With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2795-41-7,6-Fluoroindole-3-carboxaldehyde,as a common compound, the synthetic route is as follows.
To a stirring solution of 6-fluoro- ?H-indole-3 -carbaldehyde SM 1 (1 .0 g, 6 mmol) in 50% EtOH/H20 (20 mL) was added (NH4)2C03 (3.0 g, 30 mmol) followed by potassium cyanide (0.6 g, 9 mmol) at room temperature. The reaction mixture was heated to 75 C for 18 h. After consumption of the starting material (by TLC), the reactionmixture was diluted with water and extracted with EtOAc. Combined organic extracts weredried over anhydrous Na2504 and concentrated under reduced pressure to obtain crudeproduct, which was purified by silica gel column chromatography eluting with 10%MeOH/DCM to afford compound 1(0.67 g, 47 %) as a white solid. LC-MS: m/z = 234.1[(M+1)].
2795-41-7, As the paragraph descriping shows that 2795-41-7 is playing an increasingly important role.
Reference：
Patent; ABBVIE INC.; KESICKI, Edward A.; WANG, Ce; PATANE, Michael A.; KLUGE, Arthur F.; VAN DRIE, JR., John H.; (121 pag.)WO2016/44777; (2016); A1;,
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