Day: November 17, 2021

An article Host RNA quality control as a hepatitis B antiviral target WOS:000657774400001 published article about NONCANONICAL POLY(A) POLYMERASE; POLYADENYLATION SIGNAL; MOLECULAR-BIOLOGY; STEM-LOOP; VIRUS; DEGRADATION; EXOSOME; TRAMP; DECAY; TRANSCRIPTS in [Block, Timothy M.; Zhou, Tianlun] Baruch S Blumberg Inst, Doylestown, PA 18902 USA; [Young, John A. T.] F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Roche Pharma Res & Early Dev, Basel, Switzerland; [Javanbakht, Hassan] SQZ Biotechnol, 200 Arsenal Yards Blvd,Suite 210, Watertown, MA 02472 USA; [Sofia, Michael J.] Arbutus Biopharma Inc, 701 Vet Circle, Warminster, PA 18974 USA in 2021, Cited 69. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3. Formula: C9H7NO2

Inhibition of the host RNA polyadenylating polymerases, PAPD5 and PAPD7 (PAPD5/7), with dihydroquinolizinone, a small orally available, molecule, results in a rapid and selective degradation of hepatitis B virus (HBV) RNA, and hence reduction in the amounts of viral gene products. DHQ, is a first in class investigational agent and could represent an entirely new category of HBV antivirals. PAPD5 and PAPD7 are noncanonical, cell specified, polyadenylating polymerases, also called terminal nucleotidyl transferases 4B and 4A (TENT4B/A), respectively. They are involved in the degradation of poor-quality cell transcripts, mostly noncoding RNAs and in the maturation of a sub-set of transcripts. They also appear to play a role in shielding some mRNA from degradation. The results of studies with DHQ, along with other recent findings, provide evidence that repression of the PAPD5/7 arm of the cell RNA quality control pathway, causes a profound (multifold) reduction rather than increase, in the amount of HBV pre-genomic, pre-core and HBsAg mRNA levels in tissue culture and animal models, as well. In this review we will briefly discuss the need for new HBV therapeutics and provide background about HBV transcription. We also discuss cellular degradation of host transcripts, as it relates to a new family of anti-HBV drugs that interfere with these processes. Finally, since HBV mRNA maturation appears to be selectively sensitive to PAPD5/7 inhibition in hepatocytes, we discuss the possibility of targeting host RNA quality control as an antiviral strategy.

Formula: C9H7NO2. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Block, TM; Young, JAT; Javanbakht, H; Sofia, MJ; Zhou, TL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of Benzyl Alcohol. In 2021.0 RSC ADV published article about TERMINAL ARYL ALKENES; C-N; ANALOGS; CONDENSATION; DERIVATIVES; ACYLATION; C-SP3-H; ESTERS in [Sharma, Richa; Yadav, Lalit; Yadav, Ravi Kant; Chaudhary, Sandeep] Malaviya Natl Inst Technol, Dept Chem, Lab Organ & Med Chem OMC Lab, Jawaharlal Nehru Marg, Jaipur 302017, Rajasthan, India in 2021.0, Cited 42.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

An efficient, cost-effective, transition-metal-free, oxidative C-H cross-dehydrogenative coupling via a C-H bond functionalization protocol for the regioselective direct C-3 acylation/benzoylation of substituted 2H-Indazoles 1a-m with substituted aldehydes 2a-q/benzyl alcohols 5a-e/styrenes 6a-e is reported. The operationally simple protocol proceeds in the presence of tert-butyl peroxybenzoate (TBPB) as an oxidant in chlorobenzene (PhCl) as a solvent at 110 degrees C for 24 h under an inert atmosphere, which furnished a diverse variety of substituted 3-(acyl/benzoyl)-2H-indazoles 3a-q/4a-l in up to 87% yields. The reaction involves a free-radical mechanism and proceeds via the addition of an in situ generated acyl radical (from aldehydes/benzyl alcohols/styrenes) on 2H-indazoles. The functional group tolerance, broad substrate scope, control/competitive experiments and gram-scale synthesis and its application to the synthesis of anti-inflammatory agent 11 and novel indazole-fused diazepine 13 further signify the versatile nature of the developed methodology.

About Benzyl Alcohol, If you have any questions, you can contact Sharma, R; Yadav, L; Yadav, RK; Chaudhary, S or concate me.. Safety of Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Zhang, XY; Dou, PH; Lu, WY; You, Y; Zhao, JQ; Wang, ZH; Yuan, WC in ROYAL SOC CHEMISTRY published article about in [Zhang, Xia-Yan; Dou, Pei-Hao; Lu, Wen-Ya; You, Yong; Zhao, Jian-Qiang; Wang, Zhen-Hua; Yuan, Wei-Cheng] Chengdu Univ, Inst Adv Study, Chengdu 610106, Peoples R China; [Zhang, Xia-Yan; Dou, Pei-Hao; Lu, Wen-Ya] Chinese Acad Sci, Chengdu Inst Organ Chem, Natl Engn Res Ctr Chiral Drugs, Chengdu 610041, Peoples R China; [Zhang, Xia-Yan; Dou, Pei-Hao; Lu, Wen-Ya] Univ Chinese Acad Sci, Beijing 100049, Peoples R China in 2021.0, Cited 38.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

By taking advantage of benzylidene succinimides as a new class of 3C synthons, a highly diastereo- and enantioselective tandem Mannich reaction/transamidation has been established by reacting them with cyclic trifluoromethyl N-acyl ketimines. Using a Cinchona alkaloid-derived squaramide as the catalyst, the tandem reaction proceeded smoothly under mild conditions and afforded a range of F3C-containing chiral polycyclic dihydroquinazolinones with excellent results (up to 99% yield, all cases >20 : 1 dr, up to 99% ee).

Category: indole-building-block. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 CHEM PAP published article about SHAPED LIQUID-CRYSTALS; CARBOXYL CONNECTING GROUPS; SMECTIC-A PHASE; HOMOLOGOUS SERIES; LATERAL SUBSTITUENTS; MESOPHASE BEHAVIOR; LINKAGE GROUPS; POLAR ORDER; TRANSITION; MOLECULES in [Ocak, Hale; Celikel, Fulya Cagla; Eran, Belkiz Bilgin] Yildiz Tech Univ, Dept Chem, TR-34220 Istanbul, Turkey; [Ozerol, Esma Ahlatcioglu] Yildiz Tech Univ, Dept Bioengn, TR-34220 Istanbul, Turkey; [Okutan, Mustafa] Yildiz Tech Univ, Dept Phys, TR-34220 Istanbul, Turkey in 2020.0, Cited 51.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Quality Control of 3-Hydroxybenzaldehyde

The synthesis, mesomorphic and dielectric investigation of new unsymmetrical bent-core mesogens derived from 3-hydroxybenzoic acid central core with linked two rodlike units carrying (S)-3,7-dimethyloctyloxy group and an n-alkyloxy chain at both terminals are presented. The liquid crystalline properties of the new unsymmetrical bent-core materials have been investigated by polarizing optical microscopy and differential scanning calorimetry. New compounds with the reversed ester linking unit exhibit a monotropic or enantiotropic columnar mesophase at lower temperatures as compared to analogs with a straight chain depending on the presence of the branched (S)-3,7-dimethyloctyloxy terminal chain. Dielectric measurements for one of the bent-core mesogens, 3-[[4-[[4-(octyloxy)benzoyl]oxy]benzoyl]oxy]benzoic acid 4-[[4-((S)-3,7-dimethyloctyloxy)phenoxy]carbonyl]phenyl ester (OBDPE), have been carried out on the angular frequency range from 25.12 to 50265k rad/s at different temperatures. Thanks to dielectric measurements, real and imaginary dielectric constant, conductivity mechanism and dielectric relaxation mechanism of OBDPE were obtained. [GRAPHICS] .

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Ocak, H; Ozerol, EA; Celikel, FC; Okutan, M; Eran, BB or concate me.. Quality Control of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about Z ISOMERIZATION; ATOM ECONOMY; IONIC LIQUID; COUMARINS; BIOSYNTHESIS; DERIVATIVES; ALKYNOATES, Saw an article supported by the WWU Munster; CiM-IMPRS Graduate School. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Nevesely, T; Daniliuc, CG; Gilmour, R. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol. HPLC of Formula: C7H5F3O

An operationally simple one-pot protocol has been developed to enable the conversion of diversely substituted cinnamic acid derivatives into angularly-fused dihydrocoumarins (up to 94%). Inspired by coumarin biosynthesis, this reaction cascade harnesses photochemical E -> Z alkene isomerization enabled by energy transfer catalysis using inexpensive thioxanthen-9-one (TX) under irradiation at 402 nm. Subsequent lactonization generates the heterocyclic core prior to a second photosensitization event to induce a [2 + 2] cycloaddition, again mediated by TX. The tetracyclic products are generated efficiently, and proof of the structure was established by X-ray crystallography. Mechanistic investigations, including structural probes and NMR reaction monitoring, support the postulated order of events. The study underscores the synthetic value of inexpensive small-molecule organic photocatalysts in the generation of structural complexity via sequential pi-bond activation.

HPLC of Formula: C7H5F3O. Welcome to talk about 98-17-9, If you have any questions, you can contact Nevesely, T; Daniliuc, CG; Gilmour, R or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Scope and Mechanism of the Ruthenium-Catalyzed Dehydrative C-H Coupling of Phenols with alpha,beta-Unsaturated Carbonyl Compounds: Expedient Synthesis of Chromene and Benzoxacyclic Derivatives WOS:000504953300010 published article about ENANTIOSELECTIVE SYNTHESIS; BOND ACTIVATION; ARYL ETHERS; ALKYLATION; CYCLOADDITION; FLAVONOIDS; ALKYNES; ALKENYLATION; CYCLIZATION; ALCOHOLS in [Mokar, Bhanudas Dattatray; Yi, Chae S.] Marquette Univ, Dept Chem, Milwaukee, WI 53233 USA in 2019.0, Cited 62.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. SDS of cas: 150-19-6

Chromene and benzoxacyclic derivatives were efficiently synthesized from the ruthenium-catalyzed dehydrative C-H coupling reaction of phenols with alpha,beta-unsaturated carbonyl compounds. The cationic ruthenium-hydride complex was found to be an effective catalyst for the coupling and annulation of phenols with enals to form chromene products. The coupling of phenols with linear enones afforded 2,4-disubstituted chromene derivatives, whereas the analogous coupling with cyclic enones yielded 9-hydroxybenzoxazole products. The reaction of 3,5-dimethoxyphenol with PhCH=CHCDO resulted in the chromene product with a significant H/D exchange to both benzylic and vinyl positions. The most significant carbon isotope effect from the coupling of 3,5-dimethoxyphenol with 4-methoxycinnamaldehyde was observed on the a-olefinic carbon of the chromene product (C(2) = 1.067). A Hammett plot from the coupling of 3,5-dimethoxyphenol with para-substituted p-X-C6H4CH=CHCHO displayed a linear correlation, with a strong promotional effect by an electron -withdrawing group (rho = +1.5; X = OCH3, CH3, H, F, Cl). Several biologically active chromenone derivatives were synthesized by using the catalytic coupling method. The catalytic method provides an expedient synthetic protocol for the coupling of phenols with alpha,beta-unsaturated carbonyl compounds without employing reactive reagents or forming any wasteful byproducts.

SDS of cas: 150-19-6. Bye, fridends, I hope you can learn more about C7H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Light-Driven Enantioselective Synthesis of Pyrroline Derivatives by a Radical/Polar Cascade Reaction WOS:000606827600001 published article about INTRAMOLECULAR SCHMIDT REACTION; HYDROGEN-ATOM TRANSFER; PHOTOREDOX CATALYSIS; UNACTIVATED ALKENES; CYCLIC IMINES; ALKYL AZIDES; FUNCTIONALIZATION; PHOTOCATALYSIS; HYDROIMINATION; CONSTRUCTION in [Rodriguez, Ricardo I.; Mollari, Leonardo; Aleman, Jose] Univ Autonoma Madrid, Dept Organ Chem, Modulo 1, Madrid 28049, Spain in 2021.0, Cited 61.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Recommanded Product: 4-Methoxybenzaldehyde

Herein, a light-driven, atom-economical process that provides access to enantiomerically enriched substituted chiral 1-pyrroline derivatives is introduced. The strategy involves the distal functionalization of acyl heterocycles through a hydrogen-atom transfer (HAT) process and the use of tailor-made ketimines as reliable electrophilic partners. This transformation is translated into an enantiomerically controlled radical/polar cascade reaction in which water is produced as the sole by-product and stereoselectivity is dictated by coordination to a chiral-at-rhodium catalyst.

Welcome to talk about 123-11-5, If you have any questions, you can contact Rodriguez, RI; Mollari, L; Aleman, J or send Email.. Recommanded Product: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of Benzyl Alcohol. Recently I am researching about METAL-ORGANIC FRAMEWORKS; AEROBIC OXIDATION; COORDINATION MODULATION; MOLECULAR-OXYGEN; MIXED-LIGANDS; MORPHOLOGY; ACID; NANOSTRUCTURES; BENZALDEHYDES; DEGRADATION, Saw an article supported by the National Key R&D Program of China [2017YFB0307202]; Natural Science Foundation of Jiangsu Province-Outstanding Youth Foundation [BK20170104]; Six Talent Peaks Project” in Jiangsu Province [XCL037]; Strategic Pioneer Program on Space Science, Chinese, Academy of Sciences [XDA15013100, XDA15013101]; Youth Foundation of Southeast University ChengXian College [z0017]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Huang, C; Gu, XY; Su, XY; Xu, ZC; Liu, R; Zhu, HJ. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

The morphology and size of Co-MOF-74 were effectively controlled by adjusting the water portion in DMF-H2O mixed solvent system, and six different Co-MOF-74 samples were successfully obtained. The water content can alter the deprotonation rate of the organic ligand and then change the nucleation rate of crystal, thus regulate morphology and size of Co-MOF-74. The discrepancy of morphology and size has significant effect on texture structure of Co-MOF-74 but without changing their composition. The formation mechanism of crystal growth was proposed by studying the change of reaction solution pH value. These samples exhibit morphology and size dependent catalytic activity in toluene oxidation. The flower-like sample has the best catalytic performance with 12.1% toluene conversion and 63.8% benzaldehyde selectivity. Additionally, the influence of reaction parameters on the catalytic oxidation reaction was also examined. Rearserch on the structure-property relationship of catalyst would be useful for rationally synthesizing novel MOF in heterogeneous catalysis.

Welcome to talk about 100-51-6, If you have any questions, you can contact Huang, C; Gu, XY; Su, XY; Xu, ZC; Liu, R; Zhu, HJ or send Email.. Quality Control of Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents WOS:000600418500067 published article about TUBULIN POLYMERIZATION INHIBITORS; COLCHICINE BINDING-SITE; PROTEIN-LIGAND DOCKING; COMBRETASTATIN A-4; STRUCTURAL BASIS; SOLID TUMORS; APOPTOSIS; DISCOVERY; GLUCURONIDATION; IDENTIFICATION in [Alvarez, Raquel; Aramburu, Laura; Vicente-Blazquez, Alba; Medarde, Manuel; Pelaez, Rafael] Univ Salamanca, Dept Ciencias Farmaceut, Lab Quim Organ & Farmaceut, Campus Miguel de Unamuno, E-37007 Salamanca, Spain; [Gajate, Consuelo; Vicente-Blazquez, Alba; Mollinedo, Faustino] CSIC, Dept Mol Biomed, Lab Cell Death & Canc Therapy, Ctr Invest Biol Margarita Salas, E-28040 Madrid, Spain; [Alvarez, Raquel; Aramburu, Laura; Vicente-Blazquez, Alba; Medarde, Manuel; Pelaez, Rafael] Univ Salamanca, Fac Farm, Inst Invest Biomed Salamanca IBSAL, Campus Miguel de Unamuno, E-37007 Salamanca, Spain; [Alvarez, Raquel; Aramburu, Laura; Vicente-Blazquez, Alba; Medarde, Manuel; Pelaez, Rafael] Univ Salamanca, Ctr Invest Enfermedades Trop Univ Salamanca CIETU, Campus Miguel de Unamuno, E-37007 Salamanca, Spain in 2021, Cited 65. COA of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Isocombretastatins are the not isomerizable 1,1- diarylethene isomers of combretastatins. Both families of antimitotics are poorly soluble and new analogs with improved water solubility are needed. The ubiquitous 3,4,5-trimethoxyphenyl ring and most of its replacements contribute to the solubility problem. 39 new compounds belonging to two series of isocombretastatin analogs with 2-chloro-6-methylsulfanyl-4-pyridinyl or 2,6-bis(methylsulfanyl)-4-pyridinyl moieties replacing the 3,4,5-trimethoxyphenyl have been synthesized and their antimitotic activity and aqueous solubility have been studied. We show here that 2-chloro-6-methylsulfanylpyridines are more successful replacements than 2,6-bis(methylsulfanyl) pyridines, giving highly potent tubulin inhibitors and cytotoxic compounds with improved water solubilities. The optimal combination is with indole rings carrying polar substitutions at the three position. The resulting diheteroaryl isocombretastatin analogs showed potent cytotoxic activity against human cancer cell lines caused by tubulin inhibition, as shown by in vitro tubulin polymerization inhibitory assays, cell cycle analysis, and confocal microscopy studies. Cell cycle analysis also showed apoptotic responses following G(2)/M arrest after treatment. Conformational analysis and docking studies were applied to propose binding modes of the compounds at the colchicine site of tubulin and were in good agreement with the observed SAR. 2-Chloro-6-methylsulfanylpyridines represent a new and successful trimethoxyphenyl ring substitution for the development of improved colchicine site ligands. (C) 2020 Elsevier Masson SAS. All rights reserved.

COA of Formula: C8H8O2. Welcome to talk about 123-11-5, If you have any questions, you can contact Alvarez, R; Aramburu, L; Gajate, C; Vicente-Blazquez, A; Mollinedo, F; Medarde, M; Pelaez, R or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020 J CHEM INF MODEL published article about CHAGAS-DISEASE; CYSTEINE PROTEASE; LIGAND EFFICIENCY; DOCKING; LEADS; STRAINS in [de Souza, Mariana L.; Ferreira, Leonardo L. G.; Magalhaes, Luma G.; Krogh, Renata; Oliva, Glaucius; Andricopulo, Adriano D.] Univ Sao Paulo, Phys Inst Sao Carlos, Lab Med & Computat Chem, BR-13563120 Sao Carlos, SP, Brazil; [Rezende Junior, Celso de Oliveira; Espinoza Chavez, Rocio Marisol; Slafer, Brian W.; Dias, Luiz Carlos] Univ Estadual Campinas, Inst Chem, BR-13084971 Campinas, SP, Brazil; [Ferreira, Rafaela S.] Univ Fed Minas Gerais, Dept Biochem & Immunol, BR-31270901 Belo Horizonte, MG, Brazil; [Cruz, Fabio Cardoso] Univ Fed Sao Paulo, Dept Pharmacol, BR-04023062 Sao Paulo, SP, Brazil in 2020, Cited 38. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Recommanded Product: 150-19-6

A virtual screening conducted with nearly 4 000 000 compounds from lead-like and fragment-like subsets enabled the identification of a small-molecule inhibitor (1) of the Trypanosoma cruzi cruzain enzyme, a validated drug target for Chagas disease. Subsequent comprehensive structure-based drug design and structure-activity relationship studies led to the discovery of carbamoyl imidazoles as potent, reversible, and competitive cruzain inhibitors. The most potent carbamoyl imidazole inhibitor (45) exhibited high affinity with a K-i value of 20 nM, presenting both in vitro and in vivo activity against T. cruzi. Furthermore, the most promising compounds reduced parasite burden in vivo and showed no toxicity at a dose of 100 mg/kg. These carbamoyl imidazoles are structurally attractive, nonpeptidic, and easy to prepare and synthetically modify. Finally, these results further advance our understanding of the noncovalent mode of inhibition of this pharmaceutically relevant enzyme, building strong foundations for drug discovery efforts.

Welcome to talk about 150-19-6, If you have any questions, you can contact de Souza, ML; Rezende , CD; Ferreira, RS; Chavez, RME; Ferreira, LLG; Slafer, BW; Magalhaes, LG; Krogh, R; Oliva, G; Cruz, FC; Dias, LC; Andricopulo, AD or send Email.. Recommanded Product: 150-19-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles