With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.883526-76-9,1,5-Dimethyl-1H-indole-2-carbaldehyde,as a common compound, the synthetic route is as follows.,883526-76-9
General procedure: 1-methyl-1H-indole-2-carbaldehyde (6.3 mmol) wasdissolved in 20 mL of toluene. (Triphenylphosphoranylidene)-2-propanone (9.4mmol) was added and the mixture was heated at 120 C for 12 h. After cooling,the solvent was removed in vacuo. Then the residue was poured into ether andfiltered to remove Ph3P=O. The filtrate was concentrated and theresidue was purified by column chromatography (petroleum ether : ethyl acetate= 10:1 to 8:1) to give the product 1
883526-76-9 1,5-Dimethyl-1H-indole-2-carbaldehyde 23004693, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Article; Su, Tao; Han, Xiuling; Lu, Xiyan; Tetrahedron Letters; vol. 55; 1; (2014); p. 27 – 30;,
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