An article Design, synthesis, and evaluation of a water soluble C5-monoketone type curcumin analogue as a potent amyloid beta aggregation inhibitor WOS:000480235700028 published article about ALZHEIMERS; OLIGOMERS; NEURODEGENERATION; BIOAVAILABILITY; DYSFUNCTION; FIBRILS in [Hotsumi, Mayumi; Tajiri, Misato; Nikaido, Yuri; Sato, Taki; Makabe, Koki; Konno, Hiroyuki] Yamagata Univ, Grad Sch Sci & Engn, Dept Biochem Engn, Yonezawa, Yamagata 9928510, Japan in 2019.0, Cited 25.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Category: indole-building-block
A structure activity relationship study of curcumin analogues for the inhibition of amyloid beta aggregation is described. Optimization of the o-phenol and olefin spacer resulted in the identification of the C5-monoketone type curcumin analogue AY1319, which exhibited potent anti-amyloid beta aggregation activity (leading to nanorod-like fragments), sufficient water solubility, and low cytotoxicity.
Category: indole-building-block. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Hotsumi, M; Tajiri, M; Nikaido, Y; Sato, T; Makabe, K; Konno, H or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles