Day: January 25, 2022

In 2020.0 J ORGANOMET CHEM published article about N-ALKYLATION; ALCOHOLS; AMINES; WATER; OXYGENATION; REDUCTION; CHEMISTRY; COPPER in [Li, Ming; Hsu, Yen-Pin; Liu, Yi-Hung; Peng, Shie-Ming; Liu, Shiuh-Tzung] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan in 2020.0, Cited 42.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Formula: C7H8O

Complexation of 1,8-naphthyridine(Np)-2-carboxylic derivatives L-1-L-3 [L-1 = Np-2-COOH, L-2 = Np-2-CONH2, L-3 = Np-2-CONHCH2Py] with [Ir(COD)(mu-OMe)](2) yielded the corresponding complexes [Ir(COD)(L-n)] (1 similar to 3, n = 1 similar to 3, respectively). The potential tridentate L-3 behaves as a bidentate donor in the complex 3. Treatment of L-1 with [Ir(COD)Cl](2) under nitrogen atmosphere gave a Ir(III) hydride complex [Ir(COD)(L-1)HCl] (4). However, carrying out the reaction in the presence of oxygen rendered a Ir(III) dichloride species [Ir(COD)(L-1)Cl-2] (5). All these complexes were characterized by spectroscopic analyses and X-ray single crystal determination. Catalytic activity of iridium complexes in amination of amines with alcohols was screened. It appears that iridium amido complexes 2 and 3 show excellent catalytic activity on amination of anilines with alcohols in the presence of Cs2CO3 at 120 degrees C. (c) 2020 Published by Elsevier B.V.

Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Li, M; Hsu, YP; Liu, YH; Peng, SM; Liu, ST or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Elbastawesy, MAI; Aly, AA; Ramadan, M; Elshaier, YAMM; Youssif, BGM; Brown, AB; Abuo-Rahma, GEDA in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about FACTOR RECEPTOR KINASE; SUBSTITUTED QUINOLINONES; PYRAZOLE DERIVATIVES; POTENTIAL ANTICANCER; ERLOTINIB; CANCER; CRIZOTINIB; CHEMISTRY; ASSAY in [Elbastawesy, Mohammed A., I; Ramadan, Mohamed] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut 71524, Egypt; [Aly, Ashraf A.] Menia Univ, Fac Sci, Dept Chem, Al Minya 61519, Egypt; [Elshaier, Yaseen A. M. M.] Univ Sadat City, Fac Pharm, Dept Organ & Med Chem, Menoufia 32958, Egypt; [Youssif, Bahaa G. M.] Assiut Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut 71526, Egypt; [Brown, Alan B.] Florida Inst Technol, Program Chem, Melbourne, FL 32901 USA; [Abuo-Rahma, Gamal El-Din A.] Menia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt in 2019, Cited 50. Safety of 4-Hydroxyquinolin-2(1H)-one. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

Two new series of diethyl 2-[2-(substituted-2-oxo-1,2-dihydroquinolin-4-yl)hydrazono]-succinates 6a-g and 1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been designed and synthesized. The structures of the synthesized compounds were proved by IR, mass, NMR (2D) spectra and elemental analyses. The target compounds were evaluated for their in vitro cytotoxic activity against 60 cancer cell lines according to NCI protocol. Consequently, seven compounds were further examined against the most sensitive cell lines, leukemia CCRFCEM, and MOLT-4. 5-Amino-1-(6-bromo-2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazole-3,4-dicarbonitrile (7f) was the most active product, with IC50= 1.35 uM and 2.42 uM against MOLT-4 and CCRF-CEM, respectively. Also, it showed a remarkable inhibitory activity compared to erlotinib on the EGFR TK with IC50 = 247.14 nM and 208.42 nM, respectively. Cell cycle analysis of MOLT-4 cells treated with 7f showed cell cycle arrest at G2/M phase (supported by Caspases, BAX and Bcl-2 studies) with a significant pro-apoptotic activity as indicated by annexin V-FITC staining. Moreover, the docking study indicated that both the pyrazole moiety and the quinolin-2-one ring showed good fitting into EGFR (PDB code: 1M17). In order to interpret SAR of the designed compounds, and provide a basis for further optimization, molecular docking of the synthesized compounds to known EGFR inhibitors was performed. The study illustrated the effect of several factors on the compounds’ activity.

Safety of 4-Hydroxyquinolin-2(1H)-one. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Elbastawesy, MAI; Aly, AA; Ramadan, M; Elshaier, YAMM; Youssif, BGM; Brown, AB; Abuo-Rahma, GEDA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Mohareb, RM; Ibrahim, RA; Alwan, ES in SLOVENSKO KEMIJSKO DRUSTVO published article about in [Mohareb, Rafat Milad; Alwan, Ensaf Sultan] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt; [Ibrahim, Rehab Ali; Alwan, Ensaf Sultan] Higher Inst Engn & Technol, New Cairo, Egypt; Yemen Drug Co Ind & Commerce YEDCO, Dept Qual Assurance, Sanaa, Yemen in 2021, Cited 42. Recommanded Product: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

In this work the multi-component reactions of either of the arylhydrazocyclohexan-1,3-dione derivatives 3a-c with either of benzaldehyde (4a), 4-chlorobenzaldehyde (4b) or 4-methoxybenzaldehyde (4c) and either malononitrile (5a) or ethyl cyanoacetate (5b) giving the 5,6,7,8-tetrahydro-4H-chromene derivatives 6a-r, respectively, are presented. The reaction of two equivalents of cyclohexan-1,3-dione with benzaldehyde gave the hexahydro-1H-xanthene-1,8(2H)-dione derivative 7. On the other hand, the multi-component reactions of compound 1 with dimedone and benzaldehyde gave 13. Both of 7 and 13 underwent heterocyclization reactions to produce fused thiophene, pyran and thiazole derivatives. Selected compounds among the synthesized compounds were tested against six cancer cell lines where most of them gave high inhibitions; especially compounds 3b, 3c, 6b, 6c, 6d, 6f, 6i, 6m, 6n, 8b, 14a, 15 and 16 being the most cytotoxic compounds. Further tests against the five tyrosine kinases c-Kit, Flt-3, VEGFR-2, EGFR, and PDGFR and Pim-1 kinase showed that compounds 3c, 6c, 6d, 6f, 6n, 14a and 15 were the most potent of the tested compounds toward the five tyrosine kinases and compounds 3c, 6c, 6d, 6n and 15 displayed the highest inhibitions toward Pim-1 kinase.

Welcome to talk about 123-11-5, If you have any questions, you can contact Mohareb, RM; Ibrahim, RA; Alwan, ES or send Email.. Recommanded Product: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Iridium-catalyzed Annulation of alpha,beta-Unsaturated Amides with Electron-deficient Conjugated Dienes WOS:000539416400020 published article about C-H FUNCTIONALIZATION; N-METHOXYBENZAMIDES; MULTICOMPONENT SYNTHESIS; OXIDATIVE ANNULATION; BOND ACTIVATION; VINYL ETHERS; BENZAMIDES; HYDROARYLATION; ALKYNES; ALKENES in [Murakami, Kotone; Nishimura, Takahiro] Osaka City Univ, Grad Sch Sci, Dept Chem, Sumiyoshi, Osaka 5588585, Japan; [Nagamoto, Midori] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan in 2020, Cited 71. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1. Application In Synthesis of (E)-2-Methylbut-2-enoic acid

Annulation of alpha,beta-unsaturated amides with electrondeficient 1,3-dienes gave 5,6-dihydropyridin-2(1H)-ones in the presence of a hydroxoiridium catalyst. The reaction proceeded via direct C-H alkylation of acrylamides with conjugated dienes, followed by intramolecular aza-Michael addition, thus giving dihydropyridinones stereoselectively in good yields.

Application In Synthesis of (E)-2-Methylbut-2-enoic acid. Bye, fridends, I hope you can learn more about C5H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Ryu, IY; Choi, I; Jung, HJ; Ullah, S; Choi, H; Al-Amin, M; Chun, P; Moon, HR in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about MUSHROOM TYROSINASE; INHIBITORY-ACTIVITY; MOLECULAR DOCKING; MECHANISM; MELANOMA; DESIGN; FLAVONOIDS in [Ryu, Il Young; Choi, Inkyu; Jung, Hee Jin; Choi, Heejeong; Al-Amin, Md; Moon, Hyung Ryong] Pusan Natl Univ, Coll Pharm, Busan 46241, South Korea; [Ullah, Sultan] Scripps Res Inst, Dept Mol Med, Jupiter, FL 33458 USA; [Chun, Pusoon] Inje Univ, Coll Pharm, Gimhae 50834, Gyeongnam, South Korea; [Chun, Pusoon] Inje Univ, Inje Inst Pharmaceut Sci & Res, Gimhae 50834, Gyeongnam, South Korea in 2021, Cited 63. Recommanded Product: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Tyrosinase is considered a key contributor to melanogenesis, and safe, potent tyrosinase inhibitors are needed for medical and cosmetic purposes to treat skin hyperpigmentation and prevent fruit and vegetable browning. According to our accumulated SAR data on tyrosinase inhibitors, the ?-phenyl-?,?-unsaturated carbonyl scaffold in either E or Z configurations, can confer potent tyrosinase inhibitory activity. In this study, twelve indanedione derivatives were synthesized as chimeric compounds with a ?-phenyl-?,?-unsaturated dicarbonyl scaffold. Two of these derivatives, that is, compounds 2 and 3 (85% and 96% inhibition, respectively), at 50 ?M inhibited mushroom tyrosinase markedly more potently than kojic acid (49% inhibition). Docking studies predicted that compounds 2 and 3 both inhibited tyrosinase competitively, and these findings were supported by LineweaverBurk plots. In addition, both compounds inhibited tyrosinase activity and reduced melanin contents in B16F10 cells more than kojic acid without perceptible cytotoxicity. These results support the notion that chimeric compounds with the ?-phenyl-?,?-unsaturated dicarbonyl scaffold represent promising starting points for the development of potent tyrosinase inhibitors.

Recommanded Product: 4-Methoxybenzaldehyde. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Natural product-based design, synthesis and biological evaluation of 2 ‘,3,4,4 ‘-tetrahydrochalcone analogues as antivitiligo agents WOS:000469026400051 published article about OXIDATIVE STRESS; SUBSTANCE-P; MELANOGENESIS; PIGMENTATION; IMPAIRMENT; SKIN in [Zhong, Hui; Zhou, Jia; An, Xiao-Hong; Hua, Ying-Rong; Lai, Yi-Fan; Zhang, Rui; Ahmad, Owais; Shang, Jing] China Pharmaceut Univ, Sch Tradit Chinese Pharm, State Key Lab Nat Med, Jiangsu Key Lab TCM Evaluat & Translat Res, Nanjing 211198, Jiangsu, Peoples R China; [Zhang, Ye] Guilin Med Univ, Sch Pharm, Guilin 541004, Peoples R China; [Zhang, Ye] Guangxi Normal Univ, Sch Chem & Pharm, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China in 2019.0, Cited 38.0. HPLC of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A bioactive component, 2′,3,4,4′-tetrahydrochalcone (RY3-a) was first isolated from Vernohia anthelmintica (L.) willd seeds, and a set of its analogs, RY3-a-1-RY3-a-15 and RY3-c were designed and synthesized. Biological activity assays showed that RY3-c exhibited better melanogenesis and antioxidant activity and lower toxicity in comparison with RY3-a and butin. Further study tests showed that RY3-c exhibited better melanogenesis activity compared with the positive control 8-methoxypsoralan (8-MOP) in a vitiligo mouse model, suggesting that RY3-c is a good candidate antivitiligo agent. Mechanistic studies showed that RY3-c could repair cell damage induced by excessive oxidative stress and may exert melanin synthesis activity in the mouse melanoma B16F10 cell line by activating the mitogen-activated protein kinase (MAPK) pathway and the upregulation of c-kit.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zhong, H; Zhou, J; An, XH; Hua, YR; Lai, YF; Zhang, R; Ahmad, O; Zhang, Y; Shang, J or concate me.. HPLC of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Ai, HJ; Rabeah, J; Bruckner, A; Wu, XF in [Ai, Han-Jun; Rabeah, Jabor; Brueckner, Angelika; Wu, Xiao-Feng] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany; [Wu, Xiao-Feng] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Liaoning, Peoples R China published Rhodium-catalyzed carbonylative coupling of alkyl halides with thiols: a radical process faster than easier nucleophilic substitution in 2021.0, Cited 44.0. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5.

How to make a carbonylative coupling faster than the easier nucleophilic substitution? In this communication, a rhodium-catalyzed radical-based carbonylative coupling of alkyl halides with thiolphenols has been realized. Thioesters were isolated in good yields in general.

Welcome to talk about 150-76-5, If you have any questions, you can contact Ai, HJ; Rabeah, J; Bruckner, A; Wu, XF or send Email.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 100-51-6. In 2019.0 ANESTH ANALG published article about PROPYLENE-GLYCOL; INDOCYANINE-GREEN; BENZYL ALCOHOL; ADVERSE-REACTIONS; ANAPHYLACTOID REACTION; CONTACT-DERMATITIS; PANCREAS TRANSPLANTATION; CONTINUOUS-INFUSION; ALLERGIC REACTIONS; PROPOFOL in [Burbridge, Mark A.; Jaffe, Richard A.] Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, 300 Pasteur Dr, Stanford, CA 94304 USA in 2019.0, Cited 76.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Medications used in anesthesiology contain both pharmacologically active compounds and additional additives that are usually regarded as being pharmacologically inactive. These additives, called excipients, serve diverse functions. Despite being labeled inert, excipients are not necessarily benign substances. Anesthesiologists should have a clear understanding of their chemical properties and the potential for adverse reactions. This report catalogs the excipients found in drugs commonly used in anesthesiology, provides a brief description of their function, and documents examples from the literature regarding their adverse effects.

Bye, fridends, I hope you can learn more about C7H8O, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 100-51-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Mukku, N; Davanagere, PM; Chanda, K; Maiti, B in AMER CHEMICAL SOC published article about in [Mukku, Narasimharao; Davanagere, Prabhakara Madivalappa; Chanda, Kaushik; Maiti, Barnali] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Vellore, Tamil Nadu, India in 2020.0, Cited 46.0. Category: indole-building-block. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

In this study, a highly efficient two-component [3 + 2] cycloaddition reaction of substituted aryl aldehydes with 4-toluenesulfonylmethyl isocyanide (TosMIC) in the presence of 2 equiv of potassium phosphate as a base to 5-substituted oxazoles were established in a isopropanol medium under microwave irradiation. However, using 1 equiv of K3PO4 as a base resulted in the diastereoselective synthesis of 4,5-disubstituted oxazolines under identical reaction conditions. The foremost benefits of these protocols are the moderate-to-excellent yields with good functional group compatibility, simple experimental procedure, inexpensive readily available starting materials, nonchromatographic purification, and high bond-forming efficiency. The synthetic manipulation reported herein represents a cleaner route to the sustainable preparation of 5-substituted oxazoles and diastereoselective 4,5-disubstituted oxazolines derivatives.

Category: indole-building-block. Welcome to talk about 100-83-4, If you have any questions, you can contact Mukku, N; Davanagere, PM; Chanda, K; Maiti, B or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 120-14-9. Authors Kumari, M; Tahlan, S; Narasimhan, B; Ramasamy, K; Lim, SM; Shah, SAA; Mani, V; Kakkar, S in BMC published article about in [Kumari, Mukesh; Tahlan, Sumit; Narasimhan, Balasubramanian; Kakkar, Saloni] Maharshi Dayanand Univ, Fac Pharmaceut Sci, Rohtak 124001, Haryana, India; [Ramasamy, Kalavathy; Lim, Siong Meng; Shah, Syed Adnan Ali] Univ Teknol MARA UiTM, Fac Pharm, Bandar Puncak Alam 42300, Selangor Darul, Malaysia; [Ramasamy, Kalavathy; Lim, Siong Meng] Univ Teknol MARA UiTM, Collaborat Drug Discovery Res CDDR Grp, Pharmaceut Life Sci Community Res, Shah Alam 40450, Selangor Darul, Malaysia; [Shah, Syed Adnan Ali] Univ Teknol MARA UiTM, Atta Ur Rahman Inst Nat Prod Discovery AuRIns, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor Darul, Malaysia; [Mani, Vasudevan] Qassim Univ, Dept Pharmacol & Toxicol, Coll Pharm, Buraydah 51452, Saudi Arabia in 2021.0, Cited 27.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Background Triazole is an important heterocyclic moiety that occupies a unique position in heterocyclic chemistry, due to its large number of biological activities. It exists in two isomeric forms i.e. 1,2,4-triazole and 1,2,3-triazole and is used as core molecule for the design and synthesis of many medicinal compounds. 1,2,4-Triazole possess broad spectrum of therapeutically interesting drug candidates such as analgesic, antiseptic, antimicrobial, antioxidant, anti-urease, anti-inflammatory, diuretics, anticancer, anticonvulsant, antidiabetic and antimigraine agents. Methods The structures of all synthesized compounds were characterized by physicochemical properties and spectral means (IR and NMR). The synthesized compounds were evaluated for their in vitro antimicrobial activity against Gram-positive (B. subtilis), Gram-negative (P. aeruginosa and E. coli) bacterial and fungal (C. albicans and A. niger) strains by tube dilution method using ciprofloxacin, amoxicillin and fluconazole as standards. In-vitro antioxidant and anti-urease screening was done by DPPH assay and indophenol method, respectively. The in-vitro anticancer evaluation was carried out against MCF-7 and HCT116 cancer cell lines using 5-FU as standards. Results, discussion and conclusion The biological screening results reveal that the compounds T-5 (MICBS, EC = 24.7 mu M, MICPA, (CA) = 12.3 mu M) and T-17 (MICAN = 27.1 mu M) exhibited potent antimicrobial activity as comparable to standards ciprofloxacin, amoxicillin (MICCipro = 18.1 mu M, MICAmo = 17.1 mu M) and fluconazole (MICFlu = 20.4 mu M), respectively. The antioxidant evaluation showed that compounds T-2 (IC50 = 34.83 mu g/ml) and T-3 (IC50 = 34.38 mu g/ml) showed significant antioxidant activity and comparable to ascorbic acid (IC50 = 35.44 mu g/ml). Compounds T-3 (IC50 = 54.01 mu g/ml) was the most potent urease inhibitor amongst the synthesized compounds and compared to standard thiourea (IC50 = 54.25 mu g/ml). The most potent anticancer activity was shown by compounds T-2 (IC50 = 3.84 mu M) and T-7 (IC50 = 3.25 mu M) against HCT116 cell lines as compared to standard 5-FU (IC50 = 25.36 mu M).

Recommanded Product: 120-14-9. Welcome to talk about 120-14-9, If you have any questions, you can contact Kumari, M; Tahlan, S; Narasimhan, B; Ramasamy, K; Lim, SM; Shah, SAA; Mani, V; Kakkar, S or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles