Day: November 1, 2022

On February 6, 2015, Park, Jihye; Mishra, Neeraj Kumar; Sharma, Satyasheel; Han, Sangil; Shin, Youngmi; Jeong, Taejoo; Oh, Joa Sub; Kwak, Jong Hwan; Jung, Young Hoon; Kim, In Su published an article.Recommanded Product: 52537-00-5 The title of the article was Mild Rh(III)-Catalyzed C7-Allylation of Indolines with Allylic Carbonates. And the article contained the following:

The rhodium(III)-catalyzed direct allylation of indolines with allylic carbonates at room temperature is described. These transformations provide the facile and efficient construction of C7-allylated indolic scaffold I [R = Me, t-Bu, NMe2, etc; R1 = H, Me, Ph, etc.]. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Recommanded Product: 52537-00-5

The Article related to indoline allylic carbonate allylation rhodium catalyst, allylindoline preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On July 31, 2018, Bodunov, Vladimir A.; Galenko, Ekaterina E.; Galenko, Alexey V.; Novikov, Mikhail S.; Khlebnikov, Alexander F. published an article.Formula: C11H11NO2 The title of the article was Synthesis of substituted indole-3-carboxylates by iron(II)-catalyzed domino isomerization of 3-alkyl/aryl-4-aryl-5-methoxyisoxazoles. And the article contained the following:

The iron(II)-catalyzed domino isomerization of 3-alkyl/aryl-4-arylisoxazoles provided a selective access to a wide range of structurally diverse highly substituted indole-3-carboxylates such as I [R = H, 6-Me, 4-MeO, etc.; R1 = Me, 4-ClC6H4, 2-naphthyl, etc.; R2 = Me, pyrrolidin-1-yl]. The operational simplicity, high atom efficiency and the use of stable starting materials and an inexpensive and low-toxicity catalyst were some of the attractive features of this tandem double ring-opening-ring-closure strategy. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Formula: C11H11NO2

The Article related to indole carboxylate green preparation, isoxazole tandem isomerization iron catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C11H11NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 15, 2005, Mavunkel, Babu J.; Chakravarty, Sarvajit; Perumattam, John J.; Dugar, Sundeep; Lu, Qing; Liang, Xi published a patent.Recommanded Product: 256935-86-1 The title of the patent was Preparation of indolylcarboxamide derivatives as inhibitors of p38 kinase. And the patent contained the following:

Title compounds I [X independently = CA, CR4A, CR5, CR52, NR6, or N; L1 = CO, SO2, or alkylene; L2 = (un)substituted-alkylene or -alkenylene; Ar = (un)substituted aryl group with substituents consisting of alkyl, alkenyl, halo, CN, etc.; Z = N or CR7 wherein R7 = H or non-interfering substituent; R1 = H, alkyl, alkenyl, alkynyl, aryl, arylalkyl, etc.; R2 independently = halo, alkyl, OH, alkoxy, etc.; R3 independently = CN, CF3, NO2, alkyl, aryl, acyl, etc.; R4 = H, halo, alkyl or alkenyl; R5 independently = H, halo, alkyl, OH, etc.; R6 = H, alkyl, alkenyl, aryl, acyl, aroyl, etc.; A = -WiCOXjY wherein Y is COR8 wherein R8 = H, (un)substituted-alkyl, -alkenyl, -alkynyl, etc.; W and X = (un)substituted-alkylene, -alkenylene, -alkynylene; Y = tetrazole, 1,2,3-triazole, 1,2,4-triazole, or imidazole and each of i and j independently = 0 or 1; m = 0-4; n = 0-3], and their pharmaceutically acceptable salts are prepared and disclosed as useful for treatment of rheumatoid arthritis. Thus, e.g., II, was prepared by carbonylation of 6-methoxy-(4-benzylpiperidinyl)-indole-5-carboxamide with oxalyl chloride and subsequent amination using 4-methylpiperazine. ELISA assays for evaluation of inhibition of p38 kinase by I revealed that all compounds of the invention possessed IC50 values in the range of 0.1-1.5 μM. I as inhibitors of p38 kinase should prove useful in the treatment of rheumatoid arthritis. The experimental process involved the reaction of 6-Chloro-1H-indole-5-carboxylic acid(cas: 256935-86-1).Recommanded Product: 256935-86-1

The Article related to indolylcarboxamide derivative preparation p38 kinase inhibitor antirheumatic agent, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 256935-86-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 15, 2014, Luo, Ren-shi; Xie, Ling; Liao, Jian-hua; Zhang, Jian published an article.Product Details of 79815-20-6 The title of the article was Synthesis and characterization of novel indole chiral amino alcohols. And the article contained the following:

With (S)-indole-2-carboxylic acid and (S)-octahydroindole-2-carboxylic acid as raw material, processed by esterification, protection, Grignard reaction and reduction by Pd/C, two new chiral indole derivative (S)-(2-octahydroindole) di-Ph methanol and (S)-(2-indolinyl)-diphenyl methanol were synthesized in high yield. The total yields were resp. 88.3% and 83.7%, the structure of the products were characterized by 1HNMR, 13CNMR and HRMS spectra. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Product Details of 79815-20-6

The Article related to synthesis characterization indole chiral amino alc esterification grignard reduction, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On December 18, 2012, Bunescu, Ala; Wang, Qian; Zhu, Jieping published an article.SDS of cas: 65417-22-3 The title of the article was Synthesis of indoles by copper-catalyzed heteroannulation of o-aminophenylboronic acid pinacol esters with β-keto esters. And the article contained the following:

Copper-catalyzed coupling of o-aminophenylboronic acid pinacol esters with β-keto esters afforded, under mild base-free oxidative conditions, 2,3-disubstituted indoles featuring a key Chan-Lam-type carbon-carbon bond-forming reaction. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).SDS of cas: 65417-22-3

The Article related to indole preparation, aminophenylboronic acid pinacol ester keto ester copper catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.SDS of cas: 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 3, 2017, Jiang, Xue; Tang, Weijun; Xue, Dong; Xiao, Jianliang; Wang, Chao published an article.Synthetic Route of 52537-00-5 The title of the article was Divergent Dehydrogenative Coupling of Indolines with Alcohols. And the article contained the following:

The dehydrogenative coupling of indolines with alcs. catalyzed by an iridium complex has been achieved to afford both N- and C3-alkylated indoles selectively, by simply changing the addition time of a base additive. The iridacycle catalyst plays multiple roles in these reactions, which dehydrogenates both amines and alcs. and catalyzes the coupling reactions. Mechanistic studies reveal that a borrowing hydrogen-dehydrogenation process and a dehydrogenation-borrowing hydrogen process are involved in N-alkylation and C3-alkylation reactions, resp. The C3-alkylation reaction involves the direct coupling of two sp3 carbon centers. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Synthetic Route of 52537-00-5

The Article related to iridium catalyst dehydrogenative coupling indoline alc, indole alkylated preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Synthetic Route of 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On February 6, 1996, Hashimoto, Rie; Okada, Hideo; Mochizuki, Atsuya; Ooi, Hideo; Endo, Mamoru; Miki, Wataru; Konya, Kazumi published a patent.Computed Properties of 52537-00-5 The title of the patent was Preparation of 5,6-dichloro-1-methylgramine and antifouling agents against adhering aquatic organisms. And the patent contained the following:

The title compound (I) is prepared An antifouling agent against adhering aquatic organisms contains at least one compound selected from 5,6-dichlorogramine, 5-chloro-2-methylgramine, 5-bromo-2-methylgramine, 1,2-dimethyl-6-bromogramine, and I as the active ingredient. This antifouling agent prevents aquatic organisms such as sea weeds, barnacles, Mytilus edulis, etc. adhering and damaging a bottom of a ship, a fishing net, a buoy, aqueous structures such as facilities attached to a dam and bay, and water inlet channels for cooling water of a condenser for a power plant or an heat exchanger in petrochem. industry. Thus, 1.9 g 5,6-dichloroindole was dissolved in DMF, treated with NaH at 5°, stirred at 5° for 30 min, treated dropwise with 1.5 g MeI, and stirred at room temperature for 3 h to give 2.2. g crude 5,6-dichloro-1-methylindole, which was added to a solution of 1.3 mL 40% dimethylamine, 0.9 mL 35% formalin, and 1.7 mL AcOH, and stirred overnight to give 61.5% I. I (0.0025 mg) was dissolved in 0.1 mL MeOH, coated on a round petri dish (diameter 4 cm), and dried. Filtered sea water (5 mL) and 10 barnacle larvae were added to the treated petri dish and left in the dark at 23° for 24 h to show that no larvae adhered to the petri dish. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Computed Properties of 52537-00-5

The Article related to chloromethylgramine preparation antifouling agent, aquatic organism antifouling agent, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Computed Properties of 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 31, 1986, Pindur, Ulf; Flo, Camran published an article.Name: Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Reactions of electron-rich heterocycles with derivatives of carboxylic ortho acids. VII. Regioselective, mild acylation of 2-methylindole with di- and trialkoxycarbenium tetrafluoroborates. A simple procedure for deriving 3-acyl-2-methylindoles and 3-methoxycarbonyl-2-methylindole. And the article contained the following:

The regioselective acylation of 2-methylindole with RC+(OR1)2BF4- (R = H, Me, R1 = Et; R = Ph, R1 = Me; R = OMe, R1 = Me) gave indoles I [R2 = MeCOPhCO,CO2Me). The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Name: Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to methylindole acylation alkoxycarbenium tetrafluoroborate regiochem, indole acyl carboxy, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 31, 2013, Liu, Jin-Qiang; Chen, Xin-Zhi; Ji, Baoming; Zhao, Bang-Tun published an article.Application of 79815-20-6 The title of the article was Transformation of L-phenylalanine to (S)-indoline-2-carboxylic acid without group-protection. And the article contained the following:

(S)-Indoline-2-carboxylic acid was synthesized by use of a nitro amination approach with L-phenylalanine as chiral pool. The first step of the synthesis was nitration of L-phenylalanine, with urea nitrate (UN)/H2SO4 as nitrating reagent, to give 2,4-dinitro-L-phenylalanine in 75.7 % yield in one-pot synthesis and 69.1 % yield by step-wise nitration. Intramol. nitro amination of 2,4-dinitro-L-phenylalanine gave (S)-6-nitro-indoline-2-carboxylic acid in 65.7 % yield and more than 99.5 % enantiomeric excess (ee). The title compound, (S)-indoline-2-carboxylic acid, was obtained in 85.9 % yield and high ee by one-pot transformation of (S)-6-nitroindoline-2-carboxylic acid. The total synthesis consisted of three operations and gave the title compound in 42 % yield and more than 99.5 % ee. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application of 79815-20-6

The Article related to phenylalanine transformation indoline carboxylic acid preparation protection group free, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On February 4, 2016, Liu, Xiao-Guang; Li, Zi-Hao; Xie, Jian-Wei; Liu, Ping; Zhang, Jie; Dai, Bin published an article.Product Details of 65417-22-3 The title of the article was Copper-catalyzed synthesis of 2,3-disubstituted indoles from ortho-haloanilines and β-keto esters/β-diketone. And the article contained the following:

Tetrazole-1-acetic acid was identified as an efficient ligand to promote copper-catalyzed domino reaction of ortho-iodo/bromo-anilines RNH2 (R = 2-IC6H4, 2-I-5-H3CC6H3, 3-iodopyridin-2-yl, 2,4-Br2C6H3, etc.) with β-keto esters/β-diketone R1C(O)CH2C(O)R2 (R1 = CH3, (CH3)CH, C6H5, etc.; R2 = CH3, CH2CH3, OCH3, OCH2CH3) for 2,3-disubstituted indoles’ synthesis, e.g., I, with high yields under mild conditions. The protocol, with an easily-available catalytic system, shows good substrate tolerance towards various functional groups. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Product Details of 65417-22-3

The Article related to indole preparation, ortho haloaniline dicarbonyl compound domino reaction copper catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles