Day: October 28, 2022

On December 31, 2019, Xu, Shi-Ming; Wei, Liang; Shen, Chong; Xiao, Lu; Tao, Hai-Yan; Wang, Chun-Jiang published an article.Application of 883526-76-9 The title of the article was Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction. And the article contained the following:

An expedient and stereodivergent assembly of tetrahydro-γ-carbolines I [R = Ph, 4-ClC6H4, 2-furanyl, etc.; R1 = H, Me, Bn, etc.; R2 = H, 4-Me, 5-Cl, etc.] with remarkably high levels of stereoselective control in an efficient cascade process from aldimine esters and indolyl allylic carbonates via a synergistic Cu/Ir catalyst system was reported. Control experiments-guided optimization of synergistic catalysts and mechanistic investigations reveal that a stereodivergent allylation reaction and a subsequent highly stereoselective iso-Pictet-Spengler cyclization were the key elements to success. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Application of 883526-76-9

The Article related to tetrahydro gamma carboline enantioselective preparation, aldemine ester indolyl allylic carbonate tandem allylation pictet spengler, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application of 883526-76-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

He, Yi; Wu, Danjun; Li, Zhenghua; Robeyns, Koen; Van Meervelt, Luc; Van der Eycken, Erik V. published an article in 2019, the title of the article was Facile construction of diverse polyheterocyclic scaffolds via gold-catalysed dearomative spirocyclization/1,6-addition cascade.Application In Synthesis of 1,5-Dimethyl-1H-indole-2-carbaldehyde And the article contains the following content:

A gold-catalyzed post-Ugi chemo- and diastereoselective cascade dearomative spirocyclization/1,6-addition sequence was disclosed for the synthesis of diverse fused polyheterocyclic scaffolds such as I [R1 = H, Me, Ac, Bn; R2 = H, Me; R3 = n-Bu, t-Bu, cyclohexyl, Bn etc.; R4 = H, Me, n-Pr, n-Bu, Ph; R5 = H, Me] bearing indole, pyrrole, benzothiophene, furan or electron-rich arene moieties from easily available building blocks. The effectiveness and efficiency of this diversity-oriented approach had proved in the rapid construction of 28 fused polyheterocyclic scaffolds with a good building-block variability and structural complexity in two operational steps. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Application In Synthesis of 1,5-Dimethyl-1H-indole-2-carbaldehyde

The Article related to fused polyheterocycle chemoselective diastereoselective preparation, adduct ugi tandem dearomative spirocyclization addition gold catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application In Synthesis of 1,5-Dimethyl-1H-indole-2-carbaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On December 17, 2021, Uredi, Dilipkumar; Burra, Amarender Goud; Watkins, E. Blake published an article.Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde The title of the article was Rapid Access to 3-Substituted Pyridines and Carbolines via a Domino, Copper-free, Palladium-Catalyzed Sonogashira Cross-Coupling/6π-Aza Cyclization Sequence. And the article contained the following:

Herein, a one-pot, three-component method for the preparation of 3-substituted pyridines such as I [R = H, Me, Ph, tert-butoxycarbonyl; Ar = Ph, 2-MeC6H4, 3-quinolyl, etc.; R1 = H, 6-Me, 8-Me, 5-MeO], II [R2 = R2 = H; R2R3 = HCCH=CHCH; X = S, O] and carbolines via copper-free, palladium-catalyzed Sonogashira cross-coupling with aryl iodides, followed by 6π-aza cyclization was reported. This arylation cross-coupling/annulation cascade provided easy access to substituted, fused pyridines I, II from readily available substrates in good yields (67-92%) with complete selectivity. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde

The Article related to pyridoindolyl methyl aryl preparation, aryl iodide indole carboxaldehyde propargylamine domino sonogashira coupling aza, cyclization catalyst palladium, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Liu, Chao; Van Meervelt, Luc; Peshkov, Vsevolod A.; Van der Eycken, Erik V. published an article in 2022, the title of the article was The synthesis of diverse benzazepinoindoles via gold-catalyzed post-Ugi alkyne hydroarylation/Michael addition sequence.Computed Properties of 883526-76-9 And the article contains the following content:

A novel gold-catalyzed hydroarylation/Michael addition process, enabling the construction of the benzazepinoindole polycyclic scaffolds in a highly efficient manner starting from readily accessible multifunctional Ugi adducts, e.g., I, was developed. The developed methodol. is characterized by a broad substrate scope, excellent functional-group tolerance and high yields of the target benzazepinoindoles. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Computed Properties of 883526-76-9

The Article related to benzazepinoindole polycyclic compound preparation regioselective chemoselective, alkynyl amide tandem cyclization hydroarylation michael addition gold catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Computed Properties of 883526-76-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On November 30, 2004, Jung, Doo Young; Park, Doo Han; Kim, Sung Han; Kim, Yong Hae published an article.Computed Properties of 79815-20-6 The title of the article was Dual enantioselective Diels-Alder process in the cyclization of chiral acrylamide with dienes. And the article contained the following:

Diels-Alder cycloadditions of chiral acrylamides with cyclopentadiene or 2, 3-dimethyl butadiene proceed with high diastereofacial selectivity. Either endo-R or endo-S products have been obtained depending upon the structures of acrylamides and Lewis acids used. The endo form was exclusively obtained over the exo form. The dependence of the mechanism of formation of opposite configurations of endo-R or endo-S products on the Lewis acids is discussed. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Computed Properties of 79815-20-6

The Article related to dual enantioselective diels alder cyclization chiral acrylamide diene, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Computed Properties of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 19, 2010, Xiao, Jian; Xu, Feng-Xia; Lu, Yun-Peng; Loh, Teck-Peng published an article.Safety of H-Idc-OH The title of the article was Chemzymes: A New Class of Structurally Rigid Tricyclic Ambiphilic Organocatalyst Inspired by Natural Product. And the article contained the following:

A new class of structurally rigid tricyclic ambiphilic chiral catalyst was rationally designed based on the hexahydropyrrolo[2,3-b]indole skeleton as a new type of chemzyme. This new type of chemzyme possesses a structurally rigid tricyclic skeleton and a chiral pocket which provides a well-organized chiral environment for asym. induction, as well as a hydrophobic pocket to enable organocatalytic reactions to proceed smoothly both in organic solvents and in water. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Safety of H-Idc-OH

The Article related to chemzyme rigid tricyclic amphibian organocatalyst inspired natural crystallog, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Safety of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On May 31, 2008, Baumann, Thomas; Baechle, Michael; Hartmann, Caroline; Brase, Stefan published an article.Electric Literature of 79815-20-6 The title of the article was Thermal effects in the organocatalytic asymmetric α-amination of disubstituted aldehydes with azodicarboxylates: a high-temperature organocatalysis. And the article contained the following:

This article describes the thermally accelerated organocatalytic α-amination of disubstituted aldehydes with azodicarboxylates under microwave conditions. Compared to the results previously obtained at room temperature, both yield and enantioselectivity could be significantly increased. Employing microwave irradiation resulted in a considerably reduced reaction time. Therefore, this improved protocol allows the fast and efficient synthesis of α,α-disubstituted amino aldehydes and provided the best results for the α-amination of disubstituted aldehydes to date. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Electric Literature of 79815-20-6

The Article related to thermal organocatalysis asym amination disubstituted aldehyde azodicarboxylate temperature, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Electric Literature of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On August 14, 2006, Andersson, Fredrik; Hedenstroem, Erik published an article.Recommanded Product: 79815-20-6 The title of the article was Synthesis of two (S)-indoline-based chiral auxiliaries and their use in diastereoselective alkylation reactions. And the article contained the following:

Two chiral auxiliaries, 2-[(S)-indolin-2-yl]propan-2-ol (I) and (S)-2-(2-methoxypropan-2-yl)indoline, were synthesized from enantiomerically pure (S)-indoline-2-carboxylic acid. High diastereoselectivities in alkylations of enolates of the propanoylamides derived from the two auxiliaries are presented. Surprisingly, both auxiliaries induced the same selectivity at the newly created stereogenic center. The benzyl bromide and Bu iodide alkylation reactions showed diastereomeric ratios that were moderate (81:19) to very good (96:4) and with very good yields (86-98%). When LiCl was used as an enolate coordinating agent, in the benzylation of the enolate from propanoylated auxiliary I, a very high crude diastereomeric ratio was obtained (99.7:0.3). The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Recommanded Product: 79815-20-6

The Article related to acylindolinemethanol chiral auxiliary stereoselective alkylation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Recommanded Product: 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 4, 2004, Thorarensen, Atli; Ruble, Craig J.; Romero, Donna L. published a patent.Quality Control of 6-Chloro-2,3-dihydro-1H-indole The title of the patent was Preparation of aminoarylbenzoic acid derivatives as antibacterial agents for use as disinfectants and therapeutic agents. And the patent contained the following:

The title compounds I [X = NH; Y = CO, CS, C=NCN, or X and Y together form an alkene, or cycloalkyl; R1 = CO2H; R2 = electron withdrawing group; R4 = (un)substituted aryl with provisions] and their pharmaceutically acceptable salts are prepared and disclosed as antibacterial agents. Thus, e.g., II was prepared by conversion of 4-(chlorosulfonyl)benzoic acid to the acid chloride then amidated with Me 2-amino-5-bromobenzoate with subsequent reaction with di-Et amine and hydrolysis to give the benzoic acid moiety. In assays, the min. inhibitory concentration values (μg/mL) ranged from 0.125 – >128. As antibacterial agents I are useful for sterilization, sanitation, antisepsis, and disinfection. Claims for therapeutic use of I as an antibacterial agent are made. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Quality Control of 6-Chloro-2,3-dihydro-1H-indole

The Article related to benzoic acid aminoaryl preparation antibacterial agent antisepsis disinfection, aminoarylbenzoic acid preparation antibacterial agent sterilization sanitation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Quality Control of 6-Chloro-2,3-dihydro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wawryszyn, Mirella; Sauter, Paul F.; Nieger, Martin; Koos, Martin R. M.; Koehler, Christine; Luy, Burkhard; Lemke, Edward A.; Braese, Stefan published an article in 2018, the title of the article was Synthesis of Azido-Glycans for Chemical Glyco-modification of Proteins.Computed Properties of 130539-43-4 And the article contains the following content:

Chem. produced, accurately linkable oligosaccharides are of importance for the synthesis of neo-glycoproteins. On the route to high-mannose type N-glycans, we present a convenient synthesis of several glycans bearing an azide moiety at the reducing end. An azido-glycan core structure as valuable precursor was modified into the protected N-glycan pentasaccharide core structure and the possibility of modular attachment of different antenna was demonstrated through synthesis of a pentamannose donor and glycosylation with the core structure. The azido function allows for chem. ligation with modified proteins featuring noncanonical cyclooctyne amino acids, providing access to customized glyco-patterns of glycoproteins, e.g., of antibodies that are of high interest for biopharmaceutical applications. The experimental process involved the reaction of Ethyl 2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-thio-beta-D-glucopyranoside(cas: 130539-43-4).Computed Properties of 130539-43-4

The Article related to cyclooctyne amino acid glycosylation glycoprotein oligosaccharide synthesis antibody, azido glycan protein synthesis oligosaccharide glycoprotein glycosylation cyclooctyne and other aspects.Computed Properties of 130539-43-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles