Day: November 16, 2022

Zhang, Weijie published the artcileVisible Light-Driven C-3 Functionalization of Indoles over Conjugated Microporous Polymers, Name: 4-(Benzyloxy)-1-methyl-1H-indole, the main research area is visible light conjugated microporous polymer formylation thiocyanation catalyst; green indole.

Metal-free and heterogeneous organic photocatalysts provide an environmentally friendly alternative to traditional metal-based catalysts. This paper reports a series of carbazole-based conjugated microporous polymers (CMPs) with tunable redox potentials and explores their photocatalytic performance with regard to C-3 formylation and thiocyanation of indoles. Conjugated polymers were synthesized through FeCl3 mediated Friedel-Crafts reactions, and their redox potentials were well regulated by simply altering the nature of the core (i.e., 1,4-dibenzyl, 1,3,5-tribenzyl, or 1,3,5-triazin-2,4,6-triyl). The resulting CMPs exhibited high surface areas, visible light absorptions and tunable semiconductor-range band gaps. With the highest oxidative capability, CMP-CSU6 derived from 1,3,5-tri(9H-carbazol-9-yl)benzene showed the highest efficiency for C-3 formylation and thiocyanation of indoles at room temperature Notably, the as-made catalysts can be easily recovered with good retention of photocatalytic activity and reused at least five times, suggesting good recyclability. These results are significant for constructing high-performance porous polymer catalysts with tunable photoredox potentials targeting an efficient material design for catalysis.

ACS Catalysis published new progress about Cyanation catalysts, thiocyanation. 13523-93-8 belongs to class indole-building-block, name is 4-(Benzyloxy)-1-methyl-1H-indole, and the molecular formula is C16H15NO, Name: 4-(Benzyloxy)-1-methyl-1H-indole.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Qi, Liang-Wen published the artcileOrganocatalytic asymmetric arylation of indoles enabled by azo groups, Recommanded Product: 2-(tert-Butyl)-5-chloro-1H-indole, the main research area is organocatalytic asym arylation indole azo directing activating group; nucleophilic aromatic substitution asym organocatalytic; pyrroloindole preparation asym arylation azo directing activating group; arylindole preparation asym arylation azo directing activating group.

Arylation is a fundamental reaction that can be mostly fulfilled by electrophilic aromatic substitution and transition-metal-catalyzed aryl functionalization. Although the azo group has been used as a directing group for many transformations via transition-metal-catalyzed aryl carbon-hydrogen (C-H) bond activation, there remain significant unmet challenges in organocatalytic arylation. Here, we show that the azo group can effectively act as both a directing and activating group for organocatalytic asym. arylation of indoles via formal nucleophilic aromatic substitution of azobenzene derivatives Thus, a wide range of axially chiral arylindoles, e.g., I and II, have been achieved in good yields with excellent enantioselectivities by utilizing chiral phosphoric acid as catalyst. Furthermore, highly enantioenriched pyrroloindoles, e.g., III, bearing two contiguous quaternary chiral centers, have also been obtained via a cascade enantioselective formal nucleophilic aromatic substitution-cyclization process. This strategy should be useful in other related research fields and will open new avenues for organocatalytic asym. aryl functionalization.

Nature Chemistry published new progress about Arylation catalysts, stereoselective. 69622-40-8 belongs to class indole-building-block, name is 2-(tert-Butyl)-5-chloro-1H-indole, and the molecular formula is C12H14ClN, Recommanded Product: 2-(tert-Butyl)-5-chloro-1H-indole.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Xiong, Dan published the artcileRhodium-Catalyzed Mild C7-Amination of Indolines with Nitrosobenzenes, COA of Formula: C8H8ClN, the main research area is pyrimidinyl indoline nitrosobenzene rhodium catalyst regioselective amination reaction; phenylamino indolinone preparation green chem crystal structure.

A mild and practical Rh(III)-catalyzed C7-H amination of indolines were described, which allows the synthesis of a variety of 7-amino-substituted indolines with good functional group tolerance and high atom economy. Notably, nitrosobenzenes served as nitrogen source in this transformation, and therefore behave environmentally friendly for C-N bond constructions.

ChemistrySelect published new progress about Amination catalysts (regioselective). 41910-64-9 belongs to class indole-building-block, name is 4-Chloroindoline, and the molecular formula is C8H8ClN, COA of Formula: C8H8ClN.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Yang, Xiao-Hui published the artcileIntermolecular Hydroamination of 1,3-Dienes To Generate Homoallylic Amines, Name: 4-Chloroindoline, the main research area is rhodium catalyzed intermol hydroamination diene Bronsted acid BINAP effect; homoallylic amine preparation anti Markovnikov selectivity.

Authors report a Rh-catalyzed hydroamination of 1,3-dienes to generate homoallylic amines. The work show-cases the first case of anti-Markovnikov selectivity in the intermol. coupling of amines and 1,3-dienes. By tuning the ligand properties and Bronsted acid additive, it was found that a combination of rac-BINAP and mandelic acid is critical for achieving anti-Markovnikov selectivity.

Journal of the American Chemical Society published new progress about Addition reaction (anti-Markovnikov). 41910-64-9 belongs to class indole-building-block, name is 4-Chloroindoline, and the molecular formula is C8H8ClN, Name: 4-Chloroindoline.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles