A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C9H8BrN, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 10075-52-2, Name is 5-Bromo-1-methyl-1H-indole, molecular formula is C9H8BrN. In a Article, authors is Xie, Fuchun，once mentioned of 10075-52-2
Figure Presented. Members of a series of 2,4,5-substituted pyrimidine derivatives were synthesized, and their interactions with tubulin and their antiproliferative activities against the human hepatocellular carcinoma cells of liver (BEL-7402) were evaluated. One member of this family, the indole-pyrimidine 4k, having an indole-aryl-substituted aminopyrimidine structure, was observed to be an excellent inhibitor of tubulin polymerization (IC50 = 0.79 muM) and to display significantly high antiproliferative activities against several cancer cell lines with IC 50 values ranging from 16 to 62 nM. This substance displayed a high propensity to arrests cells at the G2/M phase of the cell cycle (EC50 = 20 nM). In addition, 4k was found to competitively inhibit colchicine binding to tubulin, indicating that it binds to the colchicine-binding site of tubulin. The observations made in this investigation demonstrate that 2,4,5-substituted pyrimidines represent a new class of tubulin polymerization inhibitors with significant antiproliferative activity.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 10075-52-2, help many people in the next few years.COA of Formula: C9H8BrN
Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles