Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 125872-95-9, Name is 6-Bromo-1-methyl-1H-indole,introducing its new discovery., 125872-95-9
Palladium-Catalyzed alpha-Arylation of Vinylogous Esters for the Synthesis of gamma,gamma-Disubstituted Cyclohexenones
A palladium-catalyzed alpha-arylation of cyclic vinylogous esters to form products that are converted in one step to gamma-alkyl-gamma-aryl-substituted cyclohexenones is reported. This Pd-catalyzed reaction proceeds at room temperature, is generally high-yielding, and uses an amount of a commercially available catalyst as low as 0.25 mol %. The scope of aryl bromides is particularly broad, and alkenyl bromides can also be used. This two-step protocol, comprising alpha-arylation and reductive transposition, can be performed in one pot and is applicable to gram-scale synthesis.
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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles