Month: November 2022

On May 6, 2022, Maji, Milan; Borthakur, Ishani; Srivastava, Sameer; Kundu, Sabuj published an article.Electric Literature of 52537-00-5 The title of the article was Regio-Selective C3- and N-Alkylation of Indolines in Water under Air Using Alcohols. And the article contained the following:

Authors disclosed a regio-selective C-H and N-H bond functionalization of indolines using alcs. in water via tandem dehydrogenation of N-heterocycles and alcs. A diverse range of N- and C3-alkylated indolines/indoles were accessed utilizing a new cooperative iridium catalyst. The practical applicability of this methodol. was demonstrated by the preparative-scale synthesis and synthesis of a psychoactive drug, N,N-dimethyltryptamine. A catalytic cycle is proposed based on several kinetic experiments and a series of control experiments and d. functional theory calculations The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Electric Literature of 52537-00-5

The Article related to indoline regioselective functionalization alc water iridium complex, heterocycle alc dehydrogenation tandem, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Electric Literature of 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On May 31, 2007, Kerns, Jeffrey K.; Busch-Petersen, Jakob; Li, Huijie; Boehm, Jeffrey Charles; Nie, Hong; Taggart, John J. published a patent.Application of 860624-88-0 The title of the patent was Preparation of indolecarboxamide derivatives as inhibitors of kinase activity. And the patent contained the following:

The title compounds with general formula I [wherein X = O, S, S(O), S(O)2, etc,; R1 = H, (un)substituted alkyl, haloalkyl, heterocycloalkyl, etc.; R2 = (un)substituted alkyl, aryl, cycloalkyl, etc.; R3 = independently OH, oxo, alkyl, or haloalkyl; m = 1-3] or pharmaceutically acceptable salts thereof were prepared for the treatment of disorders associated with inappropriate IKK2 activities. In particular, I can be used for the treatment and prevention of inflammatory and tissue repair disorders, including rheumatoid arthritis, asthma, and COPD. For example, compound II was prepared in a multi-step synthesis. II exhibited IKK2 inhibitory activity with pIC50 value of 4.6 in IKK2 assay. The experimental process involved the reaction of Methyl 5-bromoindoline-7-carboxylate(cas: 860624-88-0).Application of 860624-88-0

The Article related to preparation indolecarboxamide inhibitor kinase activity, treatment inflammatory tissue repair disorder human, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 860624-88-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On January 1, 2008, Sayago, Francisco J.; Isabel Calaza, M.; Jimenez, Ana I.; Cativiela, Carlos published an article.Application In Synthesis of H-Idc-OH The title of the article was Versatile methodology for the synthesis and α-functionalization of (2R,3aS,7aS)-octahydroindole-2-carboxylic acid. And the article contained the following:

An improved strategy for the effective synthesis of enantiomerically pure (2R,3aS,7aS)-octahydroindole-2-carboxylic acid, based on the formation of a trichloromethyloxazolidinone derivative, has been developed. Addnl., the completely diastereoselective α-alkylation of such oxazolidinone provides a very convenient and concise route to enantiopure α-tetrasubstituted derivatives of this stereoisomer of octahydroindole-2-carboxylic acid. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application In Synthesis of H-Idc-OH

The Article related to indolecarboxylic octahydro alkylated asym synthesis, indolooxazolidinone preparation stereoselective alkylation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application In Synthesis of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On October 1, 2021, Faltracco, Matteo; Damian, Matteo; Ruijter, Eelco published an article.Category: indole-building-block The title of the article was Synthesis of Carbazoles and Dihydrocarbazoles by a Divergent Cascade Reaction of Donor-Acceptor Cyclopropanes. And the article contained the following:

An alkylation/olefination cascade of indolecarboxaldehydes and phosphonate-functionalized donor-acceptor cyclopropanes affords functionalized dihydrocarbazoles and cyclohepta[cd]indoles in formal [3 + 3] and [4 + 3]-cycloadditions A minor modification to the reaction conditions also allowed access to the fully aromatic heterocyclic scaffolds by thermal loss of an electron-rich aryl moiety. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Category: indole-building-block

The Article related to indolecarboxaldehyde cyclopropane scandium catalyst tandem cycloaddition, carbazole dihydrocarbazole preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chen, Cong; Jiao, Hongjian; Chen, Di; Tang, Tao; Xu, Ze-Feng; Duan, Shengguo; Li, Chuan-Ying published an article in 2022, the title of the article was Access to tetrahydrocarbazoles and pyrrolo[3,4-b]carbazoles through sequential reactions of triazoles and indoles.Application In Synthesis of 1,5-Dimethyl-1H-indole-2-carbaldehyde And the article contains the following content:

Tetrahydrocarbazoles I (R = H, Me; R1 = H, OMe, F, Cl, etc.; R2 = H, Me; R3 = H, Me; R4 = Me, allyl; R5 = Et, t-Bu; R6 = Me, Ts, benzenesulfonyl, etc.; R7 = Ac, Boc, Bz, etc.) and pyrrolo[3,4-b]carbazoles II could be synthesized conveniently through sequential reactions of ester-tethered 1-sulfonyl-1,2,3-triazoles III and indoles IV. The reaction conditions were mild and the procedures were quite simple. Moreover, the key intermediate α,β-unsaturated imine acted as a [2C] synthon in the [4 + 2] cycloaddition reaction, and the imino group could be used as a nucleophile to construct the fourth ring. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Application In Synthesis of 1,5-Dimethyl-1H-indole-2-carbaldehyde

The Article related to tetrahydrocarbazole preparation, pyrrolocarbazole preparation, indole ester sulfonyl triazole diels alder reaction, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application In Synthesis of 1,5-Dimethyl-1H-indole-2-carbaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Lv, Honggui; Shi, Jingjing; Wu, Bo; Guo, Yujuan; Huang, Junjun; Yi, Wei published an article in 2017, the title of the article was One-pot synthesis of 2,3-difunctionalized indoles via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization.Recommanded Product: 65417-22-3 And the article contains the following content:

The first Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization of N-arylureas R1NHC(O)R (R = N(CH3)2, NHCH3; R1 = naphth-1-yl, 2-CH3C6H4, 3-ClC6H4, 4-CH3(O)CC6H4, etc.) and α-diazo β-keto esters R2C(O)C(=N2)C(O)R3 [R2 = H, Me, Ph, CH2OCH3, CH2CH3; R3 = C(O)OCH2CH3, C(O)OCH2C6H5, ((OCH3)2)P(O), etc.] was reported. The redox-neutral reaction has the following features: good to excellent yields, broad substrate/functional group tolerance, exclusive regioselectivity, and no need for addnl. oxidants or additives, which render this methodol. as a more efficient and versatile alternative to the existing methods for the synthesis of 2,3-difunctionalized indoles e.g., I. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Recommanded Product: 65417-22-3

The Article related to indole preparation green chem regioselective, arylurea diazo keto ester bond activation cyclization rhodium catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles