5192-03-0, 1H-Indol-5-amine is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of intermediate 16 (156?mg, 1.182?mmol, 1.0 equiv) and triethylamine (591?muL, 429?mg, 4.240?mmol, 3.6 equiv) in DCM (10?mL), acetyl chloride (101?muL, 111?mg, 1.418?mmol, 1.2 equiv) was added. The reaction was stirred at room temperature for 3?h. The mixture was poured into water and extracted with dichloromethane 3 times. The combined organic layer was washed with brine, dried over anhydrous sodium sulphate and concentrated in vacuo. Purification by flash silica gel column chromatography (7:3 hexane/ethyl acetate) afforded intermediate 7g as a clear oil (177?mg, 1.016?mmol). Yield: 85%. 1H NMR (400?MHz, CDCl3) delta 8.27 (bs, 1H), 7.80 (s, 1H), 7.30 (d, J?=?8.5?Hz, 2H), 7.20 (dd, J?=?8.8, 2.0?Hz, 2H), 6.50 (s, 1H), 2.18 (s, 3H).
5192-03-0, 5192-03-0 1H-Indol-5-amine 78867, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Article; See, Cheng Shang; Kitagawa, Mayumi; Liao, Pei-Ju; Lee, Kyung Hee; Wong, Jasmine; Lee, Sang Hyun; Dymock, Brian W.; European Journal of Medicinal Chemistry; vol. 156; (2018); p. 344 – 367;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles