With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14618-45-2,3-(Trifluoroacetyl)indole,as a common compound, the synthetic route is as follows.
A mixture of 2,2,2-trifluro-1 H-indol-3-yl)ethanone (0.55 g, 2.58 mmol), K2CO3 (0.43 g, 3.1 1 mmol) and propyrgyl bromide (2 ml) was stirred in anhydrous DMF (8 ml) for 4 h. The mixture was quenched with aqueous NH4CI and diluted to 50 ml with EtOAc. The organic layer was separated, washed with w H2O, dried over MgSO4 and filtered. The filtrate was evaporated to dryness to give the product (0.57 g; 87%), as yellow solid. 1 H-NMR (CDCI3) 2.58 (tr, 1 H, J = 2.55 Hz); 4.96 (d, 2H, J = 2.55 Hz); 7.48 – 7.31 (m, 3H); 7.99 (s, 1 H); 8.41 – 8.38 (m, 1 H)., 14618-45-2
As the paragraph descriping shows that 14618-45-2 is playing an increasingly important role.
Reference：
Patent; AKAAL PHARMA PTY LTD; GILL, Gurmit, S.; GROBELNY, Damian, W.; WO2010/42998; (2010); A1;,
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