Day: October 19, 2022

The author of 《Plant Growth Regulators Enhance Saline-Alkali Tolerance by Upregulating the Levels of Antioxidants and Osmolytes in Soybean Seedlings》 were Yu, Minglong; Wu, Qiong; Zheng, Dianfeng; Feng, Naijie; Liang, Xilong; Liu, Meiling; Li, Yao; Mou, Baomin. And the article was published in Journal of Plant Growth Regulation in . Synthetic Route of C12H12KNO2 The author mentioned the following in the article:

Soil salinization has become a global problem and seriously endangers crop growth and yield improvement. In the present study, soybean (Hefeng 50) seedlings were used as test materials to study the mitigation effect of foliar spraying of different plant growth regulators (PGRs) [50 mg L-1 indole-3-butyric acid potassium salt (IBAK), 50 mg L-1 chitosan oligosaccharide (COS), 2 mg L-1 abscisic acid (ABA), 30 mg L-1 5-aminolevulinic acid (ALA), and 1.2 mg L-1 brassinolide (BR)] on oxidative stress caused by the mixed Saline-Alkali concentration of 110 mmol L-1. The results showed that the application of PGRs promoted the growth of Saline-Alkali stressed plants, where the maximum increase in shoot FW was treated with COS, and in root FW, root length, root surface area, and root volume were obtained with the IBAK treatment. Treatments ABA, ALA, and BR had higher net photosynthetic rates, and the chlorophyll content was considerably increased under COS and BR treatments compared with Saline-Alkali treatment. Moreover, PGRs markedly enhanced the activities of antioxidant enzymes, the concentration of ascorbate (AsA), glutathione (GSH), proline, soluble protein, soluble sugar, sucrose, and starch, and the ratios of AsA/DHA and GSH/GSSG, but reduced the concentration of malondialdehyde (MDA), electrolyte leakage (EL), hydrogen peroxide (H2O2), and superoxide radical (O2·-) in soybean seedlings compared with Saline-Alkali treatment. The principal component anal. revealed that the ranking of PGRs enhancing Saline-Alkali tolerance of soybean seedlings was BR > IBAK > ABA > COS > ALA, and the most effective treatment was BR, which may be assigned to more vigorous antioxidant defense and osmotic adjustment. The experimental part of the paper was very detailed, including the reaction process of Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3Synthetic Route of C12H12KNO2)

Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3) is auxin-family plant hormone, and is thought to be a precursor of indole-3-acetic acid (IAA) the most abundant and the basic auxin natively occurring and functioning in plants. IAA generates the majority of auxin effects in intact plants, and is the most potent native auxin.Synthetic Route of C12H12KNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019,Infection and Immunity included an article by Howard, Mondraya F.; Bina, X. Renee; Bina, James E.. COA of Formula: C8H7N. The article was titled 《Indole inhibits ToxR regulon expression in Vibrio cholerae》. The information in the text is summarized as follows:

Indole is a degradation product of tryptophan that functions as a signaling mol. in many bacteria. This includes Vibrio cholerae, where indole was shown to regulate biofilm and type VI secretion in nontoxigenic environmental isolates. Indole is also produced by toxigenic V. cholerae strains in the human intestine, but its significance in the host is unknown. We investigated the effects of indole on toxigenic V. cholerae O1 El Tor during growth under virulence inducing conditions. The indole transcriptome was defined by RNA sequencing and showed widespread changes in the expression of genes involved in metabolism, biofilm production, and virulence factor production In contrast, genes involved in type VI secretion were not affected by indole. We subsequently found that indole repressed genes involved in V. cholerae pathogenesis, including the ToxR virulence regulon. Consistent with this, indole inhibited cholera toxin and toxin-coregulated pilus production in a dosedependent manner. The effects of indole on virulence factor production and biofilm were linked to ToxR and the ToxR-dependent regulator LeuO. The expression of Y was increased by exogenous indole and linked to repression of the ToxR virulence regulon. This process was dependent on the ToxR periplasmic domain, suggesting that indole was a ToxR agonist. This conclusion was further supported by results showing that the ToxR periplasmic domain contributed to indole-mediated increased biofilm production Collectively, our results suggest that indole may be a niche-specific cue that can function as a ToxR agonist to modulate virulence gene expression and biofilm production in V. cholerae. In the experimental materials used by the author, we found 1H-Indole(cas: 120-72-9COA of Formula: C8H7N)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.COA of Formula: C8H7N

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Sun, Minghe; Liu, Min; Li, Changkun published an article in 2021. The article was titled 《Rhodium-Catalyzed Chemodivergent Regio- and Enantioselective Allylic Alkylation of Indoles》, and you may find the article in Chemistry – A European Journal.Computed Properties of C8H6FN The information in the text is summarized as follows:

The control of C3/N1 chemoselectivity in indole alkylation with the same electrophiles is still challenging. An Rh/bisoxazolinephosphane-catalyzed chemodivergent regio- and enantioselective allylic alkylation of indoles was developed. Chiral C3- and N1-allylindoles was selectively obtained with high branched/linear ratio and up to 99% ee by changing the counteranion of Rh, the allylic carbonate, the reaction temperature, and the ligand. In addition to this study using 5-Fluoro-1H-indole, there are many other studies that have used 5-Fluoro-1H-indole(cas: 399-52-0Computed Properties of C8H6FN) was used in this study.

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Computed Properties of C8H6FN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H6FNIn 2019 ,《Redox-Neutral Cascade Dearomatization of Indoles via Hydride Transfer: Divergent Synthesis of Tetrahydroquinoline-Fused Spiroindolenines》 was published in Journal of Organic Chemistry. The article was written by Shen, Yao-Bin; Li, Long-Fei; Xiao, Ming-Yan; Yang, Jian-Ming; Liu, Qing; Xiao, Jian. The article contains the following contents:

The redox-neutral cascade dearomatization of indoles with o-aminobenzaldehydes was realized via the hydride transfer strategy, achieving the condition- and substrate-controlled divergent synthesis of tetrahydroquinoline-fused spiroindolenines. The integration of hydride transfer-involved C(sp3)-H functionalization with dearomatization provides a promising platform for the construction of structurally diverse mols.5-Fluoro-1H-indole(cas: 399-52-0Computed Properties of C8H6FN) was used in this study.

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Computed Properties of C8H6FN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Synthesis of Chiral Bis(3-indolyl)methanes Bearing a Trifluoromethylated All-Carbon Quaternary Stereocenter via Nickel-Catalyzed Asymmetric Friedel-Crafts Alkylation Reaction》 was written by Zhu, Wen-Jing; Gong, Jun-Fang; Song, Mao-Ping. Safety of 5-Fluoro-1H-indoleThis research focused ontrifluoromethyl bis indolyl methane nitromethyl enantioselective preparation; nitroalkene indolyl trifluoromethyl enantioselective Friedel Crafts alkylation indole nickel. The article conveys some information:

Here, an efficient method for the synthesis of chiral trifluoromethylated bis(3-indolyl)methanes I (R1 = H, 5-F, 6-Me, 7-MeO, etc.; R2 = H, 4-F, 5-CO2Me, etc.; R3 = Boc, Ts) via a catalytic asym. Friedel-Crafts (F-C) alkylation reaction of R1-substituted indoles with (nitrovinyl)indoles II has been developed. Both enantiomers of the products could be obtained by tuning chiral substituents on a catalyst. With 5 mol% of Ni(II)/(imidazoline-oxazoline) complex as catalyst, F-C reaction of indoles with β-CF3-β-(3-indolyl)nitroalkenes proceeded well to afford a series of chiral bis(3-indolyl)methanes bearing a trifluoromethylated all-carbon quaternary stereocenter I in generally good yields with excellent enantioselectivities (up to 98% yield and 94% ee). Furthermore, by interchanging indole moieties of two reactants, indole vs. β-CF3-β-(3-indolyl)nitroalkene in F-C reaction, both enantiomers of a given trifluoromethylated bis(3-indolyl)methane were obtained with high enantioselectivities (89-94% ee) upon removal of indole N-protecting group in F-C products. The current work represents the first general catalytic enantioselective approach to important class of trifluoromethylated bis(3-indolyl)methanes. In the part of experimental materials, we found many familiar compounds, such as 5-Fluoro-1H-indole(cas: 399-52-0Safety of 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Safety of 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Synthesis of β-D-mannosides from β-D-glucosides via an intramolecular SN2 reaction at C-2》 was written by Guenther, Wolfgang; Kunz, Horst. Category: indole-building-block And the article was included in Carbohydrate Research on April 10 ,1992. The article conveys some information:

The selective synthesis of β-D-mannosides was achieved by first synthesizing β-D-glucosides, e.g., I, that carry an N-phenylcarbamoyl protecting group at O-3. These derivatives were transformed into the corresponding β-D-mannosides by intramol. nucleophilic substitution with inversion of configuration at C-2, the O-triflyl group being the leaving group. Subsequent intramol. attack of the neighboring carbamoyl group resulted in the formation of the 2,3-carbonate of the desired β-D-mannoside, e.g., II.Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2Category: indole-building-block) was used in this study.

Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Category: indole-building-blockThey are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Kajihara, Yasuhiro; Kodama, Hisashi; Endo, Tsuyoshi; Hashimoto, Hironobu published an article on January 31 ,1998. The article was titled 《Novel features of acceptor recognition by β-(1→4)-galactosyltransferase》, and you may find the article in Carbohydrate Research.Formula: C22H25NO9S The information in the text is summarized as follows:

In order to understand how β-(1→4)-galactosyltransferase recognizes its glycosyl acceptor, substrate specificities were investigated using synthetic 2-acetamido-2-deoxy-D-glucopyranose (N-acetylglucosamine) derivatives in which the 1-, 2-, 3-, 4-, and 6-positions were systematically substituted. The hydroxyl groups at the 3-, 4-, and 6-positions were substituted by fluoride, thiol or hydrogen. For modification of the 2- position, the acetamido group was converted to ethylamino-, N-methylacetamido- and acetyloxy groups. For the anomeric position, several sugar residues were introduced as the aglycon of N-acetylglucosaminide. Galactose transfer assay using synthetic N-acetylglucosamine derivatives indicated that both the acetamido group and the 4-hydroxyl group were essential for binding of N-acetylglucosamine toward the β-(1→4)-galactosyltransferase. The assay also showed that the N-acetylglucosamine having a large substitution at the 6-position can be recognized as an acceptor. It is suggested that in this case the bulky substituent is positioned away from the catalytic site or out of enzyme. Since the 2-acetamido and the 4-hydroxyl group are essential for recognition, the side composed of the 2, 3, and 4-positions may face the acceptor-binding site. The experimental process involved the reaction of Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2Formula: C22H25NO9S)

Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Formula: C22H25NO9SThey are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019,Nature (London, United Kingdom) included an article by Lv, Jiahang; Chen, Xiangyang; Xue, Xiao-Song; Zhao, Binlin; Liang, Yong; Wang, Minyan; Jin, Liqun; Yuan, Yu; Han, Ying; Zhao, Yue; Lu, Yi; Zhao, Jing; Sun, Wei-Yin; Houk, Kendall. N.; Shi, Zhuangzhi. Related Products of 120-72-9. The article was titled 《Metal-free directed sp2-C-H borylation》. The information in the text is summarized as follows:

Direct borylation of 1- or 3-pivaloyl-1H-indoles was achieved by reaction with BBr3 with subsequent esterification with pinacol, yielding 7- or 4-indoleboronates, resp., without use of metal catalyst. N-acylated aromatic amines were successfully borylated into o-position with the same protocol, giving 2-pivaloylaminophenylboronic acids. Organoboron reagents are important synthetic intermediates that have a key role in the construction of natural products, pharmaceuticals and organic materials. The discovery of simpler, milder and more efficient approaches to organoborons can open addnl. routes to diverse substances. Here we show a general method for the directed C-H borylation of arenes and heteroarenes without the use of metal catalysts. C7- and C4-borylated indoles are produced by a mild approach that is compatible with a broad range of functional groups. The mechanism, which is established by d. functional theory calculations, involves BBr3 acting as both a reagent and a catalyst. The potential utility of this strategy is highlighted by the downstream transformation of the formed boron species into natural products and drug scaffolds. In addition to this study using 1H-Indole, there are many other studies that have used 1H-Indole(cas: 120-72-9Related Products of 120-72-9) was used in this study.

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Related Products of 120-72-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019,Chemistry – A European Journal included an article by Pang, Yadong; Ishiyama, Tatsuo; Kubota, Koji; Ito, Hajime. Reference of 5-Fluoro-1H-indole. The article was titled 《Iridium(I)-Catalyzed C-H Borylation in Air by Using Mechanochemistry》. The information in the text is summarized as follows:

Mechanochem. has been applied for the first time to an iridium(I)-catalyzed C-H borylation reaction. By using either none or just a catalytic amount of a liquid, the mechanochem. C-H borylation of a series of heteroaromatic compounds proceeded in air to afford the corresponding arylboronates in good-to-excellent yields. A one-pot mechanochem. C-H borylation/Suzuki-Miyaura cross-coupling sequence for the direct synthesis of 2-aryl indole derivatives is also described. The present study constitutes an important milestone towards the development of industrially attractive solvent-free C-H bond functionalization processes in air. In the part of experimental materials, we found many familiar compounds, such as 5-Fluoro-1H-indole(cas: 399-52-0Reference of 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Reference of 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The author of 《Cp*Co(III)-Catalyzed Regioselective C2-Amidation of Indoles Using Acyl Azides》 were Shah, Tariq A.; De, Pinaki Bhusan; Pradhan, Sourav; Banerjee, Sonbidya; Punniyamurthy, Tharmalingam. And the article was published in Journal of Organic Chemistry in 2019. HPLC of Formula: 399-52-0 The author mentioned the following in the article:

A cobalt-catalyzed C2-selective amidation of indoles using acyl azides has been accomplished. Isotope experiments suggest that C-H activation is reversible. The use of sustainable Co-catalysis, functional group diversity, substrate scope and regioselective are the important practical features. The experimental process involved the reaction of 5-Fluoro-1H-indole(cas: 399-52-0HPLC of Formula: 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.HPLC of Formula: 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles