler, M; Zobel, M; Senker, J; Kempe, R in WILEY-V C H VERLAG GMBH published article about in [Elfinger, Matthias; Schoenauer, Timon; Kempe, Rhett] Univ Bayreuth, Inorgan Chem Catalyst Design 2, Sustainable Chem Ctr, D-95440 Bayreuth, Germany; [Thomae, Sabrina L. J.; Zobel, Mirijam] Univ Bayreuth, Solid State Chem Mesostruct Mat, D-95440 Bayreuth, Germany; [Staeglich, Robert; Senker, Juergen] Univ Bayreuth, Inorgan Chem 3, D-95440 Bayreuth, Germany; [Staeglich, Robert; Senker, Juergen] Univ Bayreuth, North Bavarian NMR Ctr, D-95440 Bayreuth, Germany; [Drechsler, Markus] Univ Bayreuth, Bavarian Polymer Inst BPI, Keylab Electron & Opt Microscopy, D-95440 Bayreuth, Germany in 2021.0, Cited 27.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Nanostructured and reusable 3d-metal catalysts that operate with high activity and selectivity in important chemical reactions are highly desirable. Here, a cobalt catalyst was developed for the synthesis of primary amines via reductive amination employing hydrogen as the reducing agent and easy-to-handle ammonia, dissolved in water, as the nitrogen source. The catalyst operates under very mild conditions (1.5 mol% catalyst loading, 50 degrees C and 10 bar H-2 pressure) and outperforms commercially available noble metal catalysts (Pd, Pt, Ru, Rh, Ir). A broad scope and a very good functional group tolerance were observed. The key for the high activity seemed to be the used support: an N-doped amorphous carbon material with small and turbostratically disordered graphitic domains, which is microporous with a bimodal size distribution and with basic NH functionalities in the pores.

Recommanded Product: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Elfinger, M; Schonauer, T; Thoma, SLJ; Staglich, R; Drechsler, M; Zobel, M; Senker, J; Kempe, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Saka, ET; Kahriman, N in ELSEVIER SCIENCE SA published article about THIN-FILMS; COBALT PHTHALOCYANINE; ZINC PHTHALOCYANINE; CYCLOHEXENE OXIDATION; SELECTIVE OXIDATION; SUBSTITUTED CO(II); FE(II); 2,6-DI-TERT-BUTYLPHENOL; AUTOXIDATION; DEGRADATION in [Saka, Ece Tugba; Kahriman, Nuran] Karadeniz Tech Univ, Fac Sci, Dept Chem, TR-61080 Trabzon, Turkey in 2019.0, Cited 43.0. Recommanded Product: m-Methoxyphenol. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

Phenols from various man-made activities pose threats to public health and aquatic ecosystems. A number of technologies (e.g., adsorption, oxidation, and biological methods) have been proposed and tested to remove phenolic compounds from different sources. Among these technologies, oxidation process is considered one of the most efficient tools for abating phenolic compounds because of low cost, easy scalability, and ecofriendly production. In this work, we aim to synthesize and characterize potential catalysts (Co(II) and Cu(II) phthalocyanines 6 and 7) for phenolic compounds oxidation. Different parameters influenced the oxidation process were determined and phenolic compounds oxidize to the less harmful products with high conversion and yield in the presence of Co(II) and Cu(II) phthalocyanine catalysts. (c) 2019 Elsevier B.V. All rights reserved.

Recommanded Product: m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Saka, ET; Kahriman, N or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about FEATURING MORPHOLINE MOIETY; NATIONAL-CANCER-INSTITUTE; BIOLOGICAL EVALUATION; PHOSPHOINOSITIDE 3-KINASE; COLORIMETRIC ASSAY; DRUG DISCOVERY; CELL-CYCLE; PI3K-ALPHA; CYTOTOXICITY; CHEMOTHERAPY, Saw an article supported by the . Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Helwa, AA; El-Dydamony, NM; Radwan, RA; Abdelraouf, SM; Abdelnaby, RM. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Product Details of 100-83-4

Two series of novel morpholinopyrimidine derivatives were synthesized and screened for their in-vitro cytotoxic activity against 60 tumor cell line by the National Cancer Institute, USA. The in-vitro cytotoxic IC50 values for the most active compounds 6e, 6g, and 6l against the most sensitive cell line leukemia SR were estimated (IC50 = 0.76, 13.59, and 4.37 uM, respectively). To investigate their PI3K enzyme inhibition activity, the assay was done on Class IA (alpha, beta, & delta) isoforms. The IC50 values were very promising: compound [6e = 11.73 (alpha), 6.09 (beta), 11.18 (delta)], compound [6g = 8.43 (alpha), 15.84 (beta), 30.62 (delta)], and compound [6l = 13.98 (alpha), 7.22 (beta), 10.94 (delta)], compared to the reference compound LY294002 = 6.28 (alpha), 4.51 (beta), 4.60 (delta) uM, respectively. Moreover, cell cycle analysis and annexin V-FITC staining were done on Leukemia SR, there was arrest at G2/M phase and apoptosis was induced. Finally, docking study was performed to analyze the interactive mode of these derivatives in PI3K alpha ATP-binding site. These outcomes proved that compounds 6e, 6g, and 6l are potential leads for further optimization as antileukemic agents.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Helwa, AA; El-Dydamony, NM; Radwan, RA; Abdelraouf, SM; Abdelnaby, RM or concate me.. Product Details of 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles