Day: October 31, 2022

Kim, Minyoung; Kumar Mishra, Neeraj; Park, Jihye; Han, Sangil; Shin, Youngmi; Sharma, Satyasheel; Lee, Youngil; Lee, Eui-Kyung; Kwak, Jong Hwan; Kim, In Su published an article in 2014, the title of the article was Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: a facile strategy for the synthesis of 7-substituted indoles.COA of Formula: C8H8ClN And the article contains the following content:

Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C-H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles, e.g., I, known to have diverse biol. profiles. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).COA of Formula: C8H8ClN

The Article related to indoline keto acid palladium decarboxylative acylation catalyst, acylated indoline preparation oxidation, indole acylated preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C8H8ClN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On August 31, 2007, Tanimori, Shinji; Ura, Haruna; Kirihata, Mitsunori published an article.Name: Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Copper-catalyzed synthesis of 2,3-disubstituted indoles. And the article contained the following:

The copper-catalyzed one-step synthesis of 2,3-disubstituted indoles I (R = Me, Et, tert-Bu, Me2C:CHCH2CH2, etc., R1 = Me; R = Ph, 2-naphthyl, 2-furyl, 2-thienyl, 2-pyridyl, R1 = Et) from readily available starting materials, 2-iodoaniline and various β-keto esters was described. The advantage of this method is the use of cheap catalysts and simple exptl. procedures under mild reaction conditions. As the substituted indole derivatives are important starting materials for the synthesis of biol. active indole alkaloids and drug candidates, this method would have potential usage for these purposes. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Name: Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to iodoaniline keto ester copper binol ullmann coupling heterocyclization, indole alkoxycarbonyl preparation, alkoxycarbonylindole preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On June 30, 2002, Yamazaki, Kazuo; Kondo, Yoshinori published an article.Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Palladium-Catalyzed Synthesis of Indole-3-Carboxylates on a Solid Polymer Support. And the article contained the following:

The indolecarboxylates I (R = H, Me; R1 = H, 5-Me, 6-F3C, 6-O2N) were prepared via Pd-catalyzed cyclization of the resin-bound enamino esters II (X = iodo, Br; Q = hydroxymethyl polystyrene resin) and subsequent NaOMe promoted resin cleavage. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to solid polymer support indolecarboxylate preparation, indolecarboxylate preparation, palladium catalyst enamino ester solid phase cyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Martin-Mejias, Irene; Aragoncillo, Cristina; Yanai, Hikaru; Hoshikawa, Shoki; Fujimoto, Yuuki; Matsumoto, Takashi; Almendros, Pedro published an article in 2020, the title of the article was A catalyst-free bis(triflyl)ethylation/benzannulation reaction: rapid access to carbazole-based superacidic carbon acids from alkynols.Name: 1,5-Dimethyl-1H-indole-2-carbaldehyde And the article contains the following content:

Carbazoles possessing Tf2CHCH2 groups were obtained by the reaction of 1-(indol-2-yl)but-3-yn-1-ols with in-situ generated Tf2C=CH2 through vicinal difunctionalization of the alkyne moiety, where the vinyl-type carbocation intermediate was selectively attacked by the indole moiety and not by the carbanion moiety. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Name: 1,5-Dimethyl-1H-indole-2-carbaldehyde

The Article related to indolyl arylbutynol pyridiniumyl trifluoromethylsulfonyl ethanide regioselective triflylethylation benzannulation, aryl triflylethylcarbazole preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: 1,5-Dimethyl-1H-indole-2-carbaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On August 16, 2019, Khan, Faiyaz; Fatima, Mehvish; Shirzaei, Moheb; Vo, Yen; Amarasiri, Madushani; Banwell, Martin G.; Ma, Chenxi; Ward, Jas S.; Gardiner, Michael G. published an article.Application of 65417-22-3 The title of the article was Tandem Ullmann-Goldberg Cross-Coupling/Cyclopalladation-Reductive Elimination Reactions and Related Sequences Leading to Polyfunctionalized Benzofurans, Indoles, and Phthalanes. And the article contained the following:

On exposure to a combination of Cu[I]- and Pd[0]-based catalysts, compounds such as halophenols and halocycloalkenones engage in tandem Ullmann-Goldberg cross-coupling and cyclopalladation-reductive elimination reactions to give benzofurans. Related reactions involving hetero-Michael additions of o-halogenated phenols or anilines to propiolates and the Pd[0]-catalyzed cyclization of the resulting conjugates provide, in a one-pot process, alternately functionalized benzofurans, indoles, or phthalanes. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Application of 65417-22-3

The Article related to halophenol haloenone ullmann goldberg cross coupling cyclopalladation reductive elimination, benzofuran preparation, indole preparation, phthalane preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Michell, Glynn; Rees, Charles W. published an article in 1987, the title of the article was Photolysis of 1-aryl-1,2,3-triazoles; rearrangement via 1H-azirines.Name: Methyl 2-methyl-1H-indole-3-carboxylate And the article contains the following content:

Naphthyltriazoles I (R = H, Me; R1, R2 = H, Me, MeC:CH2, CO2Me, CO2Et, CHO, cyano; R1 = R2 = COPh, CO2Me, CONH2, cyano) 1 were prepared from 1-azidonaphthalenes by 1,3-dipolar cycloaddition reactions. Photolysis of I (R = H, R1 = R2 = COPh, CO2Me, CONH2, cyano; R1 = CO2Et, CO2Me, cyano; R2 = H, Me) gave good yields of the expected benz[g]indoles II. I (R = H, R1 = H, Me, R2 = CO2Et, CO2Me, cyano) also gave mixtures of the expected II and rearranged II. Photolysis of 1-phenyltriazoles III (R = H, Me; R1 = CO2Me; R = CO2Me, R1 = H, Me) gave similar results; III (R = CO2Me R1 = H, Me) gave mixtures of expected and rearranged indoles IV (R = CO2Me, R1 = H, Me; R = H, Me; R1 = CO2Me) whereas III (R = H, Me; R1 = CO2Me) gave indoles IV (R = H, Me, R1 = CO2Me) only. These results are explained by a mechanism in which the less stable carbene intermediate rearranges to the more stable carbene intermediate via a 1H-azirine intermediate, in competition with its direct cyclization. Photolysis of I (R = Me, R1 = R2 = CO2Me, cyano) follows a different salts, giving high yields of deeply colored benzoquinoline derivatives V (R1 = CO2Me, cyano). The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Name: Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to naphthyltriazole preparation photolysis, benzindole, indole, benzoquinoline, triazole aryl photolysis, azirine intermediate aryltriazole photochem rearrangement, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Yang, Qing-Qing; Marchini, Marianna; Xiao, Wen-Jing; Ceroni, Paola; Bandini, Marco published an article in 2015, the title of the article was Visible-Light-Induced Direct Photocatalytic Carboxylation of Indoles with CBr4/MeOH.Product Details of 65417-22-3 And the article contains the following content:

Photocatalysis enables the cascade reactions of indoles and CBr4 in MeOH through a C(sp2)-H functionalization/methanolysis sequence. The title reaction provides an efficient access to indole-2- and 3-carboxylates in a single operation (no preinstallation of protecting or directing groups was required) with good yields under mild reaction conditions. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Product Details of 65417-22-3

The Article related to regioselective photocatalytic carboxylation indole tetrabromomethane methanol, carboxylation, indole functionalization, methanolysis, photocatalysis, visible light, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On February 16, 2018, Huang, Honggui; Yu, Menglin; Su, Xiaolong; Guo, Peng; Zhao, Jia; Zhou, Jiabing; Li, Yi published an article.Application of 52537-00-5 The title of the article was Sustainable Radical Cascades to Synthesize Difluoroalkylated Pyrrolo[1,2-a]indoles. And the article contained the following:

We disclose herein a photocatalytic difluoroalkylation and cyclization cascade reaction of N-(but-2-enoyl)indoles with broad substrate scopes in up to 90% isolated yield. This method provides sustainable and efficient access to synthesize difluoroalkylated pyrrolo[1,2-a]indoles with a quaternary carbon center under mild conditions. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Application of 52537-00-5

The Article related to fluoroalkylated pyrroloindole synthesis photocatalytic fluoroalkylation cyclization cascade butenoylindole, radical cascade fluoroalkylated pyrroloindole synthesis, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Das, Krishna Kanta; Ghosh, Asim Kumar; Hajra, Alakananda published an article in 2022, the title of the article was Late-stage ortho-C-H alkenylation of 2-arylindazoles in aqueous medium by Manganese(I)-catalysis.Synthetic Route of 79815-20-6 And the article contains the following content:

Earth-abundant and water-tolerant manganese(I) catalyzed alkenylation of 2-arylindazoles I (R = H, F, Cl; R1 = H, 4-Me, 3-Cl, etc.) with alkyl and aryl alkynes R2CCR3 (R2 = H, Ph, Me; R3 = hexyl, Ph, thiophen-3-yl, etc.) through C-H bond activation is described with a unique level of E-selectivity. The reaction proceeds through the control of C3 nucleophilicity of 2-aryl indazoles. This method is applied to the late-stage functionalization of complex mols. including ethinylestradiol, norethisterone, and N-protected amino acid derivatives, e.g., prop-2-yn-1-yl (tert-butoxycarbonyl)-L-phenylalaninate. The kinetic isotope studies suggest that the C-H bond activation step may not be the rate-determining step. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Synthetic Route of 79815-20-6

The Article related to aryl indazole alkenyl preparation diastereoselective regioselective, alkyne aryl indazole alkenylation manganese catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Synthetic Route of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On October 26, 2012, Woolford, Alison Jo-Anne; Howard, Steven; Buck, Ildiko Maria; Chessari, Gianni; Johnson, Christopher Norbert; Tamanini, Emiliano; Day, James Edward Harvey; Chiarparin, Elisabetta; Heightman, Thomas Daniel; Frederickson, Martyn; Griffiths-Jones, Charlotte Mary published a patent.Electric Literature of 52537-00-5 The title of the patent was Preparation of bicyclic heterocycles as anticancer agents. And the patent contained the following:

The invention relates to bicyclic heterocycles of formula I and tautomeric and stereochem. isomeric forms, N-oxides, pharmaceutically acceptable salts and the solvates thereof as anticancer agents; their preparation and use in the treatment of cancer. Compounds of formula I wherein ring E is a 6-membered aromatic carbocyclyl and heterocyclyl; G and J are independently C and N; Q is CR and N; R1 is (un)substituted C1-4 alkyl, C2-4 alkenyl and C3-8 cycloalkyl; R2 and R4 are independently (un)substituted H, C1-6 alkyl, C2-6 alkenyl, etc.; R2 and R4 together with the carbon attached form 3- to 10-membered saturated carbocyclyl and heterocyclyl; R3 and R10 are independently (un)substituted H, C1-6 alkyl, C2-6 alkenyl, etc.; R2 and R4 together with the carbon attached form 3- to 10-membered saturated carbocyclyl and heterocyclyl; R is (un)substituted C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, etc.; and tautomeric and stereochem. isomeric forms, N-oxides, pharmaceutically acceptable salts and the solvates thereof, are claimed. Example compound II was prepared by BOC-deprotection of (R)-2-methyl-4-[2-6-methylsulfamoyl-2,3-dihydroindol-1-yl)-2-oxo-ethyl]piperazine-1-carboxylic acid tert-Bu ester. All the invention compounds were evaluated for their antiproliferative activity (some data given). The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Electric Literature of 52537-00-5

The Article related to bicyclic heterocycle preparation anticancer agent, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Electric Literature of 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles