With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.227960-12-5,Methyl 5-methylindole-3-carboxylate,as a common compound, the synthetic route is as follows.
Description 20Methyl 5-methyl-1 -(2-methylpropyl)-1 H-indole-3-carboxylate (D20)Methyl 5-methyl-IH-indole-S-carboxylate (may be prepared as described in D19) dissolved in DMF. K2CO3 and isobutyl bromide added and mixture heated at 6O0C. Further isobutyl bromide added after ~8h, 24.5h and 3Oh. Reaction stopped after 32h. Partitioned between H2O and Et2O. Layers separated and aqueous phase extracted further with Et2O. Organic layers combined, dried (Na2SO4), filtered and cone, to give a brown oil which was purified by chromatography on silica gel with hexane + EtOAc (5-30%) as eluent to give the title compound (1.107Og). LCMS Rt 3.41 min [ES+] 246., 227960-12-5
As the paragraph descriping shows that 227960-12-5 is playing an increasingly important role.
Reference：
Patent; GLAXO GROUP LIMITED; WO2008/6794; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles