Electric Literature of 19012-03-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.19012-03-4, Name is 1-Methyl-1H-indole-3-carbaldehyde, molecular formula is C10H9NO. In a Article£¬once mentioned of 19012-03-4
PPh3-catalyzed knoevenagel condensation: A facile synthesis of 5-(1H-indol-3-yl)meth-ylene)-2, 2-dimethyl-1, 3-dioxane-4, 6-dione, and their N-alkyl derivatives by using peg-600 as the reaction medium
Triphenylphosphine (TPP) has been utilized as a novel and efficient catalyst for the Knoevenagel condensation of indole-3-carboxaldehydes 1(a-e), 1-methyl-1H-indole-3-carboxaldehydes 4(a-e), and 1-ethyl-1H-indole-3- carboxaldehydes 6(a-e) with the active methylene compound, that is, meldrum’s acid (2), to afford substituted derivatives 5-((1H-indol-3-yl) methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 3(a-e), 2,2-dimethyl-5-((1-methyl- 1H-indol-3-yl)methylene)-1,3-dioxane-4,6-dione 5(a-e), and 2,2-dimethyl-5-((1- ethyl-1H-indol-3-yl)methylene)-1,3-dioxane-4,6-dione 7(a-e), respectively, in ethanol medium at RT just within 1 h in excellent yields. The products 3(a-e) were reacted independently with alkylating agents, that is, DMS and DES in the presence of PEG-600 as an efficient and green solvent, to afford the corresponding N-substituted methyl and ethyl derivatives 5(a-e) and 7(a-e), respectively.
The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 19012-03-4 is helpful to your research. Electric Literature of 19012-03-4
Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles