Day: November 2, 2022

On February 19, 2016, Qi, Zisong; Yu, Songjie; Li, Xingwei published an article.Reference of Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Rh(III)-Catalyzed Synthesis of N-Unprotected Indoles from Imidamides and Diazo Ketoesters via C-H Activation and C-C/C-N Bond Cleavage. And the article contained the following:

The synthesis of N-unprotected indoles has been realized via Rh(III)-catalyzed C-H activation/annulation of imidamides with α-diazo β-ketoesters. The reaction occurs with the release of an amide coproduct, which originates from both the imidamide and the diazo as a result of C=N cleavage of the imidamide and C-C(acyl) cleavage of the diazo. A rhodacyclic intermediate has been isolated and a plausible mechanism has been proposed. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Reference of Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to indole preparation, imidamide diazo ketoester cyclization rh catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On October 14, 2004, Tang, Peng Cho; Liang, Congxin; Miller, Todd; Lipson, Kenneth E. published a patent.Recommanded Product: 52537-00-5 The title of the patent was Preparation of 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors. And the patent contained the following:

The title compounds [I; R1 and R2 combine to form (un)substituted optionally fused heterocyclic ring; R3-R5 = H, alkyl, hydroxyalkyl, etc.; or R3 and R4 may combine to form a cyclic 6-membered alicyclic ring which may be substituted with one or more lower alkyl] that modulate the activity of protein kinases (“”PKs””) and are therefore useful in treating disorders related to abnormal PK activity (no biol. data), were prepared General method of synthesis of the compounds I by condensation of oxindoles and aldehydes (preparation of intermediates is given) is described. Eighty-two compounds I (e.g., II) were prepared Pharmaceutical compositions comprising the compounds I, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Recommanded Product: 52537-00-5

The Article related to indolinone sulfonamido preparation protein kinase inhibitor antitumor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On January 19, 1990, Tsuji, Yasushi; Kotachi, Shinji; Huh, Keun Tae; Watanabe, Yoshihisa published an article.Application of 52537-00-5 The title of the article was Ruthenium-catalyzed dehydrogenative N-heterocyclization. Indoles from 2-aminophenethyl alcohols and 2-nitrophenethyl alcohols. And the article contained the following:

Indole derivatives I (R = H, 6-Me, 5-MeO, 4-Cl, 6-Cl, 4-Br) were readily obtained from 2-aminophenethyl alcs. in the presence of 2 mol % of RuCl2(PPh3)3 under reflux in toluene. I(R = H) obtained from 2-aminophenethyl alc. quant. Other I were also obtained in 73-99% isolated yields. The 2-aminophenethyl alcs. were easily prepared by condensation between the corresponding 2-nitrotoluenes and aldehydes followed by reduction During the reaction, a stoichiometric amount of hydrogen was spontaneously evolved into the gas phase. With a heterogeneous and homogeneous binary catalyst system, indoles were afforded in one pot from 2-nitrophenethyl alcs. under a hydrogen atm. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Application of 52537-00-5

The Article related to indole, aminophenethyl alc dehydrogenation cyclization ruthenium catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On April 28, 2010, Guan, Zheng-Hui; Yan, Ze-Yi; Ren, Zhi-Hui; Liu, Xue-Yuan; Liang, Yong-Min published an article.Synthetic Route of 65417-22-3 The title of the article was Preparation of indoles via iron catalyzed direct oxidative coupling. And the article contained the following:

Iron-catalyzed aryl C-H and vinyl C-H bonds activation to give valuable substituted indole products, e.g. I, from 3-(phenylamino)but-2-enoates, e.g. II, was reported. The reaction shows high functional group tolerance. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Synthetic Route of 65417-22-3

The Article related to indole preparation, phenylaminobutenoate oxidative coupling iron catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Synthetic Route of 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On February 28, 2011, de Lange, Ben; Hyett, David J.; Maas, Peter J. D.; Mink, Daniel; van Assema, Friso B. J.; Sereinig, Natascha; de Vries, Andre H. M.; de Vries, Johannes G. published an article.Synthetic Route of 79815-20-6 The title of the article was Asymmetric Synthesis of (S)-2-Indolinecarboxylic Acid by Combining Biocatalysis and Homogeneous Catalysis. And the article contained the following:

The use of a combination of biocatalysis and homogeneous catalysis led to a very short synthesis route to enantiopure (S)-2-indolinecarboxylic acid. Thus, reacting 2-ClC6H4CHO with Ac2O/NaOAc gave 2-ClC6H4CH:CHCO2H in 55% yield. The latter compound was treated with phenylalanine ammonia lyase to give (S)-2-ClC6H4CH2CH(NH2)CO2H (I), that, upon addition of CuCl/H2O, produced 77% of the title compound Alternatively, treating 2-ClC6H4CH:CH(NHCOMe)CO2H with [Rh(cod)2]BF4/MonoPhos/H2CH2Cl2 gave the reduced compound which was then converted into I and taken on to the final compound as stated above. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Synthetic Route of 79815-20-6

The Article related to indolinecarboxylic acid asym synthesis biocatalysis homogeneous catalysis, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Synthetic Route of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Basolo, Luca; Bernasconi, Alice; Borsini, Elena; Broggini, Gianluigi; Beccalli, Egle M. published an article in 2011, the title of the article was Solvent-Free, Microwave-Assisted N-Arylation of Indolines by using Low Palladium Catalyst Loadings.Recommanded Product: 79815-20-6 And the article contains the following content:

A series of substituted N-arylindolines is prepared by a solvent-free, palladium-catalyzed procedure. The procedure requires only low loadings of catalyst, uses microwave irradiation, and starts from com. available substrates. The method proceeds in good yields and in short reaction times with aryl bromides, chlorides, and iodides, also on 2-substituted indolines. The combination of solvent-free methods with microwave heating will further increase in importance in the search for more environmentally acceptable synthesis methods. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Recommanded Product: 79815-20-6

The Article related to indoline aryl preparation aryl halide palladium phosphine catalyst microwave, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 15, 2011, Ali, Ashif Md.; Punniyamurthy, Tharmalingam published an article.Safety of Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Domino ligand-free copper-catalyzed synthesis of polysubstituted indoles. And the article contained the following:

The synthesis of polysubstituted indoles is described by the domino reaction of 2-haloanilines and 1,3-dicarbonyl compounds, 1,3-diketones, β-keto esters and β-keto amides, using copper catalysis under ligand-free conditions. The protocol provides a simple, general and atom economical process for the synthesis of substituted indoles at moderate temperature The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Safety of Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to indole preparation, haloaniline dicarbonyl compound cyclocondensation copper, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Safety of Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On June 30, 2006, Qian, Chao; Zhang, Jia-sen; Liu, Jian-qing; Li, Lu-zhen; Chen, Xin-zhi published an article.Reference of H-Idc-OH The title of the article was Study on the synthesis of S-(-)-2-Carboxyindoline. And the article contained the following:

A general synthetic route of S-(-)-2-carboxyindoline was proposed which started from o-nitrotoluene and di-Et oxalate, via condensation, nitro-group reduction, heterocyclic reduction and hydrolysis, 2-carboxyindoline was achieved with total yield of 40.6%. Especially, using 10% Pd-C as catalysts, the heterocycle is reduced easily with hydrogen at 160° and 6.2 MPa, the catalysts also can be reclaimed. Through steps of chlorination, esterification, fractional crystallization, and hydrolysis, the S-(-)-2-carboxyindoline was resolved with L-carnitine oxalate as the chiral resolution reagent. The titled product can be achieved with 32% yield and [α20589 = -27.5] (c = 1.0, DMSO). The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Reference of H-Idc-OH

The Article related to carboxyindoline preparation nitrotoluene chiral resolution carnitine oxalate, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Reference of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Shalygina, E. E.; Kobylinskii, D. V.; Ivanovskii, S. A.; Balakin, K. V.; Dorogov, M. V.; Toporova, T. A. published an article in 2004, the title of the article was Synthesis and properties of 1-acylindolinesulfonamides.COA of Formula: C12H12ClNO3S And the article contains the following content:

Title compounds I and II were prepared by N-acylation of indoline, bromination and chlorosulfonylation (or just chlorosulfonylation), and amidation. Several properties indicative of potential pharmacol. activities were determined The experimental process involved the reaction of 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride(cas: 879562-21-7).COA of Formula: C12H12ClNO3S

The Article related to combinatorial library acylindolinesulfonamide preparation pharmacol potential, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C12H12ClNO3S

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles