14618-45-2, As the paragraph descriping shows that 14618-45-2 is playing an increasingly important role.
14618-45-2, 3-(Trifluoroacetyl)indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a chilled (-780C) solution of 241 mg (1.13 mmol) of 2,2,2-trifluoro-l-(lH-indol-3- yl)ethanone in 5 mL of anhydrous TetaF was added 45 mg (1.13 mmol) of 60% NaH in mineral oil. In another flask, 452 muL (1.13 mmol) of n-BuLi was then added to a chilled (-780C) solution of 310 mg (1.13 mmol) of 5-bromo-l-pyridin-3-yl-lH-indazole in 10 mL of TetaF. After 1 minute, the sodium salt of 2,2,2-trifluoro-l-(lH-indol-3-yl)ethanone was added to the indazole anion via a cannula. After 1 hour, the mixture was diluted with 25 mL of saturated aqueous ammonium chloride and extracted with three 15 mL portions of ethyl acetate. The combined organic layers were washed with three 10 mL portions of brine, dried over magnesium sulfate, filtered and concentrated. The crude material was purified using Combiflash chromatography using EtOAc -hexanes (0-70% gradient) to afford 45 mg (10%) of 2,2,2-trifluoro-l-(lH-indol-3-yl)-l-(l-pyridin-3-yl-lH-indazol-5-yl)ethanol as a colorless solid.
14618-45-2, As the paragraph descriping shows that 14618-45-2 is playing an increasingly important role.
Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/70507; (2008); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles