Month: November 2021

SDS of cas: 123-11-5. In 2021 J MOL STRUCT published article about N-NITROSO COMPOUNDS; CRYSTAL-STRUCTURE; STEREOCHEMISTRY; CHEMISTRY; PREFERENCES; DOCKING; ANALOGS in [Sethuvasan, S.; Ponnuswamy, S.] Govt Arts Coll Autonomous, PG & Res Dept Chem, Coimbatore 641018, Tamil Nadu, India; [Sugumar, P.; Ponnuswamy, M. N.] Univ Madras, Ctr Adv Study Crystallog & Biophys, Guindy Campus, Chennai 600025, Tamil Nadu, India; [Sugumar, P.] Dhaanish Ahmed Coll Engn, Dept Phys, Chennai 601301, Tamil Nadu, India in 2021, Cited 39. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Nitroso derivative of 2,7-diaryl-1,4-diazepan-5-ones 9-12 are synthesized and characterized using spectroscopic techniques such as IR, EI-MS and NMR spectra. The stereochemical investigation of nitroso compounds has been carried out with 1D (H-1, C-13 & DEPT-135) and 2D (COSY & HSQC) NMR spectral data. Rotational isomers (syn and anti rotamers) of 9-12 are identified and categorized by room temperature NMR spectral studies. Furthermore, the conformation of the ring and the orientation of N-N= O function have been arrived on the basis of chemical shifts, coupling constants and dihedral angles. In solution state, syn and anti rotamers of the compounds 9-11 exist in equilibrium between flattened boat conformation with quasi-axial orientations of the aryl groups at C-2 and C-7. Nevertheless, compound 12 and its syn and anti rotamers prefer to adopt equilibrium between chair conformations with axial orientation of aryl substituents. In order to validate the solution state conformation, the compound 12 is crystallized and the crystal structure is solved by single crystal XRD study. The compound 12 exists in an alternate chair conformation and aryl groups at C-2 & C-7 occupy axial orientations in solid state also. (C) 2020 Elsevier B.V. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Sethuvasan, S; Sugumar, P; Ponnuswamy, MN; Ponnuswamy, S or concate me.. SDS of cas: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Gold-Catalyzed Hydrophenoxylation of Propargylic Alcohols and Amines: Synthesis of Phenyl Enol Ethers published in 2019. Quality Control of 3-(Trifluoromethyl)phenol, Reprint Addresses Sheppard, TD (corresponding author), UCL, Dept Chem, 20 Gordon St, London WC1H 0AJ, England.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

A practical method for the synthesis of phenyl enol ethers is reported. The combination of a gold(I) catalyst and potassium carbonate selectively mediates the addition of phenols to propargylic alcohols/amines in a chemo-, regio-, and stereoselective fashion in high yield. The resulting enol ethers are formed exclusively with a Z-configuration and can be obtained from a wide array of phenols and propargylic alcohols or amines with the reaction showing excellent functional group tolerance.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Laserna, V; Rojas, CJ; Sheppard, TD or concate me.. Quality Control of 3-(Trifluoromethyl)phenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Cheng, XC; Qin, Z; Yang, QL; Liu, HM; Wang, XD; Liu, YL in NORTH CAROLINA STATE UNIV DEPT WOOD & PAPER SCI published article about KRAFT LIGNIN; SOLVENT FRACTIONATION; ETHANOL; PRECIPITATION; HOMOGENEITY; SOFTWOOD; TOOL in [Cheng, Xi-Chuang; Qin, Zhao; Yang, Qiao-Li; Liu, Hua-Min; Wang, Xue-De; Liu, Yu-Lan] Henan Univ Technol, Coll Food Sci & Technol, Zhengzhou 450001, Henan, Peoples R China in 2021.0, Cited 33.0. Product Details of 120-14-9. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Lignin from the Chinese quince (Chaenomeles sinensis) fruit offers a promising source of natural antioxidant for industrial applications. However, the utilization of Chinese quince fruit lignin is restricted by its inhomogeneous nature. Accordingly, Chinese quince fruit lignin was sequentially fractionated with organic solvents of increasing dissolving capacity to prepare homogeneous lignin fractions. The GPC (gel permeation chromatography) results showed that the molecular weights of lignin fractions increased from dichloromethane fraction to dioxane/water fraction. The five lignin fractions were also compared with respect to yield, carbohydrate content, thermal stability, inter-unit linkages, S/G ratios, and phenolic OH content. Among the five fractions, the ethyl acetate fraction showed a lower proportion of p-o-tv linkages (48.4%), the highest thermal stability, the highest phenolic OH content (2.8 mmol/g), and the highest DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging index and reducing power. The high antioxidant performance of the ethyl acetate fraction implies that it can be used as a natural antioxidant. This study shows that sequential solvent fractionation of lignin can produce homogeneous fractions with enhanced antioxidant performance. In addition, it demonstrates that Chinese quince fruits are a potentially valuable natural resource.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Cheng, XC; Qin, Z; Yang, QL; Liu, HM; Wang, XD; Liu, YL or concate me.. Product Details of 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Spectroscopic analysis by NMR, FT-Raman, ATR-FTIR, and UV-Vis, evaluation of antimicrobial activity, and in silico studies of chalcones derived from 2-hydroxyacetophenone WOS:000670208300004 published article about RESISTANT STAPHYLOCOCCUS-AUREUS; SOFT ACIDS; HARDNESS; ELECTRONEGATIVITY; COMBINATION; MECHANISM in [Xavier, Jayze da Cunha; Rocha, Janaina E.; Freitas, Thiago S.; Freitas, Priscila R.; de Araujo, Ana C. J.; da Silva, Priscila T.; Nogueira, Carlos E. S.; Coutinho, Henrique D. M.; dos Santos, Helcio S.; Teixeira, Alexandre M. R.] Reg Univ Cariri, Dept Biol Chem, Pimenta Crato, CE, Brazil; [de Almeida-Neto, Francisco W. Q.; Juliao, Murilo S. S.] Univ Fed Ceara, Dept Analyt Chem & Phys Chem, Fortaleza, Ceara, Brazil; [Nogueira, Carlos E. S.; Teixeira, Alexandre M. R.] Reg Univ Cariri, Dept Phys, Juazeiro Do Norte, CE, Brazil; [Bandeira, Paulo N.; dos Santos, Helcio S.] Vale Acarau Univ, Ctr Exact Sci & Technol, Sobral, CE, Brazil; [Marinho, Marcia M.] Univ Estadual Ceara, Fac Educ Sci & Letters Iguatu, Iguatu, CE, Brazil; [Marinho, Emmanuel S.] Univ Estadual Ceara, Fac Philosophy Dom Aureliano Matos, Limoeiro Do Norte, CE, Brazil; [Kumar, Nitin] KR Mangalan Univ, Sohna Rd, Gurugram, India; [Barreto, Antonio C. H.] Univ Fed Ceara, Dept Phys, Fortaleza, Ceara, Brazil in 2021, Cited 58. Recommanded Product: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Six 2′-hydroxychalcones were synthesized and characterized by NMR, FT-Raman, ATR-FTIR, and UV-Vis. These chalcones alone and in combination with the ciprofloxacin, penicillin, and erythromycin antibiotics were tested against multiresistant strains of Staphylococcus aureus. It was also verified by in vitro and in silico studeis the capacity of these chalcones to inhibit the NorA efflux pump. The MICs values of ciprofloxacin were reduced in the presence of all tested chalcones. For norfloxacin antibiotic, the chalcones A1, A4, A5 and A6 promoted the reduced in the MIC values. The A2 chalcone was the only one to reduce the MIC values when associated with penicillin. Any chalcones were not able to reduce MIC values when associated with erythromycin. These results indicate that the synergistic effects demonstrated for the synthesized chalcones were influenced by the introduction of a furanic ring (A1), a chlorine atom and a methoxy group at the C4 position (A2 and A4), a second double bond (A5), and a fluorine atom at the C2 position (A6). The ADMET analysis predicts that the chalcones A2, A3, A5 and A6 have easier cell permeation. The nucleophilic region makes the A5 chalcone capable of covalently bonding with plasma proteins, and the presence of oxygenated aromatic substitutions makes the chalcones A1 and A4 more water-soluble and consequently easier to excrete. On the other hand, the substitution of the methoxy group of the A4 chalcone makes it more susceptible to O-demethylation reactions by the CYP3A4 isoenzyme. The molecular docking revealed that all six chalcones could hinder the binding of norfloxacin to the NorA efflux pump. (c) 2021 Elsevier B.V. All rights reserved.

Recommanded Product: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Xavier, JD; de Almeida-Neto, FWQ; Rocha, JE; Freitas, TS; Freitas, PR; de Araujo, ACJ; da Silva, PT; Nogueira, CES; Bandeira, PN; Marinho, MM; Marinho, ES; Kumar, N; Barreto, ACH; Coutinho, HDM; Juliao, MSS; dos Santos, HS; Teixeira, AMR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 INORG CHEM published article about ELECTRON-TRANSFER; OXIDATION; BINDING; NADPH; PRINCIPLES in [Li, Lili; Guo, Huimin; Li, Xuezhao; Wang, Hailing; He, Cheng] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China; [Yang, Linlin] Xinxiang Med Univ, Sch Forens Med, Xinxiang Key Lab Forens Sci Evidence, Xinxiang 453003, Henan, Peoples R China in 2020.0, Cited 41.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Application In Synthesis of Benzyl Alcohol

Encapsulation of flavin mononucleotide (FMN) in a porphyrinatomanganese(III)-based cubic cage allowed the fast reduction of manganese(III) porphyrin in the presence of nicotinamide adenine dinucleotide (NADH). This supramolecular system was capable of efficiently activating dioxygen and catalyzing the oxidation of benzyl alcohol. Control experiments suggested that the close proximity between FMN and manganese(III) porphyrins forced by the host-guest interaction might benefit the electron-transfer process from the FMN cofactor to the metal centers.

About Benzyl Alcohol, If you have any questions, you can contact Li, LL; Guo, HM; Yang, LL; Li, XZ; Wang, HL; He, C or concate me.. Application In Synthesis of Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H8O2. Recently I am researching about THERMOTROPIC LIQUID-CRYSTALS; MESOPHASE BEHAVIOR; SIDE-CHAIN; BENZOTHIAZOLE MESOGEN; AZOBENZENE; IMPACT; ORIENTATION; BENZOATES; MONOMERS; SERIES, Saw an article supported by the University of Malaya Research University Grant-Faculty Program [GPF060B-2018]; SATU Grant [ST001-2020]; Imam Abdulrahman Bin Faisal University; Saudi Arabian Cultural Mission. Published in ELSEVIER in AMSTERDAM ,Authors: Kamal, SJ; Salleh, NM; Mahmud, HNME; Abdullah, I; Gopal, SR; Velayutham, TS; Zahid, NI. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol

The effect of introducing a lateral methyl substituent and the two different alkoxy terminal groups on the mesophase behavior of three-benzene-ring molecular core of azo-ester compounds bearing 2-methylbutoxy unit on the opposite terminal side (C1-C6) were explored. Their structures were confirmed by several spectroscopic techniques (Fourier transform infrared spectroscopy, H-1 and C-13 nuclear magnetic resonance spectroscopy). The mesomorphic properties of these compounds were studied by differential scanning calorimetry, polarized optical microscopy, and small- and wide-angle X-ray scattering. Except for the un-substituted terminals (C1 and C4), all other derivatives are liquid crystalline, exhibiting enantiotropic nematic liquid crystal phase. The alteration of the alkoxy chain length from methoxy to butoxy at the phenyl ester terminal group (ring A) for each set of laterally-neat and laterally methyl-substituted mesogens decreases the nematic temperature range. A decrease in the mesophase temperature range is also observed when a lateral methyl substituent is incorporated into phenylazo ring of the mesogenic core (ring C). Optical study demonstrated that their absorption spectra are identical in shape due to the structural similarities of the mesogenic core. The corresponding fluorescence spectra exhibited blue-emission with the laterally methyl substituted compounds having a relatively higher fluorescence intensity compared to that of its laterally un-substituted analogues. Furthermore, the laterally methyl-substituted derivatives were subjected to the planar alignment and their dielectric and electro-optic properties were investigated. The nematic phase of the aligned samples shows antiferroelectric switching behavior with spontaneous polarization, P-s similar to 5 mu C/cm(2). (C) 2021 Elsevier B.V. All rights reserved.

About Mequinol, If you have any questions, you can contact Kamal, SJ; Salleh, NM; Mahmud, HNME; Abdullah, I; Gopal, SR; Velayutham, TS; Zahid, NI or concate me.. COA of Formula: C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. In 2021.0 DRUG METAB PHARMACOK published article about CATALYTIC-PROPERTIES; HYDROLYSIS; ISOZYMES; AGENT in [Takahashi, Masato; Hirota, Ibuki; Nakano, Tomoyuki; Kotani, Tomoyuki; Takani, Daisuke; Shiratori, Kana; Choi, Yura; Haba, Masami; Hosokawa, Masakiyo] Chiba Inst Sci, Fac Pharm, 15-8 Shiomi Cho, Choshi, Chiba 2880025, Japan in 2021.0, Cited 25.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Carboxylesterase (CES) plays an important role in the hydrolysis metabolism of ester-type drugs and prodrugs. In this study, we investigated the change in the hydrolysis rate of hCE1 by focusing on the steric hindrance of the ester structure and the electron density. For 26 kinds of synthesized indomethacin prodrugs, the hydrolytic rate was measured in the presence of human liver microsomes (HLM), human small intestine microsomes (HIM), hCE1 and hCE2. The synthesized prodrugs were classified into three types: an alkyl ester type that is specifically metabolized by hCE1, a phenyl ester type that is more easily metabolized by hCE1 than by hCE2, and a carbonate ester type that is easily metabolized by both hCE1 and hCE2. The hydrolytic rate of 1-methylpentyl (hexan-2-yl) ester was 10-times lower than that of 4-methylpentyl ester in hCE1 solution. hCE2 was susceptible to electron density of the substrate, and there was a difference in the hydrolysis rate of up to 3.5-times between p-bromophenyl ester and p-acetylphenyl ester. By changing the steric hindrance and electron density of the alkoxy group, the factors that change the hydrolysis rate by CES were elucidated. (C) 2021 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Takahashi, M; Hirota, I; Nakano, T; Kotani, T; Takani, D; Shiratori, K; Choi, Y; Haba, M; Hosokawa, M or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about REGIOSELECTIVE OXIDATION; SELECTIVE OXIDATION; AEROBIC OXIDATION; EFFICIENT ACCESS; O-QUINONES; HYPERVALENT; TYROSINASE; COMPLEXES; SPIROLACTONIZATION; FUNCTIONALIZATION, Saw an article supported by the National Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [R01 GM123098]; American Chemical Society Petroleum Research FundAmerican Chemical Society [DNI-56603]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [R01GM123098] Funding Source: NIH RePORTER. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Xiao, X; Greenwood, NS; Wengryniuk, SE. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone. Recommanded Product: 99-93-4

Despite their broad utility, the synthesis of ortho-quinones remains a significant challenge, in particular, access to electron-deficient derivatives remains an unsolved problem. Reported here is the first general method for the synthesis of electron-deficient ortho-quinones by direct oxidation of phenols. The reaction is enabled by a novel bidentate nitrogen-ligated iodine(V) reagent, a previously unexplored class of compounds which we have termed Bi(N)-HVIs. The reaction is extremely general and proceeds with excellent regioselectivity for the ortho over para isomer. Functionalization of the ortho-quinone products was examined, resulting in a facile one-pot synthesis of catechols, as well as the incorporation of a variety of heteroatom nucleophiles. This method represents the first synthetic application of Bi(N)-HVIs and demonstrates their potential as a platform for the further development of highly reactive, but also highly tunable, I(V) reagents.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Xiao, X; Greenwood, NS; Wengryniuk, SE or concate me.. Recommanded Product: 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Kucukoglu, K; Gul, HI; Taslimi, P; Gulcin, I; Supuran, CT in [Kucukoglu, Kaan] Selcuk Univ, Fac Pharm, Dept Pharmaceut Chem, Konya, Turkey; [Gul, Halise Inci] Ataturk Univ, Fac Pharm, Dept Pharmaceut Chem, Erzurum, Turkey; [Taslimi, Parham; Gulcin, Ilhami] Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey; [Supuran, Claudiu T.] Univ Firenze, Sect Pharmaceut & Nutriceut Sci, Neurofarba Dept, Florence, Italy published Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes in 2019.0, Cited 86.0. Quality Control of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have appeared as a promising approach for pharmacological intervention in a variety of disorders such as glaucoma, epilepsy, obesity, cancer, and Alzheimer’s disease. Keeping this in mind, N, N’-bis[(1-aryl-3-heteroaryl) propylidene] hydrazine dihydrochlorides, N1-N11, P1, P4-P8, and R1-R6, were synthesized to investigate their inhibitory activity against hCA I, hCA II, and AChE enzymes. All compounds in N, P, and R-series inhibited hCAs (I and II) and AChE more efficiently than the reference compounds acetazolamide (AZA), and tacrine. According to the activity results, the most effective inhibitory compounds were in R-series with the K-i values of 203 +/- 55-473 +/- 67 nM and 200 +/- 34-419 +/- 94 nM on hCA I, and hCA II, respectively. N, N’-Bis[1-(4-fluorophenyl)-3-(morpholine-4-yl) propylidene] hydrazine dihydrochlorides, N8, in N-series, N, N’-Bis[1-(4-hydroxyphenyl)-3-(piperidine-1-yl) pro-pylidene] hydrazine dihydrochlorides, P4, in P-series, and N, N’-bis[1-(4-chlorophenyl)-3-(pyrrolidine-1-yl) pro-pylidene] hydrazine dihydrochlorides, R5, in R-series were the most powerful compounds against hCA I with the K-i values of 438 +/- 65 nM, 344 +/- 64 nM, and 203 +/- 55 nM, respectively. Similarly, N8, P4, and R5 efficiently inhibited hCA II isoenzyme with the K-i values of 405 +/- 60 nM, 327 +/- 80 nM, and 200 +/- 34 nM, respectively. On the other hand, P-series compounds had notable inhibitory effect against AChE than the reference compound tacrine and the K-i values were between 66 +/- 20 nM and 128 +/- 36 nM. N, N’-Bis[1-(4-fluorophenyl)-3-(piperidine-1-yl) propylidene] hydrazine dihydrochlorides, P7, was the most potent compound on AChE with the K-i value of 66 +/- 20 nM. The other most promising compounds, N, N’-bis[1-(4-hydroxyphenyl)-3-(morpholine-4-yl) propylidene] hydrazine dihydrochlorides, N4 in N-series and N, N’-bis[1-(4-hydroxyphenyl)-3-(pyrrolidine-1-yl) propylidene] hydrazine dihydrochlorides, R4 in R-series were againts AChE with the K-i values of 119 +/- 20 nM, 88 +/- 14 nM, respectively.

Quality Control of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Kucukoglu, K; Gul, HI; Taslimi, P; Gulcin, I; Supuran, CT or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about RAPID COLORIMETRIC ASSAY; BIOLOGICAL EVALUATION; DERIVATIVES; ANTITUMOR; CHEMISTRY; ANALOGS; DESIGN; 1,3,4-OXADIAZOLES; 1,2,4-TRIAZINE; ANTIOXIDANT, Saw an article supported by the Department of Photochemistry (Heterocyclic unit); Chemical Industries research Division, National Research Centre in Cairo, Egypt. Published in WILEY in HOBOKEN ,Authors: Abu-Hashem, AA. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde. HPLC of Formula: C8H8O2

4-Oxo-4-phenylbutanehydrazide (1) reacted with many active methylene reagents such as acetylacetone, diethylmalonate, ethylacetoacetate, ethylcyanoacetate, benzoyl-acetonitrile, and malononitrile under neat conditions to afford the corresponding pyrazoles (2-7), also, treatment of butanehydrazide (1) with electrophilic reagents as triethylorthoformate, dimethylformamide-dimethylacetal, acetic anhydride, and carbon disulfide to give 1,3,4-oxadiazoles (8,10,11) and N ‘-acetyl-butanehydrazide (9). Reacted of butanehydrazide (1) with potassium thiocyanate gave 1,2,4-triazoles (12). Similarly, treatment of (1) with chloroacetamide gave 1,2,4-triazinones (13). The pyrrolotriazinones (14) was obtained by cyclization of (13). Also, butanehydrazide (1) was utilized as a starting material for the synthesized of new Schiff bases as N ‘-(4-sub-benzylidene)-phenylbutane-hydrazide (15a-c), which are used as an initiative to prepare new compounds such as 1,2,4-triazepinones (16a-c), pyrrolotriazepinones (17a-c), 1,2,4-triazines (18a-c), and pyrrolotriazines (19a-c) by reacted of (15a-c) with each chloroacetamide or formamide. The chemical structure of the newly prepared compounds was determined through the spectrum data, including IR, NMR, and MS. The prepared compounds were tested for their in vitro antitumor activities. The compounds 17a-c, 16a-c, and 19a-c displayed activity against several types of cancer cell lines.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Abu-Hashem, AA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles