Quality Control of 4′-Hydroxyacetophenone. Gong, YH; Abyaneh, HS; Drossis, N; Niederquell, A; Kuentz, M; Leroux, JC; de Haan, HW; Gauthier, MA in [Gong, Yuhui; Leroux, Jean-Christophe] Swiss Fed Inst Technol Zurich ETHZ, Dept Chem & Appl Biosci, Inst Pharmaceut Sci, Vladimir Prelog Weg 3, CH-8093 Zurich, Switzerland; [Abyaneh, Hoda Soleymani; Gauthier, Marc A.] INRS, EMT Res Ctr, 1650 Boul Lionel Boulet, Varennes, PQ J3X 1S2, Canada; [Drossis, Nicole; de Haan, Hendrick W.] Univ Ontario Inst Technol, Fac Sci, Oshawa, ON L1H 7K4, Canada; [Niederquell, Andreas; Kuentz, Martin] Univ Appl Sci Northwestern Switzerland, Sch Life Sci, Inst Pharma Technol, Hofackerstr 30, CH-4132 Muttenz, Switzerland published Ultra-sub-stoichiometric Dynamic Bioconjugation Reduces Viscosity by Disrupting Immunoglobulin Oligomerization in 2019.0, Cited 38.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.
Monoclonal antibodies (mAb) are a major focus of the pharmaceutical industry, and polyclonal immunoglobulin G (IgG) therapy is used to treat a wide variety of health conditions. As some individuals require mAb/IgG therapy their entire life, there is currently a great desire to formulate antibodies for bolus injection rather than infusion. However, to achieve the required doses, very concentrated antibody solutions may be required. Unfortunately, mAb/IgG self-assembly at high concentration can produce an unacceptably high viscosity for injection. To address this challenge, this study expands the concept of dynamic covalent chemistry to dynamic bioconjugation in order to reduce viscosity by interfering with antibody-antibody interactions. Ultra-sub-stoichiometric amounts of dynamic PEGylation agents (down to the nanomolar) significantly reduced the viscosity of concentrated antibody solutions by interfering with oligomerization.
Quality Control of 4′-Hydroxyacetophenone. Welcome to talk about 99-93-4, If you have any questions, you can contact Gong, YH; Abyaneh, HS; Drossis, N; Niederquell, A; Kuentz, M; Leroux, JC; de Haan, HW; Gauthier, MA or send Email.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles