Day: December 1, 2022

Tahata, Eiichi published the artcileMetabolism of indole, Product Details of C8H6KNO4S, the publication is Fukuoka Igaku Zasshi (1959), 4751-67, database is CAplus.

Isolated rabbit liver was perfused with heparinized blood containing indole. After 2-hrs. the perfuzate was deproteinized and treated with an aldehyde reagent. The BuOH extract of the colored substance was subjected to paper chromatography in a isoPrOH-H₂O system. The presence of indole, isatin, indican, anthranilic acid, and urochrome in the perfuzate was demonstrated by comparing their values with those of pure compounds The addition of flavine adenine dinucleotide to the perfuzate enlarged the size of the spots of these compounds except indole.

Fukuoka Igaku Zasshi published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C12H14IN, Product Details of C8H6KNO4S.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Sprince, Herbert published the artcileA modified Ehrlich benzaldehyde reagent for detection of indoles on paper chromatograms, Name: Potassium 1H-indol-3-yl sulfate, the publication is Journal of Chromatography (1960), 97-8, database is CAplus.

Indole chromatograms, sprayed first with a 2% solution of p-dimethylaminobenzaldehyde in 12.1N HCl, and, after 2-3 min., with 1% aqueous NaO₂, show deep-blue spots which appear immediately. Indican appears as an orange-brown spot and urea as a large deep-yellow spot. Colors developed with this reagent often persist for at least a month without fading.

Journal of Chromatography published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C65H82N2O18S2, Name: Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Mueting, Dieter published the artcileDisturbances in protein metabolism in renal insufficiency, Recommanded Product: Potassium 1H-indol-3-yl sulfate, the publication is Protides of the Biological Fluids (1962), 148-54, database is CAplus.

Studies were conducted in 129 patients with renal insufficiency resulting from glomerulonephritis and pyelonephritis. Total serum protein and albumin were decreased and α₁-, α₂– and γ-globulins were increased to an extent proportional to the degree of uremia. Tyrosine and tryptophan were elevated in serum, as well as their phenolic and indolyl catabolites. Increased concentrations of the latter were due not only to decreased urinary excretion but also to decrease oxidative processes. Impairment of oxidation reactions in uremia was also reflected by elevation of sulfate esters. Detoxication processes involving glucuronic acid, as well as sulfate conjugation, are impaired which further aggravates the toxic conditions produced by uremia. The most sensitive criteria of incipient renal insufficiency appeared to be the retention of creatinine and indican, obtained by analyses of their serum and urinary levels.

Protides of the Biological Fluids published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Recommanded Product: Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Melzer, Marvin S. published the artcileApplicability of the Hammett equation to the indole system: acidity of indole-3-carboxylic acids, SDS of cas: 10242-03-2, the publication is Journal of Organic Chemistry (1962), 496-9, database is CAplus.

The acidities of six 5- and 6-substituted indole-3-carboxylic acids were determined in aqueous alc. and their pK plotted against the Hammett substituent constants of the resp. substituents. A good correlation was obtained using the one-term Hammett equation (log K/K° = ρσ) using σ_m for groups in the 5-position and σ_p for groups in the 6-position. These results were taken to indicate thai electronic effects were transmitted to the acid center through the C pare to the 6-position and that virtually no transmission occurred through the indole N atom. It was also found that the 5-bromoindole-3-carboxylic acid (I) was somewhat less acidic than expected, an effect attributed to steric and electronic factors. Infrared data indicated that whereas the 6-aminoindole-3-carboxylic acid (II) existed as the free acid, the 5-amino isomer (III) existed in its zwitterionic form. All pK measurements were made in 50% and 95% alc. and the pH measured using a Beckmann meter. Indole treated with MeMgI then CO₂ gave indote-3-carboxylic acid (IV), m. 214° (decomposition). 5-Nitroindote (.5 g.) treated 1 day in a refrigerator with excess (COCl)₂ gave 5 g. 5-nitroindole-3-glyoxylyl chloride (V), m. 310° (decomposition). V refluxed with KOH gave 3.5 g. 5-nitroindole 3-carboxylic acid (VI), m. 270-2° (decomposition). VI (3.5 g.) refluxed 3 hrs. in refluxing 30% H₂O₂, filtered hot, and the solid further purified gave 2.5 g. 5-nitroindole-3-carboxylic acid (VII), m. 276-8° (decomposition). A portion of V treated directly with 30% H₂O₂ gave 47% VII. V failed to undergo decarboxylation in refluxing tetrachloroethane. VII failed to undergo cleavage on treatment with Pb(OAc)₄ in refluxing AcOH. 5-Bromoindole treated with MeMgl and carbonated gave I, m. 238-40° (decomposition). IV in AcOH treated with HNO₃ gave 6-nitroimtole-3-carboxylic acid (VIII), m. 280-1°. Reduction of VIII in MeOH with Raney Ni under 35 lb./sq. in. H pressure gave II. Another preparation using the same procedure gave a small amount of material, m. 197-9°. VI (500 mg.) in MeOH shaken 8 hrs. with Raney Ni under 50 lb./sq. in. H pressure gave 65 mg. III, m. 177-9° (decomposition). The pK of indole-3-carboxylic acids at 26° were obtained (compound, pK in 50% alc., number of determinations, pK in 95% alc., no of determinations, a used, NH (cm.^-1 given): IV, 7.00, 9, 8.92, 3, 0.00, 3247; VIII, 6.45, 3, 8.06, 2, 0.78, 8425; VI, 6.50, 6, 8.15, 3, 0.71, 3338; I, 6.96, 7, 8.72, 3, 0.391, 3310; 5-ethoxyindote-3-carboxylic acid, 6.98, 6, 8.91, 2, 0.10, 3226; II, 7.43, 2, -, -, -0.66, 3312. Reaction constants and precision of correlation of pK of indole-3-carboxylic acids with Hammett substituent constants were given in a table.

Journal of Organic Chemistry published new progress about 10242-03-2. 10242-03-2 belongs to indole-building-block, auxiliary class Indole,Nitro Compound,Carboxylic acid,Indole, name is 6-Nitro-1H-indole-3-carboxylic acid, and the molecular formula is C9H6N2O4, SDS of cas: 10242-03-2.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Matsuda, Kazuhiro published the artcileIndican as a feeding stimulant to the strawberry leaf beetle, Galerucella vittaticollis Baly attacking polygonaceous plants, Computed Properties of 2642-37-7, the publication is Applied Entomology and Zoology (1983), 18(4), 552-4, database is CAplus.

Feeding by G. vittaticollis was stimulated by indicans and K 3-indoxylsulfate at 0.001-0.1M, but not by indoxyl acetate, IAA, indigo, indole, or isatin. Indican was detected in Polygonum tinctorium leaves but not in leaves of other polygonaceous plants or strawberry leaves. Other beetles which feed on polygonaceous plant were not stimulated to feed by indican or related compounds

Applied Entomology and Zoology published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Computed Properties of 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Dittmann, Juergen published the artcileSeparation of phenols and phenol carboxylic acids by thin-layer chromatography on cellulose, Formula: C8H6KNO4S, the publication is Journal of Chromatography (1968), 32(4), 764-8, database is CAplus.

The Rf values and the detection limits are tabulated for the separation of 42 phenols and phenol carboxylic acids for 4 different developing systems by thin-layer chromatog. on cellulose. The use of 4 detection reagents is discussed. 42 references.

Journal of Chromatography published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Formula: C8H6KNO4S.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bryant, W. M. D. published the artcileFurther optical crystallographic studies of biochemical substances, Application of Potassium 1H-indol-3-yl sulfate, the publication is Microscope (1989), 37(3), 233-40, database is CAplus.

The optical crystallog. properties of 7 biochems. compounds were measured. Included are D-ribose and D-deoxyribose, structural elements of common nucleic acids; bilirubin, a blood porphyrin degradation product; glucuronic acid, K indoxyl sulfate (urine indican), and cholic acid, agents in human metabolic processes; and 3-flavonol, the parent substance of a series of bioflavonoids of plant origin, believed to be important in human nutrition. Aside from purely descriptive aspects, attention is given to techniques useful in improving precision of measurement and in extending the range of application of the polarizing microscope in the characterization of crystalline organic compounds

Microscope published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Application of Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bryan, George T. published the artcileA sensitive colorimetric method for the determination of urinary indoxyl sulfate (indican), HPLC of Formula: 2642-37-7, the publication is Analytical Biochemistry (1965), 10(1), 120-34, database is CAplus and MEDLINE.

A new, simple, rapid, and precise colorimetric method for urinary indoxyl sulfate (indican) was described. The method was based on preliminary column chromatography on a cation-exchange resin followed by diazotization and coupling. This method of analysis was compared with 2 other methods that have been used for indican analysis. It was found that 18 adult human subjects excreted 331 ± 144 micromoles (83 ± 36 mg.)/24 hrs. This quantity was several times greater than the amount generally believed to be present in human urine.

Analytical Biochemistry published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, HPLC of Formula: 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Anraku, Takao published the artcileDecomposition of tryptophan by sulfurous acid salt. III. Isolation and structure of a greenish fluorescent product, Recommanded Product: Potassium 1H-indol-3-yl sulfate, the publication is Yakugaku Zasshi (1966), 86(11), 1043-50, database is CAplus and MEDLINE.

cf. preceding abstracts The substance which shows strong green fluorescence in a solution of tryptophan with a sulfite was isolated and presumed to be dehydroindirubin-1′,2,3,3′-tetrasulfonic acid tetra-Na salt (I). I was considered to be an intermediate in the formation of a red precipitate of indirubin from tryptophan. The formation of I explains well the changes of yellow coloration, green fluorescence to precipitation, and quenching of fluorescence to yellow coloration. It was assumed that the process of this decomposition followed hydrolysis of tryptophan to form indole, serine, and alanine, oxidation of indole with concurrent addition of sulfurous acid to form dehydroindigodisulfonic acid and dehydroindirubintetrasulfonic acid, and formation of various decomposition products by catalytic oxidation in the presence of H or OH ion.

Yakugaku Zasshi published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Recommanded Product: Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Prieto, Monica published the artcileArylboronic acids and arylpinacolboronate esters in Suzuki coupling reactions involving indoles. Partner role swapping and heterocycle protection, HPLC of Formula: 642494-36-8, the publication is Journal of Organic Chemistry (2004), 69(20), 6812-6820, database is CAplus and MEDLINE.

Yields of Suzuki couplings involving indoles depended upon (i) whether arylboronic acids or arylpinacolboronate esters were used, (ii) whether the heterocycle was the aryl halide or the arylboron coupling partner, and (iii) whether the heterocycle was protected or not. Highest yields, which were unaffected by incorporating Boc or Tos protection at the heterocyclic nitrogen, were obtained when indole bromides were reacted with phenylboronic acids. When indolylboronic acids were reacted with Ph bromides, yields were somewhat lower and depended on the nitrogen substituent, being highest in the absence of protection, lower in the presence of the Boc group, and lowest of all with the Tos group. Arylpinacolboronate esters were less reactive than arylboronic acids. They required considerably longer reaction times and furnished generally lower yields of biaryl, e.g., I. Furthermore, irresp. of whether the heterocycle was the aryl bromide or the arylpinacolboronate ester, these yields were highest when it was protected with the Tos group. Yields were lower with the Boc group, and unprotected heterocycles gave only traces of biaryl. Careful selection of arylboron reagent, of coupling partner roles, and of protecting groups were essential to ensuring optimum results in these Suzuki couplings.

Journal of Organic Chemistry published new progress about 642494-36-8. 642494-36-8 belongs to indole-building-block, auxiliary class Indole,Boronic acid and ester,Indole,Boronate Esters,Boronic acid and ester, name is 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole, and the molecular formula is C14H18BNO2, HPLC of Formula: 642494-36-8.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles