In 2020.0 BIOORG CHEM published article about IN-VITRO ANTIOXIDANT; 1,3-DIPOLAR CYCLOADDITION; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; CHIRAL NITRONES; RESOLUTION; ANALOGS in [Ghabi, Ameni; Brahmi, Jihed; Aouadi, Kaiss] Univ Monastir, Fac Sci Monastir, Lab Heterocycl Chem Nat Prod & React, Ave Environm, Monastir 5019, Tunisia; [Alminderej, Fahad; Messaoudi, Sabri; Aouadi, Kaiss] Qassim Univ, Coll Sci, Dept Chem, Buraydah 51452, Saudi Arabia; [Messaoudi, Sabri] Carthage Univ, Fac Sci Bizerte, Jarzouna 7021, Tunisia; [Vidal, Sebastien] Univ Claude Bernard Lyon 1, Univ Lyon, Inst Chim & Biochim Mol & Supramol, UMR CNRS 5246,Lab Chim Organ Glycochim 2, Batiment Lederer,1 Rue Victor Grignard, F-69622 Villeurbanne, France; [Kadri, Adel] Sfax Univ, Fac Sci Sfax, Dept Chem, BP 1171, Sfax 3000, Tunisia; [Kadri, Adel] Albaha Univ, Coll Sci & Arts Baljurashi, POB 1988, Albaha, Saudi Arabia in 2020.0, Cited 31.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Quality Control of 3-Hydroxybenzaldehyde
A series of novel isoxazolidines based on benzaldehyde derivatives have been synthesized from the cycloaddition of chiral menthone-based nitrone and allyl phenyl ethers. All synthetic compounds were assessed for their in vitro PPA, HPA and HLAG inhibitory activity. The results revealed that all targets exhibited better inhibitory effect against PPA (12.3 +/- 0.4 < IC50 < 38.2 +/- 0.9 mu M), HPA (10.1 +/- 0.4 < IC50 < 26.8 +/- 0.2 mu M) and HLAG (65.4 +/- 1.2 < IC50 < 274.8 +/- 1.1 mu M) when compared with the reference inhibitor, acarbose (IC50 = 284.6 +/- 0.3 mu M for PPA, 296.6 +/- 0.8 mu M for HPA, 780.4 +/- 0.3 mu M for HLAG) with the highest PPA inhibitory activity was ascribed to compound 3g against both PPA and HPA, and 3b against HLAG enzymes, respectively. Structural activity relationships (SARs) were also established for all synthesized compounds and the interaction modes of the most potent inhibitors (3g for PPA and HPA, 3b for HLAG) and the active site with residues of three enzymes were confirmed through molecular docking studies. Furthermore, a combination of molecular docking analysis with the in vitro activities can help to improve prediction success and encourages the uses of some of these molecules as potential alternatives toward the modulation of T2D. Quality Control of 3-Hydroxybenzaldehyde. Welcome to talk about 100-83-4, If you have any questions, you can contact Ghabi, A; Brahmi, J; Alminderej, F; Messaoudi, S; Vidal, S; Kadri, A; Aouadi, K or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles