1186663-64-8, 3-Bromo-1H-indole-4-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1186663-64-8, Step 2: Preparation of Intermediate 3-Bromo-1-methyl-1H-indole-4-carbonitrile (I-146b)3-Bromo-1H-indole-4-carbonitrile (I-146a: 500 mg, 2.272 mmol) was added dropwise to a stirred mixture of NaH (0.218 g, 9.0833 mmol) in dry DMF (15 mL) at 0 C. over a period of 10 minutes. This was followed by the addition of methyl iodide and the resulting mixture was stirred at 0 C. for 2 hours. The reaction was monitored by TLC (10% ethylacetate in hexane). The reaction mixture was quenched with ice water; the precipitate formed was collected and dried to afford 0.400 g of the crude product.1H NMR (CDCl3, 300 MHz): delta 7.8-7.0 (m, 4H), 3.82 (s, 3H)
As the paragraph descriping shows that 1186663-64-8 is playing an increasingly important role.
Reference：
Patent; Novartis AG; US2010/331326; (2010); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles