Day: November 8, 2022

Jiang, Hua-Jie; Zhong, Xiu-Mei; Yu, Jie; Zhang, Ying; Zhang, Xinhao; Wu, Yun-Dong; Gong, Liu-Zhu published an article in 2019, the title of the article was Assembling a Hybrid Pd Catalyst from a Chiral Anionic CoIII Complex and Ligand for Asymmetric C(sp3)-H Functionalization.HPLC of Formula: 52537-00-5 And the article contains the following content:

An unusual hybrid palladium catalyst containing an anionic chiral CoIII complex and a chiral phosphoramidite ligand shows a high capacity for catalyzing asym. thioamide-directed C(sp3)-H arylation and delivers excellent yield and enantioselectivity (up to 99% yield, 99% ee). Significant synergy between the chiral ligand and the anion in terms of stereochem. control was observed Mechanistic studies revealed both the nature of the C-H activation and the origin of the enantioselectivity. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).HPLC of Formula: 52537-00-5

The Article related to palladium catalyst chiral ligand asym functionalization arylation, c−h functionalization, chiral phosphoramidites, cobalt, palladium, synergistic effects, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On August 18, 2016, Albrecht, Brian K.; Gehling, Victor C.; Harmange, Jean-Christophe; Vaswani, Rishi G. published a patent.Category: indole-building-block The title of the patent was Preparation of substituted indolecarboxamides as modulators of methyl modifying enzymes. And the patent contained the following:

The title compounds I [R1 = alkyl, alkoxy, or OCHF2; R2 = H, Me, Et, thiazolyl, etc.; R3, R31, R4, R41 = H, CF3, Me, Et, etc. (provided that at least one of R3, R31, R4 and R41 is not H); or R3 and R4 or R31 and R41 are taken together form a Ph or cyclohexyl ring], useful for treating a variety of diseases, disorders or conditions associated with Me modifying enzymes, notably EZH1 and EZH2, were prepared E.g., a multi-step synthesis of II, starting from Me 2-methyl-1-[1-(1-methyl-2-oxopiperidin-4- yl)ethyl]-1H-indole-3-carboxylate, was described. Exemplified compounds I were tested for their EZH2 activity (data given). Also provided are pharmaceutical compositions comprising compounds I, pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with Me modifying enzymes, such as cancer. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Category: indole-building-block

The Article related to indolecarboxamide pyridinylmethyl preparation modulator methyl modifying enzyme ezh1 ezh2, antitumor indolecarboxamide pyridinylmethyl preparation ezh1 ezh2 modulator, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On July 31, 2018, Kumar, Nadavala Siva; Sreenivasulu, Vudagandla; Ramachandra, Bondigalla; Asif, Mohammad; Ibrahim, Ahmed A. published an article.Application of 79815-20-6 The title of the article was A stability-indicating LC-MS method for determination of perindopril and its process related impurities. And the article contained the following:

Perindopril erbumine belongs to the member of angiotensin-converting enzyme inhibitors group used in the treatment of heart failure and hypertension. Asimple and highly sensitive LC-MS method has been developed for the simultaneous determination of three process-related impurities (L-norvaline, L-norvaline Et ester HCl, and (S)-indoline-2-carboxylic acid) in perindopril. Samples were separated using 5 mM ammonium formate (A) and acetonitrile/methanol (B) as the mobile phase on a Symmetry C18 column (75 mm × 4.6 mm, 3.5 μm) using gradient elution mode at a flow rate of 0.6 mL/min. The proposed method was validated as per ICH guidelines and can be used for quality testing of perindopril and determining its process-related impurities in pharmaceuticals. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application of 79815-20-6

The Article related to perindopril impurity analysis lc ms stability, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Application of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles