Day: September 16, 2022

Bioorganic & Medicinal Chemistry Letters | Cas: 165669-07-8 was involved in experiment

Synthetic Route of C9H8BrNIn addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. The best-known group of these compounds is the indole alkaloids, members of which have been isolated from plants representing more than 30 families.

Owa, Takashi;Okauchi, Tatsuo;Yoshimatsu, Kentaro;Sugi, Naoko Hata;Ozawa, Yoichi;Nagasu, Takeshi;Koyanagi, Nozomu;Okabe, Tadashi;Kitoh, Kyosuke;Yoshino, Hiroshi published 《A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors》 in 2000. The article was appeared in 《Bioorganic & Medicinal Chemistry Letters》. They have made some progress in their research.Synthetic Route of C9H8BrN The article mentions the following:

A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore, e.g. I, was synthesized and evaluated as a potential antitumor agent. Cell cycle anal. with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. The structure-activity relationships of the substituent patterns on this pharmacophore template are described. And 7-Bromo-4-methyl-1H-indole (cas: 165669-07-8) was used in the research process.

Synthetic Route of C9H8BrNIn addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. The best-known group of these compounds is the indole alkaloids, members of which have been isolated from plants representing more than 30 families.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Organic Chemistry Frontiers | Cas: 165669-07-8 was involved in experiment

Application of 165669-07-8In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. The best-known group of these compounds is the indole alkaloids, members of which have been isolated from plants representing more than 30 families.

Application of 165669-07-8In 2020, Yuan, Yumeng;Pan, Guoshuai;Zhang, Xiaofeng;Huang, Qiufeng published 《One pot synthesis of pyrrolo[3,2,1-de]phenanthridines from 7-phenylindoles via tandem C-H olefination/aza-Michael addition》. 《Organic Chemistry Frontiers》published the findings. The article contains the following contents:

The one-pot C-H olefination/aza-Michael addition tandem process was developed for the synthesis of pyrrolo[3,2,1-de]phenanthridines from 7-phenylindoles and alkenes using a [Cp*RhCl2]2/AgOAc/Me4NOAc catalytic system. A relatively wide range of functional groups were tolerated, and a variety of pyrrolo[3,2,1-de]phenanthridines were obtained in good to excellent yields. And 7-Bromo-4-methyl-1H-indole (cas: 165669-07-8) was used in the research process.

Application of 165669-07-8In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. The best-known group of these compounds is the indole alkaloids, members of which have been isolated from plants representing more than 30 families.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application of cas: 132680-54-7 | Liu, Jiang et al. published an article in 2014

The crystal structure of 6-Methoxyisoindolin-1-one(cas:132680-54-7 SDS of cas: 132680-54-7) has been determined using x-ray crystallography and cell studies. It was found that 6-Methoxyisoindolin-1-one inhibits the interactions of chk1 with substructures of DNA, such as the major groove and minor groove.

Liu, Jiang;Wang, Luyao;Guo, Na;Teng, Yu-Ou;Yu, Peng published 《Design, synthesis and biological evaluation of the novel isoindolinone derivatives》 in 2014. The article was appeared in 《Journal of Chemical and Pharmaceutical Research》. They have made some progress in their research.SDS of cas: 132680-54-7 The article mentions the following:

A series of novel isoindolinone derivatives I [R = morpholino, pyrrolidino, N-Boc-piperazino, piperazino] were designed, synthesized and screened for their antitumor activity against HT-29, K562 and HepG2 cell lines. Among the tested compounds, isoindolinone derivative I [R = N-Boc-piperazino] exhibited good antitumor activity against HepG2 cancer cell line with IC50 of 5.89 μM. And 6-Methoxyisoindolin-1-one (cas: 132680-54-7) was used in the research process.

The crystal structure of 6-Methoxyisoindolin-1-one(cas:132680-54-7 SDS of cas: 132680-54-7) has been determined using x-ray crystallography and cell studies. It was found that 6-Methoxyisoindolin-1-one inhibits the interactions of chk1 with substructures of DNA, such as the major groove and minor groove.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chen, Cong team published research on Organic & Biomolecular Chemistry in 2022 | 19005-93-7

SDS of cas: 19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings. SDS of cas: 19005-93-7.

Chen, Cong;Jiao, Hongjian;Chen, Di;Tang, Tao;Xu, Ze-Feng;Duan, Shengguo;Li, Chuan-Ying research published 《 Access to tetrahydrocarbazoles and pyrrolo[3,4-b]carbazoles through sequential reactions of triazoles and indoles》, the research content is summarized as follows. Tetrahydrocarbazoles I (R = H, Me; R1 = H, OMe, F, Cl, etc.; R2 = H, Me; R3 = H, Me; R4 = Me, allyl; R5 = Et, t-Bu; R6 = Me, Ts, benzenesulfonyl, etc.; R7 = Ac, Boc, Bz, etc.) and pyrrolo[3,4-b]carbazoles II could be synthesized conveniently through sequential reactions of ester-tethered 1-sulfonyl-1,2,3-triazoles III and indoles IV. The reaction conditions were mild and the procedures were quite simple. Moreover, the key intermediate α,β-unsaturated imine acted as a [2C] synthon in the [4 + 2] cycloaddition reaction, and the imino group could be used as a nucleophile to construct the fourth ring.

SDS of cas: 19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles