Month: February 2023

Organic Single-Crystal Actuators and Waveguides that Operate at Low Temperatures was written by Lan, Linfeng;Li, Liang;Di, Qi;Yang, Xuesong;Liu, Xiaokong;Naumov, Pance;Zhang, Hongyu. And the article was included in Advanced Materials (Weinheim, Germany) in 2022.Name: 5-Methoxy-1H-indole-3-carbaldehyde This article mentions the following:

Applications in extreme conditions, such as those encountered in space exploration, require lightweight materials that can retain their elasticity in extremely cold environments. However, cryogenic treatment of most soft polymeric and elastomeric materials results in complete loss of their ability for elastic flow, whereby such materials that are normally ductile become stiff, brittle, and prone to cracking. Here, a facile method for preparation of hybrid organic crystalline materials that are not only cryogenically robust but are also capable of large, recoverable, and reversible deformation at low temperatures is reported. To that end, flexible organic crystals are first mech. reinforced by a polymer coating and combined with a thermally responsive polymer. The resulting hybrid materials respond linearly and reversibly to temperatures from -15 to -120掳 C without fatigue in air as well as in cold vacuum. The approach proposed here not only circumvents one of the main drawbacks that are inherent to the amorphous nature and has thus far limited the applications of polymeric materials at low temperatures, but it also provides a cost-effective access to a myriad of lightweight sensing, electronic, optical or actuating devices that can operate in low-temperature environmental settings. In the experiment, the researchers used many compounds, for example, 5-Methoxy-1H-indole-3-carbaldehyde (cas: 10601-19-1Name: 5-Methoxy-1H-indole-3-carbaldehyde).

5-Methoxy-1H-indole-3-carbaldehyde (cas: 10601-19-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Name: 5-Methoxy-1H-indole-3-carbaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Comparison of the reducing effects of blueberry and propolis extracts on heterocyclic aromatic amines formation in pan fried beef was written by Gumus, Damla;Kizil, Mevlude. And the article was included in Meat Science in 2022.Recommanded Product: 244-63-3 This article mentions the following:

This study was aimed to examine the effects of natural antioxidant-based marinades on the formation of heterocyclic aromatic amines (HAAs) in cooked beef. Samples were marinated overnight with different concentrations (0, 0.25, 0.5 and 1%) of blueberry or propolis extracts, and pan fried at 150 and 200掳C for a total of 10 min. Individual and total HAAs were detected at different levels according to the cooking temperature, extract type and concentration Total HAA levels increased as the cooking temperature increased (P < 0.01), and ranged from non detectable levels to 38.27 ng/g across all samples analyzed. Mitigation up to 61.2% and 100% in total HAA levels were achieved by propolis and blueberry extracts, resp. The inhibitory effects of blueberry extract on total HAAs formation were significantly higher than propolis extract (P < 0.01). Thereby, this study showed that natural antioxidant-based marinades containing blueberry and propolis extracts had mitigating effects on HAAs formation in beef samples pan-fried at 150 and 200掳C. In the experiment, the researchers used many compounds, for example, 9H-Pyrido[3,4-b]indole (cas: 244-63-3Recommanded Product: 244-63-3).

9H-Pyrido[3,4-b]indole (cas: 244-63-3) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: 244-63-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

“Conformation Locked” Strong Electron-Deficient Poly(p-Phenylene Vinylene) Derivatives for Ambient-Stable n-Type Field-Effect Transistors: Synthesis, Properties, and Effects of Fluorine Substitution Position was written by Lei, Ting;Xia, Xin;Wang, Jie-Yu;Liu, Chen-Jiang;Pei, Jian. And the article was included in Journal of the American Chemical Society in 2014.Related Products of 1336963-95-1 This article mentions the following:

The charge carrier mobility of p-type and ambipolar polymer field-effect transistors (FETs) was improved substantially. Nonetheless, high-mobility n-type polymers are rare, and few can be operated under ambient conditions. This situation is mainly caused by the scarcity of strong electron-deficient building blocks. Herein, the authors present two novel electron-deficient building blocks, FBDOPV-1 and FBDOPV-2, with low LUMO levels down to -4.38 eV. From both building blocks, the authors develop two poly(p-phenylene vinylene) derivatives (PPVs), FBDPPV-1 and FBDPPV-2, for high-performance n-type polymer FETs. The introduction of the fluorine atoms effectively lowers the LUMO levels of both polymers, leading to LUMO levels 鈮?4.30 eV. Fluorination endows both polymers with not only lower LUMO levels, but also more ordered thin-film packing, smaller 蟺-蟺 stacking distance, stronger interchain interaction and locked conformation of polymer backbones. All these factors provide FBDPPV-1 with high electron mobilities up to 1.70 cm² V^-1 s^-1 and good stability under ambient conditions. Also, when polymers have different fluorination positions, their backbone conformations in solid state differ, eventually leading to different device performance. In the experiment, the researchers used many compounds, for example, 6-Bromo-7-fluoroindoline-2,3-dione (cas: 1336963-95-1Related Products of 1336963-95-1).

6-Bromo-7-fluoroindoline-2,3-dione (cas: 1336963-95-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Related Products of 1336963-95-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Palladium-Catalyzed C-H Ethoxycarbonyldifluoromethylation of Electron-Rich Heteroarenes was written by Shao, Changdong;Shi, Guangfa;Zhang, Yanghui;Pan, Shulei;Guan, Xiaohong. And the article was included in Organic Letters in 2015.Formula: C12H14N2O This article mentions the following:

The first Pd-catalyzed C-H ethoxycarbonyldifluoromethylation with BrCF₂CO₂Et has been developed. The use of a bidentate phosphine ligand (Xantphos) is critical for the reaction to occur. A variety of electron-rich heteroarenes, including indoles, furans, thiophenes, and pyrroles, can be ethoxycarbonyldifluoromethylated in moderate to excellent yields. The reactions take place at the C-H bonds adjacent to the heteroatoms with high regioselectivity. This method provides a new protocol for the introduction of difuoroalkyl groups into electron-rich heteroarenes. In the experiment, the researchers used many compounds, for example, N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3Formula: C12H14N2O).

N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Formula: C12H14N2O

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Oxidation of 1-acylindoles with oxodiperoxomolybdenum (VI), peroxomolybdenum.HMPA. Preparation of 2,3-dihydroxyindoline and indoxyl derivatives was written by Chien, Chun Sheng;Suzuki, Takako;Kawasaki, Tomomi;Sakamoto, Masanori. And the article was included in Chemical & Pharmaceutical Bulletin in 1984.Recommanded Product: 1-Acetylindolin-3-one This article mentions the following:

The oxidation of 1-acylindoles with MoO₅.HMPA, in dry methanol gives a variety of products depending on the indole substituents; trans (I)- and cis (II)-1-acyl-3-hydroxy-2-methoxyindolines are obtained from 2,3-unsubstituted 1-acylindoles, 1-acetyl-2-hydroxy-3-methoxy-3-methylindoline (III) from 1-acetyl-3-methylindole, 1-acetyl-2,3-dihydroxy-2,3-dimethylindoline from 1-acetyl-2,3-dimethylindole, and 1-acetyl-2-hydroxy-2-methylindoxyl from 1-acetyl-2-methylindole. Reaction of I and II with acids gives 1-acylindoxyl while reaction of III with the acid gives 3-methyloxindole. Treatment of 3-acetoxy-1-acetyl-2-methoxyindoline with SnCl₄ gives 1-acetylindoxyl and 1-acetyl-3-chloroindole. In the experiment, the researchers used many compounds, for example, 1-Acetylindolin-3-one (cas: 16800-68-3Recommanded Product: 1-Acetylindolin-3-one).

1-Acetylindolin-3-one (cas: 16800-68-3) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Recommanded Product: 1-Acetylindolin-3-one

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Novel dimeric leuco-TAM dyes, 1,4-bis{(1E,3Z)-1,3-bis(1,3,3-trimethylindolin-2-ylidene)propan-2-yl}benzene derivatives: Structure and spectroscopic characterization was written by Keum, Sam-Rok;Ma, So-Young;Kim, Do-Kyung;Lim, Hyun-Woo;Roh, Se-Jung. And the article was included in Journal of Molecular Structure in 2012.Product Details of 6872-17-9 This article mentions the following:

Novel dimeric leuco-triarylmethane (LTAM) dyes, 1,4-bis{(1E,3Z)-1,3-bis(1,3,3-trimethylindolin-2-ylidene)propan-2-yl}benzene derivatives, as precursors of dimeric TAM⁺ and TAM⁺⁺ dyes, were synthesized and characterized by 1D and 2D NMR experiments including DEPT, COSY, HSQC, HMBC and NOESY. Judging from the 1H NMR anal., the dimeric LTAM mols. were suggested to have a dual-propeller shaped structure. For the prepared dimeric leuco-TAM dyes, the ZE/EZ isomers were formed as the sole products from the reaction of 2-3 M excess Fischer base and terephthalaldehyde in absolute ethanol. The ZE/EZ isomers were equilibrated with other diastereomers (EE/EE and ZZ/ZZ) in organic solvents. UV-Vis spectroscopy of dimeric TAM⁺⁺ dyes in organic solvents show an absorption band at >700 nm in the near-IR (NIR) region. Formation of the dimeric TAM⁺⁺ mols. was further confirmed by comparison of CV diagrams for monomeric TAM⁺ and dimeric TAM⁺⁺ mols. In the experiment, the researchers used many compounds, for example, 5-Chloro-1,3,3-trimethyl-2-methyleneindoline (cas: 6872-17-9Product Details of 6872-17-9).

5-Chloro-1,3,3-trimethyl-2-methyleneindoline (cas: 6872-17-9) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Product Details of 6872-17-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I₂-Triggered N-O cleavage of ketoxime acetates for the synthesis of 3-(4-pyridyl)indoles was written by Gao, Qinghe;Wang, Yakun;Wang, Qianqian;Zhu, Yanping;Liu, Zhaomin;Zhang, Jixia. And the article was included in Organic & Biomolecular Chemistry in 2018.Computed Properties of C10H9NO2 This article mentions the following:

Synthesis of 3-(4-pyridyl)indole derivatives I (R = H, 5-OCH₂C₆H₅, 6-F, 7-NO₂, etc.; R¹ = H, CH₃; Ar = C₆H₅, 2H-1,3-benzodioxol-5-yl, naphthalen-2-yl, etc.) and II from a facile and complementary [3+2+1] annulation of aryl ketoxime acetates Ar(CH₃)C=NOC(O)CH₃ and 1,2,3,4-tetrahydronaphthalen-1-ylideneamino acetate and 3-formylindoles III is reported. The condensation reaction demonstrated that I₂ was capable of triggering N-O bond cleavage of ketoxime acetates to generate iminyl radicals via a single electron transfer pathway. This direct and operationally simple protocol provides a fundamental platform to synthesize 3-(4-pyridyl)indole derivatives I and II with high functional group compatibility and high regioselectivity. In the experiment, the researchers used many compounds, for example, 5-Methoxy-1H-indole-3-carbaldehyde (cas: 10601-19-1Computed Properties of C10H9NO2).

5-Methoxy-1H-indole-3-carbaldehyde (cas: 10601-19-1) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Computed Properties of C10H9NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Auxin production of the filamentous cyanobacterial Planktothricoides strain isolated from a polluted river in Vietnam was written by Duong, Thi Thuy;Nguyen, Thi Thu Lien;Dinh, Thi Hai Van;Hoang, Thi Quynh;Vu, Thi Nguyet;Doan, Thi Oanh;Dang, Thi Mai Anh;Le, Thi Phuong Quynh;Tran, Dang Thuan;Le, Van Nhan;Nguyen, Quang Trung;Le, Phuong Thu;Nguyen, Trung Kien;Pham, Thi Dau;Bui, Ha Manh. And the article was included in Chemosphere in 2021.Product Details of 830-96-6 This article mentions the following:

Cyanobacteria are photosynthetic microorganisms with widespread diversity and extensive global distribution. They produce a wide variety of bioactive substances (e.g., lipopeptides, fatty acids, toxins, carotenoids, vitamins and plant growth regulators) that are released into culture media. In this study, the capability of a cyanobacterial strain of Planktothricoides raciborskii to produce intra- and extracellular auxins was investigated. The filamentous cyanobacterial P. raciborskii strain was isolated from a river in Vietnam, and it was cultivated in the laboratory under the optimum conditions of the BG11 culture medium and a pH of 7.0. The auxins were identified and quantified by the Salkowski colorimetric method and high-performance liquid chromatog. coupled with mass spectrometry (HPLC-MS). Colorimetric anal. revealed that P. raciborskii produces extracellular indole-3-acetic acid (IAA) in the absence and presence of L-tryptophan. The maximum extracellular IAA concentration of the culture reached 118 卤 2渭g mL^-1, which was supplemented with 900渭g mL^-1 of L-tryptophan. HPLC-MS anal. revealed that the isolated cyanobacteria accumulate other plant-growth-promoting hormones besides IAA, such as indole-3-carboxylic acid (ICA), indole-3 butyric acid (IBA) and indole propionic acid (IPA). This is the first report on the production of auxins in an isolated strain of cyanobacteria Planktothricoides from a polluted river. The capability of producing auxins makes the P. raciborskii strain an appropriate candidate for the formulation of a biofertilizer. In the experiment, the researchers used many compounds, for example, 3-Indolepropionic acid (cas: 830-96-6Product Details of 830-96-6).

3-Indolepropionic acid (cas: 830-96-6) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Product Details of 830-96-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Hydrogen-rich water can reduce the formation of biogenic amines in butter was written by Bulut, Menekse;Celebi Sezer, Yasemin;Ceylan, M. Murat;Alwazeer, Duried;Koyuncu, Mubin. And the article was included in Food Chemistry in 2022.Reference of 61-54-1 This article mentions the following:

The formation of biogenic amines in food products forms a serious challenge for food producers and a hazard for consumers. Butter was washed by hydrogen-rich water (HRW) prepared using two methods, i.e. hydrogen-bubbled water (H2 water) and magnesium-incorporated water (Mg water). After 90 days of storage, the lowest formation levels of biogenic amines were shown for butter samples washed with HRW (H2 water and Mg water), while the highest levels were identified for the butter samples washed with normal water. Washing raw butter with HRW led to a significant decrease in tryptamine, 2-phenylethylamine, spermidine, and spermine formation. The lowest histamine level was shown for butter samples washed with H2 and Mg, while the highest level was found for butter washed with normal water. Washing butter with HRW revealed no inhibiting effect on yogurt bacteria during storage. The proposed method involves mol. hydrogen which is non-toxic for humans and the environment. In the experiment, the researchers used many compounds, for example, 2-(1H-Indol-3-yl)ethanamine (cas: 61-54-1Reference of 61-54-1).

2-(1H-Indol-3-yl)ethanamine (cas: 61-54-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Reference of 61-54-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles