Day: November 3, 2022

On May 27, 2021, Jing, Peng; Guo, Qiang; Dou, Fei; Wan, Zehong; Hu, Zhijing published a patent.Name: 6-Chloro-2,3-dihydro-1H-indole The title of the patent was Fused heterocyclic derivative and application. And the patent contained the following:

The invention disclosed a kind of fused heterocyclic derivative, its preparation method and application for treating neuropsychiatric diseases. The claimed compound is shown in structure I (Z = O or S C2-8 chain or halo substituted C2-8 chain; A = II; R = heteroaryl; Q = N or CH; Y = O or S; R1,R2,R3 = H, halo, C1-6 alkyl, etc.; n1 = 1-3 integers). The claimed compound is prepared via multiple steps (procedure given). The prepared compound can be used for treating neuropsychiatric diseases such as schizophrenia, depression, anxiety, sleep disorders, neurodegenerative diseases, bipolar disorder, post-traumatic stress syndrome, addiction disorders, abstinence syndrome, or attention deficit. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Name: 6-Chloro-2,3-dihydro-1H-indole

The Article related to fused heterocyclic derivative preparation neuropsychiatric disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Name: 6-Chloro-2,3-dihydro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chen, Xiaohong; Zheng, Guangfan; Song, Guoyong; Li, Xingwei published an article in 2018, the title of the article was Rhodium(III)-Catalyzed Synthesis of Cinnolinium Salts from Azobenzenes and Diazo Compounds.Recommanded Product: 65417-22-3 And the article contains the following content:

A Rh(III)-catalyzed C-H activation of azobenzenes in the coupling with diazo compounds has been realized, providing a straightforward strategy to access functionalized cinnolinium triflates, e.g., I in high yields. This protocol features silver free mild reaction conditions and compatibility with diverse functional groups. The coupling proceeds via initial Rh(III)-catalyzed C-H alkylation, followed by zinc triflate-mediated cyclization, where zinc triflate acts as a Lewis acid as well as a triflate source. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Recommanded Product: 65417-22-3

The Article related to cinnolinium salt preparation, azobenzene diazo compound carbon hydrogen activation coupling rhodium catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Recommanded Product: 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On September 30, 1993, Guven, Alaattin; Jones, R. Alan published an article.Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Potentially tautomeric 1,2-dihydro-1-oxo-5H-pyridazino[4,5-b]indole and 3,4-dihydro-4-oxo-5H-pyridazino[4,5-b]indole. And the article contained the following:

The potentially tautomeric title compounds I and II were synthesized from Et 2-formylindole-3-carboxylate and hydrazine and from Et 3-formylindole-2-carboxylate and hydrazine, resp., and their tautomeric equilibrium confirmed by their electronic spectra and their acidity functions. Many related compounds were examined for their tautomeric equilibrium between hydroxyl and oxo groups. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to tautomerism dihydrooxopyridazinoindole, pyridazinoidole dihydrooxo tautomerism, electronic spectra dihydrooxopyridazinoindole, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On August 11, 2015, Yang, Shyh-Ming; Kuo, Gee-Hong; Gaul, Micheal D.; Rano, Thomas A. published a patent.COA of Formula: C8H8ClN The title of the patent was Substituted piperidinyl-pyridazinyl derivatives useful as scd 1 inhibitors. And the patent contained the following:

The present invention is directed to novel piperidinyl-pyridazinyl derivatives, pharmaceutical compositions containing them and their use as inhibitors of SCD1, useful in the treatment of obesity, type-II diabetes and other related metabolic disorders. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).COA of Formula: C8H8ClN

The Article related to piperidinyl pyridazinyl derivative preparation scd1 inhibitor, obesity type 2 diabetes treatment piperidinyl pyridazinyl derivative preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.COA of Formula: C8H8ClN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On June 13, 2013, Yang, Shyh-Ming; Kuo, Gee-Hong; Gaul, Micheal D.; Rano, Thomas A. published a patent.Recommanded Product: 52537-00-5 The title of the patent was Preparation of substituted piperidinyl-pyridazinyl derivatives as SCD1 inhibitors. And the patent contained the following:

The title compounds I [R1 = P1, P2, P3, etc.; wherein m = 0-3; R2 = halo, C1-4 alkyl, C1-4 alkoxy, etc.; R3 = Q1, Q2, Q3, etc.; wherein R4 = H, halo, C1-4 alkyl, etc.] or pharmaceutically acceptable salts thereof were prepared Compounds I are useful as Stearoyl-CoA desaturase 1 (SCD1) inhibitors for treatment of obesity, type 2 diabetes and other related metabolic disorders. For example, compound II was prepared in a multi-step synthesis and displayed IC50 of 0.12 μM against SCD1 in A431 cells. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Recommanded Product: 52537-00-5

The Article related to piperidinyl pyridazinyl derivative preparation scd1 inhibitor, obesity type 2 diabetes treatment piperidinyl pyridazinyl derivative preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Recommanded Product: 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles