Day: November 7, 2022

On March 4, 2021, Dabora, Rebecca; Dingley, Amy; Patel, Suman; Swiss, Gerald F. published a patent.HPLC of Formula: 130539-43-4 The title of the patent was Tetanus toxoid and other antimicrobial vaccine compositions providing natural immunity against microbes with N-acetyl-β-(1->6)-glucosamine in cell wall. And the patent contained the following:

This invention is directed to antimicrobial vaccine compounds and compositions comprising oligosaccharide β-(1→6)- glucosamine groups having from 3 to 12 glucosamine units linked through a linker group to tetanus toxoid wherein the toxoid is primarily in its monomeric form. This invention is also directed to vaccine compositions that provide natural immunity against microbes possessing a cell wall structure that comprises oligosaccharide N-acetyl-β-(1→6)-glucosamine (PNAG) structures. The experimental process involved the reaction of Ethyl 2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-thio-beta-D-glucopyranoside(cas: 130539-43-4).HPLC of Formula: 130539-43-4

The Article related to antimicrobial vaccine cell wall beta glucosamine antigen oligosaccharide, tetanus toxoid vaccine oligosaccharide beta glucsosamine, Immunochemistry: Adjuvants, Antigens, Haptens, and Vaccines and other aspects.HPLC of Formula: 130539-43-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Hsu, Shih-Fan; Ko, Chih-Wei; Wu, Yao-Ting published an article in 2011, the title of the article was Cobalt-Catalyzed Carbon-Carbon Bond Formation: Synthesis and Applications of Enantiopure Pyrrolidine Derivatives[1] [Erratum to document cited in CA155:241131].COA of Formula: C9H9NO2 And the article contains the following content:

On page 1762, stereochem. was omitted from Reference 27; the correction is given. The graphical abstracted contained a capitalization error; the corrected abstract is given. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).COA of Formula: C9H9NO2

The Article related to erratum pyrrolidine enantiopure preparation cross coupling cobalt catalyzed, tylophorine synthesis cross coupling cobalt catalyzed erratum, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.COA of Formula: C9H9NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Jiang, Xue; Wang, Chao; Wei, Yawen; Xue, Dong; Liu, Zhaotie; Xiao, Jianliang published an article in 2014, the title of the article was A General Method for N-Methylation of Amines and Nitro Compounds with Dimethylsulfoxide.SDS of cas: 52537-00-5 And the article contains the following content:

DMSO reacts with a broad range of amines in the presence of formic acid, providing a novel, green and practical method for amine methylation. The protocol also allows the one-pot transformation of aromatic nitro compounds into di-Me amines in the presence of a simple iron catalyst. A mechanistic study indicated that the synthesis of the target compounds was achieved by a methylene group transfer from DMSO to an amine, formation of an imine intermediate and subsequent reduction of this imine by formic acid. A reaction of 2-[2-(1,3-benzodioxolyl)ethyl]-1,2,3,4-tetrahydroquinoline with DMSO/HCO2H gave 2-[2-(1,3-benzodioxolyl)ethyl]-1,2,3,4-tetrahydro-1-(methyl)quinoline (allocuspareine, galipinine). The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).SDS of cas: 52537-00-5

The Article related to methylation alkylation amine dmso, secondary primary amine nitrobenzene methylation dmso formic acid, dmso, amines, deuterium labelling, formic acid, methylation, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.SDS of cas: 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On November 1, 2006, Baran, Phil S.; Shenvi, Ryan A. published an article.Application of 152213-63-3 The title of the article was Total Synthesis of (±)-Chartelline C. And the article contained the following:

The first total synthesis of (±)-chartelline C (I) in a concise 10-step sequence is reported. Highlights of the completion of this decades-old puzzle include (1) chemo- and position-selective installation of the heteroaromatic halogens, (2) halogen-sparing monoredn. of an alkyne linker, (3) a simple strategy for placement of the sensitive β-chloroenamide, (4) an unusually facile thermolysis of a vinyl carboxylic acid, and (5) a powerful ring contraction whose potential utility in heterocyclic chem. merits further investigation. The experimental process involved the reaction of Methyl 2-(6-bromo-1H-indol-3-yl)acetate(cas: 152213-63-3).Application of 152213-63-3

The Article related to chartelline c total synthesis, Alkaloids: Alkaloids Containing Three Or More Nitrogen Atoms and other aspects.Application of 152213-63-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On May 20, 2021, Li, Jinping; Lou, Jun; Guo, Xiaodan; Zeng, Xian; Chen, Yongkai; Zhang, Yihan; Peng, Wei; Wang, Chaodong published a patent.Recommanded Product: 6-Chloro-2,3-dihydro-1H-indole The title of the patent was Preparation of the rock inhibitor and their medical applications. And the patent contained the following:

The invention is related to the preparation of the rock inhibitor I and their medical applications. The invention compounds I, wherein W and V are independently C or N;X is -C (=0) NRx-, -NRx-C (=O); Y is a chem. bond, or unsubstituted or optionally substituted by one, two or more Ry groups, etc.; ring A is unsubstituted or optionally substituted with one, etc.; ring B is unsubstituted or optionally substituted by one, etc.; ring C is unsubstituted or optionally substituted by one, two or more Rc groups as follows: C3_20 alicyclic hydrocarbon group, 3-20 no heterocyclic group, C6-20 aryl or 5-20 membered heteroaryl; ring D is the following group unsubstituted or optionally substituted by one, two or more Rd: C3_20 alicyclic hydrocarbon group, 3-20 membered heterocyclic group,C6_2() aryl or 5-20 membered heteroaryl; Ry, Rab, Rc, Rd are each independently selected from H, halogen, nitro, nitroso, etc.; and their racemates, stereoisomers, tautomers, isotopic markers, nitrogen oxides, solvates, polymorphs, metabolites, esters, pharmaceutically acceptable salts, or prodrugs are claimed. Compound I was prepared by multi-step procedure (procedure given). The invention compounds I were evaluated for their ROCK inhibitory activity. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Recommanded Product: 6-Chloro-2,3-dihydro-1H-indole

The Article related to preparation rock inhibitor medical application, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Recommanded Product: 6-Chloro-2,3-dihydro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On November 29, 2007, Teegarden, Bradley; Chapman, Dennis; Choi, Juyi; Feichtinger, Konrad; Han, Sangdon; Jayakumar, Honnappa; Tran, Thuy-Anh; Xu, Jingdong; Zou, Ning published a patent.Related Products of 52537-00-5 The title of the patent was Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto and their preparation. And the patent contained the following:

The present invention pertains to certain compounds of formula I and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggregation, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy hypertension and pain. The invention also relates to the methods for the treatment of 5-HT2A serotonin receptor associated disorders in combination with other pharmaceutical agents administered sep. or together. Compounds of formula I wherein X is O and S; V is O and NH; W and Z are independently (un)substituted C1-4 alkylene; R1 is H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-7 cycloalkyl; R2 is H, C1-6 acyl, C1-6 acyloxy, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl, etc.; R3 is H, C2-6 alkenyl, C1-6 alkyl, C1-6 alkylcarboxamide, C2-6 alkynyl, carboxamide, CN, etc.; R4a is H, R4b is H, (un)substituted C1-12 acyl, (un)substituted carbo-C1-6 alkoxy, (un)substituted CO2-aryl, etc.; R5, R6 and R7 are independently H, C1-6 acyl, C1-6 acyloxy, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl, etc.; R8 is (un)substituted C1-8 alkyl, (un)substituted (hetero)aryl, (un)substituted C3-10 cycloalkyl and (un)substituted heterocyclyl; and their pharmaceutically acceptable salts, hydrates, and solvates thereof, are claimed. Example compound II•TFA was prepared by a general procedure (procedure given). All the invention compounds were evaluated for their 5-HT2A modulatory activity (some data given). The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Related Products of 52537-00-5

The Article related to primary amine preparation 5ht2a serotonin receptor modulator treatment disease, pyrazolylphenyl amine preparation 5ht2a serotonin receptor modulator treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Related Products of 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 18, 2022, Tran, Duc N.; Zhdanko, Alexander; Barroso, Santiago; Nieste, Patrick; Rahmani, Ramdane; Holan, Jan; Hoefnagels, Roel; Reniers, Peter; Vermoortele, Frederik; Duguid, Stewart; Cazanave, Lionel; Figlus, Marek; Muir, Colin; Elliott, Alain; Zhao, Peichao; Paden, Warren; Diaz, Cristina Hernandez; Bell, Stephen J.; Hashimoto, Akihiro; Phadke, Avinash; Wiles, Jason A.; Vogels, Ilse; Farina, Vittorio published an article.Electric Literature of 79815-20-6 The title of the article was Development of a Commercial Process for Odalasvir. And the article contained the following:

Odalasvir is a selective inhibitor of hepatitis C virus NS5A protein, a key target for combination therapies. This paper described the chem. process development for the synthesis of this API and the improvements that were achieved over the medicinal chem. Optimization of all the reaction conditions and crystallizations resulted in higher throughput and a highly improved process mass intensity (PMI). The process was robust and it was scaled up to ∼100 kg batches without issues. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Electric Literature of 79815-20-6

The Article related to odalasvir preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Electric Literature of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On December 31, 2019, Li, Jie; Yao, Jiaqi; He, Weiping; Yang, Fan; Liu, Xiaoming published an article.Safety of H-Idc-OH The title of the article was Modular Synthesis of New Bicyclic Carbene Precursors. And the article contained the following:

A series of new N-heterocyclic carbene (NHC) precursors, containing bicyclic pyrrolo[1,2-c]imidazole framework, were prepared from N-(tert-butoxycarbonyl)-L-proline (1-Boc-L-proline). The sequential attachment of nitrogen nucleophiles and subsequent ring closure gave the desired bicyclic NHC precursors in good yields. The structures of these new NHC precursors were determined on the basis of spectroscopic techniques, including NMR and MS. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Safety of H-Idc-OH

The Article related to bicyclic pyrroloimidazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Safety of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On June 19, 2020, Karjee, Pallab; Sarkar, Tanumay; Kar, Subhradeep; Punniyamurthy, Tharmalingam published an article.Application of 52537-00-5 The title of the article was Transition-Metal-Free Stereospecific Oxidative Annulative Coupling of Indolines with Aziridines. And the article contained the following:

Tandem C-N bond formation for the oxidative annulation of indolines with aziridines is accomplished employing the combination of DDQ and NaOCl at ambient conditions. Optically active aziridine can be coupled with high enantiomeric purity (>99% ee). The substrate scope, stereocontrol with the enantioenriched substrate, and scale-up are the important practical advantages. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Application of 52537-00-5

The Article related to stereospecific oxidative annulative coupling indoline aziridine, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application of 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 7, 2019, Goergler, Annick; Norcross, Roger; Dey, Fabian; Kusznir, Eric Andre published a patent.COA of Formula: C8H8ClN The title of the patent was Dihydrobenzimidazolones as anticancer agents and their preparation. And the patent contained the following:

The invention provides compounds of formula I which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. Compounds of formula I are thus useful for the treatment of various cancers. Compounds of formula I wherein X1 and X2 are independently H, and C1-6 alkyl; W1, W2 and W3 are independently CH and N, provided that if one of W1 – W3 is N, then the other two are CH; Z is absent, (CH2)1-3, (CH2)0-2O(CH2)0-2, etc.; A is (un)substituted aryl, (un)substituted heteroaryl, (un)substituted heterocyclyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by amination of 4-fluoro-N-methyl-3-nitrobenzamide with 5-amino-1H-benzo[d]imidazol-2(3H)-one; the resulting N-methyl-3-nitro-4-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)amino)benzamide underwent hydrogenation to give compound II. The invention compounds were evaluated for their CRBN binding affinity. From the assay, it was determined that compound II exhibited Kd value of 0.587 μM. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).COA of Formula: C8H8ClN

The Article related to dihydrobenzimidazolone preparation anticancer crbn protein degradation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.COA of Formula: C8H8ClN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles