Month: November 2022

Bakke, Jan published an article in 1974, the title of the article was New syntheses of substituted indoles.Application of 52537-00-5 And the article contains the following content:

The indoles I (R = H, 4-Cl, 6-Cl, 4-NH2) were prepd by cyclizing RC6H3(CH2CH2Cl)(NO2)-1,2 (R = H, 6-Cl, 4-Cl, 6-O2N) with Fe and dehydration of the resulting dehydroindole with Pd/C. o-O2NC6H4Me was condensed with PhCHO to give o-O2NC6H4CH2(O)HPh which was oxidized with concentrated HNO3 and the product cyclized by catalytic reduction to give 2-phenylindole. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Application of 52537-00-5

The Article related to indole chloro phenyl, phenethyl chloride nitro cyclization, cyclization nitrophenethyl chloride, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On September 18, 2003, Albaugh, Pamela Ann; Ammenn, Jochen; Burkholder, Timothy Paul; Clayton, Joshua Ryan; Conner, Scott Eugene; Cunningham, Brian Eugene; Engler, Thomas Albert; Furness, Kelly Wayne; Henry, James Robert; Li, Yihong; Malhotra, Sushant; Tebbe, Mark Joseph; Zhu, Guoxin published a patent.SDS of cas: 52537-00-5 The title of the patent was Preparation of 3-(indol-3-yl) 4-heteroaryl substituted pyrrole-2,5-diones as GSK-3β inhibitors. And the patent contained the following:

The title compounds [I; Ar = (un)substituted benzofuryl, indolyl, quinolinyl, etc.; R1 = H, alkoxy, halo, etc.; R2 = H, alkyl, (un)substituted piperidin-4(or 3)-yl, etc.; R3 = H, halo, alkyl, cyclopropyl; or R2 and R3 taken together = CH2CH2CH(CH2OH)CH2; R4, R5 = H, halo], useful for treating GSK-3β mediated diseases such as diabetes and Alzheimer’s disease, were prepared Thus, reacting 2-[1-(3-hydroxypropyl)-1H-indol-3-yl]acetamide with Me (1-methyl-1H-indol-4-yl)oxoacetate in the presence of tert-BuOK in DMF afforded 54% I [Ar = 1-methyl-1H-indol-4-yl; R1, R3-R5 = H; R2 = 3-hydroxypropyl] which showed IC50 of 0.1757 μM against GSK-3β. Pharmaceutical composition comprising the compound I was claimed. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).SDS of cas: 52537-00-5

The Article related to indolyl heteroaryl pyrroledione preparation gsk3beta inhibitor antidiabetic alzheimer’s disease, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.SDS of cas: 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On December 10, 2020, Vu, Cuong M.; Le, Khoa B.; Vo, Uyen N.; Van, Vy D. T.; Nguyen, Anh T.; Phan, Nam T. S.; Le, Nhan T. H.; Nguyen, Tung T. published an article.COA of Formula: C11H11NO2 The title of the article was Recyclable CuFe2O4 for the synthesis of 2,3-disubstituted indoles. And the article contained the following:

A method for the CuFe2O4-catalyzed coupling of 2-iodo- or 2-bromoanilines 2-X-RC6H3NH2 (R = H, 4-trifluoromethoxy, 5-trifluoromethyl, etc.; X = I or Br) and acetylacetone or isosteric 1,3-diketones R1C(O)CH2C(O)R2 (R1 = Me, ethyl; R2 = ethoxy, methoxy) to afford 2,3-disubstituted indoles I (R3 = H, 5-bromo, 6-Me, etc.) has been developed. The superparamagnetic material showed superior activity in comparison to other ferrites or copper-based metal-organic frameworks. Functionalities including ester, cyano, and halogen groups were compatible with the reaction conditions. The CuFe2O4 catalyst was easily recoverable and reusable and offers a convenient pathway to afford synthetically useful heterocycles. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).COA of Formula: C11H11NO2

The Article related to indole preparation, haloaniline diketone heterocyclization copper ferrite nanocatalyst recycling, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C11H11NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On June 6, 2002, Dugar, Sundeep; Mavunkel, Babu J.; Luedtke, Gregory R.; Mcenroe, Glen published a patent.Formula: C9H6ClNO2 The title of the patent was Preparation of indolecarboxamides as p38-α inhibitors. And the patent contained the following:

Title compounds were prepared as p38-α inhibitors (no data). Thus, 6-chloro-1-methyl-1H-indole-5-carboxylic acid was amidated by (R)-3-aminomethyl-1-benzylpyrrolidine followed by acylation and amidation to give title compound I. The experimental process involved the reaction of 6-Chloro-1H-indole-5-carboxylic acid(cas: 256935-86-1).Formula: C9H6ClNO2

The Article related to indolecarboxamide preparation p38alpha inhibitor, antiinflammatory indolecarboxamide preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C9H6ClNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wang, Zechao; Yin, Zhiping; Wu, Xiao-Feng published an article in 2018, the title of the article was Copper-catalyzed carbonylative transformations of indoles with hexaketocyclohexane.Quality Control of Methyl 2-methyl-1H-indole-3-carboxylate And the article contains the following content:

With hexaketocyclohexane octahydrate as the carbon monoxide source, a novel procedure for copper-catalyzed direct double carbonylation of indoles was established. Using alcs. as reaction partners, moderate to good yields of the desired double carbonylation products were obtained. Wide functional group tolerance and substrate scope was observed The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Quality Control of Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to indole hexaketocyclohexane alc copper catalyst alkoxycarbonylation, indolyl oxoacetate preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On May 8, 2008, Tanimori, Shinji; Kirihata, Mitsunori published a patent.Name: Methyl 2-methyl-1H-indole-3-carboxylate The title of the patent was Preparation of indole compounds by cyclocondensation of haloanilines. And the patent contained the following:

Title compounds I [R1 = (un)substituted alkyl, cycloalkyl, heterocyclyl, alkynyl, alkoxy, aryl ether group, cyano, carboxyl, carbamoyl, etc.; R2 electron-withdrawing group; R3 = H, any group given for R2; n = 0-4], useful as intermediates for drugs, agrochems., electronic materials, etc., are prepared by reacting haloanilines II (R3, n = same as above; Hr = halo) with R1COCH2R2 (R1, R2 = same as above) in the presence of catalysts. Thus, Me 3-oxo-4-chlorobutanoate was added dropwise to a mixture of NaH and DMSO and the reaction mixture was treated with 2-IC6H4NH2, CuI, and L-proline at room temperature for 5 h to give 23% Me 2-chloromethyl-1H-indole-3-carboxylate. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Name: Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to indole compound preparation, haloaniline cyclocondensation oxochlorobutanoate cuprous iodide catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On January 18, 2013, Nguyen, Huy H.; Kurth, Mark J. published an article.Reference of Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling. And the article contained the following:

A variety of N-aryl β-nitroenamines were effectively transformed into 3-nitroindoles in good yields and with complete regioselectivity via a rapid microwave (μW) assisted intramol. arene-alkene coupling reaction. This report further demonstrates the versatility of this method by constructing 3-carboalkoxy- and 3-cyanoindoles. Optimization data, substrate scope, and applications are discussed. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Reference of Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to indole derivative preparation, aryl enamine preparation intramol coupling reaction palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Qiu, Youai; Ma, Dengke; Kong, Wangqing; Fu, Chunling; Ma, Shengming published an article in 2014, the title of the article was Regiocontrolled 1,2-migration in cyclization of 1-(indol-2-yl)-3-alkyn-1-ols: (Ph3P)Au+ vs. PtCl4.Related Products of 883526-76-9 And the article contains the following content:

A simple and efficient AuCl(PPh3)/AgBF4- and PtCl4-catalyzed reaction of 1-(indol-2-yl)-3-alkyn-1-ols I [R1 = R2 = R4 = CH3, R3 = Bu; R1 = Et, R2 = R4 = Me, R3 = Bu; R1 = allyl, R2 = H, R3 = Bu, R4 = Me; etc.] occurred smoothly in toluene to form a series of differently polysubstituted carbazole derivatives II. The regioselectivity of the 1,2-migration may be tuned by using different metal catalysts: carbazoles II could be obtained exclusively in the presence of AuCl(PPh3)/AgBF4 via a Wagner-Meerwein type 1,2-alkyl shift, whereas in some cases the use of PtCl4 afforded differently substituted carbazoles III involving a platinum-carbene intermediate. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Related Products of 883526-76-9

The Article related to carbazole regioselective preparation, alkynol indole wagner meerwein cyclization gold silver catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 883526-76-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 3, 2017, Sayyad, Masthanvali; Wani, Imtiyaz Ahmad; Babu, Raja; Nanaji, Yerramsetti; Ghorai, Manas K. published an article.Reference of 1,5-Dimethyl-1H-indole-2-carbaldehyde The title of the article was A Synthetic Route to Chiral 1,4-Disubstituted Tetrahydro-β-Carbolines via Domino Ring-Opening Cyclization of Activated Aziridines with 2-Vinylindoles. And the article contained the following:

A simple and efficient strategy for the synthesis of various 1,4-disubstituted tetrahydro-β-carbolines with excellent stereoselectivity (de, ee up to >99%) via domino ring opening cyclization (DROC) of activated aziridines with 2-vinylindoles is described. The reaction proceeds through LiClO4-catalyzed Friedel-Crafts-type alkylation of 2-vinylindoles with activated aziridines followed by an intramol. aza-Michael reaction in a domino fashion. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Reference of 1,5-Dimethyl-1H-indole-2-carbaldehyde

The Article related to carboline tetrahydro stereoselective synthesis, domino ring opening cyclization aziridine indole vinyl, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of 1,5-Dimethyl-1H-indole-2-carbaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Lafzi, Ferruh; Kilic, Haydar; Tanriver, Gamze; Avci, Oykum Naz; Catak, Saron; Saracoglu, Nurullah published an article in 2019, the title of the article was Design and synthesis of novel indoline-(thio)urea hybrids.Recommanded Product: H-Idc-OH And the article contains the following content:

A series of novel indoline-(thio)ureas e.g., (S)-2-(aminomethyl)-N-((S)-1-phenylethyl)indoline-1-carbothioamide was designed and prepared using indoline(s) e.g., (S)-2-(azidomethyl)indoline as a new platform and tested as organocatalysts in the Michael and Morita-Baylis-Hillman reactions. Most of the compounds were found to be very active catalysts although they did not promote the enantioselectivity. As agents for the conversion of thiocarbonyl compounds into carbonyl compounds, potentials of PIFA and DDQ were also displayed. Furthermore, DFT calculations rationalized the exptl. observed non-enantioselectivity of the catalysts. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Recommanded Product: H-Idc-OH

The Article related to thiourea indoline preparation enantioselective dft, indoline michael morita baylis hillman organocatalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles