An article Design, Synthesis, and Activity Study of Water-Soluble, Rapid-Release Propofol Prodrugs WOS:000555502600024 published article about PHARMACOKINETICS; ANESTHESIA; SAFETY in [Liu, Liang-Quan; Hong, Pei-Xi; Song, Xing-Hai; Zhou, Chang-Cui; Ling, Rui; Kang, Yi; Yang, Jun] Sichuan Univ, West China Hosp, Dept Anesthesiol,Lab Anesthesia & Crit Care Med, Translat Neurosci Ctr, Chengdu 610041, Peoples R China; [Liu, Liang-Quan; Qi, Qing-Rong] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist,Sichuan Engn Lab Plant Sourced Drug, Chengdu 610041, Peoples R China; [Liu, Liang-Quan; Qi, Qing-Rong] Sichuan Univ, West China Sch Pharm, Sichuan Res Ctr Drug Ind Technol, Sichuan Res Ctr Precis Engn Technol Small Mol Dru, Chengdu 610041, Peoples R China in 2020.0, Cited 23.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Safety of Benzyl Alcohol
In this work, a series of water-soluble propofol prodrugs were synthesized, and their propofol release rate and pharmacodynamic characteristics were measured. We found that inserting glycolic acid as a linker between propofol and the cyclic amino acid accelerated the release of propofol from prodrugs into the plasma while preserving its safety. In animal experiments, prodrugs (3e, 3g, and 3j) were significantly better than fospropofol (the only water-soluble propofol prodrug that has been used clinically) in terms of safety, onset, and duration time of anesthesia. Their molar dose, onset time, and anesthesia duration time were comparable to those of propofol, helping to maintain the clinical benefits of propofol. The experimental results showed the potential of such compounds as water-soluble prodrugs of propofol.
Bye, fridends, I hope you can learn more about C7H8O, If you have any questions, you can browse other blog as well. See you lster.. Safety of Benzyl Alcohol
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles